Ian-R Mackay

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. pmc Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis
    Andrew D Cook
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Arthritis Res Ther 6:R477-83. 2004
  2. ncbi request reprint The peculiar autoimmunity of primary biliary cirrhosis
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Rev 174:226-37. 2000
  3. ncbi request reprint Autoimmune epitopes: autoepitopes
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University Clayton, 3800, Victoria, Australia
    Autoimmun Rev 3:487-92. 2004
  4. ncbi request reprint History of immunology in Australia: events and identities
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Intern Med J 36:394-8. 2006
  5. ncbi request reprint Autoimmunity since the 1957 clonal selection theory: a little acorn to a large oak
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 86:67-71. 2008
  6. ncbi request reprint Humanism and the suffering of the people
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    Intern Med J 33:195-202. 2003
  7. doi request reprint The odd couple: a fresh look at autoimmunity and immunodeficiency
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Autoimmun 35:199-205. 2010
  8. pmc Historical reflections on autoimmune hepatitis
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria 3800, Australia
    World J Gastroenterol 14:3292-300. 2008
  9. doi request reprint Clustering and commonalities among autoimmune diseases
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria 3800, Australia
    J Autoimmun 33:170-7. 2009
  10. doi request reprint Travels and travails of autoimmunity: a historical journey from discovery to rediscovery
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Autoimmun Rev 9:A251-8. 2010

