S F Jackson

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi Type I phosphoinositide 3-kinases: potential antithrombotic targets?
    S F Jackson
    Australian Centre for Blood Diseases, Monash University, 6th Level Burnet Building, Alfred Medical Research and Education Precinct AMREP, 89 Commercial Road, Melbourne, Victoria, 3004, Australia
    Cell Mol Life Sci 63:1085-90. 2006
  2. ncbi Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton
    S P Jackson
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia
    Trends Cardiovasc Med 10:192-7. 2000
  3. ncbi PI 3-kinase p110beta: a new target for antithrombotic therapy
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, 6th Floor Burnet Building Alfred Medical Research and Education Precinct, Prahran, Victoria, Australia 3181
    Nat Med 11:507-14. 2005
  4. ncbi Dynamics of platelet thrombus formation
    S P Jackson
    The Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 7:17-20. 2009
  5. ncbi The growing complexity of platelet aggregation
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Blood 109:5087-95. 2007
  6. ncbi Antiplatelet therapy: in search of the 'magic bullet'
    Shaun P Jackson
    The Australian Centre for Blood Diseases, Department of Medicine, Monash University, Arnold Street, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Nat Rev Drug Discov 2:775-89. 2003
  7. ncbi Signaling events underlying thrombus formation
    S P Jackson
    Australian Center for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    J Thromb Haemost 1:1602-12. 2003
  8. ncbi PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3
    Shaun P Jackson
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne, Vic, 3004, Australia
    Curr Top Microbiol Immunol 346:203-24. 2010
  9. ncbi Phosphoinositide 3-kinases and the regulation of platelet function
    S P Jackson
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    Biochem Soc Trans 32:387-92. 2004
  10. ncbi Procoagulant platelets: are they necrotic?
    Shaun P Jackson
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Australia
    Blood 116:2011-8. 2010

Collaborators

Detail Information

Publications58

  1. ncbi Type I phosphoinositide 3-kinases: potential antithrombotic targets?
    S F Jackson
    Australian Centre for Blood Diseases, Monash University, 6th Level Burnet Building, Alfred Medical Research and Education Precinct AMREP, 89 Commercial Road, Melbourne, Victoria, 3004, Australia
    Cell Mol Life Sci 63:1085-90. 2006
    ....
  2. ncbi Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton
    S P Jackson
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia
    Trends Cardiovasc Med 10:192-7. 2000
    ..Thus a complex functional relationship appears to exist between GPIb/V/IX and the membrane skeleton that goes well beyond preserving the normal cytoskeletal architecture of resting platelets...
  3. ncbi PI 3-kinase p110beta: a new target for antithrombotic therapy
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, 6th Floor Burnet Building Alfred Medical Research and Education Precinct, Prahran, Victoria, Australia 3181
    Nat Med 11:507-14. 2005
    ..In vivo, these inhibitors eliminate occlusive thrombus formation but do not prolong bleeding time. These studies define PI3K p110beta as an important new target for antithrombotic therapy...
  4. ncbi Dynamics of platelet thrombus formation
    S P Jackson
    The Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 7:17-20. 2009
    ..Unraveling the dynamics of platelet aggregation and thrombus formation in vivo requires consideration of the cooperative interplay between rheological- and soluble agonist-dependent platelet aggregation mechanisms...
  5. ncbi The growing complexity of platelet aggregation
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Blood 109:5087-95. 2007
    ....
  6. ncbi Antiplatelet therapy: in search of the 'magic bullet'
    Shaun P Jackson
    The Australian Centre for Blood Diseases, Department of Medicine, Monash University, Arnold Street, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Nat Rev Drug Discov 2:775-89. 2003
    ....
  7. ncbi Signaling events underlying thrombus formation
    S P Jackson
    Australian Center for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    J Thromb Haemost 1:1602-12. 2003
    ..The role of soluble agonists in promoting thrombus growth will be highlighted and a model to explain the synergistic requirement for adhesive and soluble stimuli for efficient platelet aggregation will be discussed...
  8. ncbi PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3
    Shaun P Jackson
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne, Vic, 3004, Australia
    Curr Top Microbiol Immunol 346:203-24. 2010
    ....
  9. ncbi Phosphoinositide 3-kinases and the regulation of platelet function
    S P Jackson
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria, Australia
    Biochem Soc Trans 32:387-92. 2004
    ..Thus distinct co-operative PI 3-kinase signalling mechanisms appear to play an important role in regulating the adhesive function of integrin alphaIIbbeta3...
  10. ncbi Procoagulant platelets: are they necrotic?
    Shaun P Jackson
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct, Monash University, Melbourne, Australia
    Blood 116:2011-8. 2010
    ..We will also discuss the potential contribution of these pathways to the platelet storage lesion and propose a simplified nomenclature to describe procoagulant platelets...
