Geoffrey K Isbister

Summary

Affiliation: Newcastle Mater Misericordiae Hospital
Country: Australia

Publications

  1. ncbi request reprint Spider bites: addressing mythology and poor evidence
    Geoffrey K Isbister
    Am J Trop Med Hyg 72:361-4; author reply 364-7. 2005
  2. pmc Pharmacokinetic-pharmacodynamic modelling of QT interval prolongation following citalopram overdoses
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Br J Clin Pharmacol 61:177-90. 2006
  3. pmc Snake antivenom research: the importance of case definition
    G K Isbister
    Charles Darwin University, Darwin and Newcastle Mater Hospital, Newcastle, Australia
    Emerg Med J 22:399-400. 2005
  4. doi request reprint Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal
    Geoffrey K Isbister
    aDepartment of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, Australia
    Int Clin Psychopharmacol 24:174-80. 2009
  5. pmc Alprazolam is relatively more toxic than other benzodiazepines in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 58:88-95. 2004
  6. ncbi request reprint Serotonin toxicity: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 187:361-5. 2007
  7. ncbi request reprint Black house spiders are unlikely culprits in necrotic arachnidism: a prospective study
    G K Isbister
    Clinical Envenoming Research Group, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, Australia
    Intern Med J 34:287-9. 2004
  8. ncbi request reprint Clinical consequences of spider bites: recent advances in our understanding
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, Newcastle, NSW 2298, Australia
    Toxicon 43:477-92. 2004
  9. ncbi request reprint Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle and Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Clin Pharmacol Ther 81:821-7. 2007
  10. ncbi request reprint Spotted black snake (Pseudechis guttatus) envenoming
    Melanie Jansen
    School of Medical Practice and Population Health, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 186:41-2. 2007

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Spider bites: addressing mythology and poor evidence
    Geoffrey K Isbister
    Am J Trop Med Hyg 72:361-4; author reply 364-7. 2005
  2. pmc Pharmacokinetic-pharmacodynamic modelling of QT interval prolongation following citalopram overdoses
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Br J Clin Pharmacol 61:177-90. 2006
    ....
  3. pmc Snake antivenom research: the importance of case definition
    G K Isbister
    Charles Darwin University, Darwin and Newcastle Mater Hospital, Newcastle, Australia
    Emerg Med J 22:399-400. 2005
  4. doi request reprint Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal
    Geoffrey K Isbister
    aDepartment of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, Australia
    Int Clin Psychopharmacol 24:174-80. 2009
    ..SDAC seems to have only modest effects on outcomes but may be considered within 2 h for large ingestions. Electrocardiogram monitoring is unlikely to be necessary...
  5. pmc Alprazolam is relatively more toxic than other benzodiazepines in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 58:88-95. 2004
    ..To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines...
  6. ncbi request reprint Serotonin toxicity: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 187:361-5. 2007
    ..Treatment should focus on cessation of the serotonergic medication and supportive care. Some antiserotonergic agents have been used in clinical practice, but the preferred agent, dose and indications are not well defined...
  7. ncbi request reprint Black house spiders are unlikely culprits in necrotic arachnidism: a prospective study
    G K Isbister
    Clinical Envenoming Research Group, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, Australia
    Intern Med J 34:287-9. 2004
    ..5% confidence interval 0-14%). Black house spiders (Badumna spp.) are unlikely to cause necrosis, contrary to reports of suspected bites. Patients can be reassured and do not require any further investigation or treatment...
  8. ncbi request reprint Clinical consequences of spider bites: recent advances in our understanding
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, Newcastle, NSW 2298, Australia
    Toxicon 43:477-92. 2004
    ..Most spiders only cause minor effects, including a large number of groups that have been implicated in necrotic arachnidism...
  9. ncbi request reprint Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle and Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Clin Pharmacol Ther 81:821-7. 2007
    ..9-8.4 h). Charcoal was estimated to reduce fraction absorbed by 35%. Co-ingested CYP3A4 inhibitors appeared to decrease clearance and CYP3A4 inducers increase clearance. Charcoal administration may be beneficial after quetiapine overdose...
