Martin Lackmann

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. pmc PTP1B regulates Eph receptor function and trafficking
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Cell Biol 191:1189-203. 2010
  2. pmc Expression of nodal signalling components in cycling human endometrium and in endometrial cancer
    Irene Papageorgiou
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton, VIC 3168, Australia
    Reprod Biol Endocrinol 7:122. 2009
  3. doi request reprint Eph, a protein family coming of age: more confusion, insight, or complexity?
    Martin Lackmann
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Sci Signal 1:re2. 2008
  4. ncbi request reprint Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents
    Christopher Vearing
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Cancer Res 65:6745-54. 2005
  5. doi request reprint Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
    Sabine H Wimmer-Kleikamp
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 112:721-32. 2008
  6. doi request reprint Eph-dependent cell-cell adhesion and segregation in development and cancer
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Vic, 3800, Australia
    Cell Mol Life Sci 69:1813-42. 2012
  7. pmc Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    PLoS Biol 7:e1000215. 2009
  8. pmc Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function
    Lakmali Atapattu
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Cell Sci 125:6084-93. 2012
  9. ncbi request reprint Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
    Peter W Janes
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
    Cell 123:291-304. 2005
  10. pmc Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Cell Biol 195:1033-45. 2011

Collaborators

  • Dimitar B Nikolov
  • Andrew M Scott
  • Fawaz G Haj
  • Tony Pawson
  • Bryan W Day
  • Paul Saftig
  • Peter W Janes
  • Eva Nievergall
  • Sabine H Wimmer-Kleikamp
  • Andrew W Boyd
  • Lakmali Atapattu
  • Philippe I Bastiaens
  • Christopher Vearing
  • Juha Pekka Himanen
  • Mary E Vail
  • Bettina Griesshaber
  • Irene Papageorgiou
  • Nayanendu Saha
  • Samantha Adikari
  • Christopher J Vearing
  • William A Barton
  • Fiona M Smith
  • Con Stylianou
  • Michelle Down
  • Isobel D Lawrenson
  • Mark G Coulthard
  • Thomas Saunders
  • Carmen Llerena
  • Claus Jørgensen
  • Chanly Chheang
  • Anneloes Mensinga
  • Linda L Hii
  • Carolin Stegmayer
  • Shyh Wei Teng
  • Benjamin G Neel
  • Alice Y Ting
  • Markus Grabenbauer
  • Lois A Salamonsen
  • Yogeshwar Makanji
  • Peter K Nicholls
  • David M Robertson
  • Fang Wang
  • Ola Sabet
  • Achilleas S Frangakis
  • Craig A Harrison
  • Kane Treble
  • Trina Yeadon
  • Kristina Gegenbauer
  • Neill R Patani
  • Mariam Mansour
  • Momchil V Kolev
  • Sabine Wimmer-Kleikamp
  • Fook Thean Lee
  • Martin Brechbiel
  • Mark Spanevello
  • Catherine To
  • Violeta Spirkoska
  • Carl P Blobel
  • Mark Henkemeyer
  • Herbert Treutlein
  • Chen Li
  • Phillip D Jeffrey
  • Michael J Chumley
  • Anthony Squire
  • Juha Himanen
  • David A Feldheim
  • Allan Saul
  • Detlef Geleick
  • Ke Chen
  • Philippe I H Bastiaens
  • Peter Lock
  • Fiona Smith
  • Paul F Alewood
  • Andrew Oates
  • Sabine Kleikamp
  • Shannon Duffy
  • Betty Evans
  • Gordon F Burns
  • Maryanne Power
  • Simone M Schoenwaelder

