P R Gibson

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis
    P R Gibson
    Department of Gastroenterology, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 21:1399-409. 2005
  2. ncbi Reinforcing the mucus: a new therapeutic approach for ulcerative colitis?
    P R Gibson
    Monash University, Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 54:900-3. 2005
  3. ncbi Increased gut permeability in Crohn's disease: is TNF the link?
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 53:1724-5. 2004
  4. ncbi Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn's disease
    Peter R Gibson
    Monash University Department of Medicine and Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 22:1306-12. 2007
  5. ncbi Comparison of the efficacy and safety of Eudragit-L-coated mesalazine tablets with ethylcellulose-coated mesalazine tablets in patients with mild to moderately active ulcerative colitis
    P R Gibson
    The Royal Melbourne Hospital, Melbourne, Vic, Australia
    Aliment Pharmacol Ther 23:1017-26. 2006
  6. ncbi Overview of inflammatory bowel disease in Australia in the last 50 years
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 24:S63-8. 2009
  7. ncbi Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 25:252-8. 2010
  8. ncbi Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
  9. ncbi The concept of small intestinal bacterial overgrowth in relation to functional gastrointestinal disorders
    Peter R Gibson
    Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia
    Nutrition 26:1038-43. 2010
  10. ncbi Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon
    J S Barrett
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 31:874-82. 2010

Collaborators

Detail Information

Publications45

  1. ncbi Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis
    P R Gibson
    Department of Gastroenterology, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 21:1399-409. 2005
    ..The present paper describes a new hypothesis for one such environmental factor...
  2. ncbi Reinforcing the mucus: a new therapeutic approach for ulcerative colitis?
    P R Gibson
    Monash University, Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 54:900-3. 2005
    ..The simplicity and apparent safety of this therapeutic approach offers new insights into the importance of the mucus barrier in the pathogenesis and treatment of ulcerative colitis...
  3. ncbi Increased gut permeability in Crohn's disease: is TNF the link?
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 53:1724-5. 2004
  4. ncbi Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn's disease
    Peter R Gibson
    Monash University Department of Medicine and Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 22:1306-12. 2007
    ..This study aimed to correlate disease severity with health-related quality of life and with health-care resource use, to allow evaluation of the cost effectiveness of these treatments...
  5. ncbi Comparison of the efficacy and safety of Eudragit-L-coated mesalazine tablets with ethylcellulose-coated mesalazine tablets in patients with mild to moderately active ulcerative colitis
    P R Gibson
    The Royal Melbourne Hospital, Melbourne, Vic, Australia
    Aliment Pharmacol Ther 23:1017-26. 2006
    ..There are no comparative studies of coated mesalazine...
  6. ncbi Overview of inflammatory bowel disease in Australia in the last 50 years
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 24:S63-8. 2009
    ..Underpinning the success has been clinical excellence and adaptation of clinicians to the changing landscape of disease severity and therapeutic options. The future is indeed bright if such trends continue...
  7. ncbi Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 25:252-8. 2010
    ..The link between food intake and symptom induction is recognized. This review aims to describe the evidence base for restricting rapidly fermentable, short-chain carbohydrates (FODMAPs) in controlling such symptoms...
  8. ncbi Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
    ....
  9. ncbi The concept of small intestinal bacterial overgrowth in relation to functional gastrointestinal disorders
    Peter R Gibson
    Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia
    Nutrition 26:1038-43. 2010
    ..Controversy will continue until concepts are broadened, consensus in definition is reached, and evaluation of efficacy of candidate therapies is more rigorous...
  10. ncbi Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon
    J S Barrett
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 31:874-82. 2010
    ..Functional gut symptoms are induced by inclusion and reduced by dietary restriction of poorly absorbed short-chain carbohydrates (FODMAPs), but the mechanisms of action remain untested...
  11. ncbi Relationship of hydrolase activities to epithelial cell turnover in distal colonic mucosa of normal rats
    P R Gibson
    University of Melbourne Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia
    J Gastroenterol Hepatol 14:866-72. 1999
    ....