  10. ncbi request reprint Spotted black snake (Pseudechis guttatus) envenoming
    Melanie Jansen
    School of Medical Practice and Population Health, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 186:41-2. 2007
    ..Neither patient developed significant coagulopathy, myolysis or neuromuscular paralysis. Bites by this species appear to cause effects similar to those of the more common red-bellied black snake (P. porphyriacus)...
  11. ncbi request reprint Bites by Australian mygalomorph spiders (Araneae, Mygalomorphae), including funnel-web spiders (Atracinae) and mouse spiders (Actinopodidae: Missulena spp)
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, The Children s Hospital at Westmead, Sydney, Australia
    Toxicon 43:133-40. 2004
    ..Mouse spider bites are unlikely to cause major envenoming but the clinical effects are consistent with neurotoxic venom and are more severe than the trapdoor spiders...
  12. ncbi request reprint Mouse spider bites (Missulena spp.) and their medical importance. A systematic review
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, Hunter Region Mail Centre, NSW
    Med J Aust 180:225-7. 2004
    ..To determine the clinical significance of definite bites by mouse spiders (Actinopodidae: Missulena spp.) from published case reports/series and museum records...
  13. ncbi request reprint Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 184:354-6. 2006
    ....
  14. ncbi request reprint Collett's snake (Pseudechis colletti) envenoming in snake handlers
    G K Isbister
    Department of Clinical Toxicology, Newcastle Mater Hospital, Edith St, Waratah NSW 2298, Australia
    QJM 99:109-15. 2006
    ..There are no reports of bites occurring in the wild, and bites were previously thought to cause only minor effects. They are a popular snake among zoos and exotic snake keepers...
  15. ncbi request reprint The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital and University of Newcastle, NSW, Australia
    Clin Neuropharmacol 28:205-14. 2005
    ..However, the mainstay of treatment of severe cases is good supportive care and early intubation and paralysis in life-threatening serotonin toxicity...
  16. ncbi request reprint Effects of envenoming by comb-footed spiders of the genera Steatoda and Achaearanea (family Theridiidae: Araneae) in Australia
    Geoffrey K Isbister
    University of Newcastle, Newcastle, Australia
    J Toxicol Clin Toxicol 41:809-19. 2003
    ..The family Theridiidae (comb-footed spiders) contains the well-known and medically important widow spider group (Latrodectus spp.). Little is known about the effects of envenoming by other common members of this family...
  17. ncbi request reprint Australian wolf spider bites (Lycosidae): clinical effects and influence of species on bite circumstances
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, Newcastle Mater Misericordiae Hospital, University of Newcastle, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 42:153-61. 2004
    ..Necrotic arachnidism continues to be attributed to wolf spider bites. This study investigates the clinical effects of bites by wolf spiders in Australia (family Lycosidae)...
  18. ncbi request reprint Arsenic trioxide poisoning: a description of two acute overdoses
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Hum Exp Toxicol 23:359-64. 2004
    ..Arsenic quantification in blood, urine and faeces suggested that enhanced gastrointestinal decontamination was minimally effective for decontamination and that DMSA for at least two weeks was required...
  19. ncbi request reprint Scorpion stings in Australia: five definite stings and a review
    G K Isbister
    Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Intern Med J 34:427-30. 2004
    ..The stings from Australian buthid scorpions cause more severe effects than from the larger species in the families Urodacidae (genus Urodacus) and Liochelidae (genus Liocheles)...
  20. ncbi request reprint Funnel-web spider bite: a systematic review of recorded clinical cases
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 182:407-11. 2005
    ..To investigate species-specific envenoming rates and spectrum of severity of funnel-web spider bites, and the efficacy and adverse effects of funnel-web spider antivenom...
