Christina A Mitchell

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair
    Christina A Mitchell
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    IUBMB Life 53:25-36. 2002
  2. ncbi request reprint Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases
    Megan V Astle
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    IUBMB Life 58:451-6. 2006
  3. pmc The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
    J M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800 Australia
    J Cell Biol 155:1065-79. 2001
  4. ncbi request reprint Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly
    Meagan J McGrath
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Biol Chem 281:7666-83. 2006
  5. pmc SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis
    Denny L Cottle
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 Victoria, Australia
    J Biol Chem 284:26964-77. 2009
  6. pmc Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes
    Demis Balamatsias
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 286:43229-40. 2011
  7. pmc Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton
    Parvin Rahman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Biol Chem 286:29758-70. 2011
  8. ncbi request reprint FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly
    Imogen D Coghill
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Melbourne, Victoria, Australia
    J Biol Chem 278:24139-52. 2003
  9. pmc The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
    Ivan Ivetac
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia 3800
    Mol Biol Cell 16:2218-33. 2005
  10. pmc The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    Mol Biol Cell 17:607-22. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Inositol polyphosphate 5-phosphatases: lipid phosphatases with flair
    Christina A Mitchell
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    IUBMB Life 53:25-36. 2002
    ....
  2. ncbi request reprint Regulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases
    Megan V Astle
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    IUBMB Life 58:451-6. 2006
    ....
  3. pmc The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin
    J M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800 Australia
    J Cell Biol 155:1065-79. 2001
    ..Collectively these studies demonstrate that filamin-dependent SHIP-2 localization critically regulates phosphatidylinositol 3 kinase signaling to the actin cytoskeleton...
  4. ncbi request reprint Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly
    Meagan J McGrath
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Biol Chem 281:7666-83. 2006
    ..This study identified FHL1 as a novel regulator of myosin-binding protein C activity and indicates a role for FHL1 in sarcomere assembly...
  5. pmc SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis
    Denny L Cottle
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 Victoria, Australia
    J Biol Chem 284:26964-77. 2009
    ..In skeletal muscle sections from the mdx mouse model of Duchenne muscular dystrophy, SLIMMER and Siva-1 co-localized in the nucleus of apoptotic myofibers. Therefore, SLIMMER may protect skeletal muscle from apoptosis...
  6. pmc Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes
    Demis Balamatsias
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 286:43229-40. 2011
    ....
  7. pmc Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton
    Parvin Rahman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Biol Chem 286:29758-70. 2011
    ..Therefore, this study identifies SODD as a novel regulator of PI3K/Akt signaling to the actin cytoskeleton...
  8. ncbi request reprint FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly
    Imogen D Coghill
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Melbourne, Victoria, Australia
    J Biol Chem 278:24139-52. 2003
    ..FHL3 inhibited alpha-actinin-mediated actin bundling. These studies reveal FHL3 as a significant regulator of actin cytoskeletal dynamics in skeletal myoblasts...
  9. pmc The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane
    Ivan Ivetac
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia 3800
    Mol Biol Cell 16:2218-33. 2005
    ..The 4-phosphatase therefore both generates and terminates phosphoinositide 3-kinase signals at distinct subcellular locations...
  10. pmc The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    Mol Biol Cell 17:607-22. 2006
    ..PIPP therefore inhibits PI3-kinase-dependent neurite elongation in PC12 cells, via regulation of the spatial distribution of phospho-Ser473-Akt and phospho-Ser9-GSK-3beta signaling...
  11. pmc Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation
    Megan V Astle
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia
    J Biol Chem 286:23407-18. 2011
    ....
  12. pmc Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane
    Anne M Kong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Cell Biol 26:6065-81. 2006
    ..72-5ptase expression promoted GLUT4 trafficking via a Rab11-dependent pathway but not by Rab5-mediated endocytosis. Therefore, endogenous PtdIns(3)P at the plasma membrane promotes GLUT4 translocation...
  13. doi request reprint Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Methods Mol Biol 462:223-39. 2009
    ....
  14. doi request reprint Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer
    Meagan J McGrath
    Department of Biochemistry and Molecular Biology and Immunology, Monash University, Clayton Victoria, Australia
    Cancer Res 73:5066-79. 2013
    ..These results offer general import beyond prostate cancer, given that nuclear FHL2 is characteristic of other human cancers where oncogenic transcription factors that drive disease are activated like the AR in prostate cancer...
