Jennifer M Rolland

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Allergen-related approaches to immunotherapy
    Jennifer M Rolland
    Department of Immunology, Monash University, Commercial Road, Melbourne VIC 3004, Australia
    Pharmacol Ther 121:273-84. 2009
  2. doi request reprint Specific and sensitive enzyme-linked immunosorbent assays for analysis of residual allergenic food proteins in commercial bottled wine fined with egg white, milk, and nongrape-derived tannins
    Jennifer M Rolland
    Department of Immunology, Monash University, The Alfred, Commercial Road, Melbourne, Victoria, Australia 3004
    J Agric Food Chem 56:349-54. 2008
  3. ncbi request reprint Allergen immunotherapy: current and new therapeutic strategies
    J M Rolland
    Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, Victoria 3181, Australia
    Expert Opin Investig Drugs 9:515-27. 2000
  4. doi request reprint Differential uptake of nanoparticles and microparticles by pulmonary APC subsets induces discrete immunological imprints
    Charles L Hardy
    Department of Immunology, Monash University, Melbourne, Victoria 3004, Australia
    J Immunol 191:5278-90. 2013
  5. ncbi request reprint T cell targeted strategies for improved efficacy and safety of specific immunotherapy for allergic disease
    Jennifer M Rolland
    Department of Immunology, AMREP, Monash University, Commercial Road, Melbourne, VIC 3004, Australia
    Antiinflamm Antiallergy Agents Med Chem 12:201-22. 2013
  6. doi request reprint Clinical allergy to hazelnut and peanut: identification of T cell cross-reactive allergens
    Ian N Glaspole
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Vic, Australia
    Int Arch Allergy Immunol 155:345-54. 2011
  7. doi request reprint TLR ligands of ryegrass pollen microbial contaminants enhance Th1 and Th2 responses and decrease induction of Foxp3(hi) regulatory T cells
    Diana Mittag
    Department of Immunology, Monash University, Melbourne, Australia
    Eur J Immunol 43:723-33. 2013
  8. doi request reprint Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1
    Tamara Etto
    Department of Immunology, Monash University, Melbourne, Vic, Australia
    Int Arch Allergy Immunol 159:355-66. 2012
  9. ncbi request reprint Advances in development of hypoallergenic latex immunotherapy
    Jennifer M Rolland
    Cooperative Research Centre for Asthma, Sydney, New South Wales, and Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Curr Opin Allergy Clin Immunol 5:544-51. 2005
  10. doi request reprint The activin A antagonist follistatin inhibits asthmatic airway remodelling
    Charles Linton Hardy
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Thorax 68:9-18. 2013

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Allergen-related approaches to immunotherapy
    Jennifer M Rolland
    Department of Immunology, Monash University, Commercial Road, Melbourne VIC 3004, Australia
    Pharmacol Ther 121:273-84. 2009
    ..Adjunct therapies such as anti-IgE antibody and corticosteroids may minimize the likelihood of adverse reactions in those with severe allergic disease who would most benefit from this treatment...
  2. doi request reprint Specific and sensitive enzyme-linked immunosorbent assays for analysis of residual allergenic food proteins in commercial bottled wine fined with egg white, milk, and nongrape-derived tannins
    Jennifer M Rolland
    Department of Immunology, Monash University, The Alfred, Commercial Road, Melbourne, Victoria, Australia 3004
    J Agric Food Chem 56:349-54. 2008
    ....
  3. ncbi request reprint Allergen immunotherapy: current and new therapeutic strategies
    J M Rolland
    Department of Pathology and Immunology, Monash University Medical School, Commercial Road, Prahran, Victoria 3181, Australia
    Expert Opin Investig Drugs 9:515-27. 2000
    ..The identification of recombinant allergens suitable for diagnostic use and the development of reliable laboratory assays, based on T-cell function to monitor clinical efficacy of SIT, are important practical outcomes from this research...
  4. doi request reprint Differential uptake of nanoparticles and microparticles by pulmonary APC subsets induces discrete immunological imprints
    Charles L Hardy
    Department of Immunology, Monash University, Melbourne, Victoria 3004, Australia
    J Immunol 191:5278-90. 2013
    ..These findings support the development of lung-specific particulate vaccines, drug delivery systems, and immunomodulators. ..
  5. ncbi request reprint T cell targeted strategies for improved efficacy and safety of specific immunotherapy for allergic disease
    Jennifer M Rolland
    Department of Immunology, AMREP, Monash University, Commercial Road, Melbourne, VIC 3004, Australia
    Antiinflamm Antiallergy Agents Med Chem 12:201-22. 2013
    ..T cell targeted strategies will facilitate wider clinical application of SIT and reliable laboratory assays for monitoring treatment. ..