  21. ncbi request reprint Antivenom, anecdotes and evidence
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, NSW
    Med J Aust 181:685-6. 2004
  22. ncbi request reprint Necrotic arachnidism: the mythology of a modern plague
    Geoffrey K Isbister
    Clinical Envenoming Research Group, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah NSW 2298, Australia
    Lancet 364:549-53. 2004
  23. doi request reprint Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia
    J Clin Psychopharmacol 30:391-5. 2010
    ..Amisulpride overdose commonly causes QT prolongation, bradycardia, and hypotension. Torsades de pointes occurred commonly enough to suggest that amisulpride is highly cardiotoxic in overdose...
  24. ncbi request reprint Clinical effects of stings by sponges of the genus Tedania and a review of sponge stings worldwide
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Toxicon 46:782-5. 2005
    ..Blistering and desquamation occurred in the female adult and limited desquamation in one child. Similar delayed effects have been reported in Tedania spp. stings previously...
  25. ncbi request reprint Neurotoxic marine poisoning
    Geoffrey K Isbister
    Tropical Toxicology Unit, Menzies School of Health Research, Charles Darwin University, NT, and Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, NSW, Australia
    Lancet Neurol 4:219-28. 2005
    ..Because there are no antidotes, supportive care, including mechanical ventilation in patients with severe paralysis, is the mainstay of treatment...
  26. ncbi request reprint Developing a decision tree algorithm for the diagnosis of suspected spider bites
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med Australas 16:161-6. 2004
    ....
  27. ncbi request reprint Prospective cohort study of definite spider bites in Australian children
    G K Isbister
    Clinical Envenoming Research Group, University of Newcastle, and Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    J Paediatr Child Health 40:360-4. 2004
    ..To describe the clinical effects of spider bites in a paediatric population and compare to bites in an adult population...
  28. ncbi request reprint Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 42:277-85. 2004
    ..Objective: To determine the effect of SSRIs in overdose, as a group, and the relative toxicity of five different SSRIs...
  29. ncbi request reprint Aspiration pneumonitis in an overdose population: frequency, predictors, and outcomes
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Australia
    Crit Care Med 32:88-93. 2004
    ....
  30. ncbi request reprint Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP-11)
    Andrew Churchman
    Emergency Department, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Med J Aust 193:696-700. 2010
    ..To describe the clinical features and laboratory findings in patients with definite red-bellied black snake (RBBS; Pseudechis porphyriacus) bites, including correlation with results of venom assays...
  31. doi request reprint Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Ann Emerg Med 56:392-401.e1. 2010
    ..We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED)...
  32. ncbi request reprint Changes in serial laboratory test results in snakebite patients: when can we safely exclude envenoming?
    Graham Ireland
    Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
    Med J Aust 193:285-90. 2010
    ....
  33. ncbi request reprint Clinical effects of exposure to the White-stemmed gum moth (Chelepteryx collesi)
    Corrine R Balit
    NSW Poisons Information Centre, The Children s Hospital at Westmead, Australia
    Emerg Med Australas 16:74-81. 2004
    ..The clinical effects of injuries caused by its many spine-like hairs are poorly defined and concern about the numerous hairs that remain embedded following contact with the cocoon have led to heroic means of removal...
  34. pmc Clinical effects and antivenom dosing in brown snake (Pseudonaja spp.) envenoming--Australian snakebite project (ASP-14)
    George E Allen
    Emergency Department, Queen Elizabeth II Jubilee Hospital, Brisbane, Australia
    PLoS ONE 7:e53188. 2012
    ..We aimed to investigate the clinical and laboratory features of definite brown snake (Pseudonaja spp.) envenoming, and determine the dose of antivenom required...
  35. ncbi request reprint Activated charcoal decreases the risk of QT prolongation after citalopram overdose
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Ann Emerg Med 50:593-600, 600.e1-46. 2007
    ..We determine whether single-dose activated charcoal (SDAC) administration after citalopram overdose reduces the proportion of patients developing abnormal QT prolongation...
