Moira K O'Bryan

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Control of osteoblast function and regulation of bone mass
    Shun ichi Harada
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA
    Nature 423:349-55. 2003
  2. ncbi request reprint Cloning and regulation of the rat activin betaE subunit
    M K O'Bryan
    Monash Institute of Reproduction and Development, Monash Medical Centre, Clayton, Victoria 3168, Australia
    J Mol Endocrinol 24:409-18. 2000
  3. doi request reprint Inflammatory networks in the control of spermatogenesis : chronic inflammation in an immunologically privileged tissue?
    Moira K O'Bryan
    Monash Institute of Medical Research, Monash University, Clayton, 3168, Australia
    Adv Exp Med Biol 636:92-114. 2008
  4. ncbi request reprint Identification of a novel apolipoprotein, ApoN, in ovarian follicular fluid
    Moira K O'Bryan
    The Centre for Molecular Reproduction and Development, Monash Institute of Reproduction and Development, 27 31 Wright Street, Clayton 3168, Melbourne, Victoria, Australia
    Endocrinology 145:5231-42. 2004
  5. pmc Sox8 is a critical regulator of adult Sertoli cell function and male fertility
    Moira K O'Bryan
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Dev Biol 316:359-70. 2008
  6. ncbi request reprint Mouse models for genes involved in impaired spermatogenesis
    M K O'Bryan
    Monash Institute of Medical Research and The ARC Centre of Excellence in Biotechnology and Development, Monash University, Melbourne, Victoria, Australia
    Int J Androl 29:76-89; discussion 105-8. 2006
  7. ncbi request reprint Tpx-1 is a component of the outer dense fibers and acrosome of rat spermatozoa
    M K O'Bryan
    Monash Institute of Reproduction and Development, Monash Medical Centre, Clayton, Australia
    Mol Reprod Dev 58:116-25. 2001
  8. ncbi request reprint Sox8 and Sertoli-cell function
    Claire L Kennedy
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Ann N Y Acad Sci 1120:104-13. 2007
  9. doi request reprint Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding
    Gerard M Gibbs
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia
    Endocrinology 151:2331-42. 2010
  10. pmc RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly
    Jennifer C Y Lo
    Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia
    PLoS Genet 8:e1002969. 2012

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Control of osteoblast function and regulation of bone mass
    Shun ichi Harada
    Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, Pennsylvania 19002, USA
    Nature 423:349-55. 2003
    ..Recent advances, spearheaded by genetic information, offer the opportunity to stop or reverse this downhill course...
  2. ncbi request reprint Cloning and regulation of the rat activin betaE subunit
    M K O'Bryan
    Monash Institute of Reproduction and Development, Monash Medical Centre, Clayton, Victoria 3168, Australia
    J Mol Endocrinol 24:409-18. 2000
    ..These data provide evidence of a role for activin beta(E) in liver function and inflammation in the rat...
  3. doi request reprint Inflammatory networks in the control of spermatogenesis : chronic inflammation in an immunologically privileged tissue?
    Moira K O'Bryan
    Monash Institute of Medical Research, Monash University, Clayton, 3168, Australia
    Adv Exp Med Biol 636:92-114. 2008
    ....
  4. ncbi request reprint Identification of a novel apolipoprotein, ApoN, in ovarian follicular fluid
    Moira K O'Bryan
    The Centre for Molecular Reproduction and Development, Monash Institute of Reproduction and Development, 27 31 Wright Street, Clayton 3168, Melbourne, Victoria, Australia
    Endocrinology 145:5231-42. 2004
    ..These data suggest that ApoN may play a role in steroidogenesis and/or immunoregulation in the gonads of nonhuman species, as well as similar roles in other tissues...
  5. pmc Sox8 is a critical regulator of adult Sertoli cell function and male fertility
    Moira K O'Bryan
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Dev Biol 316:359-70. 2008
    ..These data show that SOX8 is a critical regulator of adult Sertoli cell function and is required for both its cytoarchitectural and paracrine interactions with germ cells...
  6. ncbi request reprint Mouse models for genes involved in impaired spermatogenesis
    M K O'Bryan
    Monash Institute of Medical Research and The ARC Centre of Excellence in Biotechnology and Development, Monash University, Melbourne, Victoria, Australia
    Int J Androl 29:76-89; discussion 105-8. 2006
    ....