  12. ncbi Colonic epithelial cell activation and the paradoxical effects of butyrate
    P R Gibson
    University of Melbourne Department of Medicine, Victoria, Australia
    Carcinogenesis 20:539-44. 1999
    ..In conclusion, some of the paradoxical effects of butyrate do not appear to represent inherent differences between normal and transformed cells. Rather, the response may be determined by the state of activation of the cells...
  13. ncbi Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals
    J R Biesiekierski
    Department of Medicine, Monash University, Box Hill, Victoria, Australia
    J Hum Nutr Diet 24:154-76. 2011
    ..These and other short-chain carbohydrates can also be poorly absorbed in the small intestine (named fermentable oligo-, di- and monosaccharides and polyols; FODMAPs) and may have important implications for the health of the gut...
  14. ncbi Comparison of the prevalence of fructose and lactose malabsorption across chronic intestinal disorders
    J S Barrett
    Department of Medicine, Monash University and Box Hill Hospital, Level 8 Clive Ward Centre, 16 Arnold Street, Box Hill, VIC 3128, Australia
    Aliment Pharmacol Ther 30:165-74. 2009
    ..Fructose malabsorption, lactose malabsorption and an early rise in breath hydrogen after lactulose (ERBHAL) may play roles in induction of symptoms in gastrointestinal conditions...
  15. ncbi Management of distal ulcerative colitis: frequently asked questions analysis
    S L James
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 38:114-9. 2008
    ..The changes in guidelines have raised several management questions, many of which are addressed in this review...
  16. ncbi Delayed adverse reactions to total-dose intravenous iron polymaltose
    M L Haines
    Department of Gastroenterology and Hepatology, Monash University, Melbourne, Victoria, Australia
    Intern Med J 39:252-5. 2009
    ..Severe systemic reactions occurred in 8%. Patients should be warned of the chance of delayed reactions and an alternative iron preparation should be considered if parenteral iron is again indicated...
  17. ncbi The potential value of faecal lactoferrin as a screening test in hospitalized patients with diarrhoea
    D R Van Langenberg
    Monash University Department of Medicine, and Department of Gastroenterology and Hepatology, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 40:819-27. 2010
    ..This study aimed to determine the utility of faecal lactoferrin (FL), a readily measurable marker of intestinal inflammation, in hospitalized patients with diarrhoea...
  18. ncbi Review article: vitamin D and inflammatory bowel disease--established concepts and future directions
    M Garg
    Department of Gastroenterology and Hepatology, Eastern Health, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 36:324-44. 2012
    ..Its influence in IBD remains uncertain...
  19. ncbi Safety of iron polymaltose given as a total dose iron infusion
    E Newnham
    Department of Gastroenterology, Box Hill Hospital, Box Hill, Vic, Australia
    Intern Med J 36:672-4. 2006
    ..Fear of anaphylaxis should not inhibit the use of total dose iron infusion and the practices of premedication and of medical supervision during the first 15 min of the infusion should be abandoned...
  20. ncbi Diarrhoea during enteral nutrition is predicted by the poorly absorbed short-chain carbohydrate (FODMAP) content of the formula
    E P Halmos
    Department of Medicine, Monash University, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 32:925-33. 2010
    ..Although it is recognized that diarrhoea commonly complicates enteral nutrition, the causes remain unknown...
  21. ncbi Measurement of faecal fat excretion: an evaluation of attitudes and practices of Australian gastroenterologists
    M Lust
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 36:77-85. 2006
    ..Rather than discard the test, efforts should more appropriately be directed to improving baseline knowledge to ensure its optimal performance and interpretation...
  22. ncbi Mechanisms by which food intake elevates circulating levels of hyaluronan in humans
    J R E Fraser
    Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Melbourne, Vic, Australia
    J Intern Med 258:460-6. 2005
    ..The discriminating value of plasma hyaluronan in clinical practice may be greatly enhanced by sampling in fasted subjects at rest...
