Richard A Scolyer

Summary

Affiliation: New South Wales
Country: Australia

Publications

  1. ncbi Tumor mitotic rate is a more powerful prognostic indicator than ulceration in patients with primary cutaneous melanoma: an analysis of 3661 patients from a single center
    Manuela F Azzola
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Cancer 97:1488-98. 2003
  2. ncbi The importance of mitotic rate as a prognostic factor for localized primary cutaneous melanoma
    Richard A Scolyer
    J Cutan Pathol 33:395-6; author reply 397-9. 2006
  3. ncbi Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004
    James Jabbour
    Sydney Cancer Centre, Sydney, Australia
    Ann Surg Oncol 14:1943-52. 2007
  4. ncbi False-negative sentinel node biopsy because of obstruction of lymphatics by metastatic melanoma: the value of ultrasound in conjunction with preoperative lymphoscintigraphy
    Tai K Lam
    Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Melanoma Res 19:94-9. 2009
  5. ncbi The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
    Therese M Becker
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute and Westmead Hospital, Australia
    Mol Cancer 8:4. 2009
  6. ncbi Combined naevus: a benign lesion frequently misdiagnosed both clinically and pathologically as melanoma
    Richard A Scolyer
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Australia
    Pathology 36:419-27. 2004
  7. ncbi Failure to remove true sentinel nodes can cause failure of the sentinel node biopsy technique: evidence from antimony concentrations in false-negative sentinel nodes from melanoma patients
    Richard A Scolyer
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, Australia
    Ann Surg Oncol 11:174S-8S. 2004
  8. ncbi Parachordoma is not distinguishable from axial chordoma using immunohistochemistry
    Richard A Scolyer
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, Australia
    Pathol Int 54:364-70. 2004
  9. ncbi Pathology of melanocytic lesions: new, controversial, and clinically important issues
    Richard A Scolyer
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    J Surg Oncol 86:200-11. 2004
  10. ncbi The detection and significance of melanoma micrometastases in sentinel nodes
    Richard A Scolyer
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Surg Oncol 17:165-74. 2008

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi Tumor mitotic rate is a more powerful prognostic indicator than ulceration in patients with primary cutaneous melanoma: an analysis of 3661 patients from a single center
    Manuela F Azzola
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Cancer 97:1488-98. 2003
    ..If confirmed by studies from other centers, it has the potential to further improve the accuracy of melanoma staging, as well as to define more rigidly the risk categories for patients entering clinical trials...
  2. ncbi The importance of mitotic rate as a prognostic factor for localized primary cutaneous melanoma
    Richard A Scolyer
    J Cutan Pathol 33:395-6; author reply 397-9. 2006
  3. ncbi Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early-stage disease--results from a review of 82 consecutive cases diagnosed between 1992 and 2004
    James Jabbour
    Sydney Cancer Centre, Sydney, Australia
    Ann Surg Oncol 14:1943-52. 2007
    ..Wide surgical excision, lymph node dissection, and radiotherapy have been used with varying efficacy in the management of early-stage Merkel cell carcinoma...
  4. ncbi False-negative sentinel node biopsy because of obstruction of lymphatics by metastatic melanoma: the value of ultrasound in conjunction with preoperative lymphoscintigraphy
    Tai K Lam
    Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Melanoma Res 19:94-9. 2009
    ..They also highlight the advantages of using ultrasound to assess lymph nodes in any node fields to which lymphatic drainage occurs from a primary tumour site...
  5. ncbi The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a
    Therese M Becker
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute and Westmead Hospital, Australia
    Mol Cancer 8:4. 2009
    ..To identify such functions we conducted a yeast-two-hybrid screen for novel p16INK4a binding partners...
  6. ncbi Combined naevus: a benign lesion frequently misdiagnosed both clinically and pathologically as melanoma
    Richard A Scolyer
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Australia
    Pathology 36:419-27. 2004
    ..They are prone to clinical and pathological misdiagnosis as melanoma. Misdiagnosis may result in inappropriate treatment, patient anxiety and medicolegal consequences...
  7. ncbi Failure to remove true sentinel nodes can cause failure of the sentinel node biopsy technique: evidence from antimony concentrations in false-negative sentinel nodes from melanoma patients
    Richard A Scolyer
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, Australia
    Ann Surg Oncol 11:174S-8S. 2004
    ..Our results suggest that an FN SNB can occur because of failure to remove the true SN as well as histopathologic misdiagnosis...
  8. ncbi Parachordoma is not distinguishable from axial chordoma using immunohistochemistry
    Richard A Scolyer
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, Australia
    Pathol Int 54:364-70. 2004
    ..The results also suggest that parachordoma might not be easily distinguished immunohistochemically from axial chordoma (and therefore also from so-called chordoma periphericum)...
