Peter G Gibson

Summary

Affiliation: New South Wales
Country: Australia

Publications

  1. pmc Validity of the common cold questionnaire (CCQ) in asthma exacerbations
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia
    PLoS ONE 3:e1802. 2008
  2. pmc Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?
    Vanessa M McDonald
    School of Nursing and Midwifery, University of Newcastle, Newcastle, New South Wales, Australia
    Thorax 68:691-4. 2013
  3. pmc Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 6:5. 2010
  4. pmc Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 5:4. 2009
  5. ncbi Allergic bronchopulmonary aspergillosis
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    Semin Respir Crit Care Med 27:185-91. 2006
  6. ncbi The overlap syndrome of asthma and COPD: what are its features and how important is it?
    P G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Mail Centre, Newcastle, NSW 2310, Australia
    Thorax 64:728-35. 2009
  7. doi Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies
    P G Gibson
    Department of Respiratory and Sleep Medicine, Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute at John Hunter Hospital, University of Newcastle, Newcastle, Australia
    Clin Exp Allergy 39:478-90. 2009
  8. ncbi Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
    Jodie L Simpson
    School of Medical Practice and Population Health, and Medical Genetics, School of Biomedical Science, Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:559-65. 2005
  9. ncbi Use of omalizumab in a severe asthma clinic
    Peter G Gibson
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan, Australia
    Respirology 12:S35-44; discussion S45-7. 2007
  10. doi Speech pathology for chronic cough: a new approach
    Peter G Gibson
    Centre for Asthma and Respiratory Diseases, John Hunter Hospital University of Newcastle, Newcastle, NSW, Australia
    Pulm Pharmacol Ther 22:159-62. 2009

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. pmc Validity of the common cold questionnaire (CCQ) in asthma exacerbations
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, New Lambton, New South Wales, Australia
    PLoS ONE 3:e1802. 2008
    ..Its usefulness in people with acute asthma is unknown. Our aim was to assess the ability of the CCQ to detect viral infection and to monitor recovery during a viral induced asthma exacerbation and confirmed by virological testing...
  2. pmc Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?
    Vanessa M McDonald
    School of Nursing and Midwifery, University of Newcastle, Newcastle, New South Wales, Australia
    Thorax 68:691-4. 2013
    ..The rising disease burden from chronic obstructive pulmonary disease (COPD) requires new approaches...
  3. pmc Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 6:5. 2010
    ..The number of treatments required to effect a response was also assessed...
  4. pmc Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 5:4. 2009
    ..Successful treatment for chronic persistent cough leads to improvements in these features of laryngeal dysfunction...
  5. ncbi Allergic bronchopulmonary aspergillosis
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    Semin Respir Crit Care Med 27:185-91. 2006
    ..Treatment involves corticosteroids and antifungal therapy with oral azoles. Additional management seeks to monitor and control the other disease components of severe asthma, bronchiectasis, and disease exacerbations...
  6. ncbi The overlap syndrome of asthma and COPD: what are its features and how important is it?
    P G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Mail Centre, Newcastle, NSW 2310, Australia
    Thorax 64:728-35. 2009
    ..Studying these events may offer new insights into the mechanisms and treatment of obstructive airway diseases...
  7. doi Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies
    P G Gibson
    Department of Respiratory and Sleep Medicine, Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute at John Hunter Hospital, University of Newcastle, Newcastle, Australia
    Clin Exp Allergy 39:478-90. 2009
    ....
  8. ncbi Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
    Jodie L Simpson
    School of Medical Practice and Population Health, and Medical Genetics, School of Biomedical Science, Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:559-65. 2005
    ..Asthma is characterized by both chronic inflammation and remodeling of the airways. Proteases are important mediators of inflammation, cytokine activation, and tissue remodeling...
  9. ncbi Use of omalizumab in a severe asthma clinic
    Peter G Gibson
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan, Australia
    Respirology 12:S35-44; discussion S45-7. 2007
    ....
  10. doi Speech pathology for chronic cough: a new approach
    Peter G Gibson
    Centre for Asthma and Respiratory Diseases, John Hunter Hospital University of Newcastle, Newcastle, NSW, Australia
    Pulm Pharmacol Ther 22:159-62. 2009
    ..Speech pathology intervention can be an effective way to treat refractory chronic cough...
  11. ncbi Initial corticosteroid therapy for asthma
    Peter G Gibson
    Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, and University of Newcastle, Australia
    Curr Opin Pulm Med 12:48-53. 2006
    ..This review examines the commencement of maintenance pharmacotherapy for asthma: inhaled corticosteroids alone or in combination with long-acting beta2 agonists...
