Evan Simpson

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Genetic mutations resulting in estrogen insufficiency in the male
    E R Simpson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    Mol Cell Endocrinol 145:55-9. 1998
  2. ncbi request reprint Aromatase--a brief overview
    Evan R Simpson
    Prince Henry s Institute of Medical Research and the Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    Annu Rev Physiol 64:93-127. 2002
  3. ncbi request reprint Sources of estrogen and their importance
    E R Simpson
    Monash Medical Center, Prince Henry s Institute of Medical Research, PO Box 5152, Clayton 3168, Vic, Australia
    J Steroid Biochem Mol Biol 86:225-30. 2003
  4. ncbi request reprint Biology of aromatase in the mammary gland
    E R Simpson
    Prince Henry s Institute of Medical Research, Clayton Vic, Australia
    J Mammary Gland Biol Neoplasia 5:251-8. 2000
  5. ncbi request reprint Estrogen, a fundamental player in energy homeostasis
    Evan Simpson
    Prince Henry s Institute of Medical Research, Clayton, VIC 3168, Australia
    J Steroid Biochem Mol Biol 95:3-8. 2005
  6. ncbi request reprint Aromatase and its inhibitors: significance for breast cancer therapy
    Evan R Simpson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    Recent Prog Horm Res 57:317-38. 2002
  7. ncbi request reprint Aromatization of androgens in women: current concepts and findings
    Evan R Simpson
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Fertil Steril 77:S6-10. 2002
  8. ncbi request reprint Tissue-specific estrogen biosynthesis and metabolism
    E R Simpson
    Prince Henry s Institute of Medical Research, Monash University, Melbourne, Australia
    Ann N Y Acad Sci 949:58-67. 2001
  9. pmc Another role highlighted for estrogens in the male: sexual behavior
    E R Simpson
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
    Proc Natl Acad Sci U S A 97:14038-40. 2000
  10. ncbi request reprint The role of local estrogen biosynthesis in males and females
    E Simpson
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Trends Endocrinol Metab 11:184-8. 2000

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Genetic mutations resulting in estrogen insufficiency in the male
    E R Simpson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    Mol Cell Endocrinol 145:55-9. 1998
    ..Development of an ER-beta knockout mouse, or else a double, or even triple, knockout model, may be required in order to resolve these issues...
  2. ncbi request reprint Aromatase--a brief overview
    Evan R Simpson
    Prince Henry s Institute of Medical Research and the Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    Annu Rev Physiol 64:93-127. 2002
    ..Thus in principle, it should be possible to develop selective aromatase modulators (SAMs) that block aromatase expression, for example, in breast, but allow unimpaired estrogen synthesis in other tissues such as bone...
  3. ncbi request reprint Sources of estrogen and their importance
    E R Simpson
    Monash Medical Center, Prince Henry s Institute of Medical Research, PO Box 5152, Clayton 3168, Vic, Australia
    J Steroid Biochem Mol Biol 86:225-30. 2003
    ....
  4. ncbi request reprint Biology of aromatase in the mammary gland
    E R Simpson
    Prince Henry s Institute of Medical Research, Clayton Vic, Australia
    J Mammary Gland Biol Neoplasia 5:251-8. 2000
    ..Thus these sources of estrogen play an important but hitherto largely unrecognized, physiological and pathophysiological role...
  5. ncbi request reprint Estrogen, a fundamental player in energy homeostasis
    Evan Simpson
    Prince Henry s Institute of Medical Research, Clayton, VIC 3168, Australia
    J Steroid Biochem Mol Biol 95:3-8. 2005
  6. ncbi request reprint Aromatase and its inhibitors: significance for breast cancer therapy
    Evan R Simpson
    Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
    Recent Prog Horm Res 57:317-38. 2002
    ....
  7. ncbi request reprint Aromatization of androgens in women: current concepts and findings
    Evan R Simpson
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Fertil Steril 77:S6-10. 2002
    ..To review the role of circulating C(19) steroids as precursors of estrogens in postmenopausal women...
