Research Topics
Genomes and GenesSpecies | Rajmohan MuraliSummaryAffiliation: New South Wales Country: Australia Publications
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Publications
Mucinous cyst exhibiting severe dysplasia in gastric heterotopic pancreas associated with gastrointestinal stromal tumourAntony Kaufman
Department of Anatomical Pathology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Sydney, Australia
World J Gastroenterol 13:5781-2. 2007..We present the first report of a patient with concurrent occurrence of heterotopic pancreas in the stomach with a gastrointestinal stromal tumour...
Interobserver variation in the histopathologic reporting of key prognostic parameters, particularly clark level, affects pathologic staging of primary cutaneous melanomaRajmohan Murali
Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
Ann Surg 249:641-7. 2009..However, detailed quantification of the magnitude of variation between observers and its effect on melanoma staging has not been reported...
Cytological features of melanoma in exfoliative fluid specimensR Murali
Department of Anatomical Pathology, Royal Prince Alfred Hospital, New South Wales, Australia
J Clin Pathol 62:638-43. 2009..To describe the cytological appearances of melanoma in fluid specimens and potential diagnostic pitfalls in interpreting such specimens, which have been infrequently reported in the literature...
Carcinoid tumors of the urinary tract and prostateRajmohan Murali
Department of Tissue Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, Australia
Arch Pathol Lab Med 130:1693-706. 2006..Carcinoid tumors are exceedingly rare in the genitourinary tract and may occur in the kidney, urinary bladder, urethra, or prostate...
Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanomaRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Ann Surg Oncol 19:1782-9. 2012..We sought to identify clinical and pathologic factors associated with distant metastasis and survival in a large number of patients with thin melanoma treated at a single institution...
Sentinel lymph nodes containing very small (<0.1 mm) deposits of metastatic melanoma cannot be safely regarded as tumor-negativeRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, and Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
Ann Surg Oncol 19:1089-99. 2012....
Diagnostic accuracy of fine needle biopsy for metastatic melanoma and its implications for patient managementAnna Doubrovsky
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, 2050, Australia
Ann Surg Oncol 15:323-32. 2008..In this study, the accuracy of FNB for the diagnosis of metastatic melanoma was investigated...
Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patientsRobert Howman-Giles
Sydney Melanoma Unit and Melanoma Institute Australia, Royal Prince Alfred and Mater Hospitals, Sydney, NSW, Australia
Ann Surg Oncol 17:138-43. 2010..The present study takes advantage of the large Sydney Melanoma Unit (SMU) database to clarify this issue...
Synchronous and metachronous malignancies in patients with melanoma: a clinicopathologic study highlighting the role of fine-needle biopsy cytology and potential diagnostic pitfallsCaroline L Cooper
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
Melanoma Res 20:203-11. 2010..Careful assessment of the FNB cytologic features and directed use of ancillary studies should enable accurate diagnosis in most cases and facilitate appropriate patient management...
Increasing tumor thickness is associated with recurrence and poorer survival in patients with Merkel cell carcinomaCathy S Lim
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Ann Surg Oncol 19:3325-34. 2012..Clinical and pathologic factors associated with disease progression and mortality in patients with MCC are poorly defined. Recently, it has been reported that p63 expression in primary MCC is strongly associated with clinical outcome...
Sentinel lymph node biopsy in patients with thin primary cutaneous melanomaRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Ann Surg 255:128-33. 2012....
Prognostic factors in cutaneous desmoplastic melanoma: a study of 252 patientsRajmohan Murali
Diagnostic Oncology and Tissue Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales, Australia
Cancer 116:4130-8. 2010..Primary melanomas either may be entirely desmoplastic or almost entirely desmoplastic (pure DM [pDM]) or may exhibit a desmoplastic component admixed with a nondesmoplastic component (combined DM [cDM])...
Factors predicting recurrence and survival in sentinel lymph node-positive melanoma patientsRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Ann Surg 253:1155-64. 2011..We investigated in detail the influence of SN tumor characteristics and clinical and primary tumor parameters on clinical outcomes in a large cohort of patients treated in a single center...
Pathologic examination of sentinel lymph nodes from melanoma patientsRichard A Scolyer
Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Semin Diagn Pathol 25:100-11. 2008..At present, the role of nonhistopathologic methods of SN evaluation, such as reverse transcription polymerase chain reaction (RT-PCR) and magnetic resonance spectroscopy, remains unclear, and these techniques require further evaluation...
