E H Walters

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi The anti-inflammatory profile of inhaled corticosteroids combined with salmeterol in asthmatic patients
    E H Walters
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Respir Med 94:S26-31. 2000
  2. ncbi Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase
    E Gabbay
    Department of Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    Am J Respir Crit Care Med 162:2182-7. 2000
  3. ncbi Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma
    C Ward
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Am J Respir Crit Care Med 164:1718-21. 2001
  4. ncbi How have we been managing chronic obstructive pulmonary disease in Australia?
    M C Matheson
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Intern Med J 36:92-9. 2006
  5. ncbi The dynamics and associations of airway neutrophilia post lung transplantation
    L Zheng
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Monash University, Monash Medical School, Melbourne, Australia
    Am J Transplant 6:599-608. 2006
  6. ncbi The usefulness of competitive PCR: airway gene expression of IL-5, IL-4, IL-4delta2, IL-2, and IFNgamma in asthma
    E M Glare
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Thorax 56:541-8. 2001
  7. ncbi Effect of inhaled fluticasone propionate on BAL TGF-beta(1) and bFGF concentrations in clinically stable lung transplant recipients
    L Zheng
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    J Heart Lung Transplant 23:446-55. 2004
  8. ncbi Possible anti-inflammatory effect of salmeterol against interleukin-8 and neutrophil activation in asthma in vivo
    D W Reid
    Dept of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Eur Respir J 21:994-9. 2003
  9. ncbi Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthma
    B E Orsida
    Department of Respiratory Medicine, The Alfred Hospital and Monash University Medical School, Melbourne, Victoria, Australia
    Am J Respir Crit Care Med 164:117-21. 2001
  10. ncbi Bronchodilator reversibility in Australian adults with chronic obstructive pulmonary disease
    D W Reid
    Department of Respiratory Medicine and Monash Medical School, Alfred Hospital, Commercial Road, Melbourne, Victoria, Australia
    Intern Med J 33:572-7. 2003

Detail Information

Publications49

  1. ncbi The anti-inflammatory profile of inhaled corticosteroids combined with salmeterol in asthmatic patients
    E H Walters
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Respir Med 94:S26-31. 2000
    ..This review presents the results of recent studies and suggests possible mechanisms for the additional antiinflammatory effects of salmeterol...
  2. ncbi Post-lung transplant bronchiolitis obliterans syndrome (BOS) is characterized by increased exhaled nitric oxide levels and epithelial inducible nitric oxide synthase
    E Gabbay
    Department of Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    Am J Respir Crit Care Med 162:2182-7. 2000
    ..Exhaled NO levels also appear to reflect the degree of airway neutrophilia in both stable LTR and BOS groups. This suggests that serial eNO measurements may be able to predict the early development of BOS...
  3. ncbi Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma
    C Ward
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Am J Respir Crit Care Med 164:1718-21. 2001
    ..Our findings support the hypothesis that DeltaVD is a physiologic test that is reflective of airway remodeling...
  4. ncbi How have we been managing chronic obstructive pulmonary disease in Australia?
    M C Matheson
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Intern Med J 36:92-9. 2006
    ..The aim of the article was to report on COPD management in a community based cohort...
  5. ncbi The dynamics and associations of airway neutrophilia post lung transplantation
    L Zheng
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Monash University, Monash Medical School, Melbourne, Australia
    Am J Transplant 6:599-608. 2006
    ....
  6. ncbi The usefulness of competitive PCR: airway gene expression of IL-5, IL-4, IL-4delta2, IL-2, and IFNgamma in asthma
    E M Glare
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Thorax 56:541-8. 2001
    ..0001), suggesting coordinated transcription. CONCLUSIONS: While the signal differentiation of competitive PCR in asthma may rival that of in situ hybridisation and immunohistochemistry, the method is expensive and wasteful of material...
  7. ncbi Effect of inhaled fluticasone propionate on BAL TGF-beta(1) and bFGF concentrations in clinically stable lung transplant recipients
    L Zheng
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    J Heart Lung Transplant 23:446-55. 2004
    ..Inhaled FP added to conventional immunosuppression had no effect on TGF-beta(1) or bFGF production in BAL fluid...
  8. ncbi Possible anti-inflammatory effect of salmeterol against interleukin-8 and neutrophil activation in asthma in vivo
    D W Reid
    Dept of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Eur Respir J 21:994-9. 2003
    ..Indeed, high-dose inhaled corticosteroid therapy alone may promote airway neutrophilia...
  9. ncbi Effect of a long-acting beta2-agonist over three months on airway wall vascular remodeling in asthma
    B E Orsida
    Department of Respiratory Medicine, The Alfred Hospital and Monash University Medical School, Melbourne, Victoria, Australia
    Am J Respir Crit Care Med 164:117-21. 2001
    ....
