F Cicuttini

..Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs...

..The aim of this cross-sectional study was to describe the relationships between parameters of patellofemoral geometry (patella inclination, sulcus angle and patella height) and knee pain and patella cartilage volume...

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..The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies...

..We aimed to characterize the beliefs that community-dwelling women have about back pain and its consequences, and to determine whether those with varying levels of pain intensity and disability differ in their beliefs...

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..It is unknown whether the adipose mass and the distribution of adipose mass are associated with the risk of primary knee and hip replacement for osteoarthritis. The aim of the present investigation was to examine this in a cohort study...

..The aim of this study was to determine whether serum levels of hsCRP are associated with the variation in tibial and patella cartilage volumes in women without evidence of OA...

..While our findings need to be confirmed by longitudinal studies, they highlight the potential of the diet to modify the risk of osteoarthritis...

..The aim of this study was to describe the associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults...

..The aim of this study was to examine the association between fatty acid consumption and the incidence of BMLs in healthy middle-aged adults without clinical knee OA...

..Joint loading mediated via gait parameters may be associated with meniscal tears, and determining whether such an association exists was the aim of this study...

..The aim of this study was to compare the rates of primary joint replacement for osteoarthritis for Italian and Greek migrants to Australia and Australian-born individuals...

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..To examine the relationship between development or resolution of bone marrow lesions (BMLs) and knee cartilage properties in a 2 year prospective study of asymptomatic middle-aged adults...

..They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI...

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..The aim of this study was to examine potential determinants of vastus medialis and lateralis cross-sectional areas and the relationship between the cross-sectional area and patella cartilage and bone volumes...

..The role of subchondral bone change in the pathogenesis of knee OA will need to be determined but may be one explanation for the mechanism of action of risk factors such as body mass index on knee OA...

..Recommendations for future studies of physical activity and the development of knee osteoarthritis are discussed...

..This may enable the prediction of cartilage change in an individual. The only significant factor affecting the loss of medial tibial cartilage was baseline knee pain, possibly through altered joint loading...

..To compare tibial cartilage volume as measured by magnetic resonance imaging (MRI) with radiologic assessment of the tibiofemoral joint...

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..We examined whether there is a difference in cartilage loss in those who undergo a partial meniscectomy compared to healthy controls...

..This study examined the effect of measures of body composition on the longitudinal change in tibial cartilage volume...

..The aim of this study was to examine the association between cartilage defects in the knee and cartilage volume both cross-sectionally and longitudinally in healthy, middle-age adults...

..The rate of change in patella articular cartilage and factors influencing it, in subjects with osteoarthritis (OA), is unknown. We performed a cohort study to determine this...

..However, the effect on patellofemoral OA is unknown. The aim of this study was to test the hypothesis that long term ERT (greater than 5 years) is associated with increased patella cartilage in post menopausal women...

..We compared cartilage volume measured from MRI of the knees using different slice thicknesses (1.5 to 7.5 mm) and assessed longitudinal change...

..In this study we compared patella cartilage volume as measured by magnetic resonance imaging (MRI) with radiological assessment of the patellofemoral joint...

..To compare radiological assessment of the patellofemoral (PF) joint and cartilage volume as measured by magnetic resonance imaging (MRI) in a longitudinal study...

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..We conducted a cross-sectional study to determine the relationship between knee cartilage volume, a direct measure of joint cartilage, and bone mineral density (BMD) in an adult population...

..To determine whether cartilage volume loss is an independent predictor of knee replacement...

..We investigated whether there are compartment differences in the volume of knee cartilage in healthy persons and identified determinants of medial and lateral tibial cartilage volume...

..CONCLUSIONS: After adjustment for multiple confounders, women using long term ERT have more knee cartilage than controls. This may indicate that ERT prevents loss of knee articular cartilage...

..We performed a longitudinal study to compare change in both JSW and articular cartilage volume in subjects with symptomatic knee OA...