  9. ncbi Pathology of melanocytic lesions: new, controversial, and clinically important issues
    Richard A Scolyer
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    J Surg Oncol 86:200-11. 2004
    ....
  10. ncbi The detection and significance of melanoma micrometastases in sentinel nodes
    Richard A Scolyer
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Surg Oncol 17:165-74. 2008
    ....
  11. ncbi Immunohistochemical stains fail to increase the detection rate of micrometastatic melanoma in completion regional lymph node dissection specimens
    Richard A Scolyer
    Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Melanoma Res 14:263-8. 2004
    ..We therefore recommend only H&E staining on sections of all lymph nodes in CLND specimens from melanoma patients...
  12. ncbi Pathologic examination of sentinel lymph nodes from melanoma patients
    Richard A Scolyer
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Semin Diagn Pathol 25:100-11. 2008
    ..At present, the role of nonhistopathologic methods of SN evaluation, such as reverse transcription polymerase chain reaction (RT-PCR) and magnetic resonance spectroscopy, remains unclear, and these techniques require further evaluation...
  13. ncbi Antimony concentrations in nodal tissue can confirm sentinel node identity
    Richard A Scolyer
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Mod Pathol 17:1191-7. 2004
    ....
  14. ncbi Interobserver reproducibility of histopathologic prognostic variables in primary cutaneous melanomas
    Richard A Scolyer
    Department of Anatomical Pathology, and Sydney Melanoma Unit, and the Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Am J Surg Pathol 27:1571-6. 2003
    ..However, few studies have assessed the accuracy and reproducibility with which these features of a melanoma are recorded by histopathologists...
  15. ncbi False negative sentinel lymph node biopsies in melanoma may result from deficiencies in nuclear medicine, surgery, or pathology
    Rooshdiya Z Karim
    Department of Anatomical Pathology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg 247:1003-10. 2008
    ..To investigate a cohort of melanoma patients with false negative (FN) sentinel node (SN) biopsies (SNBs) to identify the reasons for the FN result...
  16. ncbi Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
    Liqing Zhuang
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Mod Pathol 23:45-53. 2010
    ..The strong correlation of LDH-5 expression with Mcl-1 expression suggests that treatment strategies inhibiting the activity of Mcl-1 in melanoma patients should be investigated...
  17. ncbi Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand
    Liqing Zhuang
    Discipline of Pathology, Faculty of Medicine, University of Sydney, Sydney, New South Wales 2006, Australia
    Hum Pathol 37:1286-94. 2006
    ..This suggests that melanoma may not respond to treatment with TRAIL unless given with agents that increase the expression of TRAIL death receptors...
  18. ncbi Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg Oncol 19:1782-9. 2012
    ..We sought to identify clinical and pathologic factors associated with distant metastasis and survival in a large number of patients with thin melanoma treated at a single institution...
  19. ncbi Diagnostic accuracy of fine needle biopsy for metastatic melanoma and its implications for patient management
    Anna Doubrovsky
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
    Ann Surg Oncol 15:323-32. 2008
    ..In this study, the accuracy of FNB for the diagnosis of metastatic melanoma was investigated...
  20. ncbi Outcome in 846 cutaneous melanoma patients from a single center after a negative sentinel node biopsy
    Vivian S K Yee
    Sydney Melanoma Unit, Sydney Cancer Centre, Gloucester House, Royal Prince Alfred Hospital, Missenden Road, Camperdown, 2050 New South Wales, Australia
    Ann Surg Oncol 12:429-39. 2005
    ..In those with a negative SNB, primary tumor thickness and ulceration are independent predictors of survival. Incorrect pathologic diagnosis contributed to only a minority of the false-negative results in this study...
  21. ncbi Confirmation of sentinel lymph node identity by analysis of fine-needle biopsy samples using inductively coupled plasma-mass spectrometry
    Alison Beavis
    Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, New South Wales, Australia
    Ann Surg Oncol 15:934-40. 2008
    ..This involved the use of inductively coupled plasma-mass spectrometry (ICP-MS) to analyze antimony concentrations in fine-needle biopsy (FNB) samples from surgically procured lymph nodes...
  22. ncbi Sentinel lymph nodes containing very small (<0.1 mm) deposits of metastatic melanoma cannot be safely regarded as tumor-negative
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, and Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
    Ann Surg Oncol 19:1089-99. 2012
    ....
  23. ncbi Targeted high-resolution ultrasound is not an effective substitute for sentinel lymph node biopsy in patients with primary cutaneous melanoma
    Amira Sanki
    Melanoma Institute Australia and Sydney Melanoma Unit, Royal Prince Alfred and Mater Hospitals, Sydney, New South Wales, Australia
    J Clin Oncol 27:5614-9. 2009
    ....