  10. ncbi Bronchodilator reversibility in Australian adults with chronic obstructive pulmonary disease
    D W Reid
    Department of Respiratory Medicine and Monash Medical School, Alfred Hospital, Commercial Road, Melbourne, Victoria, Australia
    Intern Med J 33:572-7. 2003
    ..However, until the underlying immuno-pathology has been determined they cannot be assumed to have "asthma" or even an "asthmatic element"...
  11. ncbi Changes in indoor allergen and fungal levels predict changes in asthma activity among young adults
    M C Matheson
    Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Monash University, Melbourne, Australia
    Clin Exp Allergy 35:907-13. 2005
    ..We conducted a longitudinal study of indoor allergen and fungal levels in Melbourne homes between 1996 and 1998 to examine the effect of changes in allergen exposure upon asthma and associated outcomes...
  12. ncbi Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure
    S Dharmage
    Department of Epidemiology and Preventive Medicine, Monash Medical School and The Alfred Hospital, Prahran, Melbourne, Australia
    Am J Respir Crit Care Med 164:65-71. 2001
    ..Current indoor levels of fungi and Fel d 1, but not Der p 1, influenced sensitization and asthma in adults with high dust mite exposure...
  13. ncbi Airway distensibility in healthy and asthmatic subjects: effect of lung volume history
    D P Johns
    Department of Respiratory Medicine, The Alfred Hospital and Monash University Medical School, Prahran, Melbourne, Victoria 3181, Australia
    J Appl Physiol 88:1413-20. 2000
    ..3 +/- 2.19 vs. 18.8 +/- 1.68 ml/l). There was no difference in DeltaVD between groups. In conclusion, mild asthmatic subjects have stiffer airways than normal subjects, and this is not obviously affected by lung volume history...
  14. ncbi Increased human cytomegalovirus (HCMV) DNA load in peripheral blood leukocytes after lung transplantation correlates with HCMV pneumonitis
    A Michaelides
    Department of Respiratory Medicine, Alfred Hospital, Commercial Road, Prahran 3181, Melbourne, Australia
    Transplantation 72:141-7. 2001
    ....
  15. ncbi Adherence to asthma management guidelines by middle-aged adults with current asthma
    R K Kandane-Rathnayake
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
    Thorax 64:1025-31. 2009
    ..Using data from the Tasmanian Longitudinal Health Study (TAHS), the adequacy of asthma management for middle-aged adults with asthma was investigated...
  16. ncbi Normally suppressing CD40 coregulatory signals delivered by airway macrophages to TH2 lymphocytes are defective in patients with atopic asthma
    C Tang
    Department of Respiratory Medicine, Alfred Hospital, and Monash University, Melbourne, Australia
    J Allergy Clin Immunol 107:863-70. 2001
    ....
  17. ncbi Fatty acid levels and risk of asthma in young adults
    R K Woods
    Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Monash University and The Alfred Hospital, Melbourne, Victoria 3004, Australia
    Thorax 59:105-10. 2004
    ..06 to 1.48). CONCLUSION: Plasma n-3 fatty acids are not associated with a reduced risk of asthma or atopy among young adults. The association of DHGLA with asthma warrants further research to determine a cause-effect relationship...
  18. ncbi The rising prevalence of asthma in young Melbourne adults is associated with improvement in treatment
    R K Woods
    Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Prahran, Melbourne, Victoria, Australia
    Ann Allergy Asthma Immunol 87:117-23. 2001
    ..Although a number of epidemiologic studies have been conducted in Australia to determine the prevalence of asthma in adults, it is unclear whether the prevalence is changing...
  19. ncbi Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma
    C Ward
    Department of Respiratory Medicine, The Alfred Hospital and Monash University, Melbourne, Australia
    Thorax 57:309-16. 2002
    ..The results of this study support the need for early and long term intervention with ICS, even in patients with relatively mild asthma...
  20. ncbi Airway iron and iron-regulatory cytokines in cystic fibrosis
    D W Reid
    Adult Cystic Fibrosis Centre, Alfred Hospital and Monash University Medical School, Melbourne, Australia
    Eur Respir J 24:286-91. 2004
    ..Iron and iron-regulatory cytokines may play a role in cystic fibrosis lung disease and the increased iron content may even facilitate Pseudomonas aeruginosa infection...
  21. ncbi International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991-1994
    R K Woods
    Departments of Epidemiology and Preventive Medicine, Monash Medical School, The Alfred Hospital, Prahran, Victoria, Australia
    Eur J Clin Nutr 55:298-304. 2001
    ..The aim of this study was to report the prevalence, type and reported symptoms associated with food intolerance...
