M F Pera

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Scientific considerations relating to the ethics of the use of human embryonic stem cells in research and medicine
    M F Pera
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Reprod Fertil Dev 13:23-9. 2001
  2. ncbi request reprint Human embryonic stem cells
    M F Pera
    Centre for Early Human Development, Monash Institute of Reproduction and Development, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
    J Cell Sci 113:5-10. 2000
  3. ncbi request reprint Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2
    M F Pera
    Monash University Institute of Reproduction and Development, Monash Medical Centre, Clayton, Vic, Australia
    Reprod Fertil Dev 10:551-5. 1998
  4. ncbi request reprint Human pluripotent stem cells: a progress report
    M F Pera
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, 3168, Victoria, Australia
    Curr Opin Genet Dev 11:595-9. 2001
  5. ncbi request reprint Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin
    Martin F Pera
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Cell Sci 117:1269-80. 2004
  6. ncbi request reprint Human embryonic stem cells: prospects for development
    Martin F Pera
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Development 131:5515-25. 2004
  7. ncbi request reprint Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system
    Raymond C B Wong
    Monash Institute of Medical Research, Laboratory of Embryonic Stem Cell Biology, Australian Stem Cell Centre, Building 75, STRIP Monash University, Wellington Road, Clayton, VIC 3800, Australia
    Biochem Biophys Res Commun 344:181-8. 2006
  8. ncbi request reprint Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
    B E Reubinoff
    Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    Nat Biotechnol 18:399-404. 2000
  9. ncbi request reprint Isolation, characterization, and differentiation of human embryonic stem cells
    Martin F Pera
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Methods Enzymol 365:429-46. 2003
  10. ncbi request reprint Presence of functional gap junctions in human embryonic stem cells
    Raymond C B Wong
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, VIC 3168, Australia
    Stem Cells 22:883-9. 2004

