Zhi Cheng Xiao
Affiliation: Monash University
Qiu C, Liu Z, Zhang F, Zhang L, Li F, Liu S, et al
. Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice. Brain Res. 2019;1712:7-15 pubmed publisher
..Our findings suggest that gastrodin treatment following ischemic injury can induce neuroprotection, promote neurogenesis and restored the Wnt /β-Catenin signaling pathway. ..
Qiu C, Liu Z, Hou K, Liu S, Hu Y, Zhang L, et al
. Wip1 knockout inhibits neurogenesis by affecting the Wnt/β-catenin signaling pathway in focal cerebral ischemia in mice. Exp Neurol. 2018;309:44-53 pubmed publisher
..These findings indicate that WIP1 is essential for neurogenesis after brain injury by activating the Wnt/β-Catenin signaling pathway. ..
Wang W, Lu L, Bao T, Zhang H, Yuan J, Miao W, et al
. Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. J Mol Neurosci. 2016;58:210-20 pubmed publisher
..In summary, scutellarin could alleviate motor deficits in a mouse model for MS, possibly by inhibiting NSC apoptosis and promoting differentiation of NSCs to myelin-producing oligodendrocytes. ..
Liu C, Tan F, Xiao Z, Dawe G. Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression. J Biol Chem. 2015;290:12048-57 pubmed publisher
..Phosphorylation of APP695 at Thr-668 enhanced its interaction with Nav1.6. Therefore, we show that APP enhances Nav1.6 sodium channel cell surface expression through a Go-coupled JNK pathway. ..
Liu C, Zhang C, Zhou Y, Wong W, Lee L, Ong W, et al
. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018;25:661-676 pubmed publisher
..This pathway may be a novel target for neuronal protection in optic neuropathies and other forms of neurotrauma. ..