Research Topics
Species | Salvatore PepeSummaryAffiliation: Monash University Country: Australia Publications
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Detail Information
Publications
Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile functionSalvatore Pepe
Cardiac Surgical Research Unit, Alfred Hospital and Baker Medical Research Institute, Monash University Faculty of Medicine, Melbourne, Australia
Circulation 105:2303-8. 2002..Thus, direct effects on myocardial function may contribute to the altered cardiovascular disease profile associated with fish consumption...- (n-3) Long chain PUFA dose-dependently increase oxygen utilization efficiency and inhibit arrhythmias after saturated fat feeding in ratsSalvatore Pepe
Department of Surgery, Monash University, Australia
J Nutr 137:2377-83. 2007..FO at a dose as low as 3% of total fat dietary supplement effectively reversed the high oxygen requirements and pro-arrhythmic effects of a SAT-rich diet even with continued consumption of SAT (9%) in this ex vivo animal model... - Dietary polyunsaturated fatty acids and age-related membrane changes in the heartSalvatore Pepe
Laboratory of Cardiothoracic Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Melbourne, Australia
Ann N Y Acad Sci 1114:381-8. 2007..Such pervasive treatment results in manipulation of cellular function at multiple levels from cell membrane to the genome... - Coenzyme Q10 in cardiovascular diseaseSalvatore Pepe
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Australia
Mitochondrion 7:S154-67. 2007..3. Presently, due to the notable absence of clinically significant side effects and likely therapeutic benefit, CoQ(10) can be considered a safe adjunct to standard therapies in cardiovascular disease... 
Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trialJee Yoong Leong
Cardiac Surgical Research Unit, Alfred Hospital, Department of Surgery Monash University, Baker IDI Institute, Melbourne, Australia
Heart Lung Circ 19:584-91. 2010..The aim of this study was to assess the effect of perioperative metabolic therapy at a biochemical, clinical and economic level in cardiac surgical patients...- Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNAFrancis Miller
Cardiac Surgical Research Unit, Alfred Hospital, Dept of Surgery, Monash University, and Baker Heart Research Institute, Commercial Road Prahran, Victoria 3181, Australia
Mech Ageing Dev 130:742-7. 2009..We conclude that, although mtDNA mutations (as exemplified by mtDNA(4977)) accumulate in the ageing heart, they are unlikely to make a major contribution to loss of contractile function... - Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological ageFranklin Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute Wynn Domain, Melbourne, Prahran Victoria 3181, Australia
Ann N Y Acad Sci 1019:78-84. 2004.... - Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranesSalvatore Pepe
Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Vic, Australia
Exp Gerontol 40:751-8. 2005.... - Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapyAnthony Hadj
Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Monash University, Alfred Hospital, Melbourne, Vic, Australia
Heart Lung Circ 15:172-81. 2006.... - Targeting oxidative stress in surgery: effects of ageing and therapySalvatore Pepe
CJOB Department of Cardiothoracic Surgery, Alfred Hospital, PO Box 315 Prahran, Melbourne VIC 318, Australia
Exp Gerontol 43:653-7. 2008..We conclude that simultaneously targeting a number of key deficiencies with a metabolic formulation prior to surgery results in peri- and post-operative clinical and economic benefits... - Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissueFranklin Rosenfeldt
The Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital, Baker Heart Research Institute, Melbourne, Australia
J Thorac Cardiovasc Surg 129:25-32. 2005.... - Effect of dietary polyunsaturated fatty acids on age-related changes in cardiac mitochondrial membranesSalvatore Pepe
Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Vic, Australia
Exp Gerontol 40:369-76. 2005.... - p38 Mitogen-activated protein kinase inhibition reduces inflammatory cytokines in a brain-dead transplant donor animal modelTakahiro Oto
Department of Cardiothoracic Surgery, Alfred Hospital, Monash University, Melbourne, Australia
Heart Lung Circ 18:393-400. 2009.... - Cardiac reanimation for donor heart transplantation after cardiocirculatory deathStephen Repse
Department of Cardiothoracic Surgery, Alfred Hospital, Prahan, Australia
J Heart Lung Transplant 29:747-55. 2010.... - Diminished NADPH transhydrogenase activity and mitochondrial redox regulation in human failing myocardiumFreya L Sheeran
Department of Surgery, Monash University Faculty of Medicine, Alfred Hospital, Melbourne, Australia
Biochim Biophys Acta 1797:1138-48. 2010.... - Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpressionOlivier W V van den Brink
Department of Cardiothoracic Surgery, Alfred Hospital and Department of Surgery, Monash University, Melbourne, Australia
J Renin Angiotensin Aldosterone Syst 8:153-9. 2007..The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production... - Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapyFranklin L Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Heart Research Institute, Department of Surgery, Monash University, Parkville, Australia
