P R Gibson

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis
    P R Gibson
    Department of Gastroenterology, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 21:1399-409. 2005
  2. pmc Reinforcing the mucus: a new therapeutic approach for ulcerative colitis?
    P R Gibson
    Monash University, Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 54:900-3. 2005
  3. ncbi request reprint Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
  4. ncbi request reprint Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn's disease
    Peter R Gibson
    Monash University Department of Medicine and Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 22:1306-12. 2007
  5. pmc Increased gut permeability in Crohn's disease: is TNF the link?
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 53:1724-5. 2004
  6. doi request reprint The concept of small intestinal bacterial overgrowth in relation to functional gastrointestinal disorders
    Peter R Gibson
    Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia
    Nutrition 26:1038-43. 2010
  7. ncbi request reprint Comparison of the efficacy and safety of Eudragit-L-coated mesalazine tablets with ethylcellulose-coated mesalazine tablets in patients with mild to moderately active ulcerative colitis
    P R Gibson
    The Royal Melbourne Hospital, Melbourne, Vic, Australia
    Aliment Pharmacol Ther 23:1017-26. 2006
  8. doi request reprint Overview of inflammatory bowel disease in Australia in the last 50 years
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 24:S63-8. 2009
  9. doi request reprint Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 25:252-8. 2010
  10. doi request reprint Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon
    J S Barrett
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 31:874-82. 2010

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis
    P R Gibson
    Department of Gastroenterology, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 21:1399-409. 2005
    ..The present paper describes a new hypothesis for one such environmental factor...
  2. pmc Reinforcing the mucus: a new therapeutic approach for ulcerative colitis?
    P R Gibson
    Monash University, Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 54:900-3. 2005
    ..The simplicity and apparent safety of this therapeutic approach offers new insights into the importance of the mucus barrier in the pathogenesis and treatment of ulcerative colitis...
  3. ncbi request reprint Review article: fructose malabsorption and the bigger picture
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 25:349-63. 2007
    ....
  4. ncbi request reprint Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn's disease
    Peter R Gibson
    Monash University Department of Medicine and Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 22:1306-12. 2007
    ..This study aimed to correlate disease severity with health-related quality of life and with health-care resource use, to allow evaluation of the cost effectiveness of these treatments...
  5. pmc Increased gut permeability in Crohn's disease: is TNF the link?
    P R Gibson
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria 3128, Australia
    Gut 53:1724-5. 2004
  6. doi request reprint The concept of small intestinal bacterial overgrowth in relation to functional gastrointestinal disorders
    Peter R Gibson
    Department of Medicine, Monash University, Box Hill Hospital, Victoria, Australia
    Nutrition 26:1038-43. 2010
    ..Controversy will continue until concepts are broadened, consensus in definition is reached, and evaluation of efficacy of candidate therapies is more rigorous...
  7. ncbi request reprint Comparison of the efficacy and safety of Eudragit-L-coated mesalazine tablets with ethylcellulose-coated mesalazine tablets in patients with mild to moderately active ulcerative colitis
    P R Gibson
    The Royal Melbourne Hospital, Melbourne, Vic, Australia
    Aliment Pharmacol Ther 23:1017-26. 2006
    ..There are no comparative studies of coated mesalazine...
  8. doi request reprint Overview of inflammatory bowel disease in Australia in the last 50 years
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 24:S63-8. 2009
    ..Underpinning the success has been clinical excellence and adaptation of clinicians to the changing landscape of disease severity and therapeutic options. The future is indeed bright if such trends continue...
  9. doi request reprint Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach
    Peter R Gibson
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Victoria, Australia
    J Gastroenterol Hepatol 25:252-8. 2010
    ..The link between food intake and symptom induction is recognized. This review aims to describe the evidence base for restricting rapidly fermentable, short-chain carbohydrates (FODMAPs) in controlling such symptoms...
  10. doi request reprint Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon
    J S Barrett
    Monash University Department of Medicine, Box Hill Hospital, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 31:874-82. 2010
    ..Functional gut symptoms are induced by inclusion and reduced by dietary restriction of poorly absorbed short-chain carbohydrates (FODMAPs), but the mechanisms of action remain untested...
