Research Topics
Genomes and Genes | Jerzy K KulskiSummaryAffiliation: Murdoch University Country: Australia Publications
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Publications
Polymorphic Alu insertions within the Major Histocompatibility Complex class I genomic region: a brief reviewJ K Kulski
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, Western Australia
Cytogenet Genome Res 110:193-202. 2005..We show that the MHC POALINs have a potential value as lineage and linkage markers for the study of human population genetics, disease associations, genomic diversity and evolution...- Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21Jerzy K Kulski
Centre for Bioinformatics and Biological Computing, School for Information Technology, Murdoch University, Murdoch, Western Australia, Australia 6150
J Mol Evol 56:397-406. 2003..This is the first report of five copies of the S100A7 gene in the human genome, which may impact on our understanding of the possible dose effects of these genes in inflammation and normal skin development and pathogenesis... - Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complexJerzy K Kulski
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, Western Australia
Mol Biol Evol 21:2079-91. 2004.... - Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signalsJerzy K Kulski
Centre for Bioinformatics and Biological Computing, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia
J Mol Med (Berl) 83:964-75. 2005.... - Alu polymorphism within the MICB gene and association with HLA-B allelesJerzy K Kulski
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, 6150 Western Australia, Australia
Immunogenetics 53:975-9. 2002..157) [corrected] but was strongly associated with HLA-B17 (HLA-B57,HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci... - Genomic and phylogenetic analysis of the human CD1 and HLA class I multicopy genesJ K Kulski
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, Western Australia, Australia 6150
J Mol Evol 53:642-50. 2001..The IGRs seem to have been created as "buffer zones" to protect the CD1 genes from disruption by transposable elements... - ERVK9, transposons and the evolution of MHC class I duplicons within the alpha-block of the human and chimpanzeeJ K Kulski
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, Western Australia
Cytogenet Genome Res 110:181-92. 2005.... - Human endogenous retrovirus (HERVK9) structural polymorphism with haplotypic HLA-A allelic associationsJerzy K Kulski
Centre for Forensic Science, The University of Western Australia, Nedlands, Western Australia, Australia
Genetics 180:445-57. 2008.... - Polymorphic SVA retrotransposons at four loci and their association with classical HLA class I alleles in Japanese, Caucasians and African AmericansJerzy K Kulski
Centre for Forensic Science, The University of Western Australia, Nedlands, Western Australia, 6008, Australia
Immunogenetics 62:211-30. 2010.... - HLA-A allele associations with viral MER9-LTR nucleotide sequences at two distinct loci within the MHC alpha blockJerzy K Kulski
Centre for Forensic Science, The University of Western Australia, Crawley, Western Australia, Australia
Immunogenetics 61:257-70. 2009..Our study shows that the nucleotide variations of the MER9-LTR DNA sequences are additional informative markers in fine mapping HLA-A genomic haplotypes for future population, evolutionary, and disease studies... - The distribution of polymorphic Alu insertions within the MHC class I HLA-B7 and HLA-B57 haplotypesDavid S Dunn
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, Western Australia, Australia
Immunogenetics 56:765-8. 2005.... - Dimorphic Alu element located between the TFIIH and CDSN genes within the major histocompatibility complexDavid S Dunn
Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, Western Australia, Australia 6150
Electrophoresis 24:2740-8. 2003.... - Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and BAnnalise M Martin
Centre for Clinical Immunology and Biomedical Statistics, Murdoch University, Western Australia 6150, Australia
Gene 335:121-31. 2004.... - The association between HLA-A alleles and an Alu dimorphism near HLA-GJ K Kulski
Centre for Molecular Immunology and Instrumentation, The University of Western Australia, Nedlands, 6009, Western Australia, Australia
J Mol Evol 53:114-23. 2001.... - The association between HLA-A alleles and young Alu dimorphisms near the HLA-J, -H, and -F genes in workshop cell lines and Japanese and Australian populationsDavid S Dunn
Centre for Bioinformatics and Biological Computing, School for Information Technology, Murdoch University, Murdoch, Western Australia, Australia
J Mol Evol 55:718-26. 2002.... - The distribution of major histocompatibility complex class I polymorphic Alu insertions and their associations with HLA alleles in a Chinese population from MalaysiaD S Dunn
Centre for Comparative Genomics, School for Information Technology, Murdoch University, Murdoch, Western Australia, Australia
Tissue Antigens 70:136-43. 2007..The MHC POALINs are confirmed in this study to be informative genetic markers in lineage (haplotype) analysis, population genetics and evolutionary relationships, especially in studying the MHC genomic region... - Comparison between two human endogenous retrovirus (HERV)-rich regions within the major histocompatibility complexJ K Kulski
Centre for Molecular Immunology and Instrumentation, University of Western Australia, Faculty of Medicine and Dentistry, P O Box 5100, Canning Vale, 6155, Western Australia, Australia