Collaborators

Detail Information

Publications50

  1. pmc Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis
    Andrew D Cook
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Arthritis Res Ther 6:R477-83. 2004
    ..Moreover, our findings should encourage renewed interest in the role of collagen autoimmunity in the pathogenesis of RA...
  2. ncbi request reprint The peculiar autoimmunity of primary biliary cirrhosis
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Rev 174:226-37. 2000
    ....
  3. ncbi request reprint Autoimmune epitopes: autoepitopes
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University Clayton, 3800, Victoria, Australia
    Autoimmun Rev 3:487-92. 2004
    ....
  4. ncbi request reprint History of immunology in Australia: events and identities
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Intern Med J 36:394-8. 2006
    ..Australian immunology over the past 50 years has become recognized nationally and abroad as a highly visible component of the academic, research and biomedical scene and is still on a rising trajectory...
  5. ncbi request reprint Autoimmunity since the 1957 clonal selection theory: a little acorn to a large oak
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 86:67-71. 2008
    ....
  6. ncbi request reprint Humanism and the suffering of the people
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    Intern Med J 33:195-202. 2003
    ..Fortunately, however, the targets are more clearly visible than during the periods of poverty, plagues and pestilence of the past...
  7. doi request reprint The odd couple: a fresh look at autoimmunity and immunodeficiency
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Autoimmun 35:199-205. 2010
    ....
  8. pmc Historical reflections on autoimmune hepatitis
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria 3800, Australia
    World J Gastroenterol 14:3292-300. 2008
    ..New paradigms are needed to explain the occurrence, expressions and pathogenesis of such diseases...
  9. doi request reprint Clustering and commonalities among autoimmune diseases
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria 3800, Australia
    J Autoimmun 33:170-7. 2009
    ..Precisely accurate clinical data-bases and serological reactivities, combined with deepening molecular genetic analyses, have much promise for a better understanding of autoimmunity...
  10. doi request reprint Travels and travails of autoimmunity: a historical journey from discovery to rediscovery
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Autoimmun Rev 9:A251-8. 2010
    ..This present conspectus arbitrarily concludes at year 1965, recognizing that the history of autoimmunity even now is far from over...
  11. ncbi request reprint Hepatoimmunology: a perspective
    Ian R Mackay
    Department of Biochemistry and MolecularBiology, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 80:36-44. 2002
    ..Recent advances in the understanding of the immunopathogenesis of these entities are reviewed...
  12. ncbi request reprint The oratory of addiction: a 30-year perspective on alcohol and drug misuse
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    Intern Med J 31:357-63. 2001
    ..The prescience and achievements of the Ball orators provide optimism and direction for efforts in the future...
  13. ncbi request reprint The etiopathogenesis of autoimmunity
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Semin Liver Dis 25:239-50. 2005
    ..Solutions to etiopathogenesis require novel experimental models and finely designed gene-environment studies on human populations. Perhaps immunomodulatory therapies will effect cures before causes are fully understood...
  14. doi request reprint COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Diabetes 57:1293-301. 2008
    ....
  15. ncbi request reprint Autoimmune hepatitis: the way we were, the way we are today and the way we hope to be
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Autoimmunity 35:293-305. 2002
  16. pmc Cell damage and autoimmunity: a critical appraisal
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Autoimmun 30:5-11. 2008
    ..Finally an essential genetic foundation underlies all these hazards for autoimmunity in the form of risk-associated polymorphisms in immunoregulatory genes. They may be predictive of future or impending disease...
  17. ncbi request reprint Autoimmune gastritis: historical antecedents, outstanding discoveries, and unresolved problems
    Senga Whittingham
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Int Rev Immunol 24:1-29. 2005
    ..pylori infection and Type A autoimmune gastritis; and (3) the genetic contributions to gastritis, whether due to autoimmunity or to H. pylori infection...
  18. ncbi request reprint Toxic type 1 diabetes
    Mark A Myers
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria, 3800 Australia
    Rev Endocr Metab Disord 4:225-31. 2003
  19. ncbi request reprint Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling
    Karen H O'Connor
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Autoimmun 26:172-81. 2006
    ..These techniques should have broad applicability to definition of epitope structure...
  20. ncbi request reprint Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)
    Ingrid M Outschoorn
    Department of Biochemistry and Molecular Biology, Monash University Clayton, 3800 Victoria, Australia
    Autoimmunity 38:325-6. 2005
    ..569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative...
  21. ncbi request reprint Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases
    Shahnaz Fida
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Autoimmun 19:251-7. 2002
    ..Anti-SOX13 in PBC may occur merely as an immune response to products of damage to parenchymal tissue, or may be illustrative of a general proclivity of transcriptional regulatory proteins to elicit autoimmune responses...
  22. ncbi request reprint The "Autoimmune diseases" 40th anniversary
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Victoria, 3800, Australia
    Autoimmun Rev 1:5-11. 2002
  23. ncbi request reprint Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Immunol 44:1178-89. 2007
    ..The study shows the utility of using a combination of in silico techniques and experimental data for molecular characterization and localization of conformational epitopes for which crystal structures are lacking...
  24. doi request reprint Structural determinants of GAD antigenicity
    Yasir Arafat
    The Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, VIC 3800, Australia
    Mol Immunol 47:493-505. 2009
    ..This could well apply to the various other enzyme autoantigens and, if so, these features could be used as the basis of future predictive strategies...
  25. ncbi request reprint The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera
    Jonathan C Tong
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, 3800, Australia
    Ann N Y Acad Sci 958:182-9. 2002
    ..This favors the hypothesis that CBV infection causes type 1 diabetes by the process of viral mimicry with cross-reactivity to a critical epitope of GAD65...