  11. ncbi request reprint Relationship of hydrolase activities to epithelial cell turnover in distal colonic mucosa of normal rats
    P R Gibson
    University of Melbourne Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia
    J Gastroenterol Hepatol 14:866-72. 1999
    ....
  12. ncbi request reprint Colonic epithelial cell activation and the paradoxical effects of butyrate
    P R Gibson
    University of Melbourne Department of Medicine, Victoria, Australia
    Carcinogenesis 20:539-44. 1999
    ..In conclusion, some of the paradoxical effects of butyrate do not appear to represent inherent differences between normal and transformed cells. Rather, the response may be determined by the state of activation of the cells...
  13. ncbi request reprint Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals
    J R Biesiekierski
    Department of Medicine, Monash University, Box Hill, Victoria, Australia
    J Hum Nutr Diet 24:154-76. 2011
    ..These and other short-chain carbohydrates can also be poorly absorbed in the small intestine (named fermentable oligo-, di- and monosaccharides and polyols; FODMAPs) and may have important implications for the health of the gut...
  14. doi request reprint Comparison of the prevalence of fructose and lactose malabsorption across chronic intestinal disorders
    J S Barrett
    Department of Medicine, Monash University and Box Hill Hospital, Level 8 Clive Ward Centre, 16 Arnold Street, Box Hill, VIC 3128, Australia
    Aliment Pharmacol Ther 30:165-74. 2009
    ..Fructose malabsorption, lactose malabsorption and an early rise in breath hydrogen after lactulose (ERBHAL) may play roles in induction of symptoms in gastrointestinal conditions...
  15. doi request reprint Management of distal ulcerative colitis: frequently asked questions analysis
    S L James
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 38:114-9. 2008
    ..The changes in guidelines have raised several management questions, many of which are addressed in this review...
  16. doi request reprint The potential value of faecal lactoferrin as a screening test in hospitalized patients with diarrhoea
    D R Van Langenberg
    Monash University Department of Medicine, and Department of Gastroenterology and Hepatology, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 40:819-27. 2010
    ..This study aimed to determine the utility of faecal lactoferrin (FL), a readily measurable marker of intestinal inflammation, in hospitalized patients with diarrhoea...
  17. doi request reprint Delayed adverse reactions to total-dose intravenous iron polymaltose
    M L Haines
    Department of Gastroenterology and Hepatology, Monash University, Melbourne, Victoria, Australia
    Intern Med J 39:252-5. 2009
    ..Severe systemic reactions occurred in 8%. Patients should be warned of the chance of delayed reactions and an alternative iron preparation should be considered if parenteral iron is again indicated...
  18. ncbi request reprint Functional bowel symptoms and diet
    P R Gibson
    Department of Gastroenterology, Monash University and Alfred Hospital, Melbourne, Victoria, Australia
    Intern Med J 43:1067-74. 2013
    ..Future well-designed interventional studies will lead to refinement of dietary approaches taken and to a better understanding of their long-term safety. ..
  19. ncbi request reprint Dietary sorbitol and mannitol: food content and distinct absorption patterns between healthy individuals and patients with irritable bowel syndrome
    C K Yao
    Departments of Gastroenterology, Eastern Health and Central Clinical Schools, Monash University, Melbourne, Victoria, Australia
    J Hum Nutr Diet 27:263-75. 2014
    ..We aimed to expand data on food composition of these polyols, and to compare their absorptive capacities and symptom induction in patients with irritable bowel syndrome (IBS) and healthy individuals...
  20. doi request reprint Chronic pain in inflammatory bowel disease: characteristics and associations of a hospital-based cohort
    Graham Morrison
    Eastern Health Clinical School, Eastern Health, Monash University, Melbourne, Australia
    Inflamm Bowel Dis 19:1210-7. 2013
    ..This study aimed to examine its prevalence, severity, clinical associations, and impact on psychological well-being and to identify patient factors that independently predict the presence of severe/disabling pain...
  21. doi request reprint Review article: vitamin D and inflammatory bowel disease--established concepts and future directions
    M Garg
    Department of Gastroenterology and Hepatology, Eastern Health, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 36:324-44. 2012
    ..Its influence in IBD remains uncertain...