  7. ncbi request reprint Tpx-1 is a component of the outer dense fibers and acrosome of rat spermatozoa
    M K O'Bryan
    Monash Institute of Reproduction and Development, Monash Medical Centre, Clayton, Australia
    Mol Reprod Dev 58:116-25. 2001
    ..As such, tpx-1 may have functional significance in the processes of sperm head development and tail function...
  8. ncbi request reprint Sox8 and Sertoli-cell function
    Claire L Kennedy
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Ann N Y Acad Sci 1120:104-13. 2007
    ..We conclude that SOX8 transactivated genes have key roles in adult Sertoli-cell function and its elimination results in progressive male infertility...
  9. doi request reprint Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding
    Gerard M Gibbs
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia
    Endocrinology 151:2331-42. 2010
    ..Collectively these data further strengthen the role of CAP domain-containing proteins in cellular adhesion and propose a mechanism whereby CAP proteins show overlapping functional significance during fertilization...
  10. pmc RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly
    Jennifer C Y Lo
    Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia
    PLoS Genet 8:e1002969. 2012
    ..Our data demonstrate a novel function for the RABL protein family, an essential role for RABL2 in male fertility and a previously uncharacterised mechanism for protein delivery to the flagellum...
  11. doi request reprint Characterization of gametogenetin 1 (GGN1) and its potential role in male fertility through the interaction with the ion channel regulator, cysteine-rich secretory protein 2 (CRISP2) in the sperm tail
    Duangporn Jamsai
    The Centre for Reproduction and Development and The Centre for Urological Research, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton, Melbourne, Victoria 3168, Australia
    Reproduction 135:751-9. 2008
    ..These data along with data on RyR and MAP3K11 binding define the CRISP2 CRISP domain as a protein interaction motif and suggest a role for the GGN1-CRISP2 complex in sperm tail development and/or motility...
  12. doi request reprint A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse
    Duangporn Jamsai
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Melbourne, VIC 3800, Australia
    Biol Cell 102:93-106. 2010
    ..The purpose of the present study was to determine the expression, subcellular localization and the role in spermatogenesis of a novel CRISP2-binding partner, which we have designated SHTAP (sperm head and tail associated protein)...
  13. ncbi request reprint Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2
    Deborah M Hickox
    Monash Institute of Reproduction and Development, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Clayton, Victoria 3168, Australia
    Biol Reprod 67:917-27. 2002
    ..These data raise the possibility that pebp-2 is a novel participant in the MAP kinase signaling pathway, with a role in spermatogenesis or posttesticular sperm maturation...
  14. ncbi request reprint Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses
    Moira K O'Bryan
    Monash Institute of Reproduction and Development, Australian Research Council Centre of Excellence in Biotechnology and Development, Monash University, 246 Clayton Rd, Clayton, Victoria 3168, Australia
    Am J Physiol Regul Integr Comp Physiol 288:R1744-55. 2005
    ..These data have important implications for the understanding and treatment of male autoimmune infertility, testicular inflammation. and carcinogenesis...
  15. ncbi request reprint The response of testicular leukocytes to lipopolysaccharide-induced inflammation: further evidence for heterogeneity of the testicular macrophage population
    Orapin Gerdprasert
    Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    Cell Tissue Res 308:277-85. 2002
    ..It is highly probable that these different subsets have different functional roles within the testis...
  16. pmc An essential role for katanin p80 and microtubule severing in male gamete production
    Liza O'Donnell
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    PLoS Genet 8:e1002698. 2012
    ..Collectively these data demonstrate that katanin p80 serves an essential and evolutionarily conserved role in several aspects of male germ cell development...
  17. ncbi request reprint Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis
    Wendy R Winnall
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Biol Reprod 76:759-68. 2007
    ..Both observations are consistent with the reduced capacity of the testis to initiate and support inflammatory reactions...
  18. ncbi request reprint Changes in circulating and testicular levels of inhibin A and B and activin A during postnatal development in the rat
    Jeremy J Buzzard
    Monash Institute of Reproduction and Development, Monash University, 27 31 Wright Street, Clayton, Victoria 3168, Australia
    Endocrinology 145:3532-41. 2004
    ....