  24. ncbi The site of infection and ethnicity of the patient influence the biological pathways to HPV-induced mucosal cancer
    Wei Li
    Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Sydney, Australia
    Mod Pathol 17:1031-7. 2004
    ..These findings represent new evidence that the molecular pathways to human papillomavirus-induced mucosal cancer may be influenced by anatomic location and ethnicity...
  25. ncbi Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
    Liqing Zhuang
    Discipline of Pathology, Faculty of Medicine, The University of Sydney, Sydney, NSW, Australia
    Mod Pathol 20:416-26. 2007
    ..These findings have important implications for the development of treatments targeting antiapoptotic proteins in patients with melanoma...
  26. ncbi Argyrophilic staining of nucleolar organizer region count and morphometry in benign and malignant melanocytic lesions
    Ling Xi L Li
    Melanoma and Skin Cancer Research Institute, Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia
    Am J Dermatopathol 25:190-7. 2003
    ..The results suggest that both AgNOR count and morphology help to separate benign and malignant melanocytic lesions and that the combination of both sets of parameters improves their discriminating ability...
  27. ncbi Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients
    Robert Howman-Giles
    Sydney Melanoma Unit and Melanoma Institute Australia, Royal Prince Alfred and Mater Hospitals, Sydney, NSW, Australia
    Ann Surg Oncol 17:138-43. 2010
    ..The present study takes advantage of the large Sydney Melanoma Unit (SMU) database to clarify this issue...
  28. ncbi Sentinel lymph node biopsy in patients with thin primary cutaneous melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Ann Surg 255:128-33. 2012
    ....
  29. ncbi The role of cell cycle regulatory proteins in the pathogenesis of melanoma
    Wei Li
    The Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, Australia
    Pathology 38:287-301. 2006
    ..However, large validation studies linked to comprehensive clinical follow up data are necessary to clarify the prognostic significance of cell cycle regulatory proteins in individual patients...
  30. ncbi Diagnosis of metastatic melanoma by fine-needle biopsy: analysis of 2,204 cases
    Rajmohan Murali
    Department of Anatomical Pathology, Sydney Cancer Centre, Australia
    Am J Clin Pathol 127:385-97. 2007
    ..FNB is a highly accurate, rapid, and cost-effective procedure for the diagnosis of metastatic melanoma and should be considered as the initial diagnostic procedure of choice in patients with melanoma with clinically suspected metastases...
  31. ncbi New evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis
    Wei Li
    Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia
    Pathology 39:217-22. 2007
    ..This study provides the first data on HPV in tonsillar cancers from Hong Kong...
  32. ncbi Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors)
    Rajmohan Murali
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:302-9. 2008
    ..The current study evaluated the role of sentinel lymph node (SLN) biopsy in patients with such atypical spitzoid tumors...
  33. ncbi Management of merkel cell carcinoma: the roles of lymphoscintigraphy, sentinel lymph node biopsy and adjuvant radiotherapy
    Ross E Warner
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
    Ann Surg Oncol 15:2509-18. 2008
    ..However, its optimal treatment is uncertain. In this study, we aimed to assess the roles of lymphoscintigraphy and sentinel node (SN) biopsy, as well as radiotherapy, in the treatment of MCC...
  34. ncbi Pathologic review of negative sentinel lymph nodes in melanoma patients with regional recurrence: a clinicopathologic study of 1152 patients undergoing sentinel lymph node biopsy
    Ling-Xi L Li
    Melanoma and Skin Cancer Research Institute, Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NWS, Australia
    Am J Surg Pathol 27:1197-202. 2003
    ....
  35. ncbi Synchronous and metachronous malignancies in patients with melanoma: a clinicopathologic study highlighting the role of fine-needle biopsy cytology and potential diagnostic pitfalls
    Caroline L Cooper
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    Melanoma Res 20:203-11. 2010
    ..Careful assessment of the FNB cytologic features and directed use of ancillary studies should enable accurate diagnosis in most cases and facilitate appropriate patient management...
  36. ncbi Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma
    Liquing Zhuang
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Histopathology 54:462-70. 2009
    ..The aim of this study was to investigate its expression and role in the development and progression of human melanoma...
  37. ncbi The expression of key cell cycle markers and presence of human papillomavirus in squamous cell carcinoma of the tonsil
    Wei Li
    Sydney Head and Neck Cancer Institute, PO Box M 142, Missenden Road, Camperdown, NSW 2050, Australia
    Head Neck 26:1-9. 2004
    ..CONCLUSIONS: HPV-positive tonsil SCCs have distinct molecular pathways. Their association with younger patient age suggests that they are biologically distinct from HPV-negative tumors...
