Jennifer L Wilkinson-Berka

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint The Renin-angiotensin system and advanced glycation end-products in diabetic retinopathy: impacts and synergies
    Antonia G Miller
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct AMREP, Level 5 Alfred Centre, 99 Commercial Road, Melbourne, Victoria, 3004, Australia
    Curr Clin Pharmacol 8:285-96. 2013
  2. doi request reprint Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy
    Jennifer L Wilkinson-Berka
    Department of Immunology, Central Clinical School, Monash University, 99 Commercial Road, Alfred Medical Research and Education Precinct AMREP, Alfred Centre, Melbourne, Victoria 3004, Australia
    Clin Sci (Lond) 124:597-615. 2013
  3. doi request reprint The retinal renin-angiotensin system: roles of angiotensin II and aldosterone
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Melbourne, Victoria 3004, Australia
    Peptides 36:142-50. 2012
  4. doi request reprint Prorenin and the (pro)renin receptor: recent advances and implications for retinal development and disease
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Curr Opin Nephrol Hypertens 20:69-76. 2011
  5. doi request reprint Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat
    J L Wilkinson-Berka
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct AMREP, Commercial Road, Melbourne, 3004 Victoria, Australia
    Diabetologia 54:2724-35. 2011
  6. doi request reprint RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retina
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Hypertension 55:1454-60. 2010
  7. pmc Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin
    Stella Sarlos
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Pathol 163:879-87. 2003
  8. ncbi request reprint Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats
    Darren J Kelly
    Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Kidney Int 61:31-9. 2002
  9. pmc Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function
    Antonia G Miller
    Oxidative Stress Laboratory, Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes 59:3208-15. 2010
  10. ncbi request reprint Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension
    Darren J Kelly
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Diabetes 52:512-8. 2003