  8. ncbi request reprint Tissue-specific estrogen biosynthesis and metabolism
    E R Simpson
    Prince Henry s Institute of Medical Research, Monash University, Melbourne, Australia
    Ann N Y Acad Sci 949:58-67. 2001
    ..Selective aromatase modulators (SAMs) may have a role to play in the treatment of estrogen-dependent diseases, such as breast cancer...
  9. pmc Another role highlighted for estrogens in the male: sexual behavior
    E R Simpson
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
    Proc Natl Acad Sci U S A 97:14038-40. 2000
  10. ncbi request reprint The role of local estrogen biosynthesis in males and females
    E Simpson
    Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, Victoria 3168, Australia
    Trends Endocrinol Metab 11:184-8. 2000
    ..The potential clinical significance of these findings in terms of the development of new therapeutic modalities is discussed...
  11. ncbi request reprint Endogenous estrogen deficiency reduces proliferation and enhances apoptosis-related death in vascular smooth muscle cells: insights from the aromatase-knockout mouse
    Shanhong Ling
    Baker Medical Research Institute, Melbourne, Victoria, Australia
    Circulation 109:537-43. 2004
    ..Altered proliferation and death of vascular smooth muscle cells (VSMCs) are important mechanisms in vascular growth and remodeling. This study examined the effect of endogenous estrogens on VSMC proliferation...
  12. ncbi request reprint Impaired acetylcholine-induced release of nitric oxide in the aorta of male aromatase-knockout mice: regulation of nitric oxide production by endogenous sex hormones in males
    Masahiko Kimura
    Alfred and Baker Medical Unit, Wynn Domain, Baker Medical Research Institute, Prahran, Victoria, Australia
    Circ Res 93:1267-71. 2003
    ..These findings suggest that endogenous estrogen facilitate vasorelaxation in males. This may be via modulating endothelial function rather than vascular smooth muscle cell responsiveness...
  13. doi request reprint Differential effect of amphetamine on c-fos expression in female aromatase knockout (ArKO) mice compared to wildtype controls
    Carolina Chavez
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Melbourne, Australia
    Psychoneuroendocrinology 36:761-8. 2011
    ..These results could be important for our understanding of the role of sex steroid hormones in psychosis...
  14. doi request reprint In vitro estrogenic activity of two major compounds from the stem bark of Erythrina lysistemon (Fabaceae)
    Chantal Beatrice Magne Nde
    Prince Henry Institute for Medical Research, PO Box 5152, Clayton, 3168 Vic, Melbourne, Australia
    Eur J Pharmacol 674:87-94. 2012
    ..These results suggest that compounds 1 and 2 endow estrogenic activity and may be the active principles of Erythrina lysistemon...
  15. ncbi request reprint Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue
    Zongjuan Fang
    Department of Obstetrics and Gynecology, University of Illinois, 820 South Wood Street, M C 808, Chicago, IL 60612, USA
    J Clin Endocrinol Metab 87:3460-6. 2002
    ..We conclude that both an intact P450arom gene and the presence of aromatase enzyme activity are essential for the growth of ectopic uterine tissue in a mouse model of endometriosis...
  16. pmc Estrogen receptor beta protects against acoustic trauma in mice
    Inna Meltser
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Clin Invest 118:1563-70. 2008
    ..DPN treatment increased BDNF expression in ARKO mice. These data indicate ERbeta-mediated neuroprotection involving BDNF in the auditory system of males and females...
  17. ncbi request reprint Impaired spatial reference memory in aromatase-deficient (ArKO) mice
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Neuroreport 14:1979-82. 2003
    ..After gonadectomy, there was no significant difference between wildtype and ArKO mice. For the first time using ArKO mice, our findings confirm the importance of estrogen in memory in both males and females...
  18. ncbi request reprint Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment
    Gloria Bachmann
    Robert Wood Johnson Medical School, Women s Health Institute, New Jersey, New Brunswick, USA
    Fertil Steril 77:660-5. 2002
    ....