  23. ncbi Quality, clinical influence and tolerance of computed tomography enteroclysis in patients with suspected small bowel disease
    A Moss
    Department of Gastroenterology and Hepatology, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 39:733-43. 2009
    ..This study aimed to define the technical success, clinical influence and tolerance of CTE in patients with suspected small bowel disease...
  24. ncbi Vaccination and screening for infections in patients with inflammatory bowel disease: a survey of Australian gastroenterologists
    A Gupta
    Department of Gastroenterology, Westmead Hospital, Sydney, New South Wales, Australia
    Intern Med J 41:462-7. 2011
    ..To survey the practice among gastroenterologists in Australia relating to screening for latent infections and vaccination of patients with inflammatory bowel disease prior to treatment with tumour necrosis factor alpha (TNF-α) inhibitors...
  25. ncbi A rapid infusion protocol is safe for total dose iron polymaltose: time for change
    M Garg
    Department of Gastroenterology and Hepatology, Eastern Health, Melbourne, Victoria, Australia
    Intern Med J 41:548-54. 2011
    ..This results in reduced patient acceptance, and hospital resource strain. We aimed to assess prospectively the safety of a rapid intravenous protocol and compare this with historical controls...
  26. ncbi Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract
    M Garg
    Department of Gastroenterology and Hepatology, Eastern Health, Vic, Australia Eastern Health Clinical School, Monash University, 5 Arnold St, Box Hill, Victoria, Australia
    Aliment Pharmacol Ther 35:414-28. 2012
    ..The renin-angiotensin system (RAS) is a homeostatic pathway widely known to regulate cardiovascular and renal physiology; however, little is known about its influence in gastrointestinal tissues...
  27. ncbi Systematic review: The evidence base for long-term management of coeliac disease
    M L Haines
    Department of Gastroenterology, Monash University Department of Medicine, Box Hill Hospital, Box Hill, and Walter and Eliza Hall Institute, Parkville, Vic, Australia
    Aliment Pharmacol Ther 28:1042-66. 2008
    ..While gluten-free diet is an effective treatment for coeliac disease, the need for and goals of long-term management of patients are poorly defined...
  28. ncbi Systematic review: fatigue in inflammatory bowel disease
    D R Van Langenberg
    Monash University Department of Gastroenterology and Hepatology, Medicine, Box Hill Hospital, Box Hill, Melbourne, Vic, Australia
    Aliment Pharmacol Ther 32:131-43. 2010
    ..Fatigue is common, disabling yet underappreciated, in patients with chronic diseases, including inflammatory bowel disease (IBD)...
  29. ncbi Non-axial bone fracture but not depression as a risk factor for coeliac disease
    V P Tan
    Department of Gastroenterology, Monash University, and Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 40:225-7. 2010
    ..Patients presenting with non-axial fractures may be a subgroup in whom coeliac screening may be indicated. There needs to be greater awareness of atypical presentations of coeliac disease...
  30. ncbi Self-administered, inhaled methoxyflurane improves patient comfort during nasoduodenal intubation for computed tomography enteroclysis for suspected small bowel disease: a randomized, double-blind, placebo-controlled trial
    A Moss
    Department of Gastroenterology and Hepatology, Box Hill Hospital, Melbourne, Australia
    Clin Radiol 66:125-31. 2011
    ..To determine the efficacy and safety of self-administered, inhaled analgesic, methoxyflurane, used to improve patient comfort during computed tomography enteroclysis (CTE)...
  31. ncbi The fate of epithelial cells in the human large intestine
    D H Barkla
    Department of Anatomy, Monash University, Melbourne, Australia
    Pathology 31:230-8. 1999
    ..Apoptotic cells were rarely observed in the crypt epithelium. The findings of this study support the "recycling" model of epithelial cell death in the surface compartment of the human colon...
  32. ncbi Quantifying exposure to diagnostic medical radiation in patients with inflammatory bowel disease: are we contributing to malignancy?
    E Newnham
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 26:1019-24. 2007
    ..While potential risks of diagnostic medical radiation are acknowledged, actual exposure of patients in routine clinical practice is poorly documented...