J Mol Evol 48:675-83. 1999..These HERV sequences will therefore enhance further studies on disease associations and differences between human haplotypes and primates and their role in the evolution of class I genes in the MHC... - Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in the northeastern ThaisD S Dunn
Centre for Bioinformatics and Biological Computing, Murdoch University, Murdoch, 6150 Western Australia, Australia
Ann Hum Genet 69:364-72. 2005..This study confirms that the MHC POALINs are in linkage disequilibrium with HLA-A and -B alleles and that there are significant frequency differences for some of the POALINs when compared between NE Thai, Caucasians and Japanese... - The association between non-melanoma skin cancer and a young dimorphic Alu element within the major histocompatibility complex class I genomic regionD S Dunn
Centre for Bioinformatics and Biological Computing, School for Information Technology, Murdoch University, Murdoch, Western Australia, Australia
Tissue Antigens 68:127-34. 2006..This finding, using five different polymorphic Alu insertion markers, supports the previous microsatellite association study that one or more genes located in close proximity to the AluyTF insertion has a potential role in NMSC... - Identification of two new C4 alleles by DNA sequencing and evidence for a historical recombination of serologically defined C4A and C4B allelesJ Hui
School of Surgery and Pathology, Division of Pathology, The University of Western Australia, Nedlands, Western Australia, Australia
Tissue Antigens 63:263-9. 2004.... - Association of MHC dimorphic Alu insertions with HLA class I and MIC genes in Japanese HLA-B48 haplotypesD S Dunn
Center for Bioinformatics and Biological Computing, School for Information Technology, Murdoch University, Murdoch, WA, Australia
Tissue Antigens 62:259-62. 2003..We conclude that the extended HLA-B haplotypes are best defined by considering multiple genomic sites including the four polymorphic Alu insertions described in this study... - Contribution of mutation, recombination, and gene conversion to chicken MHC-B haplotype diversityKazuyoshi Hosomichi
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan
J Immunol 181:3393-9. 2008..These data provide a framework for further analyses of disease associations found among these 14 haplotypes and additional haplotypes segregating and evolving in wild and domesticated populations of chickens... - Microsatellite diversity and crossover regions within homozygous and heterozygous SLA haplotypes of different pig breedsAsako Ando
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
Immunogenetics 60:399-407. 2008.... - Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversityTakashi Shiina
Department of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Japan
Genetics 173:1555-70. 2006..This is most likely reminiscent of the fact that these hsSNV and hv1SNV have been selected in adaptation to the constantly evolving microbial antigenic repertoire... - Genomic sequence analysis of the 238-kb swine segment with a cluster of TRIM and olfactory receptor genes located, but with no class I genes, at the distal end of the SLA class I regionAsako Ando
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Immunogenetics 57:864-73. 2005.... - The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chickenKazuyoshi Hosomichi
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1143, Japan
BMC Genomics 7:322. 2006.... - Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22Tomoki Kikuchi
Department of Pathology, Sapporo Medical University School of Medicine, Hokkaido, Japan
Immunogenetics 59:99-108. 2007..This screening analysis suggests that several aGVHD-associated susceptible and protective loci exist on chromosome 22, which may encompass novel gene regions that need to be elucidated for their role in aGVHD... - A BAC-based contig map of the cynomolgus macaque (Macaca fascicularis) major histocompatibility complex genomic regionAtsushi Watanabe
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1143, Japan
Genomics 89:402-12. 2007..From these findings, we conclude that the BAC library and Mafa genomic map are useful tools for genome analysis and will have important applications for comparative genomics and identifying regions of consequence in medical research... - Nucleotide sequencing analysis of the swine 433-kb genomic segment located between the non-classical and classical SLA class I gene clustersAtsuko Shigenari
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, 259 1193, Kanagawa, Japan
Immunogenetics 55:695-705. 2004..We conclude that the swine non-class I gene region that we have sequenced is highly conserved and therefore homologous to the corresponding region located between the HLA-C and HLA-E genes in the human... - Identification of NAD+-dependent isocitrate dehydrogenase 3 gamma-like (IDH3GL) gene and its genetic polymorphismsKoichi Okamoto
Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Kanagawa 259 1193, Isehara, Japan
Gene 323:141-8. 2003..We conclude that the IDH3GL gene sequence is a splice variant of the NELL1 gene and that it probably evolved from a transposed pseudogene of the IDH3 gene... - Identification of novel candidate genes in the diffuse panbronchiolitis critical region of the class I human MHCYasunari Matsuzaka
