J W Wilson
Affiliation: Monash University
- Challenges in pulmonary fibrosis: 8--The need for an international registry for idiopathic pulmonary fibrosisJ W Wilson
Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash University, Commercial Road, Melbourne 3004, Australia
Thorax 63:285-7. 2008..We advocate for an international registry to achieve better outcomes in IPF...
- Angiogenesis and increased airway vascularity in airway diseasesJ Wilson
The Alfred Hospital and Monash Medical School, Prahan, Australia
Arch Physiol Biochem 111:361-3. 2003
- Inflammation and remodelling in the ageing airwayJohn W Wilson
Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital and Monash University, Commercial Road, Prahran, VIC 3004, Australia
Med J Aust 183:S33-4. 2005..Determine the extent to which airway remodelling plays a role in airflow obstruction in older people, specifically reversible components. Reduce the impact of smoking in young people with asthma...
- Assessing the evidence for remodelling of the airway in asthmaJ W Wilson
Department of Respiratory Medicine, Monash Medical School and The Alfred Hospital, Commercial Rd, Prahran, 3181 Australia
Pulm Pharmacol Ther 14:229-47. 2001..The useful tools of immunohistochemistry and molecular biology combined with airway biopsy and well-designed clinical trials will be essential to determine the specific roles of cells and cytokines in airway remodelling in asthma...
- Angiogenesis in paediatric airway diseaseJohn W Wilson
Department of Respiratory Medicine and Monash Medical School, The Alfred Hospital, Prahran 3181, Australia
Paediatr Respir Rev 3:219-29. 2002..New therapies may be able to improve airflow through better regulation of vessel growth, dilatation and leakage in the airway wall...
- Airway vascular remodeling in asthmaJohn W Wilson
Department of Respiratory Medicine, The Alfred Hospital, Prahran 3181, Australia
Curr Allergy Asthma Rep 3:153-8. 2003..Many commonly used airway medications are capable of modulating the vascular response to inflammatory stimuli. New therapies might improve airflow through better regulation of vessel growth, dilatation, and leakage in the airway wall...
- The importance of the airway microvasculature in asthmaJohn W Wilson
Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash Medical School, Prahran, Australia
Curr Opin Allergy Clin Immunol 6:51-5. 2006....
- Isoniazid toxicity in health care workersR L Stuart
Department of Infectious Diseases and Clinical Epidemiology, Monash Medical Centre, Clayton, Australia
Clin Infect Dis 28:895-7. 1999..39 years). The high rate of toxicity seen in this study is sufficiently notable that we advocate the use of monthly liver function testing and frequent review in those receiving isoniazid prophylactic therapy...
- Randomised placebo controlled trial of non-invasive ventilation for hypercapnia in cystic fibrosisA C Young
Department of Allergy Immunology and Respiratory Medicine, The Alfred Hospital, Commercial Rd, Prahran, Melbourne, Vic, 3181, Australia
Thorax 63:72-7. 2008..We studied the effects of nocturnal NIV on quality of life (QoL), functional and physiological outcomes in CF subjects with awake hypercapnia (arterial carbon dioxide pressure PaCO2>45 mm Hg)...
- Does expiratory flow limitation predict chronic dyspnoea in adults with cystic fibrosis?A E Holland
Dept of Physiotherapy, Alfred Hospital, Commercial Rd, Melbourne 3004, Australia
Eur Respir J 28:96-101. 2006..Expiratory flow limitation significantly contributes to chronic dyspnoea in cystic fibrosis...
- Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthmaB E Orsida
Department of Respiratory Medicine, The Alfred Hospital and Monash University Medical School, Melbourne, Victoria, Australia
Am J Respir Crit Care Med 164:117-21. 2001....
- Challenges in pulmonary fibrosis: 7--Novel therapies and lung transplantationT J Williams
Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash University, Commercial Road, Melbourne 3004, Victoria, Australia
Thorax 63:277-84. 2008..New options for therapy will lead to improved survival in coming years...
- Reduced bone density in cystic fibrosis: DeltaF508 mutation is an independent risk factorS J King
Nutrition Dept, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
Eur Respir J 25:54-61. 2005..In conclusion, reduced bone mineral density in cystic fibrosis is associated with a number of factors, including DeltaF508 genotype, male sex, greater lung disease severity and malnutrition...
- Airway remodelling in asthma: current understanding and implications for future therapiesMimi L K Tang
Department of Immunology, Murdoch Children s Research Institute, The Royal Children s Hospital, Melbourne 3052, Australia
Pharmacol Ther 112:474-88. 2006..In this review, we describe the current understanding of the airway remodelling process and the mechanisms regulating its development. The impact of currently available asthma therapies on airway remodelling is also discussed...
- Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factorReena Ghildyal
Department of Respiratory Medicine, Medicine and Surgery, Monash Medical Centre and Monash Center for Inflammatory Diseases, Monash University, 246 Clayton Road, Clayton 3168, Melbourne, Australia
J Med Virol 75:608-15. 2005....
- Inhaled steroids - too much of a good thing?John W Wilson
Med J Aust 177:288-9. 2002
- Collagen-induced resistance to glucocorticoid anti-mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airwayJohn V Bonacci
Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia
Br J Pharmacol 138:1203-6. 2003....
- Differential inhibition of thrombin- and EGF-stimulated human cultured airway smooth muscle proliferation by glucocorticoidsRoss Vlahos
Department of Pharmacology, University of Melbourne, Melbourne, Vic. 3010, Australia
Pulm Pharmacol Ther 16:171-80. 2003....
- Vascular endothelial growth factor induction by rhinovirus infectionDinesha de Silva
Department of Respiratory and Sleep Medicine, Monash Medical Centre, Melbourne, Australia
J Med Virol 78:666-72. 2006..This may aid recruitment of inflammatory cells and contribute to airway inflammation and bronchial obstruction...
- Metabolic alkalosis contributes to acute hypercapnic respiratory failure in adult cystic fibrosisAnne E Holland
Department of Physiotherapy, The Alfred Hospital, Melbourne, Vic, Australia
Chest 124:490-3. 2003..The aim of this study was to determine the prevalence of metabolic alkalosis in adults with hypercapnic respiratory failure in the setting of acute exacerbations of CF compared with COPD...
- Smoking during pregnancy is associated with alterations in markers of endothelial functionKristine Y Lain
Magee-Womens Research Institute and Department of Obstetrics, Gynecology, and Reproductive Sciences, Pittsburgh, PA, USA
Am J Obstet Gynecol 189:1196-201. 2003..These differences may be the result of different aspects of endothelial function or the source of the marker. The explanation for reduced preeclampsia in smokers remains elusive...
- P-glycoprotein activity is decreased in CD4+ but not CD8+ lung allograft-infiltrating T cells during acute cellular rejectionVera S Donnenberg
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Transplantation 77:1699-706. 2004..Modulation of P-glycoprotein (P-gp) activity in graft-infiltrating T cells may alter their susceptibility to immunosuppression...
- Bioequivalence revisited: influence of age and sex on CYP enzymesZourab Bebia
Center for Clinical Pharmacology and Department of Pharmaceutical Sciences, University of Pittsburgh, PA 15219, USA
Clin Pharmacol Ther 76:618-27. 2004..However, we suggest that sex has a limited ability to explain intersubject variation of activity for these phenotypic measures of CYP enzyme activity...
- Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fracturesNaila Khalil
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Bone Miner Res 23:1417-25. 2008..07, 2.45; p trend = 0.014) compared with women with lowest lead level. Blood lead levels are associated with an increased risk of falls and fractures, extending the negative health consequences of lead to include osteoporotic fractures...