  12. ncbi Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, New Lambton, Australia
    J Allergy Clin Immunol 119:344-50. 2007
    ..Combination therapy with long-acting beta-agonists (LABAs)/inhaled corticosteroids (ICSs) has become established as effective maintenance treatment for asthma...
  13. ncbi CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian cough guidelines summary statement
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Med J Aust 192:265-71. 2010
    ..In ADULTS, refractory cough that persists after therapy is managed by empirical inhaled corticosteroid therapy and speech pathology techniques...
  14. doi Cough pharmacotherapy: current and future status
    Peter G Gibson
    University of Newcastle, School of Medicine and Public Health, Centre for Asthma and Respiratory Diseases, Newcastle, NSW 2308, Australia
    Expert Opin Pharmacother 12:1745-55. 2011
    ..Neuromodulators for sensory neuropathic cough and new compounds to block transient receptor potential (TRP) receptors hold promise for chronic cough and upper airway hypersensitivity...
  15. doi Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    J Immunol 184:4159-69. 2010
    ..Thus, active chlamydial respiratory infection during sensitization enhances subsequent neutrophilic inflammation and Th1/Th17 responses during allergen exposure and may have a role in the pathogenesis of neutrophilic asthma...
  16. doi Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Free Radic Res 42:94-102. 2008
    ..Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention...
  17. doi Manipulating antioxidant intake in asthma: a randomized controlled trial
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, New South Wales, Australia
    Am J Clin Nutr 96:534-43. 2012
    ..Antioxidant-rich diets are associated with reduced asthma prevalence in epidemiologic studies. We previously showed that short-term manipulation of antioxidant defenses leads to changes in asthma outcomes...
  18. doi Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 125:617-25, 625.e1-625.e6. 2010
    ..The progression of aberrant T(H)2 cell responses and disease development has been attributed to a lack of infections. However, exposure to specific pathogens such as Chlamydia may alter immunologic programming and predispose to asthma...
  19. ncbi Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
    ..Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms...
  20. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
    ..The objective of this study is to investigate innate immune responses to RV infection in COPD primary BECs (pBECs) in comparison to healthy controls...
  21. ncbi Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 177:148-55. 2008
    ..Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, key inflammatory mediators in noneosinophilic asthma...
  22. doi IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  23. ncbi Airway and systemic inflammation in obese children with asthma
    Megan E Jensen
    Hunter Medical Research Institute, Newcastle
    Eur Respir J 42:1012-9. 2013
    ..However, the higher prevalence of non-eosinophilic asthma in female obese asthmatics, compared to males, warrants further investigation. ..
  24. doi A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 127:1133-40. 2011
    ..Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown...
  25. ncbi Induced sputum 8-isoprostane concentrations in inflammatory airway diseases
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    Am J Respir Crit Care Med 171:426-30. 2005
    ..Analysis of 8-iso-PGF(2alpha) concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease...
  26. doi Psychosocial variables are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma
    Heather Powell
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 50:383-9. 2013
    ..To determine the relationship between psychosocial variables, future exacerbation risk during pregnancy, and perinatal outcomes...
  27. pmc Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    PLoS Pathog 7:e1002244. 2011
    ..This results in a phenotype that is similar to neutrophilic asthma. Infection-induced neutrophilic inflammation in AAD is mediated by IL-17 responses...
  28. doi Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    J Asthma 48:1032-40. 2011
    ..Little is known about the psychosocial impact and perceived teratogenic (fetal harm due to medication) risks of asthma treatment (inhaled/oral corticosteroids and β-agonist) during pregnancy...
  29. ncbi Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae
    Julie A Preston
    Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, The University of Newcastle, Newcastle, Australia
    Vaccine 25:8154-62. 2007
    ..This indicates the potential of Spn as an IMT for asthma...
  30. doi Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    Heather Powell
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Lancet 378:983-90. 2011
    ..We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations...
  31. ncbi Older peoples' perception of tests used in the assessment and management of COPD and asthma
    Vanessa M McDonald
    Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute John Hunter Hospital, Newcastle, NSW, Australia School of Nursing and Midwifery, The University of Newcastle, Newcastle, NSW, Australia School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Clin Respir J 7:367-74. 2013
    ..This study evaluated the patient perception of tests used for the assessment of airways disease in older people...