  38. ncbi Antimony by ICP-MS as a marker for sentinel lymph nodes in melanoma patients
    Michael Dawson
    Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, 1 Broadway, Broadway, NSW 2007, Australia
    Analyst 128:217-9. 2003
    ..A sensitive, accurate and specific method for the analysis of antimony by ICP-MS is presented as a marker of the sentinel lymph node in melanoma patients...
  39. ncbi Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
    James S Wilmott
    Melanoma Institute Australia, Sydney, NSW, Australia
    Clin Cancer Res 18:1386-94. 2012
    ..To evaluate the effects of treatment with the potent mutant BRAF inhibitors GSK2118436 or vemurafenib (PLX4720) on immune responses to metastatic melanoma in tissues taken before and after treatment...
  40. ncbi A sentinel node biopsy does not increase the incidence of in-transit metastasis in patients with primary cutaneous melanoma
    Daan van Poll
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia
    Ann Surg Oncol 12:597-608. 2005
    ..2%, compared with 10.8% in patients with a tumor-positive sentinel node treated with immediate dissection (n = 102; P = .03). CONCLUSIONS: Performing an SNB in patients with melanoma treated by WLE does not increase the incidence of ITM...
  41. ncbi Prognostic factors in cutaneous desmoplastic melanoma: a study of 252 patients
    Rajmohan Murali
    Diagnostic Oncology and Tissue Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia
    Cancer 116:4130-8. 2010
    ..Primary melanomas either may be entirely desmoplastic or almost entirely desmoplastic (pure DM [pDM]) or may exhibit a desmoplastic component admixed with a nondesmoplastic component (combined DM [cDM])...
  42. ncbi Use of multiple cytometric markers improves discrimination between benign and malignant melanocytic lesions: a study of DNA microdensitometry, karyometry, argyrophilic staining of nucleolar organizer regions and MIB1-Ki67 immunoreactivity
    Ling-Xi L Li
    Melanoma and Skin Cancer Research Institute, Sydney Melanoma Unit and Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Melanoma Res 13:581-6. 2003
    ..This may be of particular significance in the diagnosis of melanocytic lesions whose biological behaviour cannot be confidently predicted by their histological features using conventional microscopy...
  43. ncbi The prognostic importance of tumor mitotic rate confirmed in 1317 patients with primary cutaneous melanoma and long follow-up
    Anne Brecht Francken
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg Oncol 11:426-33. 2004
    ..However, its predictive value was less than it was when assessed according to the 1982 revisions of the 1972 TMR recommendations...
  44. ncbi Subungual melanoma: a study of 124 cases highlighting features of early lesions, potential pitfalls in diagnosis, and guidelines for histologic reporting
    Kong Bing Tan
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Australia
    Am J Surg Pathol 31:1902-12. 2007
    ..Guidelines for the reporting of SUMs are also presented. Knowledge and recognition of the pathologic features of SUMs and the important features that distinguish them from nevi should reduce the frequency of misdiagnosis...
  45. ncbi Reduced expression of p16 and p27 is correlated with tumour progression in cutaneous melanoma
    Amira Sanki
    Sydney Melanoma Unit, Sydney Cancer Centre, Department of Anatomical Pathology, Royal Prince Alfred Hospital, and Discipline of Surgery, University of Sydney, NSW, Australia
    Pathology 39:551-7. 2007
    ..To determine if the cyclin dependent kinase inhibitors (CDKIs) p16 and p27 show reduced expression in the progression from benign to malignant melanocytic tumours, and to correlate these findings with patient prognosis...
  46. ncbi BRAF Mutation, NRAS Mutation, and the Absence of an Immune-Related Expressed Gene Profile Predict Poor Outcome in Patients with Stage III Melanoma
    Graham J Mann
    1 The University of Sydney at Westmead Millennium Institute, Westmead, New South Wales, Australia 2 Melanoma Institute Australia formerly the Sydney Melanoma Unit, Sydney, New South Wales, Australia
    J Invest Dermatol 133:509-17. 2013
    ..We conclude that the presence of BRAF mutation, NRAS mutation, and the absence of an immune-related expressed gene profile predict poor outcome in melanoma patients with macroscopic stage III disease...
  47. ncbi Increasing tumor thickness is associated with recurrence and poorer survival in patients with Merkel cell carcinoma
    Cathy S Lim
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Ann Surg Oncol 19:3325-34. 2012
    ..Clinical and pathologic factors associated with disease progression and mortality in patients with MCC are poorly defined. Recently, it has been reported that p63 expression in primary MCC is strongly associated with clinical outcome...