  36. pmc Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 56:441-50. 2003
    ..To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters...
  37. ncbi request reprint Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 188:473-6. 2008
    ..To investigate current use of Australian snake antivenoms and the frequency and severity of immediate-type hypersensitivity reactions...
  38. ncbi request reprint Envenoming by the rough-scaled snake (Tropidechis carinatus): a series of confirmed cases
    Melissa Gan
    Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
    Med J Aust 191:183-6. 2009
    ..To describe demographic, geographical and clinical features of envenoming by the rough-scaled snake (RSS) (Tropidechis carinatus)...
  39. ncbi request reprint Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studies
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NSW, Australia
    Toxicon 49:57-67. 2007
    ..One vial of antivenom appears to be sufficient to bind and neutralise all venom in patients with severe brown snake envenoming...
  40. pmc Death adder envenoming causes neurotoxicity not reversed by antivenom--Australian Snakebite Project (ASP-16)
    Christopher I Johnston
    School of Medicine Sydney, University of Notre Dame Australia, Darlinghurst, New South Wales, Australia
    PLoS Negl Trop Dis 6:e1841. 2012
    ..Death adders (Acanthophis spp) are found in Australia, Papua New Guinea and parts of eastern Indonesia. This study aimed to investigate the clinical syndrome of death adder envenoming and response to antivenom treatment...
  41. pmc The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Emerg Med 10:14. 2010
    ..Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department...
  42. doi request reprint Digital Holter measurement of QT prolongation in ziprasidone overdose
    Ingrid Berling
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, Australia
    Clin Toxicol (Phila) 49:694-6. 2011
    ..We report a case of ziprasidone overdose with QT prolongation, demonstrating different methods of measuring the QT interval...
  43. ncbi request reprint Quetiapine poisoning: a case series
    Corrine R Balit
    New South Wales Poisons Information Centre, The Children s Hospital at Westmead, Sydney, Australia
    Ann Emerg Med 42:751-8. 2003
    ..We describe the effects of quetiapine in overdose...
  44. doi request reprint Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom
    Geoffrey K Isbister
    Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Toxicon 56:75-85. 2010
    ..ETP is a useful assay to investigate mechanisms of other procoagulant venoms and is a robust method of assessing antivenom efficacy...
  45. doi request reprint Antivenom efficacy or effectiveness: the Australian experience
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Toxicology 268:148-54. 2010
    ....
  46. doi request reprint Human anti-snake venom IgG antibodies in a previously bitten snake-handler, but no protection against local envenoming
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, New South Wales, Australia
    Toxicon 55:646-9. 2010
    ..However, despite the presence of antibodies to death adder venom and free venom not being detected, the patient still developed significant local myotoxicity...
  47. ncbi request reprint Latrodectism: a prospective cohort study of bites by formally identified redback spiders
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298
    Med J Aust 179:88-91. 2003
    ..To determine the spectrum of severity and early diagnostic predictors of redback spider bites (Latrodectus hasselti), and to examine the effect of intramuscular redback antivenom...
  48. doi request reprint Sedation assessment tool to score acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Emerg Med Australas 23:732-40. 2011
    ..The objective of the study was to evaluate the effectiveness of the sedation assessment tool (SAT) in assessing patient response to treatment for acute behavioural disturbance (ABD)...
  49. doi request reprint An examination of the activity of expired and mistreated commercial Australian antivenoms
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Trans R Soc Trop Med Hyg 103:937-42. 2009
    ..CSL antivenoms are more robust than indicated on their label and maintain useful activity long past their nominated expiry dates...
  50. doi request reprint Risperidone overdose causes extrapyramidal effects but not cardiac toxicity
    Colin B Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    J Clin Psychopharmacol 30:387-90. 2010
    ..The aim of this study was to describe the clinical and electrocardiographic features of risperidone overdose, including the frequency of dystonic reactions...