  6. doi request reprint Clinical allergy to hazelnut and peanut: identification of T cell cross-reactive allergens
    Ian N Glaspole
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Vic, Australia
    Int Arch Allergy Immunol 155:345-54. 2011
    ..Currently there is no cure. While co-allergy to peanut and tree nuts is a common clinical observation, and IgE cross-reactivity between peanut and tree nuts is reported, T cell cross-reactivity is poorly defined...
  7. doi request reprint TLR ligands of ryegrass pollen microbial contaminants enhance Th1 and Th2 responses and decrease induction of Foxp3(hi) regulatory T cells
    Diana Mittag
    Department of Immunology, Monash University, Melbourne, Australia
    Eur J Immunol 43:723-33. 2013
    ..These findings show that adjuvants for specific immunotherapy should enhance Treg cells rather than target immune deviation from Th2 to Th1...
  8. doi request reprint Unique and cross-reactive T cell epitope peptides of the major Bahia grass pollen allergen, Pas n 1
    Tamara Etto
    Department of Immunology, Monash University, Melbourne, Vic, Australia
    Int Arch Allergy Immunol 159:355-66. 2012
    ..T cell-reactive but IgE nonreactive peptides provide a safer treatment option. This study aimed to identify and characterize dominant CD4(+) T cell epitope peptides of the major BaGP allergen, Pas n 1...
  9. ncbi request reprint Advances in development of hypoallergenic latex immunotherapy
    Jennifer M Rolland
    Cooperative Research Centre for Asthma, Sydney, New South Wales, and Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Curr Opin Allergy Clin Immunol 5:544-51. 2005
    ....
  10. doi request reprint The activin A antagonist follistatin inhibits asthmatic airway remodelling
    Charles Linton Hardy
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Thorax 68:9-18. 2013
    ..The aim of this study was to test the potential of follistatin as a therapeutic agent to inhibit airway remodelling in an experimental model of chronic allergic airway inflammation...
  11. doi request reprint House dust mite sublingual immunotherapy: the role for transforming growth factor-beta and functional regulatory T cells
    Robyn E O'Hehir
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia
    Am J Respir Crit Care Med 180:936-47. 2009
    ..Sublingual allergen-specific immunotherapy is gaining popularity for treatment of allergic diseases, but underlying immunological mechanisms are unresolved...
  12. ncbi request reprint IgE cross-reactivity between the major peanut allergen Ara h 2 and tree nut allergens
    M P De Leon
    Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital and Monash University, Commercial Road, Melbourne, VIC 3004, Australia
    Mol Immunol 44:463-71. 2007
    ..This indicates that the major peanut allergen, Ara h 2, shares common IgE-binding epitopes with almond and Brazil nut allergens, which may contribute to the high incidence of tree nut sensitisation in peanut allergic individuals...
  13. ncbi request reprint Characterization of a mouse model of allergy to a major occupational latex glove allergen Hev b 5
    Charles L Hardy
    Cooperative Research Centre for Asthma, Department of Pathology and Immunology, Monash Medical School, Commercial Road, Melbourne, VIC 3004, Australia
    Am J Respir Crit Care Med 167:1393-9. 2003
    ..This mouse model will aid the development of potentially curative treatments for latex-sensitized individuals, including those with occupational asthma...
  14. ncbi request reprint Anaphylaxis to lemon soap: citrus seed and peanut allergen cross-reactivity
    Ian N Glaspole
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Australia
    Ann Allergy Asthma Immunol 98:286-9. 2007
    ..Many individuals allergic to peanuts have multiple allergen sensitivity...
  15. doi request reprint The effector T cell response to ryegrass pollen is counterregulated by simultaneous induction of regulatory T cells
    Diana Mittag
    Department of Immunology, Monash University, Australia
    J Immunol 184:4708-16. 2010
    ..These results indicate that the cogeneration of Foxp3(hi) Tregs in response to allergen may be a mechanism for controlling allergic reactions in healthy individuals, which is impaired in those with allergies...
  16. doi request reprint Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation
    Charles L Hardy
    Department of Immunology, Monash University, Commercial Road, Melbourne, VIC 3004 Australia
    Am J Respir Cell Mol Biol 42:667-75. 2010
    ..Given the immunomodulatory and fibrogenic effects of activin A, our findings suggest an important role for IL-13 regulation of activin A in asthma pathogenesis...
  17. ncbi request reprint High dose allergen stimulation of T cells from house dust mite-allergic subjects induces expansion of IFN-gamma+ T Cells, apoptosis of CD4+IL-4+ T cells and T cell anergy
    Leanne M Gardner
    Department of Pathology and Immunology, Monash University, Alfred Hospital, Melbourne, Vic, Australia
    Int Arch Allergy Immunol 133:1-13. 2004
    ....