Int J STD AIDS 16:827-9. 2005..This suggests a novel therapy for further investigation targeted at ZDV induced myopathy, potentially allowing continuation of antiviral treatments including ZDV... - Mitochondrial dysfunction in CD4+ lymphocytes from stavudine-treated HIV patientsLloyd Einsiedel
Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia
Mitochondrion 10:534-9. 2010..Therapy with stavudine results in impaired mitochondrial function in CD4+PBLs that does not appear to be due to reduced mitochondrial volume or DNA content and cannot be attributed to infection with HIV... - Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animalsDavid M Kaye
Baker Heart Research Institute, Melbourne, Australia
J Am Coll Cardiol 50:253-60. 2007..The purpose of this study was to develop a clinically applicable high-efficiency percutaneous means of therapeutic gene delivery to the failing heart... - What is the role of leukocyte depletion in cardiac surgery?Hou Kiat Lim
Cardiac Surgical Research Unit, Alfred Hospital, Melbourne, Australia
Heart Lung Circ 16:243-53. 2007..Future trials should be powered to detect important clinical end points and be designed to avoid premature exhaustion of the filter... - The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanismsSiew Simg C Goh
Molecular Pharmacology Laboratory, Monash University, Alfred Hospital, Melbourne, Australia, Department of Pharmacology, The University of Melbourne, Monash University, Alfred Hospital, Melbourne, Australia
Antioxid Redox Signal 9:101-13. 2007.... - Energy deficiency in the failing heart: linking increased reactive oxygen species and disruption of oxidative phosphorylation rateFreya L Sheeran
Laboratory of Cardiac Surgical Research, Department of Surgery, Monash University, Alfred Hospital, Baker Heart Research Institute, Melbourne, VIC 8008, Australia
Biochim Biophys Acta 1757:543-52. 2006..This review also features key limitations of human heart failure studies and potential clinical therapies that target the elevated oxidative stress that is a hallmark of human heart failure... - Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failureFranklin Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne, Victoria, Australia
Biofactors 18:91-100. 2003..Further trials of CoQ10 in physical exercise and in hypertension are recommended... - The publication rate and impact of abstracts presented at the Cardiac Society of Australia and New Zealand (1999-2005)Vibhasha Chand
Department of Surgery, Monash University, Melbourne, Australia
Heart Lung Circ 17:375-9. 2008.... - Cross-talk of opioid peptide receptor and beta-adrenergic receptor signalling in the heartSalvatore Pepe
Laboratory of Cardiac Surgical Research, Wynn Domain, Baker Heart Research Institute and The Alfred Hospital, Monash University Faculty of Medicine, Melbourne, Australia
Cardiovasc Res 63:414-22. 2004..This brief review will focus on the interaction between beta-AR and OPR and its potential physiological and pathophysiological relevance in the heart... - High-flow endobronchial cooled humidified air protects non-heart-beating donor rat lungs against warm ischemiaTakahiro Oto
Heart and Lung Transplant Unit, The Alfred Hospital, Monash University, Melbourne, Australia
J Thorac Cardiovasc Surg 132:413-9. 2006..CONCLUSIONS: High-flow endobronchial cooled humidified air can decrease lung temperature and improve post-ischemic pulmonary function and adenosine triphosphate levels in non-heart-beating donor lungs... - The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardiumFranklin L Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital, Baker Institute, Melbourne, Australia
Biogerontology 3:37-40. 2002..4) Oral CoQ10 therapy before cardiac surgery improves efficiency of mitochondrial energy production, improves post-operative heart function, reduces intra-operative myocardial damage and shortens hospital stay... - Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failureOliver Zolk
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstr 17, 91054 Erlangen, Germany
Biochem Biophys Res Commun 293:1377-82. 2002..Together, these findings raise the possibility that augmented ventricular CARP expression may play a role in the pathogenesis of human heart failure... - Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive miceCatherine E Huggins
Department of Physiology, University of Melbourne, Parkville, Victoria, 3010, Australia
J Renin Angiotensin Aldosterone Syst 4:186-90. 2003..Our findings suggest that endogenous overproduction of cardiac Ang II, independent of changes in blood pressure, is sufficient to induce ventricular remodelling that culminates in impaired cardiac function which may precede failure... - The clinical application of metabolic therapy for cardiovascular diseaseAnthony Hadj
Cardiac Surgical Research Unit, Department of Cardiothoracic Surgery, Alfred Hospital and Baker Heart Research Institute, Victoria, Australia
Heart Lung Circ 16:S56-64. 2007.... - Aging hearts and vessels: masters of adaptation and survivalSalvatore Pepe
Cardiovasc Res 66:190-3. 2005 - Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patientsFranklin L Rosenfeldt
Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Prahran 3181, Australia
Ann N Y Acad Sci 959:355-9; discussion 463-5. 2002..We hypothesized that CoQ10 pretreatment prior to stress could improve the recovery of the myocardium after stress...