  51. doi request reprint Spider bite
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Lancet 378:2039-47. 2011
    ..Antivenoms are an important treatment for spider envenomation but have been less successful than have those for snake envenomation, with concerns about their effectiveness for both latrodectism and loxoscelism...
  52. doi request reprint Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers
    Jonathonm Dowling
    Clinical and Experimental Toxicology Unit, Prince of Wales Hospital and Prince of Wales Clinical School, University of NSW, Sydney, Australia
    Ther Drug Monit 30:490-6. 2008
    ..Intranasal naloxone had poor bioavailability compared with intramuscular. Combined intravenous and intramuscular administration may be a useful alternative to naloxone infusions...
  53. ncbi request reprint A prospective study of definite bites by spiders of the family Sparassidae (huntsmen spiders) with identification to species level
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Clinical Toxicologist and Emergency Physician, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building Edith St, Waratah, NSW 2298, Australia
    Toxicon 42:163-71. 2003
    ..The mechanism of effects appeared to be trauma rather than envenoming. There were no major differences between genera, and Neosparassus spp. did not cause major effects...
  54. ncbi request reprint Bupropion overdose: QTc prolongation and its clinical significance
    Geoffrey K Isbister
    University of Newcastle, Waratah, Australia
    Ann Pharmacother 37:999-1002. 2003
    ..To investigate the cardiotoxicity of bupropion hydrochloride in deliberate self-poisoning...
  55. pmc Valproate overdose: a comparative cohort study of self poisonings
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Newcastle, Australia
    Br J Clin Pharmacol 55:398-404. 2003
    ..Based on individual case reports of massive overdoses, valproate is often regarded as having significant toxicity. This study aimed to describe the epidemiology of valproate poisoning and the spectrum of its clinical effects...
  56. ncbi request reprint Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle, NSW, Australia
    Toxicon 50:206-13. 2007
    ..Single-polyvalent antivenom for brown snake and tiger snake may be feasible in the future...
  57. ncbi request reprint Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13)
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW
    Med J Aust 197:173-7. 2012
    ..To describe the clinical syndrome associated with definite tiger snake (Notechis spp) envenoming and to examine the ability of tiger snake antivenom (TSAV) to bind free venom in vivo...
  58. doi request reprint Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Vaccine 28:798-802. 2010
    ..However, they did cross-neutralise the procoagulant effects of both procoagulant venoms. This supports the idea of developing antivenoms against groups of snake toxins rather than individual snake venoms...
  59. ncbi request reprint Prospective study of definite caterpillar exposures
    Corrine R Balit
    NSW Poisons Information Centre, The Children s Hospital, Westmead, Corner Hawkesbury Rd and Hainsworth Street, Locked Bag 4001, Westmead, Sydney, NSW 2145, Australia
    Toxicon 42:657-62. 2003
    ..This is the first prospective study of caterpillar exposures within Australia and demonstrates that exposures can result in a variety of reactions depending on the family and species involved...
  60. ncbi request reprint Baclofen overdose: defining the spectrum of toxicity
    Nicola Y Leung
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Emerg Med Australas 18:77-82. 2006
    ..To describe the spectrum of toxicity of baclofen in overdose, and investigate dose-related clinical effects...
  61. ncbi request reprint Australian scorpion stings: a prospective study of definite stings
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Clinical Sciences Building, Level 5 Edith Street, Waratah, NSW 2298, Australia
    Toxicon 41:877-83. 2003
    ..This differs from other parts of the world, where severe envenoming is reported. The major clinical effect is severe pain, consistent with other scorpion stings. Most stings occurred indoors and at night...
  62. pmc The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report
    Colin Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    J Med Toxicol 5:139-43. 2009
    ..Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing...
  63. ncbi request reprint Suspected snakebite: one year prospective study of emergency department presentations
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med (Fremantle) 15:160-9. 2003
    ..Snakebite is an uncommon, but potentially life-threatening condition. The more common clinical scenario is suspected snake-bite. Our aim was to characterise the epidemiology, diagnosis and management of patients with suspected snakebites...
