Affiliation: Monash University
Antignano F, Braam M, Hughes M, Chenery A, Burrows K, Gold M, et al
. G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program. J Exp Med. 2016;213:1153-62 pubmed publisher
..Together, these results provide the first identification of an epigenetic regulatory mechanism in ILC development and function. ..
Scheer S, Ackloo S, Medina T, Schapira M, Li F, Ward J, et al
. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat Commun. 2019;10:19 pubmed publisher
..This chemical probe collection and associated data form a resource for the study of methylation-mediated signaling in epigenetics, inflammation and beyond. ..
Chenery A, Antignano F, Burrows K, Scheer S, Perona Wright G, Zaph C. Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation. Infect Immun. 2016;84:491-501 pubmed publisher
..These results provide further insight in identifying novel intersecting immune pathways elicited by gut-to-lung mucosal cross talk. ..
Oudhoff M, Braam M, Freeman S, Wong D, Rattray D, Wang J, et al
. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/?-Catenin and Hippo/YAP Signaling. Dev Cell. 2016;37:47-57 pubmed publisher
..Collectively, these results define a methyltransferase-dependent regulatory mechanism that links the Wnt/?-catenin and Hippo/YAP pathways during intestinal regeneration and tumorigenesis. ..
Chenery A, Antignano F, Hughes M, Burrows K, McNagny K, Zaph C. Chronic Trichuris muris infection alters hematopoiesis and causes IFN-?-expressing T-cell accumulation in the mouse bone marrow. Eur J Immunol. 2016;46:2587-2596 pubmed publisher
..Thus, these results demonstrate that Th1 cell-driven responses in the intestine during chronic helminth infection potently influence upstream hematopoietic processes in the BM via IFN-?. ..
Scheer S, Medina T, Murison A, Taves M, Antignano F, Chenery A, et al
. Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation. J Leukoc Biol. 2017;101:893-900 pubmed publisher
..Thus, our results suggest that early-life Abx treatment results in a stress response with high levels of corticosterone that influences CD4+ T cell function. ..
Lo B, Gold M, Scheer S, Hughes M, Cait J, Debruin E, et al
. Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury. Am J Respir Cell Mol Biol. 2017;57:651-661 pubmed publisher
..Together, our data suggest that CD34 plays an essential role in maintaining vascular integrity in the lung in response to chemical- and infection-induced tissue damage. ..