  11. ncbi Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct AMREP, 89 Commercial Road, Melbourne, Victoria, Australia
    J Biol Chem 282:28648-58. 2007
    ..These findings have potentially important implications for the rationale design of novel antiplatelet therapies targeting PI 3-kinase signaling pathways...
  12. ncbi SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets
    Mhairi J Maxwell
    Australian Centre for Blood Diseases, Department of Medicine, Monash University, Box Hill Hospital, Victoria 3128, Australia
    J Biol Chem 279:32196-204. 2004
    ..These studies define a major role for SHIP1 and Lyn as negative regulators of integrin alpha(IIb)beta(3) adhesive and signaling function...
  13. ncbi Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth
    Suhasini Kulkarni
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    J Biol Chem 279:30697-706. 2004
    ..Moreover, they demonstrate the existence of an autoregulatory feedback mechanism that serves to limit excessive platelet accumulation on highly reactive thrombogenic surfaces...
  14. ncbi Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets
    Isaac Goncalves
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Prahran, Victoria 3181, Australia
    J Biol Chem 280:15430-7. 2005
    ..Our studies demonstrate a key role for temporal shear gradients in promoting platelet activation. Moreover, they define for the first time the involvement of P2Y receptors in integrin mechanotransduction...
  15. ncbi Intercellular calcium communication regulates platelet aggregation and thrombus growth
    Warwick S Nesbitt
    Australian Centre for Blood Diseases, Department of Medicine, Monash University, Box Hill Hospital, Victoria 3128, Australia
    J Cell Biol 160:1151-61. 2003
    ..Furthermore, we demonstrate that the efficiency by which calcium signals are propagated within platelet aggregates plays an important role in dictating the rate and extent of thrombus growth...
  16. ncbi Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation
    Mhairi J Maxwell
    Australian Centre for Blood Diseases, Monash University, 89 Commercial Rd, Prahran, Australia, 3181
    Blood 109:566-76. 2007
    ..Moreover, they provide a model to explain how the discoid morphology of platelets facilitates the maintenance of adhesive interactions with thrombogenic surfaces under high shear stress conditions...
  17. ncbi Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear
    David Williamson
    Australian Centre for Blood Diseases, Department of Medicine, Monash University, Box Hill Hospital, Victoria 3128, Australia
    J Biol Chem 277:2151-9. 2002
    ..These studies define a critical role for amino acids within the 557-579 sequence of GPIbalpha for interaction with filamin-1...
  18. ncbi Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth
    Akiko Ono
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Blood 112:90-9. 2008
    ..Furthermore, they provide new insight into the underlying bleeding diathesis associated with platelet contractility defects...
  19. ncbi Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics
    Mhairi J Maxwell
    Australian Centre for Blood Diseases, Monash University, Prahran, Australia
    Arterioscler Thromb Vasc Biol 26:663-9. 2006
    ..CONCLUSIONS: These studies demonstrate that platelets undergo shear-specific morphological changes during surface translocation on vWf that may serve to regulate translocation dynamics under flow...
  20. ncbi Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow
    Warwick S Nesbitt
    Australian Centre for Blood Diseases, Monash University, Box Hill Hospital, Box Hill, Victoria 3127, Australia
    J Biol Chem 277:2965-72. 2002
    ..These studies demonstrate the existence of a dual step calcium signaling mechanism utilized by GPIb and integrin alpha(IIb)beta(3) that serves to regulate the dynamics of platelet adhesion under flow...
  21. ncbi Shear-dependent tether formation during platelet translocation on von Willebrand factor
    Sacha M Dopheide
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill, Victoria, Australia
    Blood 99:159-67. 2002
    ....
  22. ncbi Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3)
    Cindy L Yap
    Australian Centre for Blood Diseases, Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia
    Blood 99:151-8. 2002
    ..Under static conditions, platelets appear to mobilize intracellular calcium through both PI 3-kinase-dependent and -independent mechanisms, whereas under shear PI 3-kinase is indispensable for VWF-induced calcium release...
  23. ncbi The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Alfred Medical Research and Educational Precinct, Monash University, Prahran, Victoria, 3181, Australia
    J Mol Med 84:989-95. 2006
    ..This review focuses on the impact of blood rheology on the cellular and molecular events underlying thrombosis, with particular emphasis on the role of platelets in this process...
  24. ncbi Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading
    Suhasini Kulkarni
    Australian Centre for Blood Diseases, Monash University and Baker Heart Research Institute, at Alfred Medical Research and Education Precinct, Prahran, Victoria, Australia
    Blood 110:1879-86. 2007
    ..These studies define for the first time a specific proinflammatory function for annexin A5+ve platelets. Moreover, they demonstrate an important role for platelet-derived PAF in spatially regulating neutrophil adhesion under flow...
