John B Whitfield

Summary

Affiliation: New South Wales
Country: Australia

Publications

  1. ncbi request reprint Genetic covariation between serum gamma-glutamyltransferase activity and cardiovascular risk factors
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Clin Chem 48:1426-31. 2002
  2. pmc Evidence of genetic effects on blood lead concentration
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Environ Health Perspect 115:1224-30. 2007
  3. ncbi request reprint Traditional markers of excessive alcohol use
    Katherine M Conigrave
    Drug Heath Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Addiction 98:31-43. 2003
  4. ncbi request reprint The genetics of alcohol intake and of alcohol dependence
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Alcohol Clin Exp Res 28:1153-60. 2004
  5. ncbi request reprint ADH genotype does not modify the effects of alcohol on high-density lipoprotein
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Alcohol Clin Exp Res 27:509-14. 2003
  6. ncbi request reprint Relative importance of female-specific and non-female-specific effects on variation in iron stores between women
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Br J Haematol 120:860-6. 2003
  7. ncbi request reprint Alcohol and gene interactions
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Clin Chem Lab Med 43:480-7. 2005
  8. ncbi request reprint Hazardous alcohol consumption and other barriers to antiviral treatment among hepatitis C positive people receiving opioid maintenance treatment
    Bianca Watson
    Royal Prince Alfred Hospital, Sydney, Australia
    Drug Alcohol Rev 26:231-9. 2007
  9. ncbi request reprint CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project
    Katherine M Conigrave
    Drug and Alcohol Department, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Sydney, Australia
    Alcohol Clin Exp Res 26:332-9. 2002
  10. ncbi request reprint Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans
    Peter A Dickson
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 30:1093-100. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Genetic covariation between serum gamma-glutamyltransferase activity and cardiovascular risk factors
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Clin Chem 48:1426-31. 2002
    ....
  2. pmc Evidence of genetic effects on blood lead concentration
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Environ Health Perspect 115:1224-30. 2007
    ..However, there has been little investigation of individual differences in lead absorption, distribution, or toxicity, or of genetic causes of such variation...
  3. ncbi request reprint Traditional markers of excessive alcohol use
    Katherine M Conigrave
    Drug Heath Services, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Addiction 98:31-43. 2003
    ..Here we review the nature of these markers' association with alcohol use, their practical application in detecting, assessing or monitoring drinking and increases in understanding of these markers in the past 10 years...
  4. ncbi request reprint The genetics of alcohol intake and of alcohol dependence
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    Alcohol Clin Exp Res 28:1153-60. 2004
    ..The aims of this study were to assess the long-term repeatability and genetic or environmental causes of variation in alcohol intake and to estimate the degree of overlap with causes of susceptibility to alcohol dependence...
  5. ncbi request reprint ADH genotype does not modify the effects of alcohol on high-density lipoprotein
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Alcohol Clin Exp Res 27:509-14. 2003
    ..The aim of this paper was to test for effects of ADH2 and ADH3 genotypes on the response of HDL components to habitual alcohol consumption...
  6. ncbi request reprint Relative importance of female-specific and non-female-specific effects on variation in iron stores between women
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Br J Haematol 120:860-6. 2003
    ....
  7. ncbi request reprint Alcohol and gene interactions
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia
    Clin Chem Lab Med 43:480-7. 2005
    ..Genetic effects on phenotypes other than alcohol dependence are less well understood, and need to be clarified before a full picture of gene-alcohol interactions can be achieved...
  8. ncbi request reprint Hazardous alcohol consumption and other barriers to antiviral treatment among hepatitis C positive people receiving opioid maintenance treatment
    Bianca Watson
    Royal Prince Alfred Hospital, Sydney, Australia
    Drug Alcohol Rev 26:231-9. 2007
    ..Brief intervention for alcohol use problems was acceptable to OMT patients, and warrants further study...
  9. ncbi request reprint CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project
    Katherine M Conigrave
    Drug and Alcohol Department, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Sydney, Australia
    Alcohol Clin Exp Res 26:332-9. 2002
    ..The WHO/ISBRA Collaborative Study allows assessment and comparison of CDT, GGT, and aspartate aminotransferase (AST) as markers of drinking in a large, well-characterized, multicenter sample...
