Jennifer R Timoshanko

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice
    Jennifer R Timoshanko
    Center for Inflammatory Diseases, Monash University, and Department of Medicine, Monash Medical Center, Clayton, Victoria, Australia
    J Immunol 168:4135-41. 2002
  2. ncbi request reprint Resident kidney cells and their involvement in glomerulonephritis
    Jennifer R Timoshanko
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Curr Drug Targets Inflamm Allergy 4:353-62. 2005
  3. pmc Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Department of Medicine, Centre for Inflammatory Diseases, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Am J Pathol 164:1967-77. 2004
  4. ncbi request reprint Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Center, Clayton, 3168 Victoria, Australia
    J Am Soc Nephrol 16:2646-56. 2005
  5. ncbi request reprint Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma
    A Richard Kitching
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 15:1764-74. 2004
  6. ncbi request reprint Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 14:1785-93. 2003
  7. ncbi request reprint A pathogenetic role for mast cells in experimental crescentic glomerulonephritis
    Jennifer R Timoshanko
    Center for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Center, 246 Clayton Road, Melbourne, Victoria 3168, Australia
    J Am Soc Nephrol 17:150-9. 2006
  8. ncbi request reprint IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment
    A Richard Kitching
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 16:2023-33. 2005
  9. ncbi request reprint Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis
    Dragana Odobasic
    Monash University, Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 16:2012-22. 2005
  10. ncbi request reprint An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity
    Amanda Jane Ruth
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Immunol 173:136-44. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice
    Jennifer R Timoshanko
    Center for Inflammatory Diseases, Monash University, and Department of Medicine, Monash Medical Center, Clayton, Victoria, Australia
    J Immunol 168:4135-41. 2002
    ....
  2. ncbi request reprint Resident kidney cells and their involvement in glomerulonephritis
    Jennifer R Timoshanko
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Curr Drug Targets Inflamm Allergy 4:353-62. 2005
    ..Studies have demonstrated the significant contribution of intrinsic renal cell derived cytokines (e.g. TNF) in mediating GN, whereas others (IL-1beta) have a relatively minor role...
  3. pmc Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Department of Medicine, Centre for Inflammatory Diseases, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Am J Pathol 164:1967-77. 2004
    ..These studies demonstrate that leukocytes are the major cellular source of IL-1beta, and that IL-1beta acts principally via the IL-1RI on intrinsic renal cells to induce TNF expression and crescentic glomerular injury...
  4. ncbi request reprint Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Center, Clayton, 3168 Victoria, Australia
    J Am Soc Nephrol 16:2646-56. 2005
    ....
  5. ncbi request reprint Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma
    A Richard Kitching
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
    J Am Soc Nephrol 15:1764-74. 2004
    ..They lend weight to the hypothesis that depending on the context/severity of the nephritogenic immune response IFN-gamma has different effects...
  6. ncbi request reprint Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 14:1785-93. 2003
    ..These studies suggest that intrinsic renal cells are the major cellular source of TNF contributing to inflammatory injury in crescentic GN...
  7. ncbi request reprint A pathogenetic role for mast cells in experimental crescentic glomerulonephritis
    Jennifer R Timoshanko
    Center for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Center, 246 Clayton Road, Melbourne, Victoria 3168, Australia
    J Am Soc Nephrol 17:150-9. 2006
    ..These findings suggest that renal mast cells mediate crescentic GN by facilitating effector cell recruitment into glomeruli via augmentation of adhesion molecule expression...
  8. ncbi request reprint IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment
    A Richard Kitching
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 16:2023-33. 2005
    ..These studies demonstrate that in severe experimental crescentic GN, IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 has local proinflammatory roles...
  9. ncbi request reprint Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis
    Dragana Odobasic
    Monash University, Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 16:2012-22. 2005
    ..These studies show that CD80 and CD86 are expressed in glomeruli of mice with crescentic anti-GBM GN, in which they play a critical role in facilitating accumulation of Th1 effectors and macrophages, thus exacerbating renal injury...
  10. ncbi request reprint An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity
    Amanda Jane Ruth
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Immunol 173:136-44. 2004
    ..Effector cell activation, renal DTH-like injury, and dermal DTH require direct Th1 CD154/macrophage CD40 interactions...
  11. ncbi request reprint Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis
    Amanda Jane Ruth
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC 3168, Australia
    J Am Soc Nephrol 17:1940-9. 2006
    ..ANCA induces glomerular neutrophil infiltration and MPO deposition. Subsequently, anti-MPO CD4+ cells recognize MPO as a planted glomerular antigen and act with macrophages to amplify severe glomerular injury...
  12. ncbi request reprint Contributions of IL-1beta and IL-1alpha to crescentic glomerulonephritis in mice
    Jennifer R Timoshanko
    Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 15:910-8. 2004
    ..These studies indicate that IL-1beta but not IL-1alpha contributes to crescent formation and inflammatory cell recruitment, whereas IL-1alpha but not IL-1beta contributes to humoral mechanisms of glomerular injury...
  13. pmc Overlapping roles of endothelial selectins and vascular cell adhesion molecule-1 in immune complex-induced leukocyte recruitment in the cremasteric microvasculature
    M Ursula Norman
    Centre for Inflammatory Diseases, Monash University, Victoria, Australia
    Am J Pathol 163:1491-503. 2003
    ..These observations demonstrate that immune complex-mediated leukocyte recruitment in the cremaster muscle involves overlapping roles for the endothelial selectins and vascular cell adhesion molecule-1...