  22. ncbi The epidemic of asthma: too much allergen or not enough infection?
    M J Abramson
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran, Vic
    Med J Aust 172:119-21. 2000
    ..Childhood infections seem to be important in normal maturation of the immune system, with asthma a manifestation of a persistent "immature" immune system...
  23. ncbi Asthma and vaccination history in a young adult cohort
    G Benke
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clincal School, Alred Hospital, Melbourne, Victoria
    Aust N Z J Public Health 28:336-8. 2004
    ..It has been suggested that childhood vaccinations may be associated with the onset of asthma. We investigated the association between asthma, atopy and vaccination history in a cohort of young adults living in Melbourne, Australia...
  24. ncbi Asthma is more prevalent in rural New South Wales than metropolitan Victoria, Australia
    R K Woods
    Department of Epidemiology and Preventive Medicine, Monash Medical School and Alfred Hospital, Prahran, Victoria, Australia
    Respirology 5:257-63. 2000
    ..The aim of this study was to compare the prevalence of adult respiratory symptoms and conditions in a rural setting with a metropolitan setting...
  25. ncbi Reported adverse food reactions overestimate true food allergy in the community
    R K Woods
    Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Monash University and The Alfred Hospital, Australia
    Eur J Clin Nutr 56:31-6. 2002
    ..To determine the extent to which perceived adverse food reactions were associated with IgE mediated food allergy, as defined by skin prick testing (SPT)...
  26. ncbi Biological dust exposure in the workplace is a risk factor for chronic obstructive pulmonary disease
    M C Matheson
    Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, The Alfred Hospital, Commercial Road, Melbourne 3004, Victoria, Australia
    Thorax 60:645-51. 2005
    ..Although the main risk factor is smoking, 15-19% of COPD even in smokers has been attributed to occupational exposures. The aim of this study was to investigate the association between occupational exposure and risk of COPD...
  27. ncbi beta-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels
    E M Glare
    Department of Respiratory Medicine, Alfred Hospital and Monash University Medical School, Melbourne 3181, Australia
    Thorax 57:765-70. 2002
    ..We hypothesised that airway samples which differ in their cellular profiles and activation status have different levels of expression of GAPDH and beta-actin...
  28. ncbi Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure
    P Solin
    Department of Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia
    Am J Respir Crit Care Med 162:2194-200. 2000
    ....
  29. ncbi How well do doctors know their patients with severe asthma?
    M J Abramson
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Intern Med J 33:557-65. 2003
    ..Rates of asthma mortality have fallen in Australia since the commencement of the National Asthma Campaign and promotion of the Australian asthma management plan. New strategies are now needed to further reduce mortality...
  30. ncbi Asthma management: how effective is it in the community?
    M Matheson
    Department of Epidemiology and Preventive Medicine, The Alfred Hospital, Melbourne, Victoria, Australia
    Intern Med J 32:451-6. 2002
    ..The National Asthma Campaign (NAC) was launched in Australia in 1989 with the major objective of improving asthma management through the implementation of a six-step asthma management plan...
  31. ncbi Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma
    B N Feltis
    Tasmanian School of Medicine, 43 Collins St, Hobart, Tasmania, Australia 7001
    Thorax 62:314-9. 2007
    ..A study was undertaken to explore angiogenic modulation by ICS and its likely regulation via vascular endothelial growth factor (VEGF), its receptors and the angiopoietins...
  32. ncbi Childhood adiposity predicts adult-onset current asthma in females: a 25-yr prospective study
    J A Burgess
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, VIC 3053 Australia
    Eur Respir J 29:668-75. 2007
    ..Higher body mass index in nonasthmatic young females at 7 yrs of age predicts risk of current asthma developing in adult life...
  33. ncbi Inter-relationships between airway inflammation, reticular basement membrane thickening and bronchial hyper-reactivity to methacholine in asthma; a systematic bronchoalveolar lavage and airway biopsy analysis
    C Ward
    Applied Immunobiology and Transplantation Research Group, The Freeman Hospital and University of Newcastle upon Tyne, UK
    Clin Exp Allergy 35:1565-71. 2005
    ..d.), in a group of relatively mild but symptomatic, steroid naïve asthma patients...
  34. ncbi Encasement of bedding does not improve asthma in atopic adult asthmatics
    S Dharmage
    Department of Public Health, The University of Melbourne, Australia
    Int Arch Allergy Immunol 139:132-8. 2006
    ..We evaluated the impact of impermeable bed covers on asthma in asthmatics with clinically relevant house dust mite (HDM) sensitization...
  35. ncbi Nonpharmacological and pharmacological interventions to prevent or reduce airway remodelling
    E H Walters
    Cardio Respiratory Research Group, Menzies Research Institute, University of Tasmania, 43 Collins Street, Hobart 7001, Australia
    Eur Respir J 30:574-88. 2007
    ..The areas where it is believed urgent research needs to be focused have also been highlighted...