  10. ncbi request reprint Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans
    Peter A Dickson
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Clin Exp Res 30:1093-100. 2006
    ..We have tested whether other polymorphisms in the ALDH2 gene have similar effects in people of European ancestry...
  11. ncbi request reprint Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 8:574-84. 2005
    ....
  12. ncbi request reprint Genome-wide linkage scan for loci influencing plasma triglycerides
    Rita P Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Chim Acta 374:87-92. 2006
    ..Plasma triglyceride concentration is known to be a significant risk factor for cardiovascular disease (CVD). Previous studies have found that the level of triglycerides is strongly influenced by genetic factors...
  13. ncbi request reprint Longitudinal genetic analysis of plasma lipids
    Rita P Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 9:550-7. 2006
    ..In addition our data suggest that different genes may affect the risk profile at different ages...
  14. ncbi request reprint Genome-wide scan for blood pressure in Australian and Dutch subjects suggests linkage at 5P, 14Q, and 17P
    Jouke Jan Hottenga
    Department of Biological Psychology and the Center for Neurogenomics and Clinical Research, Vrije Universiteit, Amsterdam, The Netherlands
    Hypertension 49:832-8. 2007
    ..21 for systolic blood pressure was observed on chromosome 13q34. These results replicate earlier findings and add to a slowly emerging picture of multiple loci contributing to quantitative blood pressure variation...
  15. pmc Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure
    DANIEL T O'CONNOR
    Departments of Medicine and Pharmacology and Center for Human Genetics and Genomics, University of California at San Diego School of Medicine, Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093 0838, USA
    Circulation 118:247-57. 2008
    ..We approached catestatin heritability using twin pairs, coupled with genome-wide linkage, in a series of twin and sibling pairs from 2 continents...
  16. ncbi request reprint A longitudinal genetic study of uric acid and liver enzymes in adolescent twins
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 10:757-64. 2007
    ..The nonshared environment effects were generally time specific. There are developmental changes in genes affecting these traits during adolescence...
  17. doi request reprint Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study
    Penelope A Lind
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 11:174-82. 2008
    ..Because of the large number of phenotypes tested, these possibly significant findings will need to be confirmed in further studies...
  18. doi request reprint Measuring carbohydrate-deficient transferrin by direct immunoassay: factors affecting diagnostic sensitivity for excessive alcohol intake
    John B Whitfield
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Clin Chem 54:1158-65. 2008
    ..The introduction of a new direct immunoassay for CDT justifies reevaluation of test performance and reexamination of factors affecting test diagnostic sensitivity and specificity...
  19. doi request reprint Long-term stability and heritability of telephone interview measures of alcohol consumption and dependence
    Narelle K Hansell
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland, 4029, Australia
    Twin Res Hum Genet 11:287-305. 2008
    ..42 to .51 for dependence and from .31 to .51 for consumption. Consumption was significantly less heritable in the younger Phase 2 cohort (23-39 years) compared to the older Phase 1 cohort (28-90 years)...
  20. ncbi request reprint Evidence of age-dependent genetic influences on plasma total cholesterol
    Rita Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Eur J Cardiovasc Prev Rehabil 12:380-6. 2005
    ....
  21. ncbi request reprint Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions
    Bastiaan T Heijmans
    Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Hum Genet 13:1143-53. 2005
    ..In conclusion, application of a new meta-analysis approach maximised the power to detect QTLs for lipid levels and improved the precision of their location estimate...
  22. ncbi request reprint Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins
    Narelle K Hansell
    The Queensland Institute of Medical Research, Brisbane, Australia
    Alcohol Alcohol 40:343-8. 2005
    ....
  23. ncbi request reprint Combining carbohydrate-deficient transferrin and gamma-glutamyltransferase to increase diagnostic accuracy for problem drinking
    Jack Chen
    School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Alcohol Alcohol 38:574-82. 2003
    ..To examine methods for combining quantitative results for serum carbohydrate deficient transferrin (CDT), gamma-glutamyltransferase (GGT) and/or aspartate aminotransferase (AST), and refining these by inclusion of patient characteristics...
  24. ncbi request reprint Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 11:845-50. 2003
    ..Our study provides strong evidence for the presence of a QTL on chromosome 19 with a major effect on LDL-C plasma levels in outbred Caucasian populations...