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Immunogenetics 54:301-9. 2002..Taken together, these results, especially the abundant expression in lung, indicate that C6orf37 and C6orf37OS are excellent candidate genes for DPB... - Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergenceTatsuya Anzai
Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
Proc Natl Acad Sci U S A 100:7708-13. 2003..Finally, if generalized, these data suggest that evolution may have used the mechanistically more drastic indels instead of the more subtle single-nucleotide substitutions for shaping the recently emerged primate species... - hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasisYasunari Matsuzaka
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Mamm Genome 15:668-75. 2004..On this basis, we conclude that the polymorphisms that we detected for the hRDH-E2 gene do not contribute to the etiology of psoriasis but may be important in diseases of other tissues... - Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to manJerzy K Kulski
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Immunol Rev 190:95-122. 2002.... - Identification, expression analysis and polymorphism of a novel RLTPR gene encoding a RGD motif, tropomodulin domain and proline/leucine-rich regionsYasunari Matsuzaka
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Gene 343:291-304. 2004..In addition, sequence analysis of the RLTPR genes from eight psoriasis patients and eight healthy controls revealed a number of synonymous and nonsynonymous SNPs that may be useful markers for future disease association studies... - Identification and characterization of novel variants of the thioredoxin reductase 3 new transcript 1 TXNRD3NT1Yasunari Matsuzaka
Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
Mamm Genome 16:41-9. 2005..Sequence analysis of the TXNRD3NT1 gene from 8 psoriasis patients and 8 healthy controls revealed a number of synonymous SNPs that may be useful markers for future disease association studies... - High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese populationYoshiki Itoh
Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
Immunogenetics 57:717-29. 2005..It takes only approximately 5 h from DNA extraction to the definition of HLA four-digit alleles at the HLA-A, HLA-B, HLA-C, and HLA-DRB1 loci for 96 samples when handled by a single typist... - Whole genome association study of rheumatoid arthritis using 27 039 microsatellitesGen Tamiya
Department of Molecular Life Science, Course of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Bohseidai, Kanagawa, Japan
Hum Mol Genet 14:2305-21. 2005..Hence, microsatellite-based genome-wide association analysis complemented by end stage SNP typing provides a new tool for genetic dissection of multifactorial pathologies including common diseases... - Leukocyte Ig-like receptor complex (LRC) in mice and menAnnalise M Martin
Centre for Clinical Immunology and Biomedical Statistics, Murdoch University and Royal Perth Hospital, WA, Australia
Trends Immunol 23:81-8. 2002..The genomic organization of and evolutionary associations between these receptors and their domains are examined... - Analysis of the sequence variations in the Mhc DRB1-like gene of the endangered Humboldt penguin (Spheniscus humboldti)Eri F Kikkawa
Department of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan
Immunogenetics 57:99-107. 2005.... - High-resolution mapping for essential hypertension using microsatellite markersKeisuke Yatsu
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan
Hypertension 49:446-52. 2007..We identified 19 allelic loci that were significantly different between the cases of essential hypertension and the controls... - Comparative genomic analysis of two avian (quail and chicken) MHC regionsTakashi Shiina
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
J Immunol 172:6751-63. 2004.... - MHC class IIB gene sequences and expression in quails (Coturnix japonica) selected for high and low antibody responsesSayoko Shimizu
Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Bohseidai, Isehara-shi, 259-1193 Kanagawa, Japan
Immunogenetics 56:280-91. 2004..The antibody and class IIB gene expression data obtained in response to SRBC immunization provide further evidence that quails within the L line had reduced immunocompetence compared with those in the H line... - Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophreniaKatsuhito Yasuno
Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan
Am J Med Genet B Neuropsychiatr Genet 144:250-3. 2007..Our findings suggest that UCP2 and UCP4 have a modest but important involvement in the genetic etiology of schizophrenia. This is the first report of the association between schizophrenia and neuronal UCPs... - Regulation of CD93 cell surface expression by protein kinase C isoenzymesNobunao Ikewaki
Institute of Immunology, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan
Microbiol Immunol 50:93-103. 2006..Taken together, these findings indicate that the regulation of CD93 expression on these cells involves the PKC isoenzymes... - Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6Masato Ohtsuka
Division of Basic Molecular Science and Molecular Medicine, School of Medicine, Tokai University, Bohseidai, Isehara, Kanagawa 259 1193, Japan
BMC Genomics 9:178. 2008..To better understand the roles of class Ib molecules, we have characterized their gene duplication, organization and expression patterns within the H2 region of the mouse strain C57BL/6...