..This study in a healthy, pain-free population aimed to examine the natural history of BML; factors associated with incidence and progression of BML over 2 years and whether incident BML are associated with the development of pain...

..The aim of this study was to examine the progression of cartilage defects over 2 years in people with knee OA and to identify factors associated with progression...

..This cross-sectional study investigated the relationship between the shape of the trochlear groove and patella cartilage and bone morphology in healthy adults...

..CONCLUSIONS: Baseline knee angle is associated with the rate of cartilage loss in the knee. Further work will be needed to determine whether therapies aimed at modifying the knee angle will reduce the progression of knee OA...

..The aim of this study was to explore the determinants of change in patella cartilage volume over 2 yrs among healthy middle-aged women with no clinical knee OA...

..To evaluate the relationship between serum testosterone (T), preandrogens and sex hormone binding globulin (SHBG), and the knee structure in middle-aged women without knee pain...

..To evaluate the effects of age, physical activity, and body mass index (BMI) on patella cartilage volume and defects and bone volume in middle-aged women without knee pain...

..The aim of this study was to determine the risk factors for BMLs in healthy subjects and the association of BMLs with knee structure...

..to determine the effects of exercise on metabolic and morphological outcomes among people with HIV using a systematic search strategy of randomized, controlled trials (RCTs)...

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..To determine whether smoking affects knee cartilage in healthy adults by examining the association of tobacco use with tibial cartilage volume and tibiofemoral cartilage defects...

..Short term clinical studies using vitamin E in the form of alpha-tocopherol suggested a benefit over placebo of similar dimension to that of diclofenac for relief of OA pain...

..The extent and underlying mechanisms for these sex-related differences in general anaesthesia are unclear...

..Although the electoral roll mail-out and newspaper advertising were the most efficient for this study, other methods may be of value for studies with different subject selection criteria...

..To understand the factors that influence joint cartilage in health and disease as they are important for the prevention and management of osteoarthritis...

..In knee OA, the presence of bone marrow lesions (BMLs) predicts pain and progression of disease. Their occurrence has been described in healthy, pain-free subjects, but whether their presence affects change in cartilage is unknown...

..However, little work has been done to investigate the effect of fatty acids on bone marrow lesions and knee cartilage in healthy subjects. We examined this in a cohort of healthy middle-aged subjects without clinical knee OA...

..The aim of this study was to determine the cross-sectional and longitudinal relationships between frontal plane knee alignment and patella cartilage volume in people with knee OA...

..Aches and stiff joints, common in postmenopausal women, are not necessarily indicative of radiological osteoarthritis...

..Bone marrow lesions (BML) are important in established knee osteoarthritis, predicting pain and progression of disease. Whether BML are also associated with longitudinal changes in knee structure in an asymptomatic population is unknown...

..The aim of this study was to determine whether change in knee alignment between baseline and 2 years is associated with a change in knee cartilage volume in knee OA in the subsequent 2.5 years...

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..The aim of this study was to investigate the nature of orthopaedic trauma admitted to adult Level 1 Trauma Centres...

..Male gender and baseline cartilage defect score were the main factors associated with the progression of cartilage defects. Larger studies will be required to identify factors associated with the progression and regression of lesions...

..Further work is required to determine whether interventions aimed at correcting these relatively minor levels of varus and valgus angulation will have an effect on the risk of tibiofemoral OA...

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..CONCLUSIONS: With increasing severity of radiographic knee osteoarthritis, tibial plateau size increases. Whether this bone increase plays a role in the pathogenesis of osteoarthritis remains to be determined...

..To assess whether three proposed quality-of-care indicators (unplanned readmissions, hospital-acquired bacteraemia, and postoperative wound infection) can be accurately identified from State health department databases...

..The aim of this study was to examine the relationship between the femoral sulcus angle at baseline and patella cartilage volume at baseline and at 2-year follow-up among community based adults with established knee OA...