Detail Information

Publications21

  1. pmc PTP1B regulates Eph receptor function and trafficking
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Cell Biol 191:1189-203. 2010
    ..Our studies for the first time provide molecular, mechanistic, and functional insights into the role of PTP1B controlling Eph/ephrin-facilitated cellular interactions...
  2. pmc Expression of nodal signalling components in cycling human endometrium and in endometrial cancer
    Irene Papageorgiou
    Prince Henry s Institute of Medical Research, 246 Clayton Road, Clayton, VIC 3168, Australia
    Reprod Biol Endocrinol 7:122. 2009
    ..Nodal, a member of the transforming growth factor-beta superfamily, regulates the processes of pattern formation and differentiation that occur during early embryo development...
  3. doi request reprint Eph, a protein family coming of age: more confusion, insight, or complexity?
    Martin Lackmann
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Sci Signal 1:re2. 2008
    ..Undeniably, the complexity of the underlying signaling networks is considerable, and it seems probable that systems biology approaches are required to further improve our understanding of Eph function...
  4. ncbi request reprint Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents
    Christopher Vearing
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Cancer Res 65:6745-54. 2005
    ..These findings show the biological importance of EphA3/ephrin-A5 interactions and that ephrin-A5 and IIIA4 have great potential as tumor targeting reagents...
  5. doi request reprint Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
    Sabine H Wimmer-Kleikamp
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    Blood 112:721-32. 2008
    ....
  6. doi request reprint Eph-dependent cell-cell adhesion and segregation in development and cancer
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Vic, 3800, Australia
    Cell Mol Life Sci 69:1813-42. 2012
    ..This review summarises our current understanding of how Eph receptors control cell adhesion and morphology, and presents examples demonstrating the importance of these events in normal development and cancer...
  7. pmc Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    PLoS Biol 7:e1000215. 2009
    ..Our data suggest that this phosphorylation-activated conformational switch of EphA3 directly controls ADAM-mediated shedding...
  8. pmc Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function
    Lakmali Atapattu
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Cell Sci 125:6084-93. 2012
    ....
  9. ncbi request reprint Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
    Peter W Janes
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
    Cell 123:291-304. 2005
    ..Our data suggest a simple mechanism for regulating ADAM10-mediated ephrin proteolysis, which ensures that only Eph bound ephrins are recognized and cleaved...
  10. pmc Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    J Cell Biol 195:1033-45. 2011
    ..Importantly, they imply that in tumor cells coexpressing different Ephs, functional mutations in one subtype may cause phenotypes that are a result of altered signaling from heterotypic rather from homotypic Eph clusters...
  11. ncbi request reprint Eph/ephrin signalling and function in oncogenesis: lessons from embryonic development
    Peter W Janes
    Department of Biochemistry and Molecular Biology, PO Box 13D, Monash University, Victoria 3800, Australia
    Curr Cancer Drug Targets 8:473-9. 2008
    ....
  12. ncbi request reprint Targeting of EPH receptor tyrosine kinases for anticancer therapy
    Eva Nievergall
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Crit Rev Oncog 17:211-32. 2012
    ....
  13. doi request reprint Concepts and consequences of Eph receptor clustering
    Peter W Janes
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Victoria 3800, Australia
    Semin Cell Dev Biol 23:43-50. 2012
    ....
  14. ncbi request reprint "Eph receptor signalling; dimerisation just isn't enough"
    Christopher J Vearing
    Department of Biochemistry and Molecular Biology, Monash University, Australia
    Growth Factors 23:67-76. 2005
  15. pmc Recruitment of Eph receptors into signaling clusters does not require ephrin contact
    Sabine H Wimmer-Kleikamp
    Dept of Biochemistry and Molecular Biology, P O Box 13D, Monash University, Clayton, Victoria 3800, Australia
    J Cell Biol 164:661-6. 2004
    ....
  16. ncbi request reprint Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling
    Isobel D Lawrenson
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    J Cell Sci 115:1059-72. 2002
    ....
  17. pmc Crystal structure of the human ephrin-A5 ectodomain
    Dimitar Nikolov
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Protein Sci 16:996-1000. 2007
    ..The results of this study further emphasize the importance of the G-H loop for receptor recognition and selectivity, and could serve as a starting point for the development of structure-based Eph antagonists...
  18. ncbi request reprint Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
    Juha Pekka Himanen
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Neurosci 7:501-9. 2004
    ..The structural data reveal the molecular basis for EphB2-ephrin-A5 signaling and provide a framework for understanding the complexities of functional interactions and crosstalk between A- and B-subclass Eph receptors and ephrins...
  19. ncbi request reprint The role of the Eph-ephrin signalling system in the regulation of developmental patterning
    Mark G Coulthard
    Leukaemia Foundation Laboratory, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Australia
    Int J Dev Biol 46:375-84. 2002
    ..This review focuses on two vertebrate models, the zebrafish and mouse, in which experimental perturbation of Eph and/or ephrin expression in vivo have provided important insights into the role and functioning of the Eph/ephrin system...
  20. ncbi request reprint Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3
    Bryan Day
    Queensland Institute of Medical Research, P O Royal Brisbane Hospital 4029, Queensland, Australia
    J Biol Chem 280:26526-32. 2005
    ....
  21. ncbi request reprint Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen
    Fiona M Smith
    Leukaemia Foundation of Queensland Laboratory, Queensland Institute of Medical Research, P O Royal Brisbane Hospital, Queensland 4029, Australia
    J Biol Chem 279:9522-31. 2004
    ..Functional analysis of EphA3 mutants reveals that all three Eph/ephrin contact areas are essential for the assembly of signaling-competent, oligomeric receptor-ligand complexes...