Christina A Mitchell
Affiliation: Monash University
Davies E, Gurung R, Le K, Mitchell C. Effective angiogenesis requires regulation of phosphoinositide signaling. Adv Biol Regul. 2018;: pubmed publisher
..This review will examine the role phosphoinositide signaling plays in the endothelium and its contribution to sprouting angiogenesis. ..
Wilding B, McGrath M, Bonne G, Mitchell C. FHL1 mutants that cause clinically distinct human myopathies form protein aggregates and impair myoblast differentiation. J Cell Sci. 2014;127:2269-81 pubmed publisher
Lucato C, Halls M, Ooms L, Liu H, Mitchell C, Whisstock J, et al
. The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Â·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Â·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J Biol Chem. 2015;290:20827-40 pubmed publisher
Ooms L, Binge L, Davies E, Rahman P, Conway J, Gurung R, et al
. The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Cancer Cell. 2015;28:155-69 pubmed publisher
..PIPP mRNA expression is reduced in human ER-negative breast cancers associated with reduced long-term outcome. Collectively, our findings identify PIPP as a suppressor of oncogenic PI3K/AKT signaling in breast cancer. ..
Eramo M, Mitchell C. Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases. Biochem Soc Trans. 2016;44:240-52 pubmed publisher
..This review will examine 5-phosphatase regulation of PI3K/Akt signalling, focussing on the role PtdIns(3,4,5)P3 5-phosphatases play in developmental diseases and cancer. ..
Hakim S, Dyson J, Feeney S, Davies E, Sriratana A, Koenig M, et al
. Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. Hum Mol Genet. 2016;25:2295-2313 pubmed
..Therefore, we identify Inpp5e as an essential inhibitor of the PI3K/Akt/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in PKD suppression. ..
Liu H, Ooms L, Srijakotre N, Man J, Vieusseux J, Waters J, et al
. PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling. J Biol Chem. 2016;291:17258-70 pubmed publisher
..Therefore, PREX1-Rac-GEF activity is critical for PREX1-dependent anchorage-independent cell growth and xenograft tumor growth and may represent a possible therapeutic target for breast cancers that exhibit PREX1 overexpression. ..
Dyson J, Conduit S, Feeney S, Hakim S, DiTommaso T, Fulcher A, et al
. INPP5E regulates phosphoinositide-dependent cilia transition zone function. J Cell Biol. 2017;216:247-263 pubmed publisher
..Therefore, we identify INPP5E as an essential point of convergence between Hedgehog and phosphoinositide signaling at cilia that maintains TZ function and Hedgehog-dependent embryonic development. ..
Srijakotre N, Man J, Ooms L, Lucato C, Ellisdon A, Mitchell C. P-Rex1 and P-Rex2 RacGEFs and cancer. Biochem Soc Trans. 2017;45:963-77 pubmed publisher
..Emerging clinical data predict that changes in expression or mutation of P-Rex1 and P-Rex2 may lead to changes in tumour outcome, particularly in breast cancer and melanoma. ..