Clinical and pathological features of metastases of primary cutaneous desmoplastic melanomaRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Histopathology 58:886-95. 2011..Our aim was to describe the histological features of metastases of primary DM and to determine whether they were predictive of outcome...
Cytologic features of metastatic and recurrent melanoma in patients with primary cutaneous desmoplastic melanomaRajmohan Murali
Department of Anatomical Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
Am J Clin Pathol 130:715-23. 2008..010) than did "pure" DMs. Recurrent and metastatic DM has a range of cytologic appearances. Awareness of the cytologic features and careful clinicopathologic correlation will assist in accurate FNB diagnosis...
Sentinel lymph node biopsy for melanoma: aspects of pathologic assessmentRajmohan Murali
Royal Prince Alfred Hospital, Department of Anatomical Pathology, Camperdown, Sydney, NSW 2050, Australia
Future Oncol 4:535-51. 2008..Several non-histopathologic methods of SLN evaluation have been investigated, and while some of them show promise for the future, excision and histopathologic examination currently remains the gold standard for the evaluation of SLNs...
Number of primary melanomas is an independent predictor of survival in patients with metastatic melanomaRajmohan Murali
Melanoma Institute Australia, Sydney, New South Wales, Australia
Cancer 118:4519-29. 2012..The authors sought to address the latter question in the current study...
Cutaneous head and neck squamous cell carcinoma with regional metastases: the prognostic importance of soft tissue metastases and extranodal spreadWendy Kelder
Sydney Head and Neck Cancer Institute, Sydney Cancer Center, Royal Prince Alfred and Liverpool Hospitals, Sydney, Australia
Ann Surg Oncol 19:274-9. 2012..The aim of this study was to evaluate the prognosis of patients with STM from head and neck cSCC, and to compare this with that of node metastases with and without ENS...
Histologically ambiguous ("borderline") primary cutaneous melanocytic tumors: approaches to patient management including the roles of molecular testing and sentinel lymph node biopsyRichard A Scolyer
Melanoma Institute Australia, Sydney, NSW, Australia
Arch Pathol Lab Med 134:1770-7. 2010....
Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 casesJames Y Chen
Department of Radiation Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Cancer 113:2770-8. 2008..The authors investigated the local recurrence rates for patients with DNM after surgery alone or surgery followed by radiotherapy (RT)...
Confirmation of sentinel lymph node identity by analysis of fine-needle biopsy samples using inductively coupled plasma-mass spectrometryAlison Beavis
Department of Chemistry, Materials and Forensic Science, University of Technology, Sydney, New South Wales, Australia
Ann Surg Oncol 15:934-40. 2008..This involved the use of inductively coupled plasma-mass spectrometry (ICP-MS) to analyze antimony concentrations in fine-needle biopsy (FNB) samples from surgically procured lymph nodes...
Non-Sentinel Node Risk Score (N-SNORE): a scoring system for accurately stratifying risk of non-sentinel node positivity in patients with cutaneous melanoma with positive sentinel lymph nodesRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
J Clin Oncol 28:4441-9. 2010..We investigated clinicopathologic factors that predict NSN positivity in an attempt to identify patients who may be safely spared completion lymph node dissection (CLND)...
Fine-needle biopsy of metastatic melanoma: clinical use and new applicationsRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Lancet Oncol 11:391-400. 2010..In this review, the role of FNB as an important diagnostic modality in the management of suspected metastatic melanoma is described and other diagnostic and research applications of FNB are discussed...
Interobserver reproducibility of histologic parameters of melanoma deposits in sentinel lymph nodes: implications for management of patients with melanomaRajmohan Murali
Department of Anatomical Pathology, Royal Prince Alfred Hospital, Sydney, Australia
Cancer 115:5026-37. 2009....
Blue nevi and related lesions: a review highlighting atypical and newly described variants, distinguishing features and diagnostic pitfallsRajmohan Murali
Royal Prince Alfred Hospital Discipline of Pathology, The University of Sydney, Camperdown Melanoma Institute Australia, New South Wales, Australia
Adv Anat Pathol 16:365-82. 2009....
Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteinsLiqing Zhuang
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Mod Pathol 23:45-53. 2010..The strong correlation of LDH-5 expression with Mcl-1 expression suggests that treatment strategies inhibiting the activity of Mcl-1 in melanoma patients should be investigated...
Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors)Rajmohan Murali
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia
Ann Surg Oncol 15:302-9. 2008..The current study evaluated the role of sentinel lymph node (SLN) biopsy in patients with such atypical spitzoid tumors...
The detection and significance of melanoma micrometastases in sentinel nodesRichard A Scolyer
Sydney Melanoma Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
Surg Oncol 17:165-74. 2008....
Digital papillary adenocarcinoma: a tumour that should be considered in the differential diagnosis of neoplasms involving the digitsRichard A Scolyer
Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Pathology 45:55-61. 2013..Digital papillary adenocarcinoma (DPA) is a rare malignant adnexal tumour that occurs almost exclusively in a digital location. Only two case series have been reported previously...
The prognostic value of tumor mitotic rate and other clinicopathologic factors in patients with locoregional recurrences of melanomaRajmohan Murali
Royal Prince Alfred Hospital, Sydney, Camperdown, NSW, Australia
Ann Surg Oncol 17:2992-9. 2010..In this study, we sought to determine the prognostic value of MRR and other clinicopathologic factors in recurrent melanoma...
The prognostic and staging implications of bone invasion in oral squamous cell carcinomaArdalan Ebrahimi
Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital, Camperdown, Australia
Cancer 117:4460-7. 2011..A study was undertaken to determine whether bone invasion is an independent prognostic factor in oral squamous cell carcinoma (SCC) after taking into account the extent of bone invasion...
Diagnosis and management of sebaceous carcinoma: an Australian experienceMichael B Dowd
Department of Plastic Surgery, Nepean Hospital, Sydney, New South Wales, Australia
ANZ J Surg 78:158-63. 2008..Periorbital SC is approximately three times more common than extraorbital SC. To date, there are few data from an Australian source to document the prevalence or clinical outcome of this tumour...
Histiocytoid change in breast carcinoma: a report of 3 cases with an unusual cytomorphologic pattern of apocrine changeRajmohan Murali
Department of Tissue Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia
Acta Cytol 50:548-52. 2006..Breast carcinomas composed predominantly or exclusively of cells with foamy and/or granular cytoplasm have been termed histiocytoid breast carcinoma...
So-called "malignant blue nevus": a clinicopathologic study of 23 patientsRichard C W Martin
Melanoma Institute Australia incorporating the Sydney Melanoma Unit, Royal Prince Alfred and Mater Hospitals, Sydney, New South Wales, Australia
Cancer 115:2949-55. 2009..quot; The authors report on a single-institutional clinicopathologic study of "blue nevus-like melanomas" (BNLMs)...
Dabrafenib and its potential for the treatment of metastatic melanomaAlexander M Menzies
Melanoma Institute Australia, Sydney, New South Wales, Australia
Drug Des Devel Ther 6:391-405. 2012..It is expected that new combinations of targeted drugs, such as the combination of dabrafenib and trametinib (GSK1120212, a MEK inhibitor), will provide higher response rates and more durable clinical benefit than dabrafenib monotherapy...
Diagnosis of metastatic melanoma by fine-needle biopsy: analysis of 2,204 casesRajmohan Murali
Department of Anatomical Pathology, Sydney Cancer Centre, Australia
Am J Clin Pathol 127:385-97. 2007..FNB is a highly accurate, rapid, and cost-effective procedure for the diagnosis of metastatic melanoma and should be considered as the initial diagnostic procedure of choice in patients with melanoma with clinically suspected metastases...
MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcomeJennifer A Byrne
Molecular Oncology Laboratory, Children s Cancer Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales, Australia
BMC Cancer 10:497. 2010..MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown...
Cytological features of transitional cell metaplasia of the lower female genital tractRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, Australia
Pathology 42:113-8. 2010..Transitional cell metaplasia (TCM) of the cervix and vaginal vault is rarely reported. We sought to describe the clinical and cytological features and cytological differential diagnosis of TCM...