  18. ncbi request reprint Oligoclonal analysis of the atopic T cell response to the group 1 allergen of Cynodon dactylon (bermuda grass) pollen: pre- and post-allergen-specific immunotherapy
    Nirupama P Eusebius
    Department of Allergy, Asthma and Clinical Immunology, Monash University Medical School, Alfred Hospital, Prahran, VIC Australia
    Int Arch Allergy Immunol 127:234-44. 2002
    ....
  19. doi request reprint Inert 50-nm polystyrene nanoparticles that modify pulmonary dendritic cell function and inhibit allergic airway inflammation
    Charles L Hardy
    Department of Immunology, Monash University, Melbourne, Victoria 3004, Australia
    J Immunol 188:1431-41. 2012
    ..The discovery that a defined type of nanoparticle can inhibit, rather than promote, lung inflammation via modulation of DC function opens the door to the discovery of other nanoparticle types with exciting beneficial properties...
  20. ncbi request reprint Characterization of the human T cell response to rye grass pollen allergens Lol p 1 and Lol p 5
    M D Burton
    Department of Pathology and Immunology, Monash University Medical School, Victoria, Australia
    Allergy 57:1136-44. 2002
    ..This study aimed to characterize the T cell response to these allergens using a large panel of RGP-sensitive individuals...
  21. doi request reprint Functional regulatory T cells and allergen immunotherapy
    Jennifer M Rolland
    Department of Immunology, Monash University, Melbourne, Victoria, Australia
    Curr Opin Allergy Clin Immunol 10:559-66. 2010
    ..This review examines evidence for functional Treg in controlling immune responses to allergen with particular focus on allergen-specific immunotherapy...
  22. doi request reprint Ara h 2 peptides containing dominant CD4+ T-cell epitopes: candidates for a peanut allergy therapeutic
    Sara R Prickett
    Department of Immunology, Monash University, Melbourne, Australia
    J Allergy Clin Immunol 127:608-15.e1-5. 2011
    ..Peanut allergy is a life-threatening condition; there is currently no cure. Although whole allergen extracts are used for specific immunotherapy for many allergies, they can cause severe reactions, and even fatalities, in peanut allergy...
  23. ncbi request reprint Hypoallergenic variants of the major latex allergen Hev b 6.01 retaining human T lymphocyte reactivity
    Alexander C Drew
    Cooperative Research Centre for Asthma, Sydney, Australia
    J Immunol 173:5872-9. 2004
    ..The ablated allergenicity but retained T cell reactivity of the Hev b 6.02 (Cys 3, 12, 17, 41 Ala) peptide suggests this peptide is a suitable candidate for inclusion in a latex immunotherapy preparation...
  24. ncbi request reprint Sublingual allergen immunotherapy: immunological mechanisms and prospects for refined vaccine preparation
    R E O'Hehir
    Department of, Immunology, Monash University, Melbourne, Australia
    Curr Med Chem 14:2235-44. 2007
    ....
  25. ncbi request reprint Functional analysis of cross-reactive immunoglobulin E antibodies: peanut-specific immunoglobulin E sensitizes basophils to tree nut allergens
    M P De Leon
    Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Commercial Road, Melbourne, Victoria, Australia
    Clin Exp Allergy 35:1056-64. 2005
    ..It is, however, unclear whether these cross-reactive IgE antibodies are involved in effector-cell activation...
  26. ncbi request reprint Characterization of the T-cell epitopes of a major peanut allergen, Ara h 2
    I N Glaspole
    Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Australia
    Allergy 60:35-40. 2005
    ..We sought to map the T-cell epitopes of the major peanut allergen, Ara h 2 in order to develop T-cell targeted vaccines...
  27. ncbi request reprint Increased allergen concentration enhances IFN-gamma production by allergic donor T cells expressing a peripheral tissue trafficking phenotype
    L M Gardner
    Department of Pathology and Immunology, Monash University, Melbourne, Victoria, Australia
    Allergy 59:1308-17. 2004
    ....
  28. ncbi request reprint Residential characteristics predict changes in Der p 1, Fel d 1 and ergosterol but not fungi over time
    M C Matheson
    Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
    Clin Exp Allergy 33:1281-8. 2003
    ..We also examined the changes in levels of indoor allergens...
  29. ncbi request reprint Respiratory disorders and allergies in tea packers
    M J Abramson
    Departments of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
    Occup Med (Lond) 51:259-65. 2001
    ..6%) employees. As there was little evidence of specific allergic sensitization to the tea varieties tested, the excess of work-related respiratory and nasal symptoms probably represented non-specific irritation...