  32. doi Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    Thorax 67:588-99. 2012
    ..The relationship between chronic airway colonisation and the development of steroid-resistant neutrophilic asthma is unclear...
  33. pmc Relationship between body composition, inflammation and lung function in overweight and obese asthma
    Hayley A Scott
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW Australia
    Respir Res 13:10. 2012
    ..The obese-asthma phenotype is not well defined. The aim of this study was to examine both mechanical and inflammatory influences, by comparing lung function with body composition and airway inflammation in overweight and obese asthma...
  34. doi Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia
    Respirology 16:291-9. 2011
    ..This study investigates the frequency of viral persistence after acute asthma, assesses viral infectivity and determines the host inflammatory responses to viral persistence...
  35. doi Oxidized vitamin E and glutathione as markers of clinical status in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Clin Nutr 27:579-86. 2008
    ....
  36. doi Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma
    Katherine J Baines
    Priority Research Centre forAsthma and Respiratory Diseases, The University of Newcastle, Callaghan, Australia
    Thorax 66:942-7. 2011
    ..Systemic inflammation is now recognised as an important part of some airway diseases, but the involvement of systemic inflammation in the pathogenesis of airway inflammatory phenotypes of asthma remains unknown...
  37. doi Asthma in older adults
    Peter G Gibson
    School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Lancet 376:803-13. 2010
    ....
  38. doi Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  39. doi Prenatal origins of bronchiolitis: protective effect of optimised asthma management during pregnancy
    Joerg Mattes
    Experimental and Translational Respiratory Medicine Group, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
    Thorax 69:383-4. 2014
    ..Maternal asthma is the most common chronic disease complicating pregnancy and is a risk factor for bronchiolitis in infancy. Recurrent episodes of bronchiolitis are strongly associated with the development of childhood asthma...
  40. doi Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease, University of Newcastle, Newcastle, New South Wales 2300, Australia
    J Immunol 191:4112-20. 2013
    ..Therefore, bacterial components (T+P) drive the differentiation of highly suppressive Tregs, which suppress the Th2 response, prevent the Th17 response and disable the DC response resulting in the effective suppression of AAD. ..
  41. doi The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
    ..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
  42. doi Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, University of Newcastle, Callaghan, NSW, Australia
    Free Radic Res 44:146-54. 2010
    ..The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients...
  43. doi Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
    Br J Nutr 101:533-40. 2009
    ..EPA and AA did not change the release of inflammatory biomarkers significantly. It is concluded that DHA has a potential role in suppressing RV-induced airway inflammation...
  44. ncbi Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  45. doi Neutrophilic asthma has different radiographic features to COPD and smokers
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    Respir Med 103:881-7. 2009
    ..The aim of this study was to examine the airway and parenchymal abnormalities using high resolution computed tomographic (HRCT) scanning in participants with neutrophilic asthma, COPD and smoking controls...
  46. doi Diversity in the bronchial epithelial cell response to infection with different rhinovirus strains
    Peter A B Wark
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, UK
    Respirology 14:180-6. 2009
    ..Infection with rhinovirus (RV) is the most common trigger for acute asthma and COPD. The aim of this study was to characterize the variability in the response of primary bronchial epithelial cells to infection with several strains of RV...
  47. ncbi Proteomic study of plasma proteins in pregnant women with asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NWS, Australia
    Respirology 11:41-8. 2006
    ..This study used the novel proteomic technique, surface-enhanced laser desorption ionization-time of flight mass spectrometry to determine if the presence of asthma during pregnancy was associated with alterations in plasma proteins...
  48. ncbi A comparison of two approaches to the treatment of chronic cough: perceptual, acoustic, and electroglottographic outcomes
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    J Voice 22:581-9. 2008
    ..These results demonstrated that SPEICH-C can improve perceptual aspects of voice quality suggesting that dysphonia may be a fundamental characteristic of CC...
  49. doi Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma
    Lisa G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Br J Nutr 103:735-41. 2010
    ..This highlights the potential role for antioxidant supplementation in these subjects...
  50. doi Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
    Juan Juan Fu
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    OMICS 17:187-99. 2013
    ..Our findings suggest that targeting systemic inflammation might provide a novel therapeutic strategy for neutrophilic asthma...
  51. doi The importance of clinical management problems in older people with COPD and asthma: do patients and physicians agree?
    Vanessa M McDonald
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, Australia
    Prim Care Respir J 20:389-95. 2011
    ..COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physicians and the level of agreement between them is largely unknown...