  19. pmc Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'
    Claire L Borg
    Department of Anatomy and Developmental Biology, The School of Biomedical Sciences, Monash University, Clayton 3800, Australia
    Hum Reprod Update 16:205-24. 2010
    ..The review aims to act as a guide to the 'non-reproductive biologist' to facilitate a systematic analysis of sterile or subfertile mice and to assist in extracting the maximum amount of information from each model...
  20. ncbi request reprint Feto-placental hypoxemia regulates the release of fetal activin A and prostaglandin E(2)
    G Jenkin
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Endocrinology 142:963-6. 2001
    ....
  21. ncbi request reprint FGFR-1 [corrected] signaling is involved in spermiogenesis and sperm capacitation
    Leanne Cotton
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    J Cell Sci 119:75-84. 2006
    ..These data demonstrate the FGFR-1 is required for quantitatively and qualitatively normal spermatogenesis and has a key role in the regulation of the global tyrosine phosphorylation events associated with sperm capacitation...
  22. pmc Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse
    Duangporn Jamsai
    Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia
    PLoS ONE 8:e56955. 2013
    ..Together, our results suggest that GGN plays a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos...
  23. pmc The role of cysteine-rich secretory proteins in male fertility
    Adam J Koppers
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Monash University, Clayton, VIC 3800, Australia
    Asian J Androl 13:111-7. 2011
    ..Herein, we will review the current literature on the role of CRISPs in male fertility, and by inference to related non-mammalian protein, infer potential biochemical functions...
  24. doi request reprint Genetic variants in the ETV5 gene in fertile and infertile men with nonobstructive azoospermia associated with Sertoli cell-only syndrome
    Moira K O'Bryan
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Victoria, Australia
    Fertil Steril 98:827-35.e1-3. 2012
    ..To assess the association between genetic variants in the ETV5 gene with nonobstructive azoospermia (NOA) associated with Sertoli cell-only (SCO) syndrome...
  25. ncbi request reprint Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm
    Gerard M Gibbs
    Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3168, Australia
    Biol Reprod 77:108-14. 2007
    ..These data raise the possibility that CRISP2 is a MAP3K11-modifying protein or, alternatively, that MAP3K11 acts to phosphorylate CRISP2 during acrosome development...
  26. pmc Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo
    Elspeth Gold
    Centre for Urological Research, Monash Institute of Medical Research, Monash University, Clayton, Australia
    Am J Pathol 174:184-95. 2009
    ..This study provides evidence that activin-beta(C) is an antagonist of activin A and supplies an impetus to examine its role in development and disease...
  27. pmc DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription
    Natasha M Zamudio
    The Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia
    PLoS ONE 6:e18276. 2011
    ..These data provide a potential mechanism for some cases of human Klinefelter's and Turner's syndromes...
  28. ncbi request reprint Human sperm associated antigen 4 (SPAG4) is a potential cancer marker
    Claire Kennedy
    Monash Institute of Reproduction and Development and The ARC Centre of Excellence in Biotechnology and Development, Monash University, 3168 Melbourne, Australia
    Cell Tissue Res 315:279-83. 2004
    ..The data therefore strongly suggests that SPAG4 expression is a potential clinically relevant cancer marker...
  29. ncbi request reprint A mouse model of spinal and bulbar muscular atrophy
    Patrick McManamny
    Monash Institute of Reproduction and Development, Monash University, 27 31 Wright Street, Clayton, Melbourne, Victoria, 3168, Australia
    Hum Mol Genet 11:2103-11. 2002
    ..These mice represent the first model to reproduce the key features of SBMA, making them a useful resource for characterizing disease progression, and for testing therapeutic strategies for both polyglutamine and motor neuron diseases...
  30. doi request reprint The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense
    Gerard M Gibbs
    Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Australia
    Endocr Rev 29:865-97. 2008
    ....
  31. pmc Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism
    Prue A Cowin
    Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia
    Endocrinology 151:783-92. 2010
    ..These data demonstrate in utero Vinclozolin-induced male reproductive tract abnormalities are AR mediated and reversible and involve a mechanism independent of Dnmt expression...
  32. pmc RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility
    Moira K O'Bryan
    Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia The ARC Centre of Excellence in Biotechnology and Development, Monash University, Melbourne, Australia
    PLoS Genet 9:e1003628. 2013
    ..In summary, our findings reveal a critical role for RBM5 as a pre-mRNA splicing regulator in round spermatids and male fertility. Our findings also suggest that the second RRM of RBM5 is pivotal for appropriate pre-mRNA splicing. ..
