Salvatore Pepe

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function
    Salvatore Pepe
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Monash University Faculty of Medicine, Melbourne, Australia
    Circulation 105:2303-8. 2002
  2. ncbi request reprint (n-3) Long chain PUFA dose-dependently increase oxygen utilization efficiency and inhibit arrhythmias after saturated fat feeding in rats
    Salvatore Pepe
    Department of Surgery, Monash University, Australia
    J Nutr 137:2377-83. 2007
  3. ncbi request reprint Dietary polyunsaturated fatty acids and age-related membrane changes in the heart
    Salvatore Pepe
    Laboratory of Cardiothoracic Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Melbourne, Australia
    Ann N Y Acad Sci 1114:381-8. 2007
  4. ncbi request reprint Coenzyme Q10 in cardiovascular disease
    Salvatore Pepe
    CJOB Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Australia
    Mitochondrion 7:S154-67. 2007
  5. doi request reprint Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA
    Francis Miller
    Cardiac Surgical Research Unit, Alfred Hospital, Dept of Surgery, Monash University, and Baker Heart Research Institute, Commercial Road Prahran, Victoria 3181, Australia
    Mech Ageing Dev 130:742-7. 2009
  6. doi request reprint Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial
    Jee Yoong Leong
    Cardiac Surgical Research Unit, Alfred Hospital, Department of Surgery Monash University, Baker IDI Institute, Melbourne, Australia
    Heart Lung Circ 19:584-91. 2010
  7. ncbi request reprint Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute Wynn Domain, Melbourne, Prahran Victoria 3181, Australia
    Ann N Y Acad Sci 1019:78-84. 2004
  8. ncbi request reprint Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapy
    Anthony Hadj
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Monash University, Alfred Hospital, Melbourne, Vic, Australia
    Heart Lung Circ 15:172-81. 2006
  9. ncbi request reprint Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes
    Salvatore Pepe
    Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Vic, Australia
    Exp Gerontol 40:751-8. 2005
  10. doi request reprint Targeting oxidative stress in surgery: effects of ageing and therapy
    Salvatore Pepe
    CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia
    Exp Gerontol 43:653-7. 2008

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function
    Salvatore Pepe
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Monash University Faculty of Medicine, Melbourne, Australia
    Circulation 105:2303-8. 2002
    ..Fish oils modify cardiac membrane phospholipid fatty acid composition with potent antiarrhythmic effects. We tested the effects of dietary fish oil on ventricular hemodynamics and myocardial oxygen consumption (MVO2)...
  2. ncbi request reprint (n-3) Long chain PUFA dose-dependently increase oxygen utilization efficiency and inhibit arrhythmias after saturated fat feeding in rats
    Salvatore Pepe
    Department of Surgery, Monash University, Australia
    J Nutr 137:2377-83. 2007
    ..FO at a dose as low as 3% of total fat dietary supplement effectively reversed the high oxygen requirements and pro-arrhythmic effects of a SAT-rich diet even with continued consumption of SAT (9%) in this ex vivo animal model...
  3. ncbi request reprint Dietary polyunsaturated fatty acids and age-related membrane changes in the heart
    Salvatore Pepe
    Laboratory of Cardiothoracic Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Melbourne, Australia
    Ann N Y Acad Sci 1114:381-8. 2007
    ..Such pervasive treatment results in manipulation of cellular function at multiple levels from cell membrane to the genome...
  4. ncbi request reprint Coenzyme Q10 in cardiovascular disease
    Salvatore Pepe
    CJOB Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Australia
    Mitochondrion 7:S154-67. 2007
    ..3. Presently, due to the notable absence of clinically significant side effects and likely therapeutic benefit, CoQ(10) can be considered a safe adjunct to standard therapies in cardiovascular disease...
  5. doi request reprint Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA
    Francis Miller
    Cardiac Surgical Research Unit, Alfred Hospital, Dept of Surgery, Monash University, and Baker Heart Research Institute, Commercial Road Prahran, Victoria 3181, Australia
    Mech Ageing Dev 130:742-7. 2009
    ..We conclude that, although mtDNA mutations (as exemplified by mtDNA(4977)) accumulate in the ageing heart, they are unlikely to make a major contribution to loss of contractile function...