  25. ncbi Class I phosphoinositide 3-kinases
    Karen E Anderson
    Department of Medicine, Australian Centre for Blood Diseases, Monash University, Box Hill Hospital, Victoria 3128, Australia
    Int J Biochem Cell Biol 35:1028-33. 2003
    ..The future development of specific PI3-kinase isoform inhibitors may offer therapeutic benefit in a broad range of clinical settings, related to cancer, inflammatory and immunological diseases...
  26. ncbi A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex
    Fi Tjen Mu
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Blood 111:4580-7. 2008
    ..Together, these data suggest the GPIb alpha C-terminus regulates signaling through independent association of 14-3-3zeta and PI3-kinase...
  27. ncbi Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2
    Isaac Goncalves
    Australian Centre for Blood Diseases, Department of Medicine, Monash University, Box Hill Hospital, Victoria 3128, Australia
    J Biol Chem 278:34812-22. 2003
    ..Furthermore, they establish an important cooperative signaling role for PLC gamma 2 and ADP in regulating platelet adhesion efficiency on fibrinogen...
  28. ncbi RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear
    Simone M Schoenwaelder
    Department of Medicine, Australian Centre for Blood Diseases, Monash University, Box Hill Hospital, Arnold St, Box Hill, Victoria 3128, Australia
    J Biol Chem 277:14738-46. 2002
    ..These studies define a critical role for RhoA in regulating the stability of integrin alpha(IIb)beta(3) adhesion contacts under conditions of high shear stress...
  29. ncbi Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency
    Pierre Mangin
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia
    Blood 107:4346-53. 2006
    ..Moreover, they raise the interesting possibility that the full antithrombotic potential of GPVI receptor antagonists may only be realized through the concurrent administration of anticoagulant agents...
  30. ncbi Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha
    Susan L Cranmer
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, Commercial Road, Prahran, Victoria 3181, Australia
    Biochem J 387:849-58. 2005
    ..These studies demonstrate a novel filamin A binding motif in the cytoplasmic tail of GPIbalpha, which is critically dependent on both Trp570 and Phe568...
  31. ncbi Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, 89 Commercial Road, Melbourne, Victoria 3004, Australia
    J Biol Chem 285:2886-96. 2010
    ..These findings may provide new insight into the potential antithrombotic properties of PI3K p110 beta inhibitors...
  32. ncbi Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, 89 Commercial Road, Melbourne, Victoria 3004, Australia
    Blood 114:663-6. 2009
    ..These studies show the existence of 2 distinct pathways regulating the procoagulant function of platelets...
  33. ncbi New insights into the haemostatic function of platelets
    Andrew H Wei
    The Australian Centre for Blood Diseases, Monash University, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia
    Br J Haematol 147:415-30. 2009
    ....
  34. ncbi Techniques to examine platelet adhesive interactions under flow
    Suhasini Kulkarni
    Department of Medicine, Monash University, Clayton, Victoria, Australia
    Methods Mol Biol 272:165-86. 2004
  35. ncbi A shear gradient-dependent platelet aggregation mechanism drives thrombus formation
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Melbourne, Victoria, Australia
    Nat Med 15:665-73. 2009
    ..These findings provide insight into the prothrombotic effects of disturbed blood flow parameters and suggest a fundamental reinterpretation of the mechanisms driving platelet aggregation and thrombus growth...
  36. ncbi Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway
    Sapna Devi
    Centre for Inflammatory Diseases, Monash University, Department of Medicine, Clayton, Victoria, Australia
    Am J Pathol 177:1131-42. 2010
    ....
  37. ncbi A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists
    Nicole Bassler
    Centre for Thrombosis and Myocardial Infarction, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia
    Arterioscler Thromb Vasc Biol 27:e9-15. 2007
    ..However, limitations with intravenous alphaIIb beta3 antagonists and failure of oral alphaIIb beta3 antagonists prompted doubts on the current concept of ligand-mimetic integrin blockade...
  38. ncbi Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C
    Simon Giuliano
    Department of Medicine, Australian Centre for Blood Diseases, Monash University, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Biochem J 372:163-72. 2003
    ..Furthermore, we have established the existence of PKC-dependent and -independent pathways regulating integrin alphaIIbbeta3 activation and stable platelet adhesion on vWf...
  39. ncbi Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor
    Yang Shen
    Department of Immunology and the Department of Biochemistry and Molecular Biology, Monash University, Victoria, 3800, Australia
    J Biol Chem 281:26419-23. 2006
    ..Together, these data demonstrate that LRR2-4, encompassing a pronounced negative charge patch on human GPIbalpha, is essential for GPIbalpha.VWF-dependent adhesion as hydrodynamic shear increases...