  52. doi Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, School of Medicine and Public Health, The University of Newcastle, Callaghan NSW, Australia
    Exp Lung Res 35:781-94. 2009
    ..Sputum oncostatin M is increased in asthma with irreversible airflow obstruction and is present in airway neutrophils and macrophages. Oncostatin M may link airway inflammation to remodeling in asthma...
  53. doi The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
    ..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response...
  54. ncbi Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
    ..Innate immune responses of airway neutrophil cells are impaired in asthmatic subjects on prophylactic therapy and may impact on susceptibility to, and severity of, airway infections...
  55. doi Characterization of laryngeal dysfunction in chronic persistent cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, 2308, NSW, Australia
    Laryngoscope 119:640-5. 2009
    ....
  56. ncbi Acoustic and electroglottographic voice characteristics in chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Speech Pathology Department, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Newcastle, Australia
    Folia Phoniatr Logop 60:210-6. 2008
    ..Objective acoustic and electroglottographic (EGG) measures have the capacity to delineate these vocal characteristics. This study investigated acoustic and EGG voice features of CC and PVFM...
  57. ncbi Persistent airway obstruction after virus infection is not associated with airway inflammation
    Lisa G Wood
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Chest 131:415-23. 2007
    ..This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations...
  58. pmc Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW 2308, Australia
    Mediators Inflamm 2013:462934. 2013
    ..TLR2 stimulation activates neutrophils for MMP-9 release. Efforts to understand the mechanisms of TLR2 signalling and subsequent MMP-9 production in COPD may assist in understanding neutrophilic inflammation in COPD...
  59. doi Obesity and childhood asthma - mechanisms and manifestations
    Megan E Jensen
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2310, Australia
    Curr Opin Allergy Clin Immunol 12:186-92. 2012
    ..This review highlights the most recent findings over the past 18 months in understanding the presentation and potential mechanisms of obesity in childhood asthma...
  60. pmc Innate immune activation in neutrophilic asthma and bronchiectasis
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, Newcastle, Australia
    Thorax 62:211-8. 2007
    ..The inflammatory response in asthma is heterogeneous...
  61. ncbi The effect of maternal asthma on placental and cord blood protein profiles
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Soc Gynecol Investig 12:349-55. 2005
    ....
  62. doi The effect of cigarette smoking on asthma control during exacerbations in pregnant women
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle NSW 2310, Australia
    Thorax 65:739-44. 2010
    ..Smoking and severe asthma exacerbations in pregnancy are risk factors for low birth weight babies. No studies have assessed the clinical implications of smoking on asthma exacerbations in pregnancy...
  63. doi How to set up a severe asthma service
    Vanessa M McDonald
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
    Respirology 16:900-11. 2011
    ..In this article we describe the purpose of a severe asthma clinic, the necessary components of a service including staffing and facilities and the processes for trialling additional therapies used in the management of severe asthma...
  64. ncbi Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    ..The authors sought to investigate the detection of non-eosinophilic asthma using induced sputum. Although this is an important subtype of clinical asthma, its recognition is not standardized...
  65. doi Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma
    Rebecca L Vanders
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia
    Respirology 18:827-33. 2013
    ..Asthma exacerbations are caused most frequently by respiratory viruses. A balance between antiviral and inflammatory immune responses is critical during pregnancy; the balance may be altered by asthma and respiratory virus infection...
  66. ncbi Airway and circulating levels of carotenoids in asthma and healthy controls
    Lisa G Wood
    Department Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    J Am Coll Nutr 24:448-55. 2005
    ..Elevated oxidative stress and impaired antioxidant defences are increasingly recognised features of asthma. Carotenoids are potent dietary antioxidants that may protect against asthma by reducing oxidative damage...
  67. doi Components of Streptococcus pneumoniae suppress allergic airways disease and NKT cells by inducing regulatory T cells
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease, Newcastle, New South Wales 2300, Australia
    J Immunol 188:4611-20. 2012
    ..These data suggest that S. pneumoniae components may have potential as a therapeutic strategy for the suppression of allergic asthma through the induction of Tregs and suppression of NKT cells...
  68. doi Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma
    Rebecca Louise Forbes
    Department of Respiratory Medicine, Centre for Asthma and Respiratory Disease, The University of Newcastle, School of Medicine and Public Health, New Lambton, NSW, Australia, 2350
    Thorax 67:209-14. 2012
    ..Pregnant women have increased susceptibility and disease severity to viral infections like influenza and HRVs, as do asthmatics. Successful pregnancy requires immunological modulation to permit fetal tolerance...
