Tony Tiganis

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. doi request reprint PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
    Tony Tiganis
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    FEBS J 280:445-58. 2013
  2. doi request reprint Reactive oxygen species and insulin resistance: the good, the bad and the ugly
    Tony Tiganis
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Trends Pharmacol Sci 32:82-9. 2011
  3. ncbi request reprint Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signalling by the protein tyrosine phosphatase TCPTP
    Ben J Shields
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Cell Cycle 7:3405-16. 2008
  4. pmc Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP
    Sandra Galic
    Department of Biochemistry and Molecular Biology, P O Box 13D, Monash University, Victoria 3800, Australia
    Mol Cell Biol 25:819-29. 2005
  5. pmc T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis
    Atsushi Fukushima
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Diabetes 59:1906-14. 2010
  6. pmc Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance
    Kim Loh
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Cell Metab 14:684-99. 2011
  7. pmc PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
    XiaoQing Lu
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, Monash University, Victoria, Australia
    Blood 112:4098-108. 2008
  8. pmc The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
    Ivan Ivetac
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia 3800
    Mol Biol Cell 16:2218-33. 2005
  9. pmc T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
    Florian Wiede
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Clin Invest 121:4758-74. 2011
  10. pmc TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers
    Benjamin J Shields
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Mol Cell Biol 33:557-70. 2013