  36. ncbi Increased soluble CD14 in bronchoalveolar lavage fluid of stable lung transplant recipients
    C Ward
    William Leech Centre, Freeman Road Hospital, University of Newcastle upon Tyne, UK
    Eur Respir J 19:472-8. 2002
    ....
  37. ncbi Mouldy houses influence symptoms of asthma among atopic individuals
    S Dharmage
    Department of Public Health, School of Population Health, The University of Melbourne, Australia
    Clin Exp Allergy 32:714-20. 2002
    ..The influence of current levels of indoor fungi on asthma is a controversial issue that needs to be resolved in order to advise patients appropriately...
  38. ncbi A mixed methods study to compare models of spirometry delivery in primary care for patients at risk of COPD
    J A Walters
    Menzies Research Institute, PB 34, Clinical School, University of Tasmania, Hobart 7001, Australia
    Thorax 63:408-14. 2008
    ..To increase recognition of airflow obstruction in primary care, we compared two models of spirometry delivery in a target group at risk of chronic obstructive pulmonary disease (COPD)...
  39. ncbi Prediction equations for single breath diffusing capacity (Tlco) in a middle aged caucasian population
    B R Thompson
    Allergy Immunology and Respiratory Medicine, The Alfred Hospital, Commercial Rd, Melbourne 3004, Victoria, Australia
    Thorax 63:889-93. 2008
    ..However, the testing methodologies vary and there are no well documented studies that have developed reference equations for Tlco and alveolar volume (Va) in middle aged and older populations...
  40. ncbi Innate immune activation in neutrophilic asthma
    E H Walters
    Thorax 63:88-9. 2008
  41. ncbi Airway cell and cytokine changes in early asthma deterioration after inhaled corticosteroid reduction
    Y H Khor
    Respiratory Research Group, Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Clin Exp Allergy 37:1189-98. 2007
    ..We aimed at assessing the underlying pathological changes in relation to clinical deterioration...
  42. ncbi Publication of complex dataset
    E H Walters
    Thorax 58:368. 2003
  43. ncbi The relationships between patients' related variables in asthma: iplications for asthma management
    O A Abdulwadud
    Department of Epidemiology and Preventive Medicine, Monash Medical School, Victoria, Australia
    Respirology 6:105-12. 2001
    ..The findings have implications for optimizing asthma management...
  44. ncbi Bronchoalveolar lavage macrophage and lymphocyte phenotypes in lung transplant recipients
    C Ward
    William Leech Centre, Cardiothoracic Medicine, Freeman Road Hospital, University of Newcastle upon Tyne, High Heaton, UK
    J Heart Lung Transplant 20:1064-74. 2001
    ..05).These novel findings are consistent with complex lymphocyte and macrophage changes that may result from clinically silent infection, partially suppressed rejection, or both...
  45. ncbi Wheeze not current asthma affects quality of life in young adults with asthma
    M Matheson
    Department of Epidemiology and Preventive Medicine, Central and Eastern Clinical School, Monash University, Prahran, Victoria 3181, Australia
    Thorax 57:165-7. 2002
    ..CONCLUSIONS: Quality of life is severely impaired in individuals with wheeze in the previous 12 months while individuals with current asthma or bronchial hyperreactivity alone did not appear to have significantly reduced quality of life...
  46. ncbi Long-acting beta2-agonists in asthma: an overview of Cochrane systematic reviews
    J A E Walters
    Discipline of Medicine, University of Tasmania, GPO Box 252 34, Hobart, Tasmania 7001, Australia
    Respir Med 99:384-95. 2005
    ..However, guidelines may be too conservative, and more studies in stable mild asthma comparing their use and safety with placebo and ICS are required...
  47. ncbi Management of chronic obstructive pulmonary disease in the twenty-first century
    D W Reid
    Intern Med J 32:361; author reply 362-3. 2002
  48. ncbi European Community Respiratory Health Survey calibration project of dosimeter driving pressures
    R J Ward
    Dept of Psychiatry, University of Melbourne, Victoria, Australia
    Eur Respir J 19:252-6. 2002
    ..Comprehensive collection of such data to optimize quality control is practicable and has been instigated by the organizing committee for the European Community Respiratory Health Survey II...
  49. ncbi Time to death, airway wall inflammation and remodelling in fatal asthma
    A L James
    West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia
    Eur Respir J 26:429-34. 2005
    ..It suggests that in short course cases acute airway narrowing is due, predominantly, to bronchoconstriction despite higher blood levels of salbutamol. Mucus accumulation may be more important in long course cases...