  64. ncbi request reprint Bites by spiders of the family Theraphosidae in humans and canines
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Waratah, NSW 2298, Australia
    Toxicon 41:519-24. 2003
    ..Bites by these spiders are unlikely to cause major problems in humans. The study also demonstrates that the venom is far more toxic to canines...
  65. doi request reprint Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia geoffrey isbister menzies edu au
    Clin Toxicol (Phila) 47:884-8. 2009
    ..To assess interobserver agreement when trained healthcare staff measure the QT interval using a standardized approach across a range of QT lengths...
  66. ncbi request reprint Clinically applicable laboratory end-points for treating snakebite coagulopathy
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Pathology 38:568-72. 2006
    ..To determine which coagulation tests best reflect the return of clotting function after snakebite venom induced consumptive coagulopathy (VICC)...
  67. ncbi request reprint Nefazodone poisoning: toxicokinetics and toxicodynamics using continuous data collection
    Geoffrey K Isbister
    University of Newcastle, Newcastle, Australia
    J Toxicol Clin Toxicol 41:167-73. 2003
    ..Bradycardia, hypotension, and drowsiness are the most significant effects and are maximal in the first 12 hours when parent and metabolite concentrations are high...
  68. doi request reprint Investigating pressure bandaging for snakebite in a simulated setting: bandage type, training and the effect of transport
    Elizabeth Canale
    Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, and Northern Territory Clinical School, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    Emerg Med Australas 21:184-90. 2009
    ..The clinical evidence base for the use of pressure bandaging in snakebite is limited. We aimed to investigate if pressure bandages (PB) generated and maintained presumptive optimal pressures in a simulated setting...
  69. doi request reprint A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasma
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    J Pharmacol Toxicol Methods 61:27-31. 2010
    ..Assessment of the procoagulant effect of snake venoms is important for understanding their effects. The aim of this study was to develop a simple automated method to measure clotting times to assess procoagulant venoms...
  70. ncbi request reprint White-tail spider bite: a prospective study of 130 definite bites by Lampona species
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
    Med J Aust 179:199-202. 2003
    ..To investigate the circumstances and clinical effects of bites by white-tail spiders, including the two species Lampona cylindrata and L. murina commonly encountered by humans, and the incidence of necrotic lesions...
  71. ncbi request reprint Bupropion poisoning: a case series
    Corrine R Balit
    NSW Poisons Information Centre, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
    Med J Aust 178:61-3. 2003
    ..To investigate the toxicity of bupropion hydrochloride in deliberate self-poisoning in adults and accidental ingestion by children...
  72. doi request reprint A randomised controlled trial of intramuscular vs. intravenous antivenom for latrodectism--the RAVE study
    G K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    QJM 101:557-65. 2008
    ..Widow spider-bite causes latrodectism and is associated with significant morbidity worldwide. Antivenom is given by both the intravenous (IV) and intramuscular (IM) routes and it is unclear which is more effective...
  73. ncbi request reprint Failure of intramuscular antivenom in Red-back spider envenoming
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Hospital, Edith St, Waratah NSW 2298, Australia
    Emerg Med (Fremantle) 14:436-9. 2002
    ..Controlled studies should be undertaken to establish the effectiveness of intravenous and intramuscular Red-back antivenom...
  74. pmc Electrocardiogram changes and arrhythmias in venlafaxine overdose
    Geoffrey K Isbister
    Charles Darwin University, Darwin and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, Australia
    Br J Clin Pharmacol 67:572-6. 2009
    ..To investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias following venlafaxine overdose...
  75. ncbi request reprint Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Intensive Care Med 32:1060-5. 2006
    ..To develop guidelines for the management of QT prolongation after citalopram overdose, including decontamination with single-dose activated charcoal (SDAC) and cardiac monitoring...
  76. ncbi request reprint Thrombotic microangiopathy from Australian brown snake (Pseudonaja) envenoming
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Intern Med J 37:523-8. 2007
    ..A proportion of cases go on to develop thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic haemolytic anaemia (MAHA) and acute renal failure (ARF)...