  69. ncbi The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children
    Paul S Thomas
    Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    J Asthma 42:291-5. 2005
    ..eNO appears to be a useful indicator of atopy and airway inflammation, but in this population it was not closely related to airway hyperresponsiveness...
  70. doi Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute and The University of Newcastle, Newcastle, New South Wales, Australia
    Thorax 65:1053-60. 2010
    ..Components of S pneumoniae may have the potential to modulate allergic inflammatory responses and suppress the development of asthma...
  71. doi Chronic refractory cough as a sensory neuropathy: evidence from a reinterpretation of cough triggers
    Anne E Vertigan
    Department of Speech Pathology, John Hunter Hospital, Newcastle, Australia
    J Voice 25:596-601. 2011
    ....
  72. doi Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
    J Nutr Biochem 20:577-85. 2009
    ..Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. We conclude that lycopene has a potential role in suppressing rhinovirus induced airway inflammation...
  73. doi Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Lancet 380:1583-9. 2012
    ..We established the efficacy of gabapentin in patients with refractory chronic cough...
  74. doi Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308 NSW, Australia
    Respir Med 106:138-44. 2012
    ..This study sought to investigate the prevalence, characteristics and mechanism of chronic cough following laboratory-confirmed H1N1 2009 influenza...
  75. doi Asthma in pregnancy
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, HRMC, Newcastle, New South Wales 2310, Australia
    Clin Chest Med 32:93-110, ix. 2011
    ..Barriers to effective asthma management and opportunities for optimized care and treatment are discussed, and a summary of the clinical guidelines for the management of asthma during pregnancy is presented...
  76. doi Multidimensional assessment of older people with asthma and COPD: clinical management and health status
    Vanessa M McDonald
    School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Age Ageing 40:42-9. 2011
    ..the diagnosis and management of obstructive airway diseases (OADs) such as asthma and chronic obstructive pulmonary disease (COPD) can be challenging in older people...
  77. doi Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease
    Nicole M Verrills
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 183:1633-43. 2011
    ..Proteomics may identify a useful panel of biomarkers for identification of asthma and chronic obstructive pulmonary disease (COPD)...
  78. ncbi Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease
    Jay C Horvat
    Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 176:556-64. 2007
    ..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown...
  79. ncbi Migration to a western country increases asthma symptoms but not eosinophilic airway inflammation
    Peter G Gibson
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, New South Wales, Australia
    Pediatr Pulmonol 36:209-15. 2003
    ..The development of wheeze after migration to Australia was independent of eosinophilic inflammation and consistent with noneosinophilic asthma mechanisms...
  80. ncbi Perceptual voice characteristics in chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    Folia Phoniatr Logop 59:256-67. 2007
    ..These results have implications for the identification and management of voice disorders in CC and PVFM and suggest that clinicians should be alert to the incidence of voice abnormalities in these populations...
  81. ncbi Interleukin-10 gene expression in acute virus-induced asthma
    Terry V Grissell
    School of Medical Practice and Population Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:433-9. 2005
    ..Virus-induced asthma is characterized by marked neutrophil influx and eosinophil degranulation, suggesting a mode of immunopathogenesis different from that of allergen-induced asthma...
  82. doi Premenstrual asthma: prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 45:696-704. 2008
    ..PMA resulting in increased symptoms and medication use occurred in 57% of subjects studied for 2-4 menstrual cycles. The use of oral contraceptives is not protective and further work is required to elucidate the mechanisms of PMA...
  83. ncbi Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children
    Terry V Grissell
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, New Lambton, Australia
    Pediatr Pulmonol 42:380-5. 2007
    ..There is evidence for co-regulation of neurokinin (TAC1) and TLR4 gene expression in airway cells from children with airway bacterial colonization and their reduced expression may be associated with an impaired bacterial clearance...
  84. ncbi Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales 2310, Australia
    J Clin Virol 26:339-46. 2003
    ..Sputum was assayed using IFA and RT-PCR for flu and RSV. Flu serology was performed acutely and at convalescence, 4-5 weeks later...
  85. doi Dietary factors lead to innate immune activation in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Pharmacol Ther 123:37-53. 2009
    ..Therapeutic strategies aimed at addressing diet-induced innate immune activation are warranted...
