D J Chan

Summary

Affiliation: New South Wales
Country: Australia

Publications

  1. ncbi request reprint Quantification of antiretroviral drugs for HIV-1 in the male genital tract: current data, limitations and implications for laboratory analysis
    Derek J Chan
    Division of Sexual Health, Albion Street Centre, Sydney, Australia
    J Pharm Pharmacol 59:1451-62. 2007
  2. ncbi request reprint Assays for the determination of HIV-1 load in semen: a review of indications, methods and performance in vitro
    Derek J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Curr HIV Res 6:182-8. 2008
  3. doi request reprint Clinical experience with nevirapine combined with tenofovir plus emtricitabine or lamivudine-containing regimens in HIV-infected subjects
    D E Smith
    Albion Street Centre, Surry Hills, Australia
    Int J STD AIDS 22:228-30. 2011
  4. doi request reprint Can HIV-1 incidence be estimated from plasma viral load and sexual behaviour?
    D J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, NSW, Australia
    Int J STD AIDS 23:724-8. 2012
  5. ncbi request reprint HIV-1 transmission amongst men who have sex with men: a probabilistic model incorporating antiretroviral treatment optimism-scepticism, sexual beliefs and sexual behaviour
    Derek J Chan
    Division of Sexual Health Medicine, Albion Street Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Curr HIV Res 7:231-6. 2009
  6. ncbi request reprint Correlation between HIV-1 RNA load in blood and seminal plasma depending on antiretroviral treatment status, regimen and penetration of semen by antiretroviral drugs
    Derek J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, Australia
    Curr HIV Res 6:477-84. 2008
  7. ncbi request reprint Relationship between HIV-RNA load in blood and semen in antiretroviral-naïve and experienced men and effect of asymptomatic sexually transmissible infections
    Derek J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Curr HIV Res 6:138-42. 2008
  8. ncbi request reprint Erectile dysfunction in men with HIV-1: effect of hypogonadism and antiretroviral therapy
    Derek J Chan
    Sexualt Health Medicine, Albion Street Centre, Surry Hills, NSW, Australia
    J HIV Ther 12:54-8. 2007
  9. ncbi request reprint Fatal attraction: sex, sexually transmitted infections and HIV-1
    D J Chan
    Division of Sexual Health, Albion Street Centre, 150 154 Albion Street, Surry Hills, Sydney, New South Wales 2010, Australia
    Int J STD AIDS 17:643-51. 2006
  10. ncbi request reprint Prevalence of antimicrobial resistance in Neisseria gonorrhoeae in an HIV/AIDS clinic
    D J Chan
    Division of Sexual Health, Albion Street Centre, 150 154 Albion Street, Surry Hills, NSW 2010, Australia
    Int J STD AIDS 17:410-2. 2006