  77. doi request reprint Failure of antivenom to improve recovery in Australian snakebite coagulopathy
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    QJM 102:563-8. 2009
    ..Venom-induced consumption coagulopathy (VICC) is an important feature of snake envenoming...
  78. doi request reprint Development of a sensitive enzyme immunoassay for measuring taipan venom in serum
    S Kulawickrama
    Emergency Department, Gold Coast Hospital, Queensland, Australia
    Toxicon 55:1510-8. 2010
    ..The use of biotinylation and the antivenom difference method in venom EIA produces a highly sensitive assay that will be useful for determining antivenom dose, forensic and clinical diagnosis...
  79. ncbi request reprint Antipsychotic poisoning in young children: a systematic review
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School for Health Research, Sydney, Australia
    Drug Saf 28:1029-44. 2005
    ..Most cases resolve with good supportive care. Toxic doses are only estimates that are based on limited data and should be used with caution until prospective studies are undertaken...
  80. ncbi request reprint Two cases of bites by the black-bellied swamp snake (Hemiaspis signata)
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Locked Bag 7, Hunter Region Main Centre, Newcastle, NSW 2310, Australia
    Toxicon 40:317-9. 2002
    ..These cases indicate the potential for coagulopathy and local symptoms following bites by large specimens of H. signata in young children...
  81. ncbi request reprint Antivenom treatment in arachnidism
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, NSW, Australia
    J Toxicol Clin Toxicol 41:291-300. 2003
    ..Although envenomation from arthropods is common, no antivenoms exist for these, excepting Lonomia caterpillars in South America, and Ixodes paralysis ticks in Australia...
  82. ncbi request reprint Data collection in clinical toxinology: debunking myths and developing diagnostic algorithms
    Geoffrey K Isbister
    University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 40:231-7. 2002
    ....
  83. pmc A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Br J Clin Pharmacol 65:139-43. 2008
    ..There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV)...
  84. ncbi request reprint 'Red as a beet and blind as a bat' Anticholinergic delirium in adolescents: lessons for the paediatrician
    Kim A Ramjan
    The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    J Paediatr Child Health 43:779-80. 2007
    ..A high index of suspicion is often required in the paediatric setting due to infrequent acute hospital presentation...
  85. ncbi request reprint Acute allergic reaction following contact with a spider
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building, Edith Street, Waratah, NSW 2298, Australia
    Toxicon 40:1495-7. 2002
    ..He recovered within 6 h and had no further problems. The early allergic reaction in this case was most likely the result of contact with the spider...
  86. ncbi request reprint Acute conjunctival inflammation following contact with squashed spider contents
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, and Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Am J Ophthalmol 136:563-4. 2003
    ..To report the effects to the eye following contact with spider contents...
  87. doi request reprint Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal
    C B Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, NSW 2310, Australia
    QJM 102:123-31. 2009
    ..The aim of this study was to describe the clinical effects of promethazine in overdose and explore the relationship between delirium and possible predictor variables...
  88. ncbi request reprint A prospective study of 750 definite spider bites, with expert spider identification
    G K Isbister
    Discipline of Clinical Pharmacology, Level 5, Clinical Sciences Building, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah NSW 2298, Sydney, Australia
    QJM 95:723-31. 2002
    ..Clinical experience and small studies suggest otherwise, but this has not been confirmed by prospective studies of bites by identified spiders...
  89. doi request reprint Commercial monovalent antivenoms in Australia are polyvalent
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    Toxicon 54:192-5. 2009
    ..However, it would be possible for the manufacturer to reduce the number of types of snake antivenoms available in Australia to two polyvalent antivenoms which would simplify treatment of snakebite...