  26. ncbi request reprint GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, VIC 3800, Australia
    Nat Struct Mol Biol 14:280-6. 2007
    ..Kinetic studies suggest that mobility in the catalytic loop promotes a side reaction that results in cofactor release and GAD65 autoinactivation. These data reveal the molecular basis for regulation of GABA homeostasis...
  27. ncbi request reprint Amino acids critical for binding of autoantibody to an immunodominant conformational epitope of the pyruvate dehydrogenase complex subunit E2: identification by phage display and site-directed mutagenesis
    Marita Scealy
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, Clayton, VIC 3800, Australia
    Mol Immunol 43:745-53. 2006
    ..Ensuing data could be generally applicable to search for occult extrinsic agents as initiators of autoimmunity...
  28. ncbi request reprint Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells
    S Fatemah Amirahmadi
    Monash University, Clayton, Victoria, Australia
    Arthritis Rheum 52:1897-906. 2005
    ..Some monoclonal antibodies (mAb) to type II collagen (CII) are arthritogenic upon passive transfer to mice. We undertook this study to investigate whether such mAb are pathogenic in the absence of mediators of inflammation...
  29. ncbi request reprint Enzymatic characterization of a recombinant isoform hybrid of glutamic acid decarboxylase (rGAD67/65) expressed in yeast
    Jonathan C Tong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3800, Australia
    J Biotechnol 97:183-90. 2002
    ..We here report on enzymatic and molecular properties of rGAD67/65...
  30. ncbi request reprint Measurement of antibodies to collagen II by inhibition of collagen fibril formation in vitro
    Robyn E Gray
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Immunol Methods 285:55-61. 2004
    ....
  31. ncbi request reprint Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5
    Karen H O'Connor
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    J Immunol Methods 299:21-35. 2005
    ..Thus conformational epitopes can be identified using phage display, but optimal mapping of complex epitopes can require the use of multiple peptide libraries...
  32. ncbi request reprint Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients
    Yongsoo Park
    Department of Internal Medicine, Hanyang University Hospital, 249 1 Kyomun dong, Kuri, Kyunggi Do, 471 020, Korea
    Ann N Y Acad Sci 1037:104-9. 2004
    ..Design of the antigen-specific immunointervention trials should take into account such HLA DR and DQ association...
  33. ncbi request reprint The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:13-9. 2008
  34. pmc Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice
    Guo Xiang Yang
    Division of Rheumatology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 47:1974-82. 2008
    ..In contrast, B6/Rag(-/-) recipients of CD4(+) T cells from dnTGFbetaRII mice predominantly developed inflammatory bowel disease associated with higher levels of serum interferon gamma and tumor necrosis factor alpha...
  35. ncbi request reprint AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers
    Yuki Moritoki
    Division of Rheumatology, Allergy, and Clinical Immunology and the University of California at Davis, Davis, CA 95616, USA
    Hepatology 45:314-22. 2007
    ..Conclusion: These data suggest that the hyperresponsiveness of B cells in PBC accelerates B cell-mediated autoimmunity...
  36. ncbi request reprint From bases to basis: linking genetics to causation in primary biliary cirrhosis
    Pietro Invernizzi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    Clin Gastroenterol Hepatol 3:401-10. 2005
    ....
  37. pmc Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 48:531-40. 2008
    ....
  38. ncbi request reprint Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California School of Medicine, Davis, CA 95616, USA
    J Immunol 177:1655-60. 2006
    ....
  39. ncbi request reprint The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 47:737-45. 2008
    ....
  40. pmc NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
    Junichiro Irie
    Division of Rheumatology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Exp Med 203:1209-19. 2006
    ..Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the first spontaneous mouse model of PBC...
  41. ncbi request reprint Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group
    Diego Vergani
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Hepatol 41:677-83. 2004
  42. ncbi request reprint The immunological milieu of the liver
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, California 95616, USA
    Semin Liver Dis 27:129-39. 2007
    ..Herein we review the available data on immune responses in the liver with particular emphasis on the unique structural and functional features of this "lymphoid" organ...
  43. pmc Autophagy: highlighting a novel player in the autoimmunity scenario
    Ana Lleo
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    J Autoimmun 29:61-8. 2007
    ..We review herein the role of autophagy in immune function and its possible contribution to breakdown of tolerance and development of autoimmunity...
  44. ncbi request reprint Collagen of articular cartilage: the neglected autoantigen of rheumatoid arthritis
    Ian R Mackay
    J Rheumatol 35:731-3. 2008
  45. ncbi request reprint Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry
    Christoph Konigs
    Georg Speyer Haus, Institute for Biomedical Research, Frankfurt am Main, Germany
    Immunol Cell Biol 85:511-7. 2007
    ....
  46. pmc Regulatory T cells in the prevention of mucosal inflammatory diseases: patrolling the border
    Ruth Y Lan
    Division of Rheumatology, Allergy and Clinical Immunology, Genome and Biomedical Sciences Facility, University of California at Davis, 451 E Health Sciences Drive, Suite 6510, Davis, CA 95616, USA
    J Autoimmun 29:272-80. 2007
    ..Finally there are now potential therapies predicated on reconstitution of effective function of Treg cells...
  47. ncbi request reprint Genetic susceptibility to chronic hepatitis B virus infection
    Ian R Mackay
    J Gastroenterol Hepatol 21:1087-8. 2006
  48. ncbi request reprint IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Hepatology 44:1240-9. 2006
    ....
  49. ncbi request reprint IL-2 receptor alpha deficiency and features of primary biliary cirrhosis
    Christopher A Aoki
    Division of Gastroenterology, University of California at Davis, 95616, USA
    J Autoimmun 27:50-3. 2006
    ..This case illustrates the role of deficiency of CD4+CD25+ Treg cells in causing autoimmunity, and speaks to the potential use of allogenic stem cell transplantation for immunoreconstitution in adult PBC...
  50. ncbi request reprint Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis
    Roman Rieger
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, GBSF 6510, 95616, USA
    J Autoimmun 27:7-16. 2006
    ..Our findings illustrate an unusual polyreactivity of anti-PDC-E2 and support the idea of epitope mimicry in the genesis of this autoantibody and perhaps of PBC itself...