  22. ncbi request reprint Safety of iron polymaltose given as a total dose iron infusion
    E Newnham
    Department of Gastroenterology, Box Hill Hospital, Box Hill, Vic, Australia
    Intern Med J 36:672-4. 2006
    ..Fear of anaphylaxis should not inhibit the use of total dose iron infusion and the practices of premedication and of medical supervision during the first 15 min of the infusion should be abandoned...
  23. doi request reprint Nutritional inadequacies of the gluten-free diet in both recently-diagnosed and long-term patients with coeliac disease
    S J Shepherd
    Department of Gastroenterology and Central Clinical School, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    J Hum Nutr Diet 26:349-58. 2013
    ..Life-long gluten-free diet (GFD) is the only recognised treatment for coeliac disease (CD). The present study aimed to determine the nutritional adequacy of the 'no detectable gluten' diet...
  24. doi request reprint Diarrhoea during enteral nutrition is predicted by the poorly absorbed short-chain carbohydrate (FODMAP) content of the formula
    E P Halmos
    Department of Medicine, Monash University, Box Hill, Vic, Australia
    Aliment Pharmacol Ther 32:925-33. 2010
    ..Although it is recognized that diarrhoea commonly complicates enteral nutrition, the causes remain unknown...
  25. ncbi request reprint Mechanisms by which food intake elevates circulating levels of hyaluronan in humans
    J R E Fraser
    Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Melbourne, Vic, Australia
    J Intern Med 258:460-6. 2005
    ..It rises after eating, but mechanisms by which this occurs are not known. The study aimed at defining the effect of different food and liquid intake on plasma hyaluronan and to address mechanisms...
  26. doi request reprint Quality, clinical influence and tolerance of computed tomography enteroclysis in patients with suspected small bowel disease
    A Moss
    Department of Gastroenterology and Hepatology, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 39:733-43. 2009
    ..This study aimed to define the technical success, clinical influence and tolerance of CTE in patients with suspected small bowel disease...
  27. ncbi request reprint Measurement of faecal fat excretion: an evaluation of attitudes and practices of Australian gastroenterologists
    M Lust
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 36:77-85. 2006
    ....
  28. ncbi request reprint Delving into disability in Crohn's disease: dysregulation of molecular pathways may explain skeletal muscle loss in Crohn's disease
    D R Van Langenberg
    Department of Gastroenterology and Hepatology, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia Electronic address
    J Crohns Colitis 8:626-34. 2014
    ..This study aimed to measure and compare skeletal muscle size and molecular targets involved in skeletal muscle growth, in CD subjects and healthy controls...
  29. ncbi request reprint Cognitive impairment in coeliac disease improves on a gluten-free diet and correlates with histological and serological indices of disease severity
    I T Lichtwark
    School of Psychological Sciences, Monash University, Clayton, Australia
    Aliment Pharmacol Ther 40:160-70. 2014
    ..Mild impairments of cognition or 'Brain fog' are often reported by patients with coeliac disease but the nature of these impairments has not been systematically investigated...
  30. doi request reprint Association of doxycycline use with the development of gastroenteritis, irritable bowel syndrome and inflammatory bowel disease in Australians deployed abroad
    T W Lee
    Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia
    Intern Med J 43:919-26. 2013
    ..The risks are unknown for developing chronic gastrointestinal illness when personnel are relocated short term to other countries and when taking antibiotic prophylaxis in areas where malaria is endemic...
  31. doi request reprint Vaccination and screening for infections in patients with inflammatory bowel disease: a survey of Australian gastroenterologists
    A Gupta
    Department of Gastroenterology, Westmead Hospital, Sydney, New South Wales, Australia
    Intern Med J 41:462-7. 2011
    ..To survey the practice among gastroenterologists in Australia relating to screening for latent infections and vaccination of patients with inflammatory bowel disease prior to treatment with tumour necrosis factor alpha (TNF-α) inhibitors...
  32. doi request reprint A rapid infusion protocol is safe for total dose iron polymaltose: time for change
    M Garg
    Department of Gastroenterology and Hepatology, Eastern Health, Melbourne, Victoria, Australia
    Intern Med J 41:548-54. 2011
    ..This results in reduced patient acceptance, and hospital resource strain. We aimed to assess prospectively the safety of a rapid intravenous protocol and compare this with historical controls...