  25. ncbi request reprint Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Twin Res 6:322-4. 2003
    ..Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs...
  26. pmc Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations
    John B Whitfield
    Am J Hum Genet 71:1247-50; author reply 1250-1. 2002
  27. ncbi request reprint Association of the gastric alcohol dehydrogenase gene ADH7 with variation in alcohol metabolism
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Hum Mol Genet 17:179-89. 2008
    ..The region accounts for 18% of the linkage for alcohol concentration associated with the ADH region, or approximately 11% of the genetic variance...
  28. ncbi request reprint Transferrin isoform analysis for the diagnosis and management of hazardous or dependent drinking
    John B Whitfield
    Clin Chem 48:2095-6. 2002
  29. ncbi request reprint A longitudinal genetic study of plasma lipids in adolescent twins
    Rita P S Middelberg
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia
    Twin Res Hum Genet 10:127-35. 2007
    ..Our study suggested that there are developmental changes in the genes affecting plasma lipid concentrations across adolescence...
  30. ncbi request reprint Heritabilities of apolipoprotein and lipid levels in three countries
    Marian Beekman
    Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Center, Leiden, The Netherlands
    Twin Res 5:87-97. 2002
    ..Although sample specific effects are present, we have shown that genes play a major role in determining the variance of apolipoprotein and lipid levels in four independent twin samples from three different countries...
  31. ncbi request reprint The genetics of coronary heart disease: the contribution of twin studies
    Alun Evans
    Department of Epidemiology and Public Health, Queen s University Belfast, Belfast, Northern Ireland, UK
    Twin Res 6:432-41. 2003
    ..Twin studies have also contributed to our understanding of the life course hypothesis, and GenomEUtwin has the potential to add to this...
  32. ncbi request reprint Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method
    Jan Olof Jeppsson
    Malmo University Hospital, Malmo, Sweden
    Clin Chem Lab Med 45:558-62. 2007
    ..In clinical use, CDT should be expressed in a relative amount (% CDT), to compensate for variations in the total transferrin concentration...
  33. ncbi request reprint Serum gamma-glutamyltransferase and risk of disease
    John B Whitfield
    Clin Chem 53:1-2. 2007
  34. ncbi request reprint Genetic epidemiology of alcohol-induced blackouts
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine and St Louis University School of Public Health, St Louis, O 63108, USA
    Arch Gen Psychiatry 61:257-63. 2004
    ..Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention...
  35. ncbi request reprint Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors
    Valerie S Knopik
    Missouri Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Psychol Med 34:1519-30. 2004
    ..Genetic influences have been shown to play a major role in determining the risk of alcohol dependence (AD) in both women and men; however, little attention has been directed to identifying the major sources of genetic variation in AD risk...
  36. ncbi request reprint Choice of residential location: chance, family influences, or genes?
    John B Whitfield
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 8:22-6. 2005
    ..Comparisons between countries with different demography are needed to confirm and further characterize these effects...
  37. ncbi request reprint Heritability and stability of resting blood pressure in Australian twins
    Jouke Jan Hottenga
    Department of Biological Psychology and the Center for Neurogenomics and Clinical Research, Vrije Universiteit, Amsterdam, The Netherlands
    Twin Res Hum Genet 9:205-9. 2006
    ..These results replicate an earlier finding in Dutch twins that also showed stability of the contribution of genetic factors to blood pressure tracking...
  38. ncbi request reprint Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity
    Anne Valle
    Department of Pharmacology, University of California at San Diego School of Medicine, and VA San Diego Healthcare System, La Jolla, CA, USA
    Clin Chem 52:1014-20. 2006
    ....
  39. ncbi request reprint The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression
    Nathan A Gillespie
    Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Psychol Med 35:101-11. 2005
    ....
  40. ncbi request reprint Genetics of serum dehydroepiandrosterone sulfate and its relationship to insulin in a population-based cohort of twin subjects
    John E Nestler
    Division of Endocrinology, Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23398, USA
    J Clin Endocrinol Metab 87:682-6. 2002
    ..Variations in DHEA-S are due to age, sex, obesity, and substantial polygenic genetic influences...