  86. doi Impact of inhaled corticosteroids on cortisol suppression in adults with asthma: a quantitative review
    John H Wlodarczyk
    John Wlodarczyk Consulting Services, New Lambton, New South Wales, Australia
    Ann Allergy Asthma Immunol 100:23-30. 2008
    ..Studies examining the effects of inhaled corticosteroids (ICSs) on cortisol suppression show inconsistent results, and there is uncertainty regarding the dose-response relationship between ICSs and cortisol suppression...
  87. doi Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Prog Lipid Res 48:27-43. 2009
    ..Finally, the review will discuss how the recognition of NEFA as important inflammatory stimulants in respiratory disease, leads to the possibility that pathways involved in lipid metabolism may provide therapeutic targets...
  88. ncbi Inhaled corticosteroid doses in asthma: an evidence-based approach
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Mail Centre, Newcastle, NSW 2310, Australia
    Med J Aust 178:223-5. 2003
    ..To define the evidence for doses of inhaled corticosteroids in asthma and describe this in clinically meaningful, evidence-based terms...
  89. ncbi Voice and upper airway symptoms in people with chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Division of Speech Pathology, University of Queensland, Brisbane, Australia
    J Voice 21:361-83. 2007
    ..A template has been provided that is a practical method of designing an integrated behavioral treatment program based on those individual patient characteristics...
  90. ncbi The relationship between chronic cough and paradoxical vocal fold movement: a review of the literature
    Anne E Vertigan
    Division of Speech Pathology, University of Queensland, Brisbane, Australia
    J Voice 20:466-80. 2006
    ....
  91. doi Assessment and reproducibility of non-eosinophilic asthma using induced sputum
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Callaghan, NSW, Australia
    Respiration 79:147-51. 2010
    ..The stability of airway inflammation in asthma over time is not known, yet this information is crucial to inflammation-based patient management...
  92. ncbi IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations
    Peter A B Wark
    Brooke Laboratories, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 120:586-93. 2007
    ..Rhinovirus-induced acute asthma is the most frequent trigger for asthma exacerbations...
  93. ncbi Involuntary glottal closure during inspiration in muscle tension dysphonia
    Anne E Vertigan
    Division of Speech Pathology, University of Queensland, Brisbane, Queensland, Australia
    Laryngoscope 116:643-9. 2006
    ..The purpose of this study was to examine respiratory function in a group of patients with muscle tension dysphonia (MTD) DESIGN: Cross-sectional analytical study...
  94. ncbi A review of voice and upper airway function in chronic cough and paradoxical vocal cord movement
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    Curr Opin Allergy Clin Immunol 7:37-42. 2007
    ..Chronic cough and paradoxical vocal fold movement (PVFM) are perplexing conditions. This paper reviews the recent literature in relation to the nature of PVFM and chronic cough and the management of symptoms associated with these disorders...
  95. ncbi The role of sensory dysfunction in the development of voice disorders, chronic cough and paradoxical vocal fold movement
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Newcastle, Australia
    Int J Speech Lang Pathol 10:231-44. 2008
    ..Dysphonia can occur in CC/PVFM and may improve following behavioural treatment of CC...
  96. ncbi Role of atypical bacterial infection of the lung in predisposition/protection of asthma
    Philip M Hansbro
    Discipline of Immunology and Microbiology, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Pharmacol Ther 101:193-210. 2004
    ....
  97. doi Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, NSW, Australia
    Pharmacol Ther 124:86-95. 2009
    ..Studies also show improvements in quality of life and exacerbation rates in airways diseases...
  98. ncbi Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, University of Newcastle, New South Wales, Australia
    J Clin Endocrinol Metab 87:1660-8. 2002
    ....
  99. ncbi Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patients
    Lisa G Wood
    Discipline of Nutrition and Dietetics, The University of Newcastle, Callaghan, New South Wales, Australia
    Am J Clin Nutr 75:668-75. 2002
    ..Oxidative stress and depleted antioxidant defenses occur in stable cystic fibrosis patients. During acute infection, the balance between oxidants and antioxidants may be further disturbed...
  100. ncbi Circulating markers to assess nutritional therapy in cystic fibrosis
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310, NSW, Australia
    Clin Chim Acta 353:13-29. 2005
    ..This article provides an overview of the biomarkers useful in the prediction of the efficacy of nutritional therapy on improvements in quality and quantity of life in CF...
  101. ncbi Outpatient monitoring of asthma
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Curr Opin Allergy Clin Immunol 2:161-6. 2002
    ..Additional monitoring tools are under evaluation, and these include measures of airway responsiveness, airway inflammation, and Internet-based monitoring systems...