  6. doi request reprint Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial
    Jee Yoong Leong
    Cardiac Surgical Research Unit, Alfred Hospital, Department of Surgery Monash University, Baker IDI Institute, Melbourne, Australia
    Heart Lung Circ 19:584-91. 2010
    ..The aim of this study was to assess the effect of perioperative metabolic therapy at a biochemical, clinical and economic level in cardiac surgical patients...
  7. ncbi request reprint Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute Wynn Domain, Melbourne, Prahran Victoria 3181, Australia
    Ann N Y Acad Sci 1019:78-84. 2004
    ....
  8. ncbi request reprint Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapy
    Anthony Hadj
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Monash University, Alfred Hospital, Melbourne, Vic, Australia
    Heart Lung Circ 15:172-81. 2006
    ....
  9. ncbi request reprint Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes
    Salvatore Pepe
    Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Vic, Australia
    Exp Gerontol 40:751-8. 2005
    ....
  10. doi request reprint Targeting oxidative stress in surgery: effects of ageing and therapy
    Salvatore Pepe
    CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia
    Exp Gerontol 43:653-7. 2008
    ..We conclude that simultaneously targeting a number of key deficiencies with a metabolic formulation prior to surgery results in peri- and post-operative clinical and economic benefits...
  11. ncbi request reprint Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue
    Franklin Rosenfeldt
    The Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Baker Heart Research Institute, Melbourne, Australia
    J Thorac Cardiovasc Surg 129:25-32. 2005
    ....
  12. doi request reprint Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: a randomized controlled trial
    Bryn O Jones
    Department of Cardiology, Royal Children s Hospital, Melbourne, Victoria, Australia Heart Research Group, Murdoch Children s Research Institute, Parkville, Victoria, Australia Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
    J Thorac Cardiovasc Surg 146:1334-40. 2013
    ..No studies have examined this technique in neonates. The present study was performed to examine the remote ischemic preconditioning efficacy in this high-risk patient group...
  13. doi request reprint p38 Mitogen-activated protein kinase inhibition reduces inflammatory cytokines in a brain-dead transplant donor animal model
    Takahiro Oto
    Department of Cardiothoracic Surgery, Alfred Hospital, Monash University, Melbourne, Australia
    Heart Lung Circ 18:393-400. 2009
    ....
  14. ncbi request reprint Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranes
    Salvatore Pepe
    Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Vic, Australia
    Exp Gerontol 40:369-76. 2005
    ....
  15. pmc Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1(2-26)
    Chengxue Qin
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Br J Pharmacol 168:238-52. 2013
    ..We now test the hypothesis that ANX-A1 preserves post-ischaemic recovery of left ventricular (LV) function...
  16. doi request reprint Cardiac reanimation for donor heart transplantation after cardiocirculatory death
    Stephen Repse
    Department of Cardiothoracic Surgery, Alfred Hospital, Prahan, Australia
    J Heart Lung Transplant 29:747-55. 2010
    ....
  17. ncbi request reprint Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapy
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia
    Int J STD AIDS 16:827-9. 2005
    ..This suggests a novel therapy for further investigation targeted at ZDV induced myopathy, potentially allowing continuation of antiviral treatments including ZDV...
  18. ncbi request reprint Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardium
    Freya L Sheeran
    Department of Surgery, Monash University Faculty of Medicine, Alfred Hospital, Melbourne, Australia
    Biochim Biophys Acta 1797:1138-48. 2010
    ....
  19. doi request reprint Mitochondrial dysfunction in CD4+ lymphocytes from stavudine-treated HIV patients
    Lloyd Einsiedel
    Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
    Mitochondrion 10:534-9. 2010
    ..Therapy with stavudine results in impaired mitochondrial function in CD4+PBLs that does not appear to be due to reduced mitochondrial volume or DNA content and cannot be attributed to infection with HIV...
  20. doi request reprint Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression
    Olivier W V van den Brink
    Department of Cardiothoracic Surgery, Alfred Hospital and Department of Surgery, Monash University, Melbourne, Australia
    J Renin Angiotensin Aldosterone Syst 8:153-9. 2007
    ..The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production...
  21. pmc Effect of remote ischemic preconditioning on phosphorylated protein signaling in children undergoing tetralogy of Fallot repair: a randomized controlled trial
    Salvatore Pepe
    Heart Research Group, Murdoch Childrens Research Institute, University of Melbourne, Melbourne, Australia
    J Am Heart Assoc 2:e000095. 2013
    ..RIPC may augment phosphorylated protein signaling in myocardium and circulating leukocytes during tetralogy of Fallot (ToF) repair...