  33. doi request reprint Epigenetic regulation in male germ cells
    Natasha M Zamudio
    Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3168, Australia
    Reproduction 136:131-46. 2008
    ..In many cases, these epigenetic effects resulted in impaired fertility and potentially long-ranging affects underlining the importance of research in this area...
  34. pmc The generation of live offspring from vitrified oocytes
    L Gabriel Sanchez-Partida
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Victoria, Australia
    PLoS ONE 6:e21597. 2011
    ..We conclude that these studies highlight the importance of the endometrial environment for the maintenance of genetic stability and thus the propagation of specific genetic traits...
  35. pmc Glucocorticoid-induced leucine zipper (GILZ) regulates testicular FOXO1 activity and spermatogonial stem cell (SSC) function
    Devi Ngo
    Department of Medicine, Centre for Inflammatory Diseases, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    PLoS ONE 8:e59149. 2013
    ..These findings provide a mechanism for the effects of GILZ on spermatogenesis and strengthen the case for GILZ being a critical molecule in the regulation of male fertility...
  36. pmc Mouse models in male fertility research
    Duangporn Jamsai
    Department of Anatomy and Developmental Biology, The Australian Research Council ARC, Centre of Excellence in Biotechnology and Development, Monash University, Melbourne, Victoria 3800, Australia
    Asian J Androl 13:139-51. 2011
    ..The current review is by no means a comprehensive list of these mouse models, rather it contains examples of how mouse models have advanced our knowledge of post-natal germ cell development and male fertility regulation...
  37. pmc Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function
    Gerard M Gibbs
    Department of Anatomy and Developmental Biology, Monash University, VIC 3800, Australia
    Proc Natl Acad Sci U S A 108:7034-9. 2011
    ..Collectively, these data identify CRISP4 as an endogenous regulator of TRPM8 with a role in normal sperm function...
  38. pmc Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts
    Jun Liu
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Diabetes 60:1393-8. 2011
    ..The objective of this study was to determine whether somatic fibroblasts from NOD mice could be reprogrammed to become iPSCs, providing an alternative source of stem cells for the production of genetically modified NOD cells and mice...
  39. doi request reprint Cysteine-rich secretory proteins are not exclusively expressed in the male reproductive tract
    Thulasimala Reddy
    Monash Institute of Medical Research, Monash University, Melbourne, Australia
    Dev Dyn 237:3313-23. 2008
    ..These investigations raise the potential for a role for CRISPs in general mammalian physiology...
  40. doi request reprint Genome-wide ENU mutagenesis for the discovery of novel male fertility regulators
    Duangporn Jamsai
    The Department of Anatomy and Developmental Biology and The Australian Research Council ARC Centre of Excellence in Biotechnology and Development, Monash University, Melbourne, Victoria, Australia
    Syst Biol Reprod Med 56:246-59. 2010
    ..In this review, we focus on the utility of ENU mutagenesis for the discovery of novel male fertility regulators...
  41. doi request reprint Molecular analysis of the PArkin co-regulated gene and association with male infertility
    Gabrielle R Wilson
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Children s Research Institute, Melbourne, 3052, Victoria, Australia
    Fertil Steril 93:2262-8. 2010
    ..To investigate the potential role of PArkin co-regulated gene (PACRG) in human male infertility...
  42. doi request reprint Clinical Review#: State of the art for genetic testing of infertile men
    Robert I McLachlan
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Australia
    J Clin Endocrinol Metab 95:1013-24. 2010
    ..Testing for less common genetic associations/defects linked with different reproductive dysfunction may be applicable to specific patients but have not entered routine practice...
  43. ncbi request reprint Developmental regulation of the bcl-2 family during spermatogenesis: insights into the sterility of bcl-w-/- male mice
    T Meehan
    Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria 3168, Australia
    Cell Death Differ 8:225-33. 2001
    ..A similar shift was evident in Sertoli cells. This developmental regulation may co-ordinate physiological germ cell apoptosis in wild type mice and account for the time of onset for pathological germ cell apoptosis in bcl-w -/- animals...
  44. ncbi request reprint Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs
    M H Lahoud
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    Genome Res 11:1327-34. 2001
    ..These data show that this novel DNA-binding protein, Desrt, has a nonredundant function during growth and in the development of the reproductive system...