  48. ncbi Distinguishing clinicopathologic features of patients with V600E and V600K BRAF-mutant metastatic melanoma
    Alexander M Menzies
    Melanoma Institute Australia, Disciplines of Medicine, Surgery, Pathology, and Westmead Institute for Cancer Research, Westmead Millennium Institute, The University of Sydney, Sydney, New South Wales, Australia
    Clin Cancer Res 18:3242-9. 2012
    ..Methods: A prospectively assembled cohort of Australian patients were followed from diagnosis of metastatic melanoma (N = 308). Clinicopathologic variables were correlated with BRAF mutational status, genotype, and survival...
  49. ncbi Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 cases
    James Y Chen
    Department of Radiation Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Cancer 113:2770-8. 2008
    ..The authors investigated the local recurrence rates for patients with DNM after surgery alone or surgery followed by radiotherapy (RT)...
  50. ncbi The history and future of melanoma staging
    John F Thompson
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    J Surg Oncol 86:224-35. 2004
    ..A further advantage would be that because there would be a direct link between staging and prognostic estimate, such a system would be more readily able to be understood in an intuitive fashion...
  51. ncbi Interobserver variation in the histopathologic reporting of key prognostic parameters, particularly clark level, affects pathologic staging of primary cutaneous melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Ann Surg 249:641-7. 2009
    ..However, detailed quantification of the magnitude of variation between observers and its effect on melanoma staging has not been reported...
  52. ncbi The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face
    Pascale Guitera
    Sydney Melanoma Diagnostic Centre and Dermatology Department, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    J Invest Dermatol 130:2080-91. 2010
    ..In a test set of 29 LMs and 44 BMs, the OR for LM was 60.7 (confidence interval: 11.9-309) (93% sensitivity, 82% specificity)...
  53. ncbi p16 and pRb immunohistochemical expression increases with increasing tumour grade in mammary phyllodes tumours
    Rooshdiya Z Karim
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Histopathology 56:868-75. 2010
    ....
  54. ncbi Sentinel lymph node biopsy for melanoma: aspects of pathologic assessment
    Rajmohan Murali
    Royal Prince Alfred Hospital, Department of Anatomical Pathology, Camperdown, Sydney, NSW 2050, Australia
    Future Oncol 4:535-51. 2008
    ..Several non-histopathologic methods of SLN evaluation have been investigated, and while some of them show promise for the future, excision and histopathologic examination currently remains the gold standard for the evaluation of SLNs...
  55. ncbi Differentiating benign nevi from malignant melanoma using DNA microdensitometry and karyometry and maturation: a zonal comparison, correlation and multivariate analysis
    Ling Xi L Li
    Melanoma and Skin Cancer Research Institute, and Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Anal Quant Cytol Histol 24:234-43. 2002
    ..To evaluate the diagnostic effectiveness of cytometric features of DNA microdensitometry, karyometry (nuclear morphometry) and maturation and their combinations in separating benign nevi from malignant melanomas...
  56. ncbi Factors predicting recurrence and survival in sentinel lymph node-positive melanoma patients
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Ann Surg 253:1155-64. 2011
    ..We investigated in detail the influence of SN tumor characteristics and clinical and primary tumor parameters on clinical outcomes in a large cohort of patients treated in a single center...
  57. ncbi Clinical and pathological features of metastases of primary cutaneous desmoplastic melanoma
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Histopathology 58:886-95. 2011
    ..Our aim was to describe the histological features of metastases of primary DM and to determine whether they were predictive of outcome...
  58. ncbi In vivo confocal microscopy for diagnosis of melanoma and basal cell carcinoma using a two-step method: analysis of 710 consecutive clinically equivocal cases
    Pascale Guitera
    Department of Dermatology, Sydney Melanoma Diagnostic Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia
    J Invest Dermatol 132:2386-94. 2012
    ..RCM is a highly accurate non-invasive technique for BCC diagnosis. Good diagnostic accuracy was achieved also for MM diagnosis, although rare variants of melanocytic tumors may limit the strict application of the algorithm...
  59. ncbi Absence of distinguishing senescence traits in human melanocytic nevi
    Sieu L Tran
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, New South Wales, Australia
    J Invest Dermatol 132:2226-34. 2012
    ..We conclude that on the basis of current evidence it cannot be reasonably inferred that nevi are permanently growth arrested via senescence...
  60. ncbi Interobserver reproducibility of histologic parameters of melanoma deposits in sentinel lymph nodes: implications for management of patients with melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, Australia
    Cancer 115:5026-37. 2009
    ....
  61. ncbi Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    Georgina V Long
    Melanoma Institute Australia, 40 Rocklands Rd, North Sydney, New South Wales, 2060, Australia
    J Clin Oncol 29:1239-46. 2011
    ..To assess the frequency and type of oncogenic BRAF mutations in metastatic melanoma and correlate BRAF status with clinicopathologic features and outcome...