  33. doi request reprint Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract
    M Garg
    Department of Gastroenterology and Hepatology, Eastern Health, Vic, Australia Eastern Health Clinical School, Monash University, 5 Arnold St, Box Hill, Victoria, Australia
    Aliment Pharmacol Ther 35:414-28. 2012
    ..The renin-angiotensin system (RAS) is a homeostatic pathway widely known to regulate cardiovascular and renal physiology; however, little is known about its influence in gastrointestinal tissues...
  34. ncbi request reprint Dietary fibre: a roughage guide
    S L James
    Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    Intern Med J 33:291-6. 2003
    ..Nevertheless, encouraging the intake of a high-fibre diet is likely to have a range of health benefits and physicians are encouraged to follow simple practical guidelines in their everyday practice...
  35. ncbi request reprint The fate of epithelial cells in the human large intestine
    D H Barkla
    Department of Anatomy, Monash University, Melbourne, Australia
    Pathology 31:230-8. 1999
    ..Apoptotic cells were rarely observed in the crypt epithelium. The findings of this study support the "recycling" model of epithelial cell death in the surface compartment of the human colon...
  36. doi request reprint Self-administered, inhaled methoxyflurane improves patient comfort during nasoduodenal intubation for computed tomography enteroclysis for suspected small bowel disease: a randomized, double-blind, placebo-controlled trial
    A Moss
    Department of Gastroenterology and Hepatology, Box Hill Hospital, Melbourne, Australia
    Clin Radiol 66:125-31. 2011
    ..To determine the efficacy and safety of self-administered, inhaled analgesic, methoxyflurane, used to improve patient comfort during computed tomography enteroclysis (CTE)...
  37. doi request reprint Systematic review: fatigue in inflammatory bowel disease
    D R Van Langenberg
    Monash University Department of Gastroenterology and Hepatology, Medicine, Box Hill Hospital, Box Hill, Melbourne, Vic, Australia
    Aliment Pharmacol Ther 32:131-43. 2010
    ..Fatigue is common, disabling yet underappreciated, in patients with chronic diseases, including inflammatory bowel disease (IBD)...
  38. doi request reprint Non-axial bone fracture but not depression as a risk factor for coeliac disease
    V P Tan
    Department of Gastroenterology, Monash University, and Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 40:225-7. 2010
    ..Patients presenting with non-axial fractures may be a subgroup in whom coeliac screening may be indicated. There needs to be greater awareness of atypical presentations of coeliac disease...
  39. doi request reprint Systematic review: The evidence base for long-term management of coeliac disease
    M L Haines
    Department of Gastroenterology, Monash University Department of Medicine, Box Hill Hospital, Box Hill, and Walter and Eliza Hall Institute, Parkville, Vic, Australia
    Aliment Pharmacol Ther 28:1042-66. 2008
    ..While gluten-free diet is an effective treatment for coeliac disease, the need for and goals of long-term management of patients are poorly defined...
  40. ncbi request reprint Quantifying exposure to diagnostic medical radiation in patients with inflammatory bowel disease: are we contributing to malignancy?
    E Newnham
    Department of Gastroenterology and Monash University Department of Medicine, Box Hill Hospital, Victoria, Australia
    Aliment Pharmacol Ther 26:1019-24. 2007
    ..While potential risks of diagnostic medical radiation are acknowledged, actual exposure of patients in routine clinical practice is poorly documented...
  41. ncbi request reprint Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity - an exploratory clinical study
    S L Peters
    Department of Gastroenterology, Central Clinical School, Monash University, The Alfred Hospital, Melbourne, Vic, Australia
    Aliment Pharmacol Ther 39:1104-12. 2014
    ..Current evidence suggests that many patients with self-reported non-coeliac gluten sensitivity (NCGS) retain gastrointestinal symptoms on a gluten-free diet (GFD) but continue to restrict gluten as they report 'feeling better'...
  42. doi request reprint Effects of methylnaltrexone in patients with narcotic bowel syndrome: a pilot observational study
    P R Gibson
    Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia
    Intern Med J 42:907-12. 2012
    ..Narcotic bowel syndrome (NBS) describes disabling chronic severe abdominal pain that worsens despite continuing or escalating doses of opiates. Therapy is very limited...
