Daniel P Poole
Affiliation: Monash University
DiCello J, Saito A, Rajasekhar P, Sebastian B, McQuade R, Gondin A, et al
. Agonist-dependent development of delta opioid receptor tolerance in the colon. Cell Mol Life Sci. 2019;: pubmed publisher
..These findings demonstrate that SNC80 has a prolonged inhibitory effect on propagating colonic motility. ARM390 had no effect on motor patterns and thus may have fewer gastrointestinal side-effects. ..
Poole D, Lieu T, Pelayo J, Eriksson E, Veldhuis N, Bunnett N. Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2015;309:G248-59 pubmed publisher
..Defective recycling may be secondary to upregulation of Î²-arrestin2 and downregulation of ECE-1. Internalized NK1R may generate sustained proinflammatory signals that disrupt normal neuronal functions. ..
Lay J, Carbone S, DiCello J, Bunnett N, Canals M, Poole D. Distribution and trafficking of the ?-opioid receptor in enteric neurons of the guinea pig. Am J Physiol Gastrointest Liver Physiol. 2016;311:G252-66 pubmed publisher
..In summary, we have identified the neurochemical coding of MOR-positive enteric neurons and have demonstrated differential trafficking of MOR in these neurons in response to established and putative MOR agonists. ..
Poole D, Bunnett N. G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future. Adv Exp Med Biol. 2016;891:145-52 pubmed publisher
..The latency between the endocytosis of GPCRs and their recycling and resensitization is a major determinant of the cell's ability to respond to subsequent exposure to agonists. ..
Fothergill L, Callaghan B, Rivera L, Lieu T, Poole D, Cho H, et al
. Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine. Nutrients. 2016;8: pubmed
..Thus, functional TRPA1 channels are expressed by enterocytes of the duodenum and colon. Activation of enterocyte TRPA1 by food components has the potential to facilitate nutrient absorption. ..
Jensen D, Zhao P, Jimenez Vargas N, Lieu T, Gerges M, Yeatman H, et al
. Protein Kinase D and G?? Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane. J Biol Chem. 2016;291:11285-99 pubmed publisher
..Our results reveal a major role for PKD and G?? in agonist-evoked mobilization of intracellular PAR2 stores that is required for sustained signaling by extracellular proteases. ..