Collaborators

Detail Information

Publications29

  1. doi request reprint PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
    Tony Tiganis
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    FEBS J 280:445-58. 2013
    ....
  2. doi request reprint Reactive oxygen species and insulin resistance: the good, the bad and the ugly
    Tony Tiganis
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Trends Pharmacol Sci 32:82-9. 2011
    ..Here I review evidence indicating that ROS promote insulin sensitivity versus insulin resistance and discuss the potential complications associated with the widespread use of antioxidants...
  3. ncbi request reprint Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signalling by the protein tyrosine phosphatase TCPTP
    Ben J Shields
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Cell Cycle 7:3405-16. 2008
    ..These results identify TCPTP as a negative regulator of the cell cycle...
  4. pmc Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP
    Sandra Galic
    Department of Biochemistry and Molecular Biology, P O Box 13D, Monash University, Victoria 3800, Australia
    Mol Cell Biol 25:819-29. 2005
    ..These results demonstrate that PTP1B and TCPTP are not redundant in insulin signaling and that they act to control both common as well as distinct insulin signaling pathways in the same cell...
  5. pmc T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis
    Atsushi Fukushima
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Diabetes 59:1906-14. 2010
    ..Homozygous TCPTP-deficiency results in perinatal lethality prohibiting any informative assessment of TCPTP's role in glucose homeostasis. Here we have used Ptpn2+/- mice to investigate TCPTP's function in glucose homeostasis...
  6. pmc Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance
    Kim Loh
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Cell Metab 14:684-99. 2011
    ..Our results identify TCPTP as a critical negative regulator of hypothalamic leptin signaling and causally link elevated TCPTP to the development of cellular leptin resistance in obesity...
  7. pmc PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
    XiaoQing Lu
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, Monash University, Victoria, Australia
    Blood 112:4098-108. 2008
    ..These observations identify a novel regulatory loop for the regulation of IL-4-induced STAT6 signaling that may have important implications in both neoplastic and inflammatory processes...
  8. pmc The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
    Ivan Ivetac
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia 3800
    Mol Biol Cell 16:2218-33. 2005
    ..The 4-phosphatase therefore both generates and terminates phosphoinositide 3-kinase signals at distinct subcellular locations...
  9. pmc T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
    Florian Wiede
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Clin Invest 121:4758-74. 2011
    ..These data indicate that TCPTP is a critical negative regulator of TCR signaling that sets the threshold for TCR-induced naive T cell responses to prevent autoimmune and inflammatory disorders arising...
  10. pmc TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers
    Benjamin J Shields
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Mol Cell Biol 33:557-70. 2013
    ..These studies establish TCPTP's potential to serve as a tumor suppressor in human breast cancer...
  11. pmc Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes
    Demis Balamatsias
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 286:43229-40. 2011
    ....
  12. pmc The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis
    Patricia Bukczynska
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia
    Biochem J 380:939-49. 2004
    ..In addition, recombinant CDKs, but not the Polo-like kinase Plk1, phosphorylated Ser-304 in vitro. Our studies identify Ser-304 as a major phosphorylation site in human TCPTP, and the TC45 variant as a novel mitotic CDK substrate...
  13. pmc Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
    Ivan Ivetac
    Department of Biochemistry, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    EMBO Rep 10:487-93. 2009
    ..This study provides the first evidence, to our knowledge, that 4-ptase-1 controls the activation of Akt and thereby cell proliferation, survival and tumorigenesis...
  14. ncbi request reprint Replication checkpoint control by a PTK/STAT3/cyclin D1 axis
    Ben J Shields
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Cell Cycle 8:223-30. 2009
    ..We argue for the need for integrated responses and highlight the potential for oncogenic PTK pathways to bypass the replication checkpoint and contribute to genomic instability...
  15. pmc Reactive oxygen species enhance insulin sensitivity
    Kim Loh
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Cell Metab 10:260-72. 2009
    ..These studies provide causal evidence for the enhancement of insulin signaling by ROS in vivo...
  16. pmc Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice
    Florian Wiede
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 7:e36703. 2012
    ..Taken together these results reaffirm TCPTP's important role in lymphocyte development and indicate that the effects on morbidity, mortality, bone development and the myeloid compartment are strain-dependent...
  17. pmc Protein tyrosine phosphatase function: the substrate perspective
    Tony Tiganis
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Biochem J 402:1-15. 2007
    ..Finally, the progress that has been made in defining the biological roles of PTPs through the identification of their substrates will be discussed...
  18. pmc Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization
    Michelle T Fodero-Tavoletti
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia
    Biochem J 389:343-54. 2005
    ..The present study identifies hPTPN20a as a novel and widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization...
  19. ncbi request reprint Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
    Catherine van Vliet
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Nat Immunol 6:253-60. 2005
    ..These results link TCPTP and Src tyrosine kinases to the selective regulation of TNF-induced MAPK signaling and identify a previously unknown mechanism for modulating inflammatory responses mediated by TNF...
  20. pmc Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton
    Parvin Rahman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Biol Chem 286:29758-70. 2011
    ..Therefore, this study identifies SODD as a novel regulator of PI3K/Akt signaling to the actin cytoskeleton...
  21. pmc The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity
    Bree J Buszard
    School of Biological Sciences, Monash University, Clayton, Victoria, Australia
    Mol Cell Biol 33:1345-56. 2013
    ..Our findings define the role of PTP61F in life span and fecundity and reinforce the importance of subcellular localization in mediating PTP function in vivo...
  22. doi request reprint The structural basis for autonomous dimerization of the pre-T-cell antigen receptor
    Siew Siew Pang
    The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Nature 467:844-8. 2010
    ..This unusual dual-chaperone-like sensing function of pre-Tα represents a unique mechanism in nature whereby developmental quality control regulates the expression and signalling of an integral membrane receptor complex...
  23. doi request reprint DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression
    Ben J Shields
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Cancer Cell 14:166-79. 2008
    ..Therefore, inactivating JAK, Src, and STAT3 signaling pathways in response to DNA replication stress may be essential for the suppression of S phase progression and the maintenance of genomic stability...
  24. pmc Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
    Clare G Fedele
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:22231-6. 2010
    ....
  25. doi request reprint Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1
    Stephen Wong
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    Endocrinology 151:185-94. 2010
    ..These results suggest that Sult1d1 in mice is directly induced by glucocorticoids and may attenuate elevated catecholamine activity during the stress response...
  26. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells
    Manuela Klingler-Hoffmann
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Int J Cancer 105:331-9. 2003
    ..Our study provides insight into the mechanism by which deltaEGFR may contribute to glioblastoma development...
  27. doi request reprint Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase
    Joanne Pagnon
    Department of Physiology, Monash University, Clayton, 3800 Victoria, Australia
    Endocrinology 153:4278-89. 2012
    ..Our studies suggest that β-adrenergic activation can result in PKA-mediated phosphorylation of ATGL Ser(406), to moderately increase ATGL-mediated lipolysis...
  28. pmc Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP
    Sandra Galic
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Mol Cell Biol 23:2096-108. 2003
    ..These results indicate that the differentially localized variants of TCPTP may dephosphorylate the IR and downregulate insulin-induced signaling in vivo...
  29. doi request reprint Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor
    Travis Beddoe
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia
    Immunity 30:777-88. 2009
    ..Collectively, our findings provide a basis for the earliest molecular events that underlie Ag-induced T cell triggering...