Genomes and Genes


Padma Murthi


Affiliation: Monash University
Country: Australia


  1. Borg A, Yong H, Lappas M, Degrelle S, Keogh R, da Silva Costa F, et al. Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction. Reproduction. 2015;149:523-32 pubmed publisher
    ..In conclusion, we report that decreased STAT3 expression in placentae may contribute to abnormal trophoblast function in idiopathic FGR-affected pregnancies. ..
  2. Gunatillake T, Yong H, Dunk C, Keogh R, Borg A, Cartwright J, et al. Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction. Reproduction. 2016;152:457-65 pubmed publisher
    ..Collectively, these results show that TGIF-1 regulates EC function and the expression of angiogenic molecules; and when abnormally expressed, may contribute to the aberrant placental angiogenesis observed in FGR. ..
  3. Murthi P, van Zanten D, Eijsink J, Borg A, Stevenson J, Kalionis B, et al. Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth. Placenta. 2016;45:58-62 pubmed publisher
    ..05). This is the first study to report a temporal relationship between altered placental DCN expression and subsequent development of SGA. ..
  4. Panagodage S, Yong H, da Silva Costa F, Borg A, Kalionis B, Brennecke S, et al. Low-Dose Acetylsalicylic Acid Treatment Modulates the Production of Cytokines and Improves Trophoblast Function in an in Vitro Model of Early-Onset Preeclampsia. Am J Pathol. 2016;186:3217-3224 pubmed publisher
  5. Novakovic B, Fournier T, Harris L, James J, Roberts C, Yong H, et al. Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation. Sci Rep. 2017;7:4523 pubmed publisher
    ..Our data suggest that loss of DLX5, TLX1 and HOXA10 expression in late gestation is required for proper placental differentiation and function. ..
  6. Chollangi T, Clabault H, Thibeault A, Yong H, Narula S, Menkhorst E, et al. An Electrical Impedance-Based Assay to Examine Functions of Various Placental Cell Types In Vitro. Methods Mol Biol. 2018;1710:267-276 pubmed publisher
    ..Here, we describe an electrical impedance-based tool that allows real-time monitoring of cells, which enables the efficient assessment of multiple time points over the duration of a single experiment. ..