Diagnosis of cutaneous melanocytic tumours by four-colour fluorescence in situ hybridisationAdrienne L Morey
Department of Anatomical Pathology, St Vincent s Hospital, Darlinghurst, NSW, Australia
Pathology 41:383-7. 2009..We performed four-colour fluorescence in situ hybridisation (FISH) analysis of melanocytic tumours to determine the accuracy of the technique in classifying melanocytic tumours as benign or malignant...
Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomasRajmohan Murali
Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia
Ann Surg Oncol 19:1024-33. 2012....
Fine-needle biopsy as a diagnostic technique for metastatic melanomaRajmohan Murali
Royal Prince Alfred Hospital, Department of Anatomical Pathology, Camperdown, NSW, 2050, Australia 61 2 9515 7011 61 2 9515 8405
Expert Opin Med Diagn 2:1-10. 2008....
Outcome of cervical intraepithelial neoplasia 2 diagnosed by punch biopsy in 131 womenZongqun Ding
Sydney Gynaecologic Oncology Group, Sydney Cancer Centre, Sydney, New South Wales, Australia
J Obstet Gynaecol Res 37:754-61. 2011..To study the outcome of biopsy-diagnosed cervical intraepithelial neoplasia (CIN) 2 in patients treated by loop electrosurgical excision procedure (LEEP) or cold knife cone biopsy (CKC)...
Outcomes following parotidectomy for metastatic squamous cell carcinoma with microscopic residual disease: implications for facial nerve preservationN Gopalakrishna Iyer
Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia
Head Neck 31:21-7. 2009..This study aims to determine whether facial nerve preservation followed by radiotherapy is a reasonable option in patients with microscopic residual disease involving the facial nerve...
Primary calvarial meningiomaDarweesh Al-Khawaja
Department of Neurosurgery, Building 1, Nepean Hospital, Penrith, Sydney, New South Wales 2751, Australia
J Clin Neurosci 14:1235-9. 2007..The patient underwent wide surgical excision, dural repair, and mesh cranioplasty, following which his headaches ceased. Histological examination showed WHO grade I meningioma...
Usefulness of smears in intra-operative diagnosis of newly described entities of CNSWinny Varikatt
Institute of Clinical Pathology and Medical Research, Institute of Clinical Pathology and Medical Research, University of Western Sydney, Westmead Hospital, New South Wales, Australia
Neuropathology 29:641-8. 2009..These two tumours can further be differentiated based on their cell morphology and background...
An asymptomatic, incidentally discovered pulmonary tumor in a 41-year-old womanRajmohan Murali
Department of Tissue Pathology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
Arch Pathol Lab Med 129:e191-4. 2005
TACI mutation with invasive polyclonal CD8+ T-cell lymphoproliferation in a patient with common variable immunodeficiencyLucinda J Berglund
Immunology Unit, Westmead Hospital, Westmead, Sydney, NSW, Australia
J Allergy Clin Immunol 117:870-7. 2006....
Disseminated mucormycosis and orbital ischaemia in combination immunosuppression with a tumour necrosis factor alpha inhibitorPritpal Singh
Department of Ophthalmology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Affiliated Teaching Hospital with the University of Sydney, Sydney, New South Wales, Australia
Clin Experiment Ophthalmol 35:275-80. 2007..To the best of the authors' knowledge, this is the first reported case of disseminated mucormycosis in a patient treated with a tumour necrosis factor inhibitor. Important pathophysiological factors are considered...
The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitroP M O'Brien
Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia
Br J Cancer 98:1085-93. 2008....
The prognostic significance of isolated immunohistochemically positive cells in sentinel lymph nodes of melanoma patientsRajmohan Murali
Am J Surg Pathol 32:1106-7; author reply 1107-8. 2008
Clear cell atypical fibroxanthoma - report of a case with review of the literatureRajmohan Murali
Department of Histopathology, Douglass Hanly Moir Laboratories, North Ryde, NSW, Australia
J Cutan Pathol 33:343-8. 2006..Murali R, Palfreeman S. Clear cell atypical fibroxanthoma - report of a case with review of the literature...
A 57-year-old man with a dural-based parietal lobe tumorRajmohan Murali
Brain Pathol 17:460-3, 474. 2007
Chordoid meningioma masquerading as chordomaRajmohan Murali
Pathology 36:198-201. 2004
Merkel cell carcinoma with fibrosarcomatous differentiationKong-Bing Tan
Pathology 40:314-6. 2008