  45. ncbi request reprint Genetic screening of infertile men
    David Cram
    Monash Institute of Reproduction and Development, Monash University, Clayton, Australia
    Reprod Fertil Dev 16:573-80. 2004
    ..Such information will form the basis of new genetic tests that will allow the clinician to make an accurate diagnosis of the male partner and a more informed decision about treatment options for the couple...
  46. ncbi request reprint The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling
    Gerard M Gibbs
    Monash Institute of Medical Research, Monash University, Clayton, Melbourne, Victoria, Australia
    J Biol Chem 281:4156-63. 2006
    ..These data show that the Tpx-1 Crisp domain on its own can regulate ion channel activity and provide compelling evidence for a role for Tpx-1 in the regulation of Ca(2+) fluxes observed during sperm capacitation...
  47. doi request reprint Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype
    Francois Xavier Hubert
    Division of Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 182:3902-18. 2009
    ....
  48. ncbi request reprint Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit
    S L Mellor
    Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    J Clin Endocrinol Metab 85:4851-8. 2000
    ..Thus, the evidence of formation of activin AC or BC heterodimers may have significant implications in the regulation of levels and/or biological activity of other activins in these tissues...
  49. doi request reprint Normal live birth after testicular sperm extraction and intracytoplasmic sperm injection in variant primary ciliary dyskinesia with completely immotile sperm and structurally abnormal sperm tails
    Robert I McLachlan
    Monash IVF, Hawthorn, Australia
    Fertil Steril 97:313-8. 2012
    ..To report on the investigation and fertility management of variant primary ciliary dyskinesia (PCD)...
  50. ncbi request reprint Physiological and regulatory roles of activin A in late pregnancy
    G Jenkin
    Department of Physiology, Monash University, 3800, Clayton Victoria, Australia
    Mol Cell Endocrinol 180:131-8. 2001
    ....
  51. pmc A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling
    Hirochika Kitagawa
    Department of Molecular Endocrinology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Mol Cell Biol 27:7486-96. 2007
    ..These data describe regulatory convergence between Nurr1 and beta-catenin, providing a mechanism by which Nurr1 could be regulated by Wnt signaling...
  52. ncbi request reprint Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland
    Pascale V Nantermet
    Department of Molecular Endocrinology and Bone Biology, Merck Research Laboratories, West Point, PA 19486, USA
    J Biol Chem 279:1310-22. 2004
    ..In summary these data provide a comprehensive view of the earliest events in AR-mediated prostate cell proliferation in vivo, and suggest that nuclear exclusion of p53 is a critical step in prostate growth...
  53. ncbi request reprint Receptor tyrosine kinases inhibit bone morphogenetic protein-Smad responsive promoter activity and differentiation of murine MC3T3-E1 osteoblast-like cells
    Konosuke Nakayama
    Division of Endocrinology, Department of Medicine, University of Tokyo School of Medicine, Tokyo, Japan
    J Bone Miner Res 18:827-35. 2003
    ..Because direct phosphorylation of Smad1 by ERKs is not required for the inhibition, other transcriptional factors that are phosphorylated by ERKs might be involved in the regulation of osteoblastic differentiation by ERKs...
  54. ncbi request reprint Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling
    Yuji Mishina
    Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:27560-6. 2004
    ..These results demonstrate essential and age-dependent roles for BMP signaling mediated by BMPRIA (a type IA receptor for BMP) in osteoblasts for bone remodeling...
  55. ncbi request reprint Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals
    Kristine M Wiren
    Base and Mineral Research Unit, Portland Veterans Affairs Medical Center P3 R and D39, 3710 Southwest Veterans Hospital Road, Portland, Oregon 97239, USA
    Endocrinology 145:3507-22. 2004
    ..These results indicate that AR action is important in the development of a sexually dimorphic skeleton and argue for a direct role for androgen transactivation of AR in osteoblasts in modulating skeletal development and homeostasis...
  56. ncbi request reprint Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways
    Pascale V Nantermet
    Department of Molecular Endocrinology, Merck and Co Inc, P O Box 4, WP26A1000, West Point Pennsylvania 19401, USA
    Endocrinology 146:564-78. 2005
    ..Thus androgens regulate the trophic environment and architecture of the rodent uterus via a gene expression program that is overlapping but distinct from the estrogen response...