Collaborators

Detail Information

Publications32

  1. ncbi request reprint The Renin-angiotensin system and advanced glycation end-products in diabetic retinopathy: impacts and synergies
    Antonia G Miller
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct AMREP, Level 5 Alfred Centre, 99 Commercial Road, Melbourne, Victoria, 3004, Australia
    Curr Clin Pharmacol 8:285-96. 2013
    ..This review will discuss the role of both the RAS and AGEs in diabetic retinopathy, and how the identification of interactions between the two pathways may have implications for the development of new treatment strategies. ..
  2. doi request reprint Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy
    Jennifer L Wilkinson-Berka
    Department of Immunology, Central Clinical School, Monash University, 99 Commercial Road, Alfred Medical Research and Education Precinct AMREP, Alfred Centre, Melbourne, Victoria 3004, Australia
    Clin Sci (Lond) 124:597-615. 2013
    ..Whether the RAAS influences the production of ROS derived from Nox in retinopathy is yet to be fully determined. These topics will be reviewed with a particular emphasis on ROP and DR...
  3. doi request reprint The retinal renin-angiotensin system: roles of angiotensin II and aldosterone
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Melbourne, Victoria 3004, Australia
    Peptides 36:142-50. 2012
    ..The therapeutic utility of inhibiting key components of the renin-angiotensin system is complex, but may hold promise for the prevention and improvement of vision threatening diseases...
  4. doi request reprint Prorenin and the (pro)renin receptor: recent advances and implications for retinal development and disease
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Curr Opin Nephrol Hypertens 20:69-76. 2011
    ..This review discusses the possibility that prorenin, which initiates the RAS, and the (pro)renin receptor [(P)RR] are potential candidates...
  5. doi request reprint Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat
    J L Wilkinson-Berka
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct AMREP, Commercial Road, Melbourne, 3004 Victoria, Australia
    Diabetologia 54:2724-35. 2011
    ..We examined whether the renin inhibitor, aliskiren, provides similar or greater protection than ACE inhibition from non-proliferative diabetic retinopathy and from the proliferative neoangiogenesis of oxygen-induced retinopathy...
  6. doi request reprint RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retina
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Hypertension 55:1454-60. 2010
    ....
  7. pmc Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin
    Stella Sarlos
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Pathol 163:879-87. 2003
    ..This study has identified a potential retinoprotective role for AT2-RB possibly mediated via interactions with VEGF- and angiopoietin-dependent pathways...
  8. ncbi request reprint Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats
    Darren J Kelly
    Department of Medicine, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Kidney Int 61:31-9. 2002
    ..The effects of renoprotective therapy with blockade of the renin-angiotensin system (RAS) also were examined...
  9. pmc Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function
    Antonia G Miller
    Oxidative Stress Laboratory, Diabetes Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes 59:3208-15. 2010
    ..The angiotensin type 1 receptor blocker, candesartan, rectifies this imbalance and protects against retinal vasculopathy...
  10. ncbi request reprint Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension
    Darren J Kelly
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Diabetes 52:512-8. 2003
    ..In vivo inhibition of PKC beta with LY333531 led to a reduction in albuminuria, structural injury, and TGF-beta expression, despite continued hypertension and hyperglycemia...
  11. pmc Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy
    Jennifer L Wilkinson-Berka
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Pathol 164:1263-73. 2004
    ..In conclusion, PDGF is required for pericyte viability and the subsequent prevention of VEGF/VEGFR-2 overexpression and angiogenesis in ROP...
  12. ncbi request reprint ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat
    Jennifer L Wilkinson-Berka
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Diabetes 51:3283-9. 2002
    ....
  13. ncbi request reprint Retinal dysfunction in diabetic ren-2 rats is ameliorated by treatment with valsartan but not atenolol
    Joanna A Phipps
    Department of Anatomy and Cell Biology, The University of Melbourne, Grattan Street, Parkville 3010, Victoria, Australia
    Invest Ophthalmol Vis Sci 48:927-34. 2007
    ....
  14. ncbi request reprint Neuronal and glial cell changes are determined by retinal vascularization in retinopathy of prematurity
    Laura E Downie
    Department of Anatomy and Cell Biology, The University of Melbourne, Parkville, Victoria, Australia
    J Comp Neurol 504:404-17. 2007
    ..We find that ROP produces complex vascular, neural, and glial changes that relate to the proximity of inner retinal blood vessels...
  15. doi request reprint Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy
    Devy Deliyanti
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Hypertension 59:607-13. 2012
    ..These findings indicate that aldosterone inhibition may be a potential treatment for retinal neovascularization...
  16. ncbi request reprint COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity
    Jennifer L Wilkinson-Berka
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Invest Ophthalmol Vis Sci 44:974-9. 2003
    ..This study was conducted to determine the cellular location of COX-2 in the retina and whether the inhibition of COX-2 would reduce retinal angiogenesis in a rodent model of retinopathy of prematurity (ROP)...