Research Grants

  1. Regulation of embryonic stem cells
    Martin Pera; Fiscal Year: 2005

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Scientific considerations relating to the ethics of the use of human embryonic stem cells in research and medicine
    M F Pera
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Reprod Fertil Dev 13:23-9. 2001
    ....
  2. ncbi request reprint Human embryonic stem cells
    M F Pera
    Centre for Early Human Development, Monash Institute of Reproduction and Development, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
    J Cell Sci 113:5-10. 2000
    ..Although our understanding of the control of growth and differentiation of human ES cells is quite limited, it is clear that the development of these cell lines will have a widespread impact on biomedical research...
  3. ncbi request reprint Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2
    M F Pera
    Monash University Institute of Reproduction and Development, Monash Medical Centre, Clayton, Vic, Australia
    Reprod Fertil Dev 10:551-5. 1998
    ..Models of endoderm differentiation in humans will be useful for identifying the molecules which mediate cell interactions in development, and in achieving directed differentiation of cells for use in transplantation...
  4. ncbi request reprint Human pluripotent stem cells: a progress report
    M F Pera
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, 3168, Victoria, Australia
    Curr Opin Genet Dev 11:595-9. 2001
    ..In some studies, committed progenitor cell populations have been isolated from mixed cultures of differentiating ES cells...
  5. ncbi request reprint Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin
    Martin F Pera
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Cell Sci 117:1269-80. 2004
    ....
  6. ncbi request reprint Human embryonic stem cells: prospects for development
    Martin F Pera
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Development 131:5515-25. 2004
    ....
  7. ncbi request reprint Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system
    Raymond C B Wong
    Monash Institute of Medical Research, Laboratory of Embryonic Stem Cell Biology, Australian Stem Cell Centre, Building 75, STRIP Monash University, Wellington Road, Clayton, VIC 3800, Australia
    Biochem Biophys Res Commun 344:181-8. 2006
    ..Altogether, these results suggest that gap junctions play an important role in hESC maintenance...
  8. ncbi request reprint Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
    B E Reubinoff
    Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    Nat Biotechnol 18:399-404. 2000
    ..Embryonic stem cells provide a model to study early human embryology, an investigational tool for discovery of novel growth factors and medicines, and a potential source of cells for use in transplantation therapy...
  9. ncbi request reprint Isolation, characterization, and differentiation of human embryonic stem cells
    Martin F Pera
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Methods Enzymol 365:429-46. 2003
  10. ncbi request reprint Presence of functional gap junctions in human embryonic stem cells
    Raymond C B Wong
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, VIC 3168, Australia
    Stem Cells 22:883-9. 2004
    ..Moreover, scrape loading/dye transfer assay indicates that human ES cells are coupled through functional gap junctions that are inhibited by protein kinase C activation and extracellular signal-regulated kinase inhibition...
  11. ncbi request reprint Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells
    Alice Pebay
    Monash Institute of Medical Research, Laboratory of Embryonic Stem Cell Biology, Australian Stem Cell Centre, STRIP Monash University, Clayton VIC 3800, Australia
    Stem Cells 23:1541-8. 2005
    ..This study is the first demonstration of a role for lysophospholipid receptor signaling in the maintenance of stem cell pluri-potentiality...
  12. ncbi request reprint Characterization and culture of human embryonic stem cells
    Andrew L Laslett
    Monash Institute of Reproduction and Development, Monash University, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Trends Cardiovasc Med 13:295-301. 2003
    ....
  13. ncbi request reprint Gap junction mediated transport of shRNA between human embryonic stem cells
    Ernst J Wolvetang
    The Australian Stem Cell Centre and Department of Anatomy and Cell Biology, Monash University, Building 75 STRIP, Wellington Road, Clayton, VIC 3800, Australia
    Biochem Biophys Res Commun 363:610-5. 2007
    ..This novel intercellular gene expression regulatory mechanism may offer new approaches to manipulation of hESC...
  14. ncbi request reprint Identification and characterisation of known and novel transcripts expressed during the final stages of human oocyte maturation
    Tetsuya Goto
    Centre for Early Human Development, Institute of Reproduction and Development, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Mol Reprod Dev 62:13-28. 2002
    ..1-kb transcript is restricted to the testis and ovary, and its expression correlates with cell pluripotency in that it is expressed in embryonal carcinoma cells, but not in their differentiated derivative cells...
  15. ncbi request reprint CD30 and its ligand: possible role in regulation of teratoma stem cells
    M F Pera
    Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    APMIS 106:169-72; discussion 173. 1998
    ..CD30 and its ligand are candidate stem cell identity factors, juxtacrine regulators whose sole function is to identify a cell's position in a developmental hierarchy...
  16. ncbi request reprint A novel cell-surface marker found on human embryonic hepatoblasts and a subpopulation of hepatic biliary epithelial cells
    Lincon Stamp
    Monash Institute of Reproduction and Development, Monash University, Clayton 3168, Victoria, Australia