Detail Information

Publications22

  1. ncbi request reprint Quantification of antiretroviral drugs for HIV-1 in the male genital tract: current data, limitations and implications for laboratory analysis
    Derek J Chan
    Division of Sexual Health, Albion Street Centre, Sydney, Australia
    J Pharm Pharmacol 59:1451-62. 2007
    ..This review critically appraises current studies of antiretroviral drug quantification in semen and suggests recommendations to address observed limitations...
  2. ncbi request reprint Assays for the determination of HIV-1 load in semen: a review of indications, methods and performance in vitro
    Derek J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Curr HIV Res 6:182-8. 2008
    ..Sensitivity is increased when silica extraction methods are used...
  3. doi request reprint Clinical experience with nevirapine combined with tenofovir plus emtricitabine or lamivudine-containing regimens in HIV-infected subjects
    D E Smith
    Albion Street Centre, Surry Hills, Australia
    Int J STD AIDS 22:228-30. 2011
    ..6%). Long-term follow-up with a NVP/TDF-based regimen showed a low rate of discontinuation and enabled physicians to extend the use of ART over a long period, often with simplified (once-daily) regimens...
  4. doi request reprint Can HIV-1 incidence be estimated from plasma viral load and sexual behaviour?
    D J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, NSW, Australia
    Int J STD AIDS 23:724-8. 2012
    ..The model can be used to counsel individuals or predict epidemics, and to assess behaviour change or the impact of public health interventions...
  5. ncbi request reprint HIV-1 transmission amongst men who have sex with men: a probabilistic model incorporating antiretroviral treatment optimism-scepticism, sexual beliefs and sexual behaviour
    Derek J Chan
    Division of Sexual Health Medicine, Albion Street Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Curr HIV Res 7:231-6. 2009
    ..A sub-group reported frequent unprotected anal intercourse with their partners. Our model may be used to quantify risk behavior during individual counselling or to develop targeted prevention programmes at the public health level...
  6. ncbi request reprint Correlation between HIV-1 RNA load in blood and seminal plasma depending on antiretroviral treatment status, regimen and penetration of semen by antiretroviral drugs
    Derek J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, Australia
    Curr HIV Res 6:477-84. 2008
    ..We find that there is compartmentalisation of HIV-1 within the male genital tract and propose that new infections may originate from untreated men and that suppressive antiretroviral regimens may reduce the risk of sexual transmission...
  7. ncbi request reprint Relationship between HIV-RNA load in blood and semen in antiretroviral-naïve and experienced men and effect of asymptomatic sexually transmissible infections
    Derek J Chan
    Albion Street Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Curr HIV Res 6:138-42. 2008
    ..STIs minimally increase, or do not increase, SPVL in untreated patients. Our data supports the role of ART in lowering the risk of sexual transmission of HIV-1...
  8. ncbi request reprint Erectile dysfunction in men with HIV-1: effect of hypogonadism and antiretroviral therapy
    Derek J Chan
    Sexualt Health Medicine, Albion Street Centre, Surry Hills, NSW, Australia
    J HIV Ther 12:54-8. 2007
  9. ncbi request reprint Fatal attraction: sex, sexually transmitted infections and HIV-1
    D J Chan
    Division of Sexual Health, Albion Street Centre, 150 154 Albion Street, Surry Hills, Sydney, New South Wales 2010, Australia
    Int J STD AIDS 17:643-51. 2006
    ..An understanding of the interplay between sexual practices, STIs and HIV-1 may facilitate the development of effective treatment and prevention strategies. These topics are the subject of this review...
  10. ncbi request reprint Prevalence of antimicrobial resistance in Neisseria gonorrhoeae in an HIV/AIDS clinic
    D J Chan
    Division of Sexual Health, Albion Street Centre, 150 154 Albion Street, Surry Hills, NSW 2010, Australia
    Int J STD AIDS 17:410-2. 2006
    ..Continued surveillance of antimicrobial resistance in the pathogen, with communication between clinic and laboratory, is needed to ensure optimal treatment of infection...
  11. doi request reprint Factors associated with unprotected anal intercourse between HIV-positive men and regular male partners in a Sydney cohort
    K Begley
    Albion Street Centre, Prince of Wales Hospital, Sydney, Australia
    Int J STD AIDS 20:704-7. 2009
    ..Treatment optimism was not associated with UAI. In this cohort, sexual practices were based more upon knowledge of biomedical factors rather than attitudes regarding transmission risks...
  12. ncbi request reprint What's in a word? Case definitions in sexual health medicine
    D J Chan
    Albion Street Centre, 150 154 Albion Street, Surry Hills, New South Wales 2010, Australia
    Int J STD AIDS 16:91-4. 2005
    ..There is also the problem of reaching a consensus, especially for complex syndromes such as pelvic inflammatory disease...
  13. ncbi request reprint Getting to the bottom of anal itch - a cautionary tale
    D J Chan
    Albion Street Centre, 150 154 Albion Street, Surry Hills, Sydney, New South Wales 2010, Australia
    Int J STD AIDS 15:772-4. 2004
    ..We report an unusual case of dual pathology in the anal region, which highlights the need to thoroughly investigate peri-anal symptoms in HIV-positive men...
  14. ncbi request reprint A diagnosis unmasked by an unusual reaction to ceftriaxone therapy for gonorrhoeal infection
    Derek J Chan
    Department of HIV Medicine, Albion Street Centre, 150 154 Albion Street, Sydney, NSW 2010, Australia
    Med J Aust 178:404-5. 2003
  15. ncbi request reprint HIV-1 superinfection: evidence and impact
    Derek J Chan
    Albion Street Centre, Sydney, New South Wales 2010, Australia
    Curr HIV Res 2:271-4. 2004
    ..Estimating the overall impact of HIV-1 superinfection on pathogenesis and attempts to create a broadly protective prophylactic HIV-1 vaccine is complicated by our inability to quantify the true incidence and prevalence...
  16. ncbi request reprint Correlates of unprotected anal intercourse in HIV positive men attending an HIV/AIDS clinic in Sydney
    Kim Begley
    Albion Street Centre, Prince of Wales Hospital, Sydney, Australia
    Curr HIV Res 6:579-84. 2008
    ..014). We found between-group differences in variables associated with different types of unprotected anal intercourse that may guide the development of prevention strategies...
  17. ncbi request reprint Syphilis and HIV co-infection: when is lumbar puncture indicated?
    Derek J Chan
    Albion Street Centre, 150 154 Albion Street, Surry Hills, Sydney, New South Wales 2010, Australia
    Curr HIV Res 3:95-8. 2005
    ..This article reviews the current literature on the relative utility and indications for LP in syphilis/HIV co-infected patients and new research in this area...
  18. ncbi request reprint Things that go bump on the right
    Derek J Chan
    Division of Sexual Health, Albion Street Centre, 150 154 Albion Street, Surry Hills, Sydney, New South Wales 2010, Australia
    Int J STD AIDS 18:869-70. 2007
    ..Groin masses are common and the differential diagnosis is wide. It is important to distinguish surgical and medical causes. A rare surgical cause--that may be associated with cryptorchidism--is presented here...
  19. ncbi request reprint Pathophysiology of HIV-1 in semen: current evidence for compartmentalisation and penetration by antiretroviral drugs
    Derek J Chan
    Albion Street Centre, 150 154 Albion Street, Surry Hills, Sydney, New South Wales 2010, Australia
    Curr HIV Res 3:207-22. 2005
    ....
  20. ncbi request reprint Factors affecting sexual transmission of HIV-1: current evidence and implications for prevention
    Derek J Chan
    Albion Street Centre, 150 154 Albion Street, Surry Hills, Sydney, New South Wales 2010, Australia
    Curr HIV Res 3:223-41. 2005
    ..A redistribution of global aid funding would do much to alleviate the pandemic in developed countries...
  21. ncbi request reprint A sexual health strategy for Australia--time for action
    D J Chan
    Albion Street Centre, 150 154 Albion Street, Surry Hills, NSW 2010, Australia
    Sex Health 1:197-9. 2004
    ..We propose a public health framework for the development of a national sexual health strategy that will bring Australia in line with the United Kingdom and New Zealand...
  22. ncbi request reprint Treating primary HIV infection--is your HAART in it?
    Don E Smith
    Sex Health 1:131-5. 2004