  15. pmc Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy
    Belinda S Cowling
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    J Cell Biol 183:1033-48. 2008
    ..NFATc1 also colocalizes with mutant FHL1 to reducing bodies in RBM-afflicted skeletal muscle. Therefore, via NFATc1 signaling regulation, FHL1 appears to modulate muscle mass and strength enhancement...
  16. ncbi request reprint P-Rex1 - a multidomain protein that regulates neurite differentiation
    Joanne E Waters
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    J Cell Sci 121:2892-903. 2008
    ..This study has identified P-Rex1 as a Rac3-GEF in neuronal cells that localises to, and regulates, actin cytoskeletal dynamics at the axonal growth cone to in turn regulate neurite differentiation...
  17. doi request reprint The myotubularin phosphatase MTMR4 regulates sorting from early endosomes
    Monica J Naughtin
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton 3800, Australia
    J Cell Sci 123:3071-83. 2010
    ..Therefore, MTMR4 localizes at the interface of early and recycling endosomes to regulate trafficking through this pathway...
  18. ncbi request reprint FHL3 binds MyoD and negatively regulates myotube formation
    Denny L Cottle
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, 3800, Australia
    J Cell Sci 120:1423-35. 2007
    ..These findings reveal that FHL3 association with MyoD may contribute to the regulation of MyoD-dependent transcription of muscle genes and thereby myogenesis...
  19. pmc Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
    Ivan Ivetac
    Department of Biochemistry, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    EMBO Rep 10:487-93. 2009
    ..This study provides the first evidence, to our knowledge, that 4-ptase-1 controls the activation of Akt and thereby cell proliferation, survival and tumorigenesis...
  20. ncbi request reprint SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton
    Jennifer M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    Blood 102:940-8. 2003
    ..These studies demonstrate a functionally active complex between SHIP-2, filamin, actin, and GPIb-IX-V that may orchestrate the localized hydrolysis of PtdIns(3,4,5)P3 and thereby regulate cortical and submembraneous actin...
  21. doi request reprint The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
    Lisa M Ooms
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Biochem J 419:29-49. 2009
    ..Emerging studies have implicated their loss or gain of function in human disease...
  22. ncbi request reprint Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces alpha 5 beta 1-integrin-dependent myocyte elongation
    Meagan J McGrath
    Dept of Biochemistry and Molecular Biology, Monash Univ, Wellington Rd, Clayton, VIC 3800, Australia
    Am J Physiol Cell Physiol 285:C1513-26. 2003
    ..These results suggest that SLIM1 may play an important role during the early stages of skeletal muscle differentiation, specifically in alpha5beta1-integrin-mediated signaling pathways...
  23. ncbi request reprint Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epide
    Rajendra Gurung
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Biol Chem 278:11376-85. 2003
    ..Collectively, these studies demonstrate a novel membrane-targeting domain that serves to recruit SKIP and PIPP to membrane ruffles...
  24. ncbi request reprint TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7
    Xiang Ming Zhang
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Biochem Biophys Res Commun 335:154-61. 2005
    ..These data increase the number of mammalian TBC domain family members with demonstrated Rab-GAP activity to four, and suggest that TBC1D15 may be involved in Rab7-mediated late endosomal trafficking...
  25. pmc Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity
    Meredith J Layton
    The Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    BMC Biochem 13:30. 2012
    ..The best described substrate for its protein kinase activity is its regulatory subunit, p85α, which becomes phosphorylated on Serine 608. Phosphorylation of Serine 608 has been reported to down-regulate its lipid kinase activity...
  26. ncbi request reprint The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2
    Jennifer M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, VIC 3800, Australia
    Int J Biochem Cell Biol 37:2260-5. 2005
    ..Therefore, SHIP2 remains a significant therapeutic target for the treatment of both obesity and type 2 diabetes...
  27. ncbi request reprint Sec15 is an effector for the Rab11 GTPase in mammalian cells
    Xiang Ming Zhang
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 279:43027-34. 2004
    ..These findings provide the first evidence that the exocyst functions as a Rab effector complex in mammalian cells...
  28. ncbi request reprint Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-bisphosphate on vacuole membranes and vacuolar fusion defects
    Fenny Wiradjaja
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    J Biol Chem 282:16295-307. 2007
    ....
  29. ncbi request reprint Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the ph
    Kristy A Horan
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 110:4480-91. 2007
    ..Therefore, 72-5ptase and SHIP1 exhibit specificity in regulating FcgammaR- versus CR3-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup...