  30. ncbi request reprint Molecular cloning, expression and immunological characterisation of Lol p 5C, a novel allergen isoform of rye grass pollen demonstrating high IgE reactivity
    C Suphioglu
    Department of Allergy, Asthma and Clinical Immunology, Monash University Medical School, Alfred Hospital, Prahran, Vic, Australia
    FEBS Lett 462:435-41. 1999
    ..In comparison, recombinant Lol p 5A showed IgE reactivity in less than 64% of the patients. Therefore, Lol p 5C represents a novel and highly IgE-reactive isoform allergen of rye grass pollen...
  31. ncbi request reprint Molecular basis of IgE-recognition of Lol p 5, a major allergen of rye-grass pollen
    C Suphioglu
    School of Botany, University of Melbourne, Parkville, Victoria, Australia
    Mol Immunol 35:293-305. 1998
    ..The fact that such an allergenic synthetic epitope has the capacity to strongly inhibit IgE-binding to natural allergens highlight its potential for use as a candidate in future therapeutics to treat pollen-associated allergies...
  32. pmc MHC class II expression in human basophils: induction and lack of functional significance
    Astrid L Voskamp
    Department of Immunology, Monash University, Melbourne, Victoria, Australia Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia
    PLoS ONE 8:e81777. 2013
    ....
  33. ncbi request reprint The peanut allergy epidemic: allergen molecular characterisation and prospects for specific therapy
    Maria P de Leon
    Department of Immunology, Monash University, Melbourne, Victoria 3004, Australia
    Expert Rev Mol Med 9:1-18. 2007
    ..These include T-cell-epitope peptide and hypoallergenic mutant vaccines. Alternative routes of administration such as sublingual are also considered, and appropriate adjuvants for delivering effective treatments at these sites examined...
  34. ncbi request reprint Specific monoclonal antibodies and human immunoglobulin E show that Hev b 5 is an abundant allergen in high protein powdered latex gloves
    M F Sutherland
    Department of Allergy, Asthma and Clinical Immunology, The Alfred Hospital and Monash University, Victoria, Australia
    Clin Exp Allergy 32:583-9. 2002
    ..Moreover, standardized immunological assays for the detection of Hev b 5 are currently lacking and may have important implications for both allergen avoidance and diagnosis in latex allergy...
  35. doi request reprint Latex allergy: a model for therapy
    J M Rolland
    Department of Immunology, Monash University, Melbourne, Vic, Australia
    Clin Exp Allergy 38:898-912. 2008
    ..The co-administration of adjunct therapies such as anti-IgE or corticosteroids and of appropriate adjuvants for induction of regulatory T cell response offers promise for clinically effective, safe latex-specific vaccines...
  36. ncbi request reprint Anaphylaxis to Gelofusine confirmed by in vitro basophil activation test: a case series
    E Apostolou
    Department of Immunology, Monash University, Commercial Road, Melbourne VIC 3004, Australia
    Anaesthesia 61:264-8. 2006
    ..5%. Our findings suggest that basophil activation testing is a safe and reliable in vitro assay for prediction or confirmation of Gelofusine sensitivity in patients with high clinical suspicion of Gelofusine-induced anaphylaxis...
  37. ncbi request reprint Induction of T 'regulatory' cells by standardized house dust mite immunotherapy: an increase in CD4+ CD25+ interleukin-10+ T cells expressing peripheral tissue trafficking markers
    L M Gardner
    Department of Pathology and Immunology, Monash University, Melbourne, Victoria, Australia
    Clin Exp Allergy 34:1209-19. 2004
    ....
  38. ncbi request reprint Follistatin is a candidate endogenous negative regulator of activin A in experimental allergic asthma
    C L Hardy
    Department of Immunology, Monash University, Melbourne, Australia
    Clin Exp Allergy 36:941-50. 2006
    ..In vitro, the biological effects of activin A are neutralized by the soluble binding protein follistatin...
  39. ncbi request reprint Latex allergy: towards immunotherapy for health care workers
    M F Sutherland
    Department of Allergy, Asthma and Clinical Immunology, The Alfred Hospital and Monash University, Victoria, Australia
    Clin Exp Allergy 32:667-73. 2002
    ..Elucidation of the molecular and cellular mechanisms of the immune response to these allergens is pivotal to facilitate the search for safer immunotherapy of latex allergy among HCW...
  40. ncbi request reprint What's in a kiss: peanut allergen transmission as a sensitizer?
    Richard C Nolan
    J Allergy Clin Immunol 119:755. 2007