  43. doi request reprint Hypoalbuminaemia and coeliac disease
    V Tan
    Department of Medicine, Box Hill Hospital, Box Hill, Victoria 3128 Australia
    Gut 57:922, 930. 2008
  44. ncbi request reprint Review article: appropriate use of corticosteroids in Crohn's disease
    P M Irving
    Department of Gastroenterology, Box Hill Hospital and Monash University, Melbourne, Australia
    Aliment Pharmacol Ther 26:313-29. 2007
    ..Furthermore, their use is associated with a range of side effects, such that long-term treatment carries unacceptable risk...
  45. ncbi request reprint Dietary fiber and colorectal neoplasia
    S Sengupta
    Department of Surgery, Colorectal Unit, Royal Melbourne Hospital and the University of Melbourne, Melbourne, Australia
    Dis Colon Rectum 44:1016-33. 2001
    ..Lifelong and early exposure may be important but are difficult to study. Other risk factors interact with the effects of dietary fiber...
  46. ncbi request reprint Effect of dietary fatty acids on the intestinal permeability of marker drug compounds in excised rat jejunum
    D F Vine
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Parkville, Australia
    J Pharm Pharmacol 54:809-19. 2002
    ..These studies indicate that dietary fatty acid changes can result in moderate changes to the active and passive transport properties of excised rat jejunum...
  47. pmc Urokinase and the intestinal mucosa: evidence for a role in epithelial cell turnover
    P R Gibson
    Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia
    Gut 43:656-63. 1998
    ..The functions of urokinase in intestinal epithelia are unknown...
  48. doi request reprint Objectively measured muscle fatigue in Crohn's disease: correlation with self-reported fatigue and associated factors for clinical application
    D R Van Langenberg
    Department of Gastroenterology and Hepatology, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia Electronic address
    J Crohns Colitis 8:137-46. 2014
    ..We aimed to measure and compare self-reported fatigue with skeletal muscle fatigue in CD subjects and healthy controls, and to identify associated factors that may be amenable to change...
  49. ncbi request reprint Annular purpura and ulcerative colitis: response to infliximab
    V Tan
    Department of Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia
    Dig Liver Dis 39:488-9. 2007
  50. ncbi request reprint Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation
    J M Mariadason
    University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia
    Gastroenterology 120:889-99. 2001
    ..We determined whether response to butyrate is dependent on the basal differentiation status of colonic epithelial cells...
  51. ncbi request reprint Total body dual X-ray absorptiometry is a good measure of both fat mass and fat-free mass in liver cirrhosis compared to "gold-standard" techniques. Melbourne Liver Group
    B J Strauss
    Body Composition Laboratory, Monash Medical Centre, Victoria, Australia
    Ann N Y Acad Sci 904:55-62. 2000
    ....
  52. doi request reprint Use and abuse of faecal occult blood tests in an acute hospital inpatient setting
    A Friedman
    Eastern Health and Monash University, Department of Medicine, Box Hill Hospital, Melbourne, Victoria, Australia
    Intern Med J 40:107-11. 2010
    ..The role of the faecal occult blood test (FOBT) is untested. The aims of this study were to define the use of FOBT in a general hospital setting and to determine its influence on patient management...
  53. ncbi request reprint Management of iron deficiency in patients admitted to hospital: time for a rethink of treatment principles
    I Ahmad
    Monash University Department of Medicine, Melbourne, Victoria, Australia
    Intern Med J 36:347-54. 2006
    ..Iron deficiency is very common in patients admitted to hospital. Its management is changing with new insights into iron absorption and therapeutic options...
  54. ncbi request reprint Early Australian experience with infliximab, a chimeric antibody against tumour necrosis factor-alpha, in the treatment of Crohn's disease: is its efficacy augmented by steroid-sparing immunosuppressive therapy? The Infliximab User Group
    M Mortimore
    Royal Brisbane Hospital, Queensland, Australia
    Intern Med J 31:146-50. 2001
    ..The factors that determine a clinical response in some patients but not others are unknown...