  33. ncbi Dietary fibre: a roughage guide
    S L James
    Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    Intern Med J 33:291-6. 2003
    ..Nevertheless, encouraging the intake of a high-fibre diet is likely to have a range of health benefits and physicians are encouraged to follow simple practical guidelines in their everyday practice...
  34. ncbi Effect of dietary fatty acids on the intestinal permeability of marker drug compounds in excised rat jejunum
    D F Vine
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Australia
    J Pharm Pharmacol 54:809-19. 2002
    ..These studies indicate that dietary fatty acid changes can result in moderate changes to the active and passive transport properties of excised rat jejunum...
  35. ncbi Dietary fiber and colorectal neoplasia
    S Sengupta
    Department of Surgery, Colorectal Unit, Royal Melbourne Hospital and the University of Melbourne, Melbourne, Australia
    Dis Colon Rectum 44:1016-33. 2001
    ..Lifelong and early exposure may be important but are difficult to study. Other risk factors interact with the effects of dietary fiber...
  36. ncbi Review article: appropriate use of corticosteroids in Crohn's disease
    P M Irving
    Department of Gastroenterology, Box Hill Hospital and Monash University, Melbourne, Australia
    Aliment Pharmacol Ther 26:313-29. 2007
    ..Furthermore, their use is associated with a range of side effects, such that long-term treatment carries unacceptable risk...
  37. ncbi Hypoalbuminaemia and coeliac disease
    V Tan
    Department of Medicine, Box Hill Hospital, Box Hill, Victoria 3128 Australia
    Gut 57:922, 930. 2008
  38. ncbi Urokinase and the intestinal mucosa: evidence for a role in epithelial cell turnover
    P R Gibson
    Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia
    Gut 43:656-63. 1998
    ..The functions of urokinase in intestinal epithelia are unknown...
  39. ncbi Effects of methylnaltrexone in patients with narcotic bowel syndrome: a pilot observational study
    P R Gibson
    Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia
    Intern Med J 42:907-12. 2012
    ..Narcotic bowel syndrome (NBS) describes disabling chronic severe abdominal pain that worsens despite continuing or escalating doses of opiates. Therapy is very limited...
  40. ncbi Total body dual X-ray absorptiometry is a good measure of both fat mass and fat-free mass in liver cirrhosis compared to "gold-standard" techniques. Melbourne Liver Group
    B J Strauss
    Body Composition Laboratory, Monash Medical Centre, Victoria, Australia
    Ann N Y Acad Sci 904:55-62. 2000
    ....
  41. ncbi Use and abuse of faecal occult blood tests in an acute hospital inpatient setting
    A Friedman
    Eastern Health and Monash University, Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 40:107-11. 2010
    ..The role of the faecal occult blood test (FOBT) is untested. The aims of this study were to define the use of FOBT in a general hospital setting and to determine its influence on patient management...
  42. ncbi Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation
    J M Mariadason
    University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia
    Gastroenterology 120:889-99. 2001
    ..We determined whether response to butyrate is dependent on the basal differentiation status of colonic epithelial cells...
  43. ncbi Management of iron deficiency in patients admitted to hospital: time for a rethink of treatment principles
    I Ahmad
    Monash University Department of Medicine, Melbourne, Victoria, Australia
    Intern Med J 36:347-54. 2006
    ..CONCLUSION: Current management is haphazard, with underutilization of i.v. iron and failure to initiate any regimen for iron repletion being common. It may be time for a change in approach to repletion of iron in ill patients...
  44. ncbi Annular purpura and ulcerative colitis: response to infliximab
    V Tan
    Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    Dig Liver Dis 39:488-9. 2007
  45. ncbi Early Australian experience with infliximab, a chimeric antibody against tumour necrosis factor-alpha, in the treatment of Crohn's disease: is its efficacy augmented by steroid-sparing immunosuppressive therapy? The Infliximab User Group
    M Mortimore
    Royal Brisbane Hospital, Queensland, Australia
    Intern Med J 31:146-50. 2001
    ..The factors that determine a clinical response in some patients but not others are unknown...