  30. pmc Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization
    Michelle T Fodero-Tavoletti
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia
    Biochem J 389:343-54. 2005
    ..The present study identifies hPTPN20a as a novel and widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization...
  31. doi request reprint Inositol polyphosphate phosphatases in human disease
    Sandra Hakim
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, Clayton 3800, Australia
    Curr Top Microbiol Immunol 362:247-314. 2012
    ....
  32. doi request reprint Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy
    Colleen E D'Arcy
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Hum Mol Genet 23:618-36. 2014
    ....
  33. doi request reprint Phosphoinositide 3-kinase and INPP4B in human breast cancer
    Micka C Bertucci
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Ann N Y Acad Sci 1280:1-5. 2013
    ..Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor suppressor in breast cancer. This short review discusses these issues and the possibility that INPP4B is an important regulator in many cancers...
  34. pmc TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers
    Benjamin J Shields
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Mol Cell Biol 33:557-70. 2013
    ..These studies establish TCPTP's potential to serve as a tumor suppressor in human breast cancer...
  35. doi request reprint Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies
    Sarah E Conduit
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    FEBS Lett 586:2846-57. 2012
    ..Joubert syndrome has been extensively linked to primary cilia defects, and Lowe's may represent a new class of 'ciliopathy associated' syndromes...
  36. doi request reprint Phosphoinositide phosphatases: just as important as the kinases
    Jennifer M Dyson
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, 3800, Clayton, Australia
    Subcell Biochem 58:215-79. 2012
    ..Therefore the phosphatases, like the lipid kinases, play major roles in regulating cellular functions and their mutation or altered expression leads to many human diseases...
  37. ncbi request reprint Skeletal muscle LIM protein 1 regulates integrin-mediated myoblast adhesion, spreading, and migration
    Paul A Robinson
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia 3168
    Am J Physiol Cell Physiol 284:C681-95. 2003
    ..These studies show SLIM1 localizes in an integrin-dependent manner to the nucleus and focal adhesions where it functions downstream of integrin activation to promote cell spreading and migration...
  38. ncbi request reprint FHL1 mutants that cause clinically distinct human myopathies form protein aggregates and impair myoblast differentiation
    Brendan R Wilding
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC 3800, Australia
    J Cell Sci 127:2269-81. 2014
    ....
  39. pmc A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart
    Shehnaaz S M Manji
    Genetic Hearing Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS ONE 6:e17607. 2011
    ....
  40. pmc Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
    Clare G Fedele
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 107:22231-6. 2010
    ....
  41. pmc Reactive oxygen species enhance insulin sensitivity
    Kim Loh
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Cell Metab 10:260-72. 2009
    ..These studies provide causal evidence for the enhancement of insulin signaling by ROS in vivo...
  42. doi request reprint Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor
    Marguerite S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    J Biol Chem 283:22498-504. 2008
    ..GrB also cleaves the matrix form of fibrinogen at several sites. These studies suggest extracellular GrB may help control localized coagulation during inflammation...
  43. pmc Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
    Harshal H Nandurkar
    St Vincent s Hospital, 3065 Melbourne, Australia
    Proc Natl Acad Sci U S A 100:8660-5. 2003
    ..Collectively these studies indicate 3-PAP functions as an "adapter" for myotubularin, regulating myotubularin intracellular location and thereby altering the phenotype resulting from myotubularin overexpression...
  44. ncbi request reprint Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation
    Annette C Schmid
    Department of Biological Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    FEBS Lett 576:9-13. 2004
    ..This suggests that the phosphatase domains fulfil a unique catalytic function that cannot be fully compensated by other phosphatases...
  45. ncbi request reprint SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling
    Yijie Wang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and The Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH 43210, USA
    J Immunol 173:6820-30. 2004
    ..Finally, fetal liver-derived macrophages from SHIP2 gene knockout mice enhanced activation of Akt in response to M-CSF treatment. These data suggest a novel regulatory role for SHIP2 in M-CSF-stimulated myeloid cells...
  46. pmc The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis
    Hayley S Ramshaw
    Cytokine Receptor Laboratory, Division of Human Immunology, Institute of Medical and Veterinary Science, Hanson Institute, Adelaide, Australia
    Blood 110:3582-90. 2007
    ..These results reveal a previously unrecognized negative signaling role for Tyr577 in beta(c) and demonstrate that uncoupling Shc from cytokine receptors enhances PI3K signaling as well as survival and proliferation...