M Leech

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor
    Derek Lacey
    Monash University Medical Centre, Clayton, Melbourne, Australia
    Arthritis Rheum 48:103-9. 2003
  2. ncbi request reprint Macrophage migration inhibitory factor: an emerging therapeutic target in rheumatoid arthritis
    Eric F Morand
    Monash Medical Centre, Clayton, Melbourne, Victoria, Australia
    Arthritis Rheum 48:291-9. 2003
  3. ncbi request reprint Macrophage migration inhibitory factor in rheumatoid arthritis
    Eric F Morand
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Melbourne, VIC 3168, Australia
    Front Biosci 10:12-22. 2005
  4. ncbi request reprint MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis
    Eric F Morand
    Centre for Inflammatory Diseases, Monash Institute for Medical Research, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Nat Rev Drug Discov 5:399-410. 2006
  5. ncbi request reprint Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis
    Michelle Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Locked Bag Number 29, Clayton, Melbourne, Victoria 3168, Australia
    Arthritis Rheum 48:1881-9. 2003
  6. pmc Endogenous glucocorticoids modulate experimental anti-glomerular basement membrane glomerulonephritis
    M Leech
    Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Australia
    Clin Exp Immunol 119:161-8. 2000
  7. pmc Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factor
    Elliott Taranto
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
    J Inflamm (Lond) 6:24. 2009
  8. pmc The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response
    M Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
    Clin Exp Immunol 152:345-53. 2008
  9. ncbi request reprint Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations
    E F Morand
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Melbourne, South Australia, Australia
    Rheumatology (Oxford) 41:558-62. 2002
  10. ncbi request reprint Macrophage migration inhibitory factor and glucocorticoid sensitivity
    D Aeberli
    Centre for Inflammatory Diseases, Monash Medical Centre, Locked Bag No 29, Clayton Melbourne 3168, Australia
    Rheumatology (Oxford) 45:937-43. 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Control of fibroblast-like synoviocyte proliferation by macrophage migration inhibitory factor
    Derek Lacey
    Monash University Medical Centre, Clayton, Melbourne, Australia
    Arthritis Rheum 48:103-9. 2003
    ..This study sought to identify the mechanisms of activation of FLS by MIF, and to assess the effects of MIF on synovial cell proliferation...
  2. ncbi request reprint Macrophage migration inhibitory factor: an emerging therapeutic target in rheumatoid arthritis
    Eric F Morand
    Monash Medical Centre, Clayton, Melbourne, Victoria, Australia
    Arthritis Rheum 48:291-9. 2003
  3. ncbi request reprint Macrophage migration inhibitory factor in rheumatoid arthritis
    Eric F Morand
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Melbourne, VIC 3168, Australia
    Front Biosci 10:12-22. 2005
    ....
  4. ncbi request reprint MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis
    Eric F Morand
    Centre for Inflammatory Diseases, Monash Institute for Medical Research, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Nat Rev Drug Discov 5:399-410. 2006
    ....
  5. ncbi request reprint Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis
    Michelle Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Locked Bag Number 29, Clayton, Melbourne, Victoria 3168, Australia
    Arthritis Rheum 48:1881-9. 2003
    ..To study the capacity of macrophage migration inhibitory factor (MIF) to regulate proliferation, apoptosis, and p53 in an animal model of rheumatoid arthritis (RA) and in fibroblast-like synoviocytes (FLS) from humans with RA...
  6. pmc Endogenous glucocorticoids modulate experimental anti-glomerular basement membrane glomerulonephritis
    M Leech
    Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Australia
    Clin Exp Immunol 119:161-8. 2000
    ..These results suggest that endogenous GC modulate heterologous anti-GBM nephritis in rats and that this may be attributable, in part, to regulation of P-selectin expression...
  7. pmc Modulation of expression and cellular distribution of p21 by macrophage migration inhibitory factor
    Elliott Taranto
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
    J Inflamm (Lond) 6:24. 2009
    ..In this study we investigated the effect of MIF on the expression and cellular distribution of the CDK inhibitor p21...
  8. pmc The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response
    M Leech
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
    Clin Exp Immunol 152:345-53. 2008
    ..p53 is involved in the modulation of adaptive and innate immune responses relevant to arthritis models and is also involved in the modulation of severity of AIA by both cell-cycle dependent and cell-cycle-independent mechanisms...
  9. ncbi request reprint Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations
    E F Morand
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Melbourne, South Australia, Australia
    Rheumatology (Oxford) 41:558-62. 2002
    ..Evidence of the expression and proinflammatory activity of MIF has recently been demonstrated in RA synovium and in animal models of RA. We wished to assess the relationship between MIF expression in synovium and clinical disease...
  10. ncbi request reprint Macrophage migration inhibitory factor and glucocorticoid sensitivity
    D Aeberli
    Centre for Inflammatory Diseases, Monash Medical Centre, Locked Bag No 29, Clayton Melbourne 3168, Australia
    Rheumatology (Oxford) 45:937-43. 2006
    ..In this review, we summarize the pro-inflammatory actions of MIF with respect to RA, describe the interactions between MIF and GC and examine new evidence, which identifies MIF as a specific target for steroid sparing...
