David A Jans

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. Yang S, Atkinson S, Fraser J, Wang C, Maher B, Roman N, et al. Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer. Cells. 2019;8: pubmed publisher
    ..This work highlights DENV NS5 nuclear targeting as a viable target for anti-flaviviral therapeutics. ..
  2. Jans D, Martin A, Wagstaff K. Inhibitors of nuclear transport. Curr Opin Cell Biol. 2019;58:50-60 pubmed publisher
    ..Selectively inhibiting the nucleocytoplasmic trafficking of specific proteins of interest remains a challenge, but progress in the area of the host-pathogen interface holds promise for the future. ..
  3. Debono A, Thomas D, Lundberg L, Pinkham C, Cao Y, Graham J, et al. Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity. Sci Rep. 2019;9:2634 pubmed publisher
    ..2 µM and no detectable PR antagonism activity. Finally, based on our SAR analysis we propose avenues for the further development of these analogues as safe and effective anti-VEEV agents. ..
  4. Alvisi G, Jans D. Basis of cargo recognition by importin αs: the power of structure. Structure. 2015;23:251-2 pubmed publisher
    ..Combining molecular dynamics with structural and biochemical data, the so-far elusive basis for selectivity of binding to distinct different importin αs is beginning to become accessible. ..
  5. Jans D, Martin A. Nucleocytoplasmic Trafficking of Dengue Non-structural Protein 5 as a Target for Antivirals. Adv Exp Med Biol. 2018;1062:199-213 pubmed publisher
    ..Targeting nucleocytoplasmic trafficking of flavivirus proteins promises to be a powerful strategy to counter flaviviruses, for which the development of protective vaccines has thus far proven problematic. ..
  6. Kuusisto H, Jans D. Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1. Biochim Biophys Acta. 2015;1853:1870-8 pubmed publisher
    ..This hypersensitivity of malignant cell types to Impβ1 knockdown raises the exciting possibility of anti-cancer therapies targeted at Impβ1. ..
  7. Liu X, Lin W, Shi X, Davies R, Wagstaff K, Tao T, et al. PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function. Biochem J. 2018;475:2699-2712 pubmed publisher
  8. Thomas D, Lundberg L, Pinkham C, Shechter S, Debono A, Baell J, et al. Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening. Antiviral Res. 2018;151:8-19 pubmed publisher
  9. Atkinson S, Audsley M, Lieu K, Marsh G, Thomas D, Heaton S, et al. Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V. Sci Rep. 2018;8:358 pubmed publisher
    ..These findings emphasize the critical role of host-virus interactions in HeV infection, and potential use of compounds targeting nuclear transport, such as the FDA-approved agent ivermectin, as anti-HeV agents. ..

More Information

Publications21

  1. Caly L, Li H, Bogoyevitch M, Jans D. c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production. Biochem Biophys Res Commun. 2017;483:64-68 pubmed publisher
    ..The results implicate JNK1/2 as a key host factor for RSV virus production, raising the possibility of agents targeting JNK activity as potential anti-RSV therapeutics. ..
  2. Shechter S, Thomas D, Lundberg L, Pinkham C, Lin S, Wagstaff K, et al. Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design. Sci Rep. 2017;7:17705 pubmed publisher
  3. Wang C, Yang S, Smith K, Forwood J, Jans D. Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection. Biochem Biophys Res Commun. 2017;493:1555-1559 pubmed publisher
    ..Importantly, we show that 4-HPR has potent anti-ZIKV activity at low ?M concentrations. With an established safety profile for human use, 4-HPR represents an exciting possibility as an anti-ZIKV agent...
  4. Hu M, Li H, Bogoyevitch M, Jans D. Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production. Biochem Biophys Res Commun. 2017;489:460-465 pubmed publisher
    ..The results implicate p32 as a key host factor for RSV virus production, and bring to light the potential importance of mitochondria in RSV infection. ..
  5. Davies R, Wagstaff K, McLaughlin E, Loveland K, Jans D. The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins. Biochim Biophys Acta. 2013;1833:3436-3444 pubmed publisher
    ..These results imply for the first time that BRAP2 may have an important role in modulating subcellular localization during testicular development. ..
  6. Fatima S, Wagstaff K, Lieu K, Davies R, Tanaka S, Yamaguchi Y, et al. Interactome of the inhibitory isoform of the nuclear transporter Importin 13. Biochim Biophys Acta Mol Cell Res. 2017;1864:546-561 pubmed publisher
    ..Collectively, our findings show, for the first time, that tImp13 may have a functional role in the mature spermatozoa, in addition to that in the meiotic germ cells of the testis. ..
  7. Fraser J, Rawlinson S, Heaton S, Jans D. Dynamic Nucleolar Targeting of Dengue Virus Polymerase NS5 in Response to Extracellular pH. J Virol. 2016;90:5797-5807 pubmed publisher
    ..Overall, this study identifies a unique subcellular trafficking event and suggests that DENV is able to detect and respond dynamically to environmental changes. ..
  8. Caly L, Kassouf V, Moseley G, Diefenbach R, Cunningham A, Jans D. Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein; impaired trafficking in a clinical isolate. Biochem Biophys Res Commun. 2016;470:735-740 pubmed publisher
    ..The results implicate MTs/DYNLT1 as drivers of Vpr nuclear import and HIV infection, with important therapeutic implications. ..
  9. Nastasie M, Thissen H, Jans D, Wagstaff K. Enhanced tumour cell nuclear targeting in a tumour progression model. BMC Cancer. 2015;15:76 pubmed publisher
  10. Fraser J, Wang C, Chan K, Vasudevan S, Jans D. Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells. Antiviral Res. 2016;130:1-6 pubmed publisher
    ..This study provides the first detailed insight into the cellular effects modulated by 4-HPR in DENV-infected cells, critical to progressing 4-HPR towards the clinic. ..
  11. Fulcher A, Sivakumaran H, Jin H, Rawle D, Harrich D, Jans D. The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention. Biochim Biophys Acta. 2016;1863:254-62 pubmed publisher
    ..To our knowledge, this is the first report of specific protein methylation inhibiting nucleolar retention. ..
  12. Suarez Sanchez R, Aguilar A, Wagstaff K, Velez G, Azuara Medina P, Gomez P, et al. Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin ?/? and CRM1 nuclear transporters and microtubule motor dynein. Biochim Biophys Acta. 2014;1843:985-1001 pubmed publisher
    ..The clear implication is that Dp71d's previously unrecognised nuclear transport properties likely contribute to various, important physiological roles. ..