  40. ncbi Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury
    Kevin J Woollard
    Baker IDI Heart and Diabetes Institute, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Biol Chem 284:13110-8. 2009
    ....
  41. ncbi Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket
    Mark Frazzetto
    Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia
    Biochem J 414:383-90. 2008
    ....
  42. ncbi Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation
    Kevin J Woollard
    Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, 3004, Australia
    Circ Res 103:1128-38. 2008
    ....
  43. ncbi Imaging signaling processes in platelets
    Warwick S Nesbitt
    The Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Educational Precinct, Prahran, Victoria 3181, Australia
    Blood Cells Mol Dis 36:139-44. 2006
    ..This review broadly covers the application of existing imaging techniques to the investigation of platelet function and examines new developments in the area of live cell imaging that may have future applications in the field...
  44. ncbi Boosting platelet production
    Andrew Wei
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, 89 Commercial Road, Melbourne, Victoria 3004, Australia
    Nat Med 14:917-8. 2008
  45. ncbi A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood
    Francisco Javier Tovar-Lopez
    School of Electrical and Computer Engineering, RMIT University, Melbourne, Victoria, Australia
    Lab Chip 10:291-302. 2010
    ....
  46. ncbi Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha
    Pierre Mangin
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    Blood 104:420-7. 2004
    ..These studies demonstrate the existence of a second major 14-3-3zeta binding site within the cytoplasmic tail of GPIbalpha that has an important functional role in regulating integrin-dependent cell spreading...
  47. ncbi Novel role for insulin as an autocrine growth factor for malignant brain tumour cells
    Alexandre Arcaro
    Division of Clinical Chemistry and Biochemistry, University Children s Hospital Zurich, CH 8032 Zurich, Switzerland
    Biochem J 406:57-66. 2007
    ..Taken together, our results reveal a novel role for autocrine signalling by insulin and the IR in growth and survival of malignant human CNS tumour cells via the PI3K/Akt pathway...
  48. ncbi Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization
    Judith M E M Cosemans
    Department of Biochemistry and Human Biology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Blood 108:3045-52. 2006
    ..This novel concept of intrinsic, dynamic thrombus instability gives possibilities for the use of antiplatelet therapy...
  49. ncbi Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform
    Soochong Kim
    Department of Physiology and Pharmacology and the Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 110:4206-13. 2007
    ..These results demonstrate that IGF-1 plays a role in potentiating platelet aggregation by complementing G(i)- but not G(q)-signaling pathways via PI3-K p110alpha...
  50. ncbi Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
    Alison M Condliffe
    The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Blood 106:1432-40. 2005
    ..These results start to define which PI3K isoforms are responsible for modulating neutrophil responsiveness to infection and inflammation...
  51. ncbi Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA
    Pierre Mangin
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    J Biol Chem 278:32880-91. 2003
    ..Moreover, they demonstrate that GPIb-dependent calcium flux and cytoskeletal reorganization involves a signaling pathway distinct from that utilized by ITAM-containing receptors...
  52. ncbi Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex
    Christelle Perrault
    INSERM U311, Etablissement Français du Sang, Alsace, Strasbourg, France
    Blood 101:3477-84. 2003
    ....
  53. ncbi Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity
    Paola E J van der Meijden
    Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
    FEBS J 275:371-85. 2008
    ..Taken together, these results demonstrate a dual P2Y(12)-dependent signaling mechanism, which increases the platelet-activating effect of thrombin by prolongation of Ca(2+) elevation, thereby facilitating the coagulation process...
  54. ncbi Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling
    Claire Chaussade
    Maurice Wilkins Centre for Molecular Biodiscovery, Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem J 404:449-58. 2007
    ..Further, our results indicate that the degree of functional redundancy is linked to the relative levels of expression of each isoform in the target cells...
  55. ncbi Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors
    Jackie D Kendall
    Auckland Cancer Society Research Centre, School of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1020, New Zealand
    Bioorg Med Chem 15:7677-87. 2007
    ..Molecular modelling provides a rationalisation for the observed SAR...
  56. ncbi The clot thickens--oxidized lipids and thrombosis
    Shaun P Jackson
    Nat Med 13:1015-6. 2007
  57. ncbi A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis
    Matthew P McCormack
    Bone Marrow Research Laboratories, Royal Melbourne Hospital, Melbourne Health Research Directorate, c o Royal Melbourne Hospital Post Office, Grattan St, Parkville VIC 3050 Australia
    Blood 108:2248-56. 2006
    ..These findings suggest that Scl acts up-stream of NF-E2 expression to control megakaryocyte development and platelet release in settings of thrombopoietic stress...
  58. ncbi Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb
    Shaun P Jackson
    Blood 109:846-7; discussion 847-8. 2007