D R Williams
Affiliation: Monash University
- Using the presence of visual hallucinations to differentiate Parkinson's disease from atypical parkinsonismD R Williams
Faculty of Medicine, Neurosciences, Monash University, Alfred Hospital Campus, Commercial Rd, Melbourne 3004, Australia
J Neurol Neurosurg Psychiatry 79:652-5. 2008..To address the issue of diagnosis in patients with parkinsonism, we developed instructions for a structured interview (Queen Square Visual Hallucination Inventory (QSVHI)), capable of rapidly screening for VH in the outpatient setting...
- What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy-parkinsonism (PSP-P)?David R Williams
Van Cleef Roet Centre for Nervous Diseases, Monash University, Melbourne, Victoria, Australia
Mov Disord 25:357-62. 2010..PSP-P shares many clinical features with PD and DLB, MSA and VP, but visual hallucinations, drug induced dyskinesias and autonomic dysfunction are very uncommon and may be helpful exclusion criteria...
- Pure akinesia with gait freezing: a third clinical phenotype of progressive supranuclear palsyDavid R Williams
Faculty of Medicine Neurosciences, Monash University Alfred Hospital Campus, Melbourne, Australia
Mov Disord 22:2235-41. 2007..This relatively uncommon presentation of PSP-tau pathology has less severe tau accumulation than in the more common, "classic" PSP clinical phenotype: Richardson's disease...
- James Parkinson's LondonDavid R Williams
Reta Lila Weston Institute of Neurological Studies and Queen Square Brain Bank, London
Mov Disord 22:1857-9. 2007..James Parkinson's London was filmed in 2005 to celebrate the 250th anniversary of Parkinson's birth, and to give the viewer a glimpse of the streets where he lived...
- Psychogenic propriospinal myoclonusDavid R Williams
Faculty of Medicine Neurosciences, Monash University, Alfred Hospital Campus, Melbourne, Australia
Mov Disord 23:1312-3. 2008..Spontaneous remissions and disappearance of the jerks, sustained for 2 years, following removal of superficial surgical screws support the diagnosis of a psychogenic movement disorder...
- How do patients with parkinsonism present? A clinicopathological studyD R Williams
Faculty of Medicine Neurosciences, Monash University Alfred Hospital Campus, Commercial Road, Melbourne, VIC 3004, Australia
Intern Med J 39:7-12. 2009..The early clinical features of neurodegenerative parkinsonism can be subtle and often coexist with autonomic, sensory and psychic symptoms, making accurate early diagnosis challenging...
- The auditory startle response in parkinsonism may reveal the extent but not type of pathologyDavid R Williams
Faculty of Medicine Neurosciences, Monash University Alfred Hospital Campus
J Neurol 255:628-32. 2008....
- J. Clifford Richardson and 50 years of progressive supranuclear palsyDavid R Williams
Faculty of Medicine, Monash University, Alfred Hospital Campus, Melbourne, Australia
Neurology 70:566-73. 2008..To trace the historical events leading to Richardson's clinical description of progressive supranuclear palsy (PSP) in the context of subsequent observations of its clinical heterogeneity and pathologic overlap with other tauopathies...
- Biological fluid biomarkers in neurodegenerative parkinsonismMichael Eller
Department of Neurosciences, Alfred Hospital, Melbourne, Victoria, Australia
Nat Rev Neurol 5:561-70. 2009..Despite such difficulties, improved technology, in conjunction with advances in nosology and pathology, means that biomarkers are poised to enter routine clinical practice to aid the differentiation of parkinsonian disorders...
- My hands shake--classification and treatment of tremorDharshana Sirisena
Van Cleef Roet Centre for Nervous Diseases, Monash University, Melbourne, Victoria
Aust Fam Physician 38:678-83. 2009..Most tremors can be separated according to the state in which they occur, that is, during rest or action. Other clinical features, including frequency, amplitude and associated neurological signs, further define tremor...
- Progressive supranuclear palsy: clinicopathological concepts and diagnostic challengesDavid R Williams
Faculty of Medicine Neurosciences, Monash University, Melbourne, Australia
Lancet Neurol 8:270-9. 2009..In this way, the development of the clinical features can be informative in assigning less common nosological categories that give clues to the underlying pathology and an understanding of the expected clinical course...
- Gaze-evoked brainstem myoclonusDavid R Williams
Neurology Registrar, St Vincent s Hospital, Melbourne, Australia
Mov Disord 19:346-9. 2004..It had the unusual characteristic of being evoked by sustained up gaze and left gaze...
- Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndromeDavid R Williams
Queen Square Brain Bank for Neurological Disorders, London, UK
Brain 130:1566-76. 2007..The grading system we have developed provides an easy-to-use and sensitive tool for the morphological assessment of PSP-tau pathology and allows for consideration of the clinical diversity that is known to occur in PSP...
- Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonismDavid R Williams
The Queen Square Brain Bank for Neurological Disorders, University College London, UK
Brain 128:1247-58. 2005..The different tau isoform deposition in the basal pons suggests that this may ultimately prove to be a discrete nosological entity...
- Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy studyDavid R Williams
Queen Square Brain Bank for Neurological Disorders and Institute of Neurology, University College London, London, UK
Lancet Neurol 4:605-10. 2005..The cause of VH is now thought to be nerve-cell loss and Lewy-body pathology in the ventral-temporal regions of the brain. However, the use of VH as a clinical sign of PD has not been investigated...
- Nonmotor symptoms as presenting complaints in Parkinson's disease: a clinicopathological studySean S O'Sullivan
Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 23:101-6. 2008..Presenting with NMS does not affect the motor response to medication, but is associated with shorter disease duration (chi(2) P = 0.016)...
- Health disparities based on socioeconomic inequities: implications for urban health careKevin Fiscella
Department of Family Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Acad Med 79:1139-47. 2004....
- The National Survey of American Life: a study of racial, ethnic and cultural influences on mental disorders and mental healthJames S Jackson
Research Center for Group Dynamics, University of Michigan, USA
Int J Methods Psychiatr Res 13:196-207. 2004..Unique features of sample design, including special screening and listing procedures, interviewer training and supervision, and response rate outcomes are described...
- Neighbourhood characteristics, individual level socioeconomic factors, and depressive symptoms in young adults: the CARDIA studyClaire Henderson
Public Psychiatry Fellowship, Room 317, 722 W 168th Street, New York, NY 10032, USA
J Epidemiol Community Health 59:322-8. 2005..To investigate the relation between neighbourhood socioeconomic and ethnic characteristics with depressive symptoms in a population based sample...
- Physical violence against intimate partners and related exposures to violence among South African menJhumka Gupta
Yale School of Public Health and Center for Interdisciplinary Research on AIDS, Yale University, New Haven, Connecticut, USA
CMAJ 179:535-41. 2008..Despite high rates of intimate partner violence in South Africa, there have been no national studies of men's perpetration of violence against female partners...
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control studyDaniel G Healy
Department of Clinical Neurosciences, Institute of Neurology, University College London, London, UK
Lancet Neurol 7:583-90. 2008..LRRK2-associated PD be distinguished from idiopathic PD; which mutations in LRRK2 are pathogenic; and what is the age-specific cumulative risk of PD for individuals who inherit or are at risk of inheriting a deleterious mutation in LRRK2?..
- Non-fatal suicidal behavior among South Africans : results from the South Africa Stress and Health StudySean Joe
School of Social Work, University of Michigan, 1080 South University Ave, Room 2780, Ann Arbor, MI 48109, USA
Soc Psychiatry Psychiatr Epidemiol 43:454-61. 2008..This study examines the prevalence, age of onset and sociodemographic correlates of suicide ideation, planning, and attempts among South Africans...
- The impact of the Truth and Reconciliation Commission on psychological distress and forgiveness in South AfricaDan J Stein
University of Cape Town, Cape Town, South Africa
Soc Psychiatry Psychiatr Epidemiol 43:462-8. 2008..However, there was also a concern that individuals with TRC relevant experience would simply be re-traumatized by participation in the process. To date, there has been little empirical data for either hypothesis...
- Modified-Symbol Digit Modalities Test for African Americans, Caribbean Black Americans, and non-Latino Whites: nationally representative normative data from the National Survey of American LifeHector M Gonzalez
Institute of Gerontology and the School of Medicine, Department of Family Medicine, Wayne State University, 87 East Ferry Street, Detroit, MI 48202, USA
Arch Clin Neuropsychol 22:605-13. 2007..Unlike previous work, this study supports the consideration of Black ethnicity when evaluating Black neuropsychological test performance...
- Kufor Rakeb disease: autosomal recessive, levodopa-responsive parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementiaDavid R Williams
The Queen Square Brain Bank for Neurological Disorders Reta Lila Weston Institute for Neurological Studies, University College London, London, United Kingdom
Mov Disord 20:1264-71. 2005..Several new features were identified, including facial-faucial-finger mini-myoclonus, visual hallucinations, and oculogyric dystonic spasms...
- Racial segregation and disparities in cancer stage for seniorsJennifer S Haas
Division of General Medicine and Primary Care, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Gen Intern Med 23:699-705. 2008..Disparities in cancer survival may be related to differences in stage. Segregation may be associated with disparities in stage, particularly for cancers for which screening promotes survival...
- Social determinants of psychological distress in a nationally-representative sample of South African adultsLandon Myer
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Soc Sci Med 66:1828-40. 2008....
- Shunt responsive progressive supranuclear palsy?Jonathan M Schott
Mov Disord 22:902-3. 2007
- Genetic variation at the tau locus and clinical syndromes associated with progressive supranuclear palsyDavid R Williams
The Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 22:895-7. 2007..No mutations were found in 75 patients (21 PSP-P), and H1c was associated with both Richardson's syndrome and PSP-P compared with controls. Routine screening for MAPT mutations in atypical PSP is not recommended...