  17. doi request reprint Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Commercial Rd, Prahran, Victoria, Australia, 3004
    Circ Res 104:124-33. 2009
    ..We make the first report that MR and aldosterone influence retinal vasculopathy, which may involve inflammatory and G6PD mechanisms. MR antagonism may be relevant when developing treatments for retinopathies that target the RAAS...
  18. ncbi request reprint Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: attenuation with renin-angiotensin blockade
    Darren J Kelly
    Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Melbourne, Victoria, Australia
    Nephrology (Carlton) 9:7-13. 2004
    ..The effects of renoprotective therapy with blockade of the renin-angiotensin (RAS) system were also examined...
  19. ncbi request reprint The renin-angiotensin system and the developing retinal vasculature
    Stella Sarlos
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 46:1069-77. 2005
    ..To determine the location and activity of renin-angiotensin system (RAS) components in the developing rat retina and whether the RAS influences retinal vascularization...
  20. doi request reprint The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature
    Erica L Fletcher
    Department of Anatomy and Cell Biology, The University of Melbourne, Parkville 3010, Victoria, Australia
    Prog Retin Eye Res 29:284-311. 2010
    ..With the emergence of novel compounds targeting different aspects of the RAS even more effective ways of blocking the RAS may be possible in the future...
  21. ncbi request reprint Prorenin and the (pro)renin receptor: do they have a pathogenic role in the retina?
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Front Biosci (Elite Ed) 2:1054-64. 2010
    ....
  22. ncbi request reprint Diabetes and retinal vascular disorders: role of the renin-angiotensin system
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan St, Parkville, Victoria, Australia
    Expert Rev Mol Med 6:1-18. 2004
    ..This review examines the role of the RAS in diabetic retinopathy and retinopathy of prematurity, and the potential of RAS blockade as a treatment strategy for these vision-threatening diseases...
  23. ncbi request reprint Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan Street, Parkville 3010, Victoria, Australia
    Mol Cell Endocrinol 194:201-9. 2002
    ..In conclusion, macrophages and epithelial cells are the source of active renin in the rat thymus. The thymic RAS may have actions systemically and may also influence local processes such as blood flow and cell growth...
  24. doi request reprint AT1 receptor inhibition prevents astrocyte degeneration and restores vascular growth in oxygen-induced retinopathy
    Laura E Downie
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    Glia 56:1076-90. 2008
    ..This study identifies a glio-vascular protective effect with AT(1)-RB in OIR...
  25. doi request reprint Update on the treatment of diabetic retinopathy
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Alfred and Medical Research andEducation Precinct AMREP, Commercial Road, Prahran, Victoria, Australia
    ScientificWorldJournal 8:98-120. 2008
    ....
  26. ncbi request reprint Cardiorenal protective effects of vasopeptidase inhibition with omapatrilat in hypertensive transgenic (mREN-2)27 rats
    Sally A Mifsud
    Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia
    Clin Exp Hypertens 26:69-80. 2004
    ....
  27. ncbi request reprint An antisense oligonucleotide targeting the growth hormone receptor inhibits neovascularization in a mouse model of retinopathy
    Jennifer L Wilkinson-Berka
    Department of Immunology, Monash University, Alfred and Medical Research Precinct, Melbourne, Victoria, Australia
    Mol Vis 13:1529-38. 2007
    ..We tested whether this systemically delivered antisense oligonucleotide could inhibit neovascularization in mice with oxygen induced retinopathy (OIR)...
  28. ncbi request reprint Intervention with tranilast attenuates renal pathology and albuminuria in advanced experimental diabetic nephropathy
    Sally Mifsud
    Department of Physiology, University of Melbourne and St Vincent s Hospital, Melbourne, Vic, Australia
    Nephron Physiol 95:p83-91. 2003
    ..However, its effects on diabetic renal pathology are unknown...
  29. doi request reprint Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system
    Claudia A McCarthy
    Department of Pharmacology, Monash University, Clayton, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 40:571-9. 2013
    ..Understanding the actions of these angiotensin receptors will be important in defining whether microglia are an important therapeutic target for RAS blockade in brain and ocular diseases. ..
  30. doi request reprint Lack of the antioxidant glutathione peroxidase-1 (GPx1) exacerbates retinopathy of prematurity in mice
    Sih Min Tan
    Oxidative Stress Group, Division of Diabetic Complications, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Invest Ophthalmol Vis Sci 54:555-62. 2013
    ..We postulated that GPx1 plays an important role in protecting the premature retina from oxidative injury in a mouse model of ROP...
  31. pmc The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes: transgenic and interventional studies
    Christina J Moravski
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Pathol 162:151-60. 2003
    ..RAS blockade is a potential treatment for vision-threatening diabetic microvascular complications...
  32. ncbi request reprint The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy
    Jennifer L Wilkinson-Berka
    Department of Physiology, University of Melbourne, Grattan St, Parkville, Victoria, Australia
    Curr Med Chem 13:3307-17. 2006
    ..These approaches may also prove to have benefits for improving vascular patency and vision in patients with diabetic retinopathy...