Ian R Mackay

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. doi request reprint Structural determinants of GAD antigenicity
    Yasir Arafat
    The Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, VIC 3800, Australia
    Mol Immunol 47:493-505. 2009
  2. doi request reprint Autoimmune hepatitis: what must be said
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Exp Mol Pathol 93:350-3. 2012
  3. doi request reprint A 50-year experience with autoimmune hepatitis: and where are we now?
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic, 3800, Australia
    J Gastroenterol 46:17-28. 2011
  4. doi request reprint COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Diabetes 57:1293-301. 2008
  5. ncbi request reprint Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Immunol 44:1178-89. 2007
  6. ncbi request reprint Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling
    Karen H O'Connor
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Autoimmun 26:172-81. 2006
  7. pmc Historical reflections on autoimmune hepatitis
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria 3800, Australia
    World J Gastroenterol 14:3292-300. 2008
  8. ncbi request reprint Autoimmunity since the 1957 clonal selection theory: a little acorn to a large oak
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 86:67-71. 2008
  9. pmc Cell damage and autoimmunity: a critical appraisal
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Autoimmun 30:5-11. 2008
  10. ncbi request reprint Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells
    S Fatemah Amirahmadi
    Monash University, Clayton, Victoria, Australia
    Arthritis Rheum 52:1897-906. 2005

Collaborators

Detail Information

Publications23

  1. doi request reprint Structural determinants of GAD antigenicity
    Yasir Arafat
    The Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, VIC 3800, Australia
    Mol Immunol 47:493-505. 2009
    ..This could well apply to the various other enzyme autoantigens and, if so, these features could be used as the basis of future predictive strategies...
  2. doi request reprint Autoimmune hepatitis: what must be said
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Exp Mol Pathol 93:350-3. 2012
    ..Insufficiency in numbers and function of Treg populations appears important in the promotion of this autoimmune process...
  3. doi request reprint A 50-year experience with autoimmune hepatitis: and where are we now?
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic, 3800, Australia
    J Gastroenterol 46:17-28. 2011
    ....
  4. doi request reprint COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Diabetes 57:1293-301. 2008
    ....
  5. ncbi request reprint Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Immunol 44:1178-89. 2007
    ..The study shows the utility of using a combination of in silico techniques and experimental data for molecular characterization and localization of conformational epitopes for which crystal structures are lacking...
  6. ncbi request reprint Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling
    Karen H O'Connor
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    J Autoimmun 26:172-81. 2006
    ..These techniques should have broad applicability to definition of epitope structure...
  7. pmc Historical reflections on autoimmune hepatitis
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria 3800, Australia
    World J Gastroenterol 14:3292-300. 2008
    ..New paradigms are needed to explain the occurrence, expressions and pathogenesis of such diseases...
  8. ncbi request reprint Autoimmunity since the 1957 clonal selection theory: a little acorn to a large oak
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 86:67-71. 2008
    ....
  9. pmc Cell damage and autoimmunity: a critical appraisal
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Autoimmun 30:5-11. 2008
    ..Finally an essential genetic foundation underlies all these hazards for autoimmunity in the form of risk-associated polymorphisms in immunoregulatory genes. They may be predictive of future or impending disease...
  10. ncbi request reprint Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells
    S Fatemah Amirahmadi
    Monash University, Clayton, Victoria, Australia
    Arthritis Rheum 52:1897-906. 2005
    ..Some monoclonal antibodies (mAb) to type II collagen (CII) are arthritogenic upon passive transfer to mice. We undertook this study to investigate whether such mAb are pathogenic in the absence of mediators of inflammation...
  11. ncbi request reprint GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop
    Gustavo Fenalti
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, VIC 3800, Australia
    Nat Struct Mol Biol 14:280-6. 2007
    ..Kinetic studies suggest that mobility in the catalytic loop promotes a side reaction that results in cofactor release and GAD65 autoinactivation. These data reveal the molecular basis for regulation of GABA homeostasis...
  12. ncbi request reprint Amino acids critical for binding of autoantibody to an immunodominant conformational epitope of the pyruvate dehydrogenase complex subunit E2: identification by phage display and site-directed mutagenesis
    Marita Scealy
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, Clayton, VIC 3800, Australia
    Mol Immunol 43:745-53. 2006
    ..Ensuing data could be generally applicable to search for occult extrinsic agents as initiators of autoimmunity...
  13. ncbi request reprint Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)
    Ingrid M Outschoorn
    Department of Biochemistry and Molecular Biology, Monash University Clayton, 3800 Victoria, Australia
    Autoimmunity 38:325-6. 2005
    ..569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative...
  14. ncbi request reprint The etiopathogenesis of autoimmunity
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Semin Liver Dis 25:239-50. 2005
    ..Solutions to etiopathogenesis require novel experimental models and finely designed gene-environment studies on human populations. Perhaps immunomodulatory therapies will effect cures before causes are fully understood...
  15. doi request reprint The odd couple: a fresh look at autoimmunity and immunodeficiency
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Autoimmun 35:199-205. 2010
    ....
  16. doi request reprint Clustering and commonalities among autoimmune diseases
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Victoria 3800, Australia
    J Autoimmun 33:170-7. 2009
    ..Precisely accurate clinical data-bases and serological reactivities, combined with deepening molecular genetic analyses, have much promise for a better understanding of autoimmunity...
  17. ncbi request reprint Autoimmune gastritis: historical antecedents, outstanding discoveries, and unresolved problems
    Senga Whittingham
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Int Rev Immunol 24:1-29. 2005
    ..pylori infection and Type A autoimmune gastritis; and (3) the genetic contributions to gastritis, whether due to autoimmunity or to H. pylori infection...
  18. doi request reprint Travels and travails of autoimmunity: a historical journey from discovery to rediscovery
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Autoimmun Rev 9:A251-8. 2010
    ..This present conspectus arbitrarily concludes at year 1965, recognizing that the history of autoimmunity even now is far from over...
  19. ncbi request reprint The "Autoimmune diseases" 40th anniversary
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Victoria, 3800, Australia
    Autoimmun Rev 1:5-11. 2002
  20. ncbi request reprint Autoimmune epitopes: autoepitopes
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University Clayton, 3800, Victoria, Australia
    Autoimmun Rev 3:487-92. 2004
    ....
  21. ncbi request reprint Toxic type 1 diabetes
    Mark A Myers
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria, 3800 Australia
    Rev Endocr Metab Disord 4:225-31. 2003
  22. ncbi request reprint Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5
    Karen H O'Connor
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia
    J Immunol Methods 299:21-35. 2005
    ..Thus conformational epitopes can be identified using phage display, but optimal mapping of complex epitopes can require the use of multiple peptide libraries...
  23. ncbi request reprint Autoimmune hepatitis: the way we were, the way we are today and the way we hope to be
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Autoimmunity 35:293-305. 2002