    Stem Cells 23:103-12. 2005
    ..These results suggest that GCTM-5 will be a useful reagent for defining cell lineage relationships between putative progenitor populations in embryonic liver and in the biliary epithelium during tissue repair...
  17. doi request reprint Neural differentiation of human embryonic stem cells
    Mirella Dottori
    Monash Institute of Medical Research and the Australian Stem Cell Centre, Clayton, Victoria, Australia
    Methods Mol Biol 438:19-30. 2008
    ..This complete protocol of neural differentiation, from hESCs to mature neuronal cells, can be used as an in vitro model to study human neurogenesis and neurodegeneration...
  18. ncbi request reprint The hESC line Envy expresses high levels of GFP in all differentiated progeny
    Magdaline Costa
    Monash Immunology and Stem Cell Laboratories, STRIP 1, West Ring Road, Monash University Campus, Clayton, Victoria, 3800, Australia
    Nat Methods 2:259-60. 2005
    ..We have generated a hESC line designated 'Envy', in which robust levels of green fluorescent protein (GFP) are expressed in stem cells and all differentiated progeny...
  19. doi request reprint BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures
    Nicholas R F Hannan
    Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3168, Australia
    Cloning Stem Cells 11:427-35. 2009
    ..Our data show that members of the TGF-beta superfamily, other than Activin-A and GDF3, are able to maintain hES cells in an undifferentiated state under feeder free conditions...
  20. ncbi request reprint Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells
    Kathryn C Davidson
    Monash Institute of Medical Research, Monash University, The Australian Stem Cell Center, Clayton, Australia
    Mol Cell Neurosci 36:408-15. 2007
    ..These findings demonstrate a requirement of Wnt signaling for maintenance, proliferation, and survival of NP when cultured in neurosphere conditions...
  21. doi request reprint CD133 expression by neural progenitors derived from human embryonic stem cells and its use for their prospective isolation
    Gary S L Peh
    Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Stem Cells Dev 18:269-82. 2009
    ..CD133(+)GCTM-2(-) cells formed neurospheres at the relative highest frequency. Thus, negative selection with GCTM-2 may be useful for the purification of specific cell types differentiated from hES cells...
  22. ncbi request reprint CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells
    Daniella Herszfeld
    Monash Institute of Medical Research, Monash University, and the Australian Stem Cell Centre, Bldg 75 STRIP, Wellington Road, Clayton, Victoria 3800 Australia
    Nat Biotechnol 24:351-7. 2006
    ..Here we show that CD30, a member of the tumor necrosis factor receptor superfamily, is expressed on transformed but not normal hES cells, and that CD30 expression protects hES cells against apoptosis...
  23. ncbi request reprint Human cloning 2001
    David L Healy
    Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia
    Hum Fertil (Camb) 5:75-7. 2002
    ..Unlike the early clinical years of in vitro fertilization, with cloning there is no animal model that is safe and dependable. Until there is such a model, 'Dolly'-style human cloning is medically unacceptable...
  24. pmc Biochemical properties of a keratan sulphate/chondroitin sulphate proteoglycan expressed in primate pluripotent stem cells
    Susan Cooper
    University College London, UK
    J Anat 200:259-65. 2002
    ..Immunofluorescence and immunoblotting data show that monkey and human pluripotent stem cells react with antibodies directed against epitopes on either carbohydrate side chains or the protein core of the molecule...
  25. ncbi request reprint Stem cell culture, one step at a time
    Martin F Pera
    Nat Methods 2:164-5. 2005
  26. ncbi request reprint Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
    Oluseun Adewumi
    UK Stem Cell Bank, Division of Cell Biology and Imaging, National Institute for Biological Standards and Control, South Mimms, Herts, EN6 3QG, UK
    Nat Biotechnol 25:803-16. 2007
    ..Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected...
  27. pmc Transcriptional analysis of early lineage commitment in human embryonic stem cells
    Andrew L Laslett
    Monash Institute of Medical Research, Monash University and the Australian Stem Cell Centre, Clayton, Victoria Australia
    BMC Dev Biol 7:12. 2007
    ..In fact, even our knowledge of the phenotype of hESC is limited, because the immunological and molecular criteria presently used to define this phenotype describe the properties of a heterogeneous population of cells...
  28. ncbi request reprint Derivation of neural precursors from human embryonic stem cells in the presence of noggin
    Pavel Itsykson
    The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and The Department of Gynecology, Hadassah University Hospital, Ein Kerem, Jerusalem 91120, Israel
    Mol Cell Neurosci 30:24-36. 2005
    ....
  29. doi request reprint Simpler and safer cell reprogramming
    Martin F Pera
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Nat Biotechnol 26:59-60. 2008
  30. doi request reprint Stem cells. A new year and a new era
    Martin F Pera
    Nature 451:135-6. 2008
  31. ncbi request reprint Unnatural selection of cultured human ES cells?
    Martin F Pera
    Nat Biotechnol 22:42-3. 2004
  32. ncbi request reprint The International Stem Cell Initiative: toward benchmarks for human embryonic stem cell research
    Peter W Andrews
    Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Nat Biotechnol 23:795-7. 2005

Research Grants3

  1. Regulation of embryonic stem cells
    Martin Pera; Fiscal Year: 2005
    ..This project will use stem cell lines ES 01 02 03 04 05 06 on the NIH Embryonic Stem Cell Registry. ..