  11. ncbi request reprint Hypothalamic-pituitary-adrenal axis regulation of inflammation in rheumatoid arthritis
    E F Morand
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Victoria, Australia
    Immunol Cell Biol 79:395-9. 2001
    ..Manipulation of HPA axis-driven endogenous anti-inflammatory responses may provide new methods for the therapeutic control of inflammatory diseases...
  12. ncbi request reprint Detection of the p53 regulator murine double-minute protein 2 in rheumatoid arthritis
    Elliott Taranto
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Locked Bag No 29, Clayton, Melbourne, 3168 Australia
    J Rheumatol 32:424-9. 2005
    ..The detection of MDM2 in rheumatoid synovium has not previously been described. We investigated whether this protein is detectable in cells and tissues derived from patients with RA...
  13. ncbi request reprint Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor
    Leilani L Santos
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Melbourne, Australia
    J Rheumatol 31:1038-43. 2004
    ....
  14. ncbi request reprint Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoids
    Myew Ling Toh
    Monash Medical Centre, Clayton, Melbourne, Australia
    Arthritis Rheum 50:3118-28. 2004
    ..Since MAPKs are known to be important in rheumatoid arthritis (RA) synoviocyte activation, this study assessed the expression, regulation, and function of MKP-1 in RA...
  15. ncbi request reprint IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis
    Leilani L Santos
    Centre for Inflammatory Diseases, Monash Institute of Medical Research, Monash Medical Centre, Melbourne, Australia
    Immunol Cell Biol 84:166-73. 2006
    ..In conclusion, IL-18 is redundant both as a Th1 response cofactor and inflammatory cytokine, whereas IL-12p40-/- is a key cytokine, in AIA in C57Bl/6 mice...
  16. ncbi request reprint Glucocorticoid regulation of inflammation: the plot thickens
    E F Morand
    Centre for Inflammatory Diseases, Monash University, Dept of Medicine, Monash Medical Centre, Melbourne, Australia
    Inflamm Res 48:557-60. 1999
    ..This observation has the potential to explain key aspects of the biphasic regulation of inflammatory response by endogenous glucocorticoids...
  17. ncbi request reprint Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase
    Daniel Aeberli
    Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, Melbourne, Australia
    FEBS Lett 580:974-81. 2006
    ..These results demonstrate that MIF regulates GC sensitivity by phosphorylation of p38, and provides a cellular mechanism for this observation, indicating that MKP-1 is a central target of this regulation...
  18. ncbi request reprint Annexin 1 negatively regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1
    Yuan H Yang
    Centre for Inflammatory Diseases, Department of Medicine, Monash University Medical Centre, Clayton, Victoria 3168, Australia
    J Immunol 177:8148-53. 2006
    ..Therapeutic manipulation of Anx-1 could provide glucocorticoid-mimicking effects in inflammatory disease...
  19. ncbi request reprint Is macrophage migration inhibitory factor a therapeutic target in systemic lupus erythematosus?
    Alberta Y Hoi
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia
    Immunol Cell Biol 81:367-73. 2003
    ..By virtue of its pluripotent functions, we propose that MIF may be a critical mediator of inflammation and damage in SLE, and that targeting of MIF may offer therapeutic benefits in this disease...
  20. ncbi request reprint Expression and function of cell cycle proteins in rheumatoid arthritis synovial tissue
    E Taranto
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Melbourne, Australia
    Histol Histopathol 21:205-11. 2006
    ..By contributing to the overgrowth of synovial tissue, factors such as dysregulated proliferation or reduced apoptosis of cells can directly influence the pathological outcome of RA...
  21. ncbi request reprint Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis
    M Leech
    Monash University, Monash Medical Centre, Clayton, Melbourne, Australia
    Arthritis Rheum 43:827-33. 2000
    ..To explore the regulation of macrophage migration inhibitory factor (MIF) by endogenous glucocorticoids in adjuvant-induced arthritis (AIA)...
  22. pmc Independent roles of macrophage migration inhibitory factor and endogenous, but not exogenous glucocorticoids in regulating leukocyte trafficking
    Julia L Gregory
    Monash University Department of Medicine, Monash Medical Center, Clayton, Victoria, Australia
    Microcirculation 16:735-48. 2009
    ..The aim of this study was to examine whether interaction between MIF and GC underlies the ability of MIF to promote leukocyte-endothelial cell (EC) interactions...
  23. ncbi request reprint Macrophage migration inhibitory factor in systemic lupus erythematosus
    Andrew Foote
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Victoria, Australia
    J Rheumatol 31:268-73. 2004
    ..To examine associations between serum macrophage migration inhibitory factor (MIF) and disease-related variables and corticosteroid use in patients with systemic lupus erythematosus (SLE)...