..CONCLUSIONS: Mean tibial cartilage volume loss in healthy postmenopausal women is between 1.5% and 3.2% a year. Whether this rate of change is similar throughout adult life or in men will require further investigation...

..057). CONCLUSIONS: Further studies will be required to determine whether hormonal manipulation or treatment with antiresorptive drugs will reduce the risk of knee osteoarthritis in men in later life...

..The aim of this study was to determine whether measures of obesity and adiposity are associated with the rate of patella cartilage volume loss in healthy adults...

..6, 22.3), independently of potential confounders. CONCLUSIONS: Articular cartilage defects are associated with disease severity in knee OA and predict patellar cartilage loss and knee replacement...

..No consistent relationship between the severity of symptoms of knee osteoarthritis (OA) and radiographic change has been demonstrated...

..These results may have important implications for people who hyperextend their knee during gait and the pathogenesis of patellofemoral osteoarthritis...

..This chapter will examine imaging modalities in the assessment of knee OA, and the impact of these on our understanding of the pathogenesis of this disease...

..To determine the question that best predicts radiographic evidence of non-axial osteoarthritis (OA)...

..Further work will be needed to determine the effect of subchondral bone change in the pathogenesis of knee OA...

..The most appropriate method of cast immobilisation is presently unclear but evidence exists for improved clinical outcomes in those that have both the thumb and elbow immobilised for the first six weeks...

..The aim of this cross-sectional study was to determine the relationship between the vasti muscles and patella cartilage volume and defects and patella bone volume...

..6mg fluoride per day for one-four years. CONCLUSION: These studies provide a substantial body of evidence that fluoride at up to 1ppm does not have an adverse effect on bone strength, bone mineral density or fracture incidence...

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..There is controversy about whether pain and radiographic osteoarthritis (ROA) predict subsequent cartilage loss. The aim of this study was to describe the relationship between ROA, pain and cartilage loss in the knee...

..These gender differences seem to be more pronounced in premenopausal women, suggesting hormonal mechanisms are a major contributing factor...

..These findings are of concern, given the evidence-based benefits of regular physical activity. Further work is needed to identify barriers to participation and interventions that can improve uptake...

..Obesity is the main preventable risk factor that has been identified. Given that obesity is modifiable by conservative treatment such as weight loss, its potential importance in reducing the incidence of OA cannot be underestimated...

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..To examine the relationships between well-being and different levels of both low back pain intensity and disability in women living in the community...

..This paper hypothesizes that leptin may be an unexamined systemic or local factor that may mediate the metabolic link between obesity and OA and partially account for the gender disparity toward the disease...

..It may be that the effect of the knee adduction moment differs in healthy subjects compared with those with established knee OA...

..Biomedical studies are required to differentiate between the causes and results of knee osteoarthritis...

..To estimate prospectively any association between measures of physical activity and the risk of either primary knee or hip replacement due to osteoarthritis (OA)...

..Although obesity is a risk factor for patellofemoral osteoarthritis (OA), it is unclear whether the components of body composition, such as muscle and fat mass, are major determinants of articular cartilage properties at the patella...

..The aim of this study was to examine the cross-sectional relationship between exercise and knee joint cartilage in women at midlife...

..Further study is required to determine whether the rate of cartilage loss in OA is steady or phasic, and to identify factors amenable to intervention to reduce cartilage loss...

..Studies are needed to determine the role of bone metabolism in the pathogenesis of knee OA...

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..The current study aimed to investigate the outcomes of patients admitted with a range of orthopaedic injuries to adult Level 1 trauma centres...

..Further work will be required to determine whether the rate of patella cartilage loss in healthy subjects is steady or phasic, and to determine which factors can be modified to reduce cartilage loss...

..Little is known about their role in the knee in those without clinical OA. Our aim was to examine the prevalence and risk factors for BML, and their relationship with other knee structures in community-based adults without clinical OA...