  90. ncbi request reprint Use of high performance liquid chromatography to measure tetrodotoxin in serum and urine of poisoned patients
    Margaret A O'Leary
    Discipline of Clinical Pharmacology, University of Newcastle, Waratah, NSW, Australia
    Toxicon 44:549-53. 2004
    ..With appropriately collected and timed serum and urine specimens it will be possible to properly define the pharmacokinetics of TTX in humans...
  91. pmc Paracetamol overdose in a preterm neonate
    G K Isbister
    Royal Darwin Hospital, Northern Territory, Australia
    Arch Dis Child Fetal Neonatal Ed 85:F70-2. 2001
    ..Treatment includes N-acetylcysteine and supportive care, with activated charcoal for oral poisoning...
  92. ncbi request reprint QTc abnormalities in deliberate self-poisoning with moclobemide
    M A Downes
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, New South Wales, Australia
    Intern Med J 35:388-91. 2005
    ..Several medications have been found to prolong the QT interval in overdose. This can predispose to torsade de pointes-type ventricular tachycardia...
  93. ncbi request reprint Suspected white-tail spider bite and necrotic ulcers
    G K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
    Intern Med J 34:38-44. 2004
    ..To describe the clinical features, investigation, diagnosis and treatment of ulcers attributed to white-tail (WT) spider bites or necrotic arachnidism...
  94. ncbi request reprint Acute myocardial injury caused by Sydney funnel-web spider (Atrax robustus) envenoming
    G K Isbister
    Newcastle Mater Misericordiae Hospital, Waratah, New South Wales
    Anaesth Intensive Care 31:672-4. 2003
    ..The mechanism by which funnel-web spider envenomation caused myocardial injury is unclear but follow-up nuclear studies in the patient demonstrated that she had minimal atherosclerotic disease...
  95. ncbi request reprint Clinical effects of bites from formally identified spiders in tropical Northern Territory
    G K Isbister
    Royal Darwin Hospital, Darwin, NT
    Med J Aust 174:79-82. 2001
    ..To determine the types of spiders causing bites and the clinical effects of their bites in tropical Northern Territory (north of the town of Katherine)...
  96. ncbi request reprint Safety of i.v. administration of redback spider antivenom
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Intern Med J 37:820-2. 2007
    ..In 32 patients followed up for 2 weeks, three (10%) developed serum sickness. RBSAV given i.v. had a low reaction rate...
  97. pmc Delayed asystolic cardiac arrest after diltiazem overdose; resuscitation with high dose intravenous calcium
    G K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle and Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, NSW, Australia
    Emerg Med J 19:355-7. 2002
    ..It should be considered early in cases of cardiac arrest after diltiazem overdose. The case also highlights the problems with delayed toxicity when whole bowel irrigation is not administered...
  98. ncbi request reprint Prospective study of jellyfish stings from tropical Australia, including the major box jellyfish Chironex fleckeri
    G K Isbister
    Royal Darwin Hospital, Darwin, NT
    Med J Aust 175:652-5. 2001
    ..fleckeri, severe envenomation was rare. There was a strong association between clinical features and sticky-tape identification of nematocysts. Delayed hypersensitivity was common after C. fleckeri stings...
  99. pmc Feasibility of prehospital treatment with activated charcoal: Who could we treat, who should we treat?
    G K Isbister
    Newcastle Mater Misericordiae Hospital, University of Newcastle, Waratah, Australia
    Emerg Med J 20:375-8. 2003
    ..To investigate the feasibility and potential risk benefit of prehospital administration of activated charcoal...
  100. ncbi request reprint Coagulopathy from tiger snake envenoming and its treatment
    Geoffrey K Isbister
    Pathology 34:588-90; author reply 590. 2002
  101. ncbi request reprint Randomized controlled trial of topical aspirin in the treatment of bee and wasp stings
    Corrine R Balit
    NSW Poisons Information Centre, The Children s Hospital Westmead, Westmead, Australia
    J Toxicol Clin Toxicol 41:801-8. 2003
    ..Anecdotal evidence from calls suggested it was effective in reducing the swelling and duration of pain, but a literature search found no evidence to support this...