  62. ncbi Diagnostic value of 8.5 T magnetic resonance spectroscopy of benign and malignant skin lesion biopsies
    Pascale Guitera
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Melanoma Res 20:311-7. 2010
    ....
  63. ncbi The complex relationships between sentinel node positivity, patient age, and primary tumor desmoplasia: analysis of 2303 melanoma patients treated at a single center
    Sander Sassen
    Sydney Melanoma Unit, Sydney Cancer Centre, Gloucester House, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Ann Surg Oncol 15:630-7. 2008
    ..In addition, desmoplastic melanomas are associated with a lower frequency of SN positivity, although this is less well documented...
  64. ncbi Selective sentinel lymphadenectomy: progress to date and prospects for the future
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
    Cancer Treat Res 127:269-87. 2005
    ....
  65. ncbi Micromorphometric features of positive sentinel lymph nodes predict involvement of nonsentinel nodes in patients with melanoma
    Richard A Scolyer
    Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Am J Clin Pathol 122:532-9. 2004
    ..05). Our results indicate that some morphologic features of melanoma metastases in SLNs predict the likelihood of further nodal involvement in CLND specimens...
  66. ncbi Melanoma - a management guide for GPs
    John F Thompson
    Surgery Melanoma and Surgical Oncology, University of Sydney, Melanoma Institute Australia and Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, New South Wales
    Aust Fam Physician 41:470-3. 2012
    ..The incidence of melanoma in Australia continues to rise. Early diagnosis and management before the melanoma has metastasised provides the best opportunity for a favourable outcome...
  67. ncbi Treatment and prognostic significance of positive interval sentinel nodes in patients with primary cutaneous melanoma
    Nick Verwer
    Melanoma Institute Australia, Sydney, Australia
    Ann Surg Oncol 18:3292-9. 2011
    ..In this study, the incidence, location, and treatment of interval SNs in melanoma patients were analyzed to develop recommendations regarding the treatment of patients with interval SNs...
  68. ncbi The prognostic value of tumor mitotic rate and other clinicopathologic factors in patients with locoregional recurrences of melanoma
    Rajmohan Murali
    Royal Prince Alfred Hospital, Sydney, Camperdown, NSW, Australia
    Ann Surg Oncol 17:2992-9. 2010
    ..In this study, we sought to determine the prognostic value of MRR and other clinicopathologic factors in recurrent melanoma...
  69. ncbi Ultrasound examination of sentinel nodes in the initial assessment of patients with primary cutaneous melanoma
    Emma C Starritt
    Sydney Melanoma Unit, Sydney Cancer Centre and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales, 2050, Australia
    Ann Surg Oncol 12:18-23. 2005
    ..5 mm in diameter. However, most metastatic melanoma deposits in SLNs are considerably smaller than this at the time of initial staging, and US therefore cannot be considered cost-effective in this setting...
  70. ncbi Correlation between preoperative lymphoscintigraphy and metastatic nodal disease sites in 362 patients with cutaneous melanomas of the head and neck
    Johannes H W de Wilt
    Sydney Melanoma Unit and the Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, New South Wales, Australia
    Ann Surg 239:544-52. 2004
    ..7%). CONCLUSIONS: Metastases from head and neck melanomas can occur in any SN demonstrated by lymphoscintigraphy. SNs in discordant as well as predicted node fields should be removed and examined to optimize the accuracy of staging...
  71. ncbi Melanoma metastases in regional lymph nodes are accurately detected by proton magnetic resonance spectroscopy of fine-needle aspirate biopsy samples
    Jonathan R Stretch
    Sydney Melanoma Unit and Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia
    Ann Surg Oncol 12:943-9. 2005
    ..These data indicate the potential for SN staging of melanoma without surgical biopsy and histopathological evaluation...
  72. ncbi Angiotropism is an independent predictor of local recurrence and in-transit metastasis in primary cutaneous melanoma
    Simone L Van Es
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Am J Surg Pathol 32:1396-403. 2008
    ..Our findings support the hypothesis that angiotropism represents a pathogenic mechanism for metastasis in patients with PCM...
  73. ncbi Non-Sentinel Node Risk Score (N-SNORE): a scoring system for accurately stratifying risk of non-sentinel node positivity in patients with cutaneous melanoma with positive sentinel lymph nodes
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    J Clin Oncol 28:4441-9. 2010
    ..We investigated clinicopathologic factors that predict NSN positivity in an attempt to identify patients who may be safely spared completion lymph node dissection (CLND)...