  22. ncbi request reprint Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals
    David M Kaye
    Baker Heart Research Institute, Melbourne, Australia
    J Am Coll Cardiol 50:253-60. 2007
    ..The purpose of this study was to develop a clinically applicable high-efficiency percutaneous means of therapeutic gene delivery to the failing heart...
  23. ncbi request reprint Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rate
    Freya L Sheeran
    Laboratory of Cardiac Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Baker Heart Research Institute, Melbourne, VIC 8008, Australia
    Biochim Biophys Acta 1757:543-52. 2006
    ..This review also features key limitations of human heart failure studies and potential clinical therapies that target the elevated oxidative stress that is a hallmark of human heart failure...
  24. ncbi request reprint Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure
    Franklin Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne, Victoria, Australia
    Biofactors 18:91-100. 2003
    ..Further trials of CoQ10 in physical exercise and in hypertension are recommended...
  25. ncbi request reprint The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms
    Siew Simg C Goh
    Molecular Pharmacology Laboratory, Monash University, Alfred Hospital, Melbourne, Australia, Department of Pharmacology, The University of Melbourne, Monash University, Alfred Hospital, Melbourne, Australia
    Antioxid Redox Signal 9:101-13. 2007
    ....
  26. ncbi request reprint What is the role of leukocyte depletion in cardiac surgery?
    Hou Kiat Lim
    Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia
    Heart Lung Circ 16:243-53. 2007
    ..Future trials should be powered to detect important clinical end points and be designed to avoid premature exhaustion of the filter...
  27. doi request reprint The publication rate and impact of abstracts presented at the Cardiac Society of Australia and New Zealand (1999-2005)
    Vibhasha Chand
    Department of Surgery, Monash University, Melbourne, Australia
    Heart Lung Circ 17:375-9. 2008
    ....
  28. ncbi request reprint Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heart
    Salvatore Pepe
    Laboratory of Cardiac Surgical Research, Wynn Domain, Baker Heart Research Institute and The Alfred Hospital, Monash University Faculty of Medicine, Melbourne, Australia
    Cardiovasc Res 63:414-22. 2004
    ..This brief review will focus on the interaction between beta-AR and OPR and its potential physiological and pathophysiological relevance in the heart...
  29. ncbi request reprint The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital, Baker Institute, Melbourne, Australia
    Biogerontology 3:37-40. 2002
    ..4) Oral CoQ10 therapy before cardiac surgery improves efficiency of mitochondrial energy production, improves post-operative heart function, reduces intra-operative myocardial damage and shortens hospital stay...
  30. ncbi request reprint High-flow endobronchial cooled humidified air protects non-heart-beating donor rat lungs against warm ischemia
    Takahiro Oto
    Heart and Lung Transplant Unit, The Alfred Hospital, Monash University, Melbourne, Australia
    J Thorac Cardiovasc Surg 132:413-9. 2006
    ..This study investigated the preservative effect of high-flow endobronchial cooled humidified air during warm ischemia in non-heart-beating donor rat lungs...
  31. ncbi request reprint Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure
    Oliver Zolk
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstr 17, 91054 Erlangen, Germany
    Biochem Biophys Res Commun 293:1377-82. 2002
    ..Together, these findings raise the possibility that augmented ventricular CARP expression may play a role in the pathogenesis of human heart failure...
  32. ncbi request reprint Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice
    Catherine E Huggins
    Department of Physiology, University of Melbourne, Parkville, Victoria, 3010, Australia
    J Renin Angiotensin Aldosterone Syst 4:186-90. 2003
    ..We hypothesised that primary cardiac hypertrophy is associated with mechanical dysfunction in the basal state...
  33. ncbi request reprint Aging hearts and vessels: masters of adaptation and survival
    Salvatore Pepe
    Cardiovasc Res 66:190-3. 2005
  34. ncbi request reprint The clinical application of metabolic therapy for cardiovascular disease
    Anthony Hadj
    Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital and Baker Heart Research Institute, Victoria, Australia
    Heart Lung Circ 16:S56-64. 2007
    ....
  35. ncbi request reprint Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients
    Franklin L Rosenfeldt
    Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Prahran 3181, Australia
    Ann N Y Acad Sci 959:355-9; discussion 463-5. 2002
    ..We hypothesized that CoQ10 pretreatment prior to stress could improve the recovery of the myocardium after stress...