  74. ncbi Absence of human papillomavirus in tonsillar squamous cell carcinomas from Chinese patients
    Wei Li
    Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Sydney, Australia
    Am J Pathol 163:2185-9. 2003
    ..They also support the hypothesis that molecular pathways to tonsil cancer mediated by HPV are distinct from those induced by mutagens present in cigarette smoke or alcohol...
  75. ncbi Sentinel node biopsy for melanoma: Where have we been and where are we going?
    John F Thompson
    Sydney Melanoma Unit and the Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital, New South Wales, Australia
    Ann Surg Oncol 11:147S-51S. 2004
    ..Techniques such as in vivo proton magnetic resonance spectroscopy hold great promise and suggest that this goal might be achievable...
  76. ncbi Myxoid variant of adrenocortical carcinoma: report of a unique case
    Rooshdiya Z Karim
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Pathol Int 56:89-94. 2006
    ..Clinicoradiological correlation may be helpful, but special stains, immunohistochemistry and ultrastructural examination may be necessary to establish the diagnosis...
  77. ncbi Surgical management of primary cutaneous melanoma: excision margins and the role of sentinel lymph node examination
    John F Thompson
    Sydney Melanoma Unit, Level 3, Gloucester House, Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2006, Australia
    Surg Oncol Clin N Am 15:301-18. 2006
    ..Minimally invasive and noninvasive methods of SN assessment, such as magnetic resonance spectroscopy, are being evaluated...
  78. ncbi Histologically ambiguous ("borderline") primary cutaneous melanocytic tumors: approaches to patient management including the roles of molecular testing and sentinel lymph node biopsy
    Richard A Scolyer
    Melanoma Institute Australia, Sydney, NSW, Australia
    Arch Pathol Lab Med 134:1770-7. 2010
    ....
  79. ncbi Fine-needle biopsy of metastatic melanoma: clinical use and new applications
    Rajmohan Murali
    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Lancet Oncol 11:391-400. 2010
    ..In this review, the role of FNB as an important diagnostic modality in the management of suspected metastatic melanoma is described and other diagnostic and research applications of FNB are discussed...
  80. ncbi Diagnosis of cutaneous melanocytic tumours by four-colour fluorescence in situ hybridisation
    Adrienne L Morey
    Department of Anatomical Pathology, St Vincent s Hospital, Darlinghurst, NSW, Australia
    Pathology 41:383-7. 2009
    ..We performed four-colour fluorescence in situ hybridisation (FISH) analysis of melanocytic tumours to determine the accuracy of the technique in classifying melanocytic tumours as benign or malignant...
  81. ncbi Histological expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in human primary melanoma
    Luc P Bron
    Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Sydney, Australia
    Pathology 36:561-5. 2004
    ..Analysis of a larger group of patients with longer follow-up is required to determine whether TRAIL expression correlates with survival of patients...
  82. ncbi Increased expression of apoptotic markers in melanoma
    Michael Slater
    Institute for Biomedical Research, Department of Anatomy and Histology, The University of Sydney, Sydney, NSW 2006, Australia
    Melanoma Res 13:137-45. 2003
    ..In addition, keratinocyte regulation of the epidermis and dermis is severely compromised by the loss of E-cadherin and P2X(1-3) and P2Y(2) receptors, resulting in a lesion that is aggressive and malignant...
  83. ncbi Quality of histopathological reporting on melanoma and influence of use of a synoptic template
    Lauren E Haydu
    The University of Sydney, Sydney, NSW, Australia
    Histopathology 56:768-74. 2010
    ....
  84. ncbi Melanin bleaching in argyrophilic staining of AgNORs in pigmented lesions: a morphometric evaluation
    Ling Xi L Li
    Melanoma and Skin Cancer Research Institute, Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Australia
    Anal Quant Cytol Histol 24:166-72. 2002
    ..To establish a procedure that can effectively bleach melanin from pigmented lesions without affecting quantification of argyrophilic staining of nucleolar organizer regions (AgNORs)...
  85. ncbi Sentinel node positive melanoma patients: prediction and prognostic significance of nonsentinel node metastases and development of a survival tree model
    Martin Wiener
    Melanoma Institute Australia formerly Sydney Melanoma Unit, Sydney, NSW, Australia
    Ann Surg Oncol 17:1995-2005. 2010
    ..This study aimed to establish whether NSN status can be predicted, to determine its effect on survival, and to develop survival tree models for the sentinel node (SN) positive population...
  86. ncbi Elemental bio-imaging of melanoma in lymph node biopsies
    Dominic Hare
    Elemental Bio imaging Facility, University of Technology, Department of Chemistry and Forensic Science, Sydney, Broadway, New South Wales, Australia
    Analyst 134:450-3. 2009
    ..Further enhancement of the tumour boundary was achieved by imaging the (31)P/(34)S ratio. (31)P/(66)Zn ratio images showed a decreasing ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue...
  87. ncbi Cytoplasmic expression of nm23 predicts the potential for cerebral metastasis in patients with primary cutaneous melanoma
    Maria Sarris
    Neuroscience Institute of Schizophrenia and Allied Disorders, Darlinghurst, New South Wales, Australia
    Melanoma Res 14:23-7. 2004
    ..Patients with cutaneous melanomas with a low expression of nm23 appear to be more at risk of developing brain metastases...
  88. ncbi Cutaneous melanoma
    John F Thompson
    Sydney Melanoma Unit, University of Sydney at Royal Prince Alfred Hospital, Sydney, Camperdown, New South Wales, Australia
    Lancet 365:687-701. 2005
    ....
  89. ncbi Spitz naevus versus Spitzoid melanoma: when and how can they be distinguished?
    Kerry A Crotty
    Department of Anatomical Pathology, Melanoma and Skin Cancer Research Institute, Sydney, NSW, Australia
    Pathology 34:6-12. 2002
    ..This report highlights these new data and speculates on their possible future role in the diagnosis of borderline lesions...
  90. ncbi The prognostic significance of isolated immunohistochemically positive cells in sentinel lymph nodes of melanoma patients
    Rajmohan Murali
    Am J Surg Pathol 32:1106-7; author reply 1107-8. 2008
  91. ncbi Test and teach. Diagnosis: Subcutaneous Rosai-Dorfman disease
    Rooshdiya Karim
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Pathology 34:466-70. 2002
  92. ncbi Cooperation between surgical oncologists and pathologists: a key element of multidisciplinary care for patients with cancer
    John F Thompson
    Sydney Melanoma Unit, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
    Pathology 36:496-503. 2004
    ..By cooperating fully and communicating freely with each other, surgical oncologists and pathologists can ensure high standards of initial and subsequent care for cancer patients...
  93. ncbi Desmoplastic melanoma: a diagnostic trap for the unwary
    Stanley W McCarthy
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Pathology 36:445-51. 2004
    ..DM may also present as a recurrence or occasionally as a metastasis from other types of melanoma. A high index of suspicion and knowledge of its often subtle morphological appearance are necessary to avoid misdiagnosis...
  94. ncbi Intraoperative frozen-section evaluation can reduce accuracy of pathologic assessment of sentinel nodes in melanoma patients
    Richard A Scolyer
    J Am Coll Surg 201:821-3; author reply 823-4. 2005
  95. ncbi Sentinel lymph nodes in malignant melanoma: extended histopathologic evaluation improves diagnostic precision
    Richard A Scolyer
    Cancer 101:2141-2; author reply 2142-3. 2004
  96. ncbi In vivo and ex vivo proton MR spectroscopy of primary and secondary melanoma
    Roger M Bourne
    Institute for Magnetic Resonance Research, Department of Magnetic Resonance in Medicine, University of Sydney, Block 3, Level 3, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia
    Eur J Radiol 53:506-13. 2005
    ..Elevated levels of choline, lactate, taurine, and amino acids appear to be clinically useful markers for identifying the pathology of primary and metastatic melanoma...
  97. ncbi Rapid detection of metastatic melanoma in lymph nodes using proton magnetic resonance spectroscopy of fine needle aspiration biopsy specimens
    Cynthia L Lean
    Institute for Magnetic Resonance Research, University of Sydney, PO Box 148, St Leonards, NSW 1590, Australia
    Melanoma Res 13:259-61. 2003
    ....
  98. ncbi Frontiers in melanocytic pathology
    Richard A Scolyer
    Pathology 36:385-6. 2004
  99. ncbi Incomplete biopsy of melanocytic lesions can impair the accuracy of pathological diagnosis
    Richard A Scolyer
    Australas J Dermatol 47:71-3; author reply 74-5. 2006
  100. ncbi Activation of CCR9/CCL25 in cutaneous melanoma mediates preferential metastasis to the small intestine
    Farin F Amersi
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Cancer Res 14:638-45. 2008
    ..The integrin heterodimers alphabeta are also known to be important mediators of cellular adhesion. We hypothesize that the mechanism of small intestinal metastasis by melanoma is via the CCR9-CCL25 axis and specific integrins...
  101. ncbi Cytologic features of metastatic and recurrent melanoma in patients with primary cutaneous desmoplastic melanoma
    Rajmohan Murali
    Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
    Am J Clin Pathol 130:715-23. 2008
    ..010) than did "pure" DMs. Recurrent and metastatic DM has a range of cytologic appearances. Awareness of the cytologic features and careful clinicopathologic correlation will assist in accurate FNB diagnosis...