Affiliation: Monash University
Allan K, Perez K, Barnham K, Camakaris J, Burke R. A commonly used Drosophila model of Alzheimer's disease generates an aberrant species of amyloid-Î² with an additional N-terminal glutamine residue. FEBS Lett. 2014;588:3739-43 pubmed publisher
..These data reveal that a commonly used model of Alzheimer's disease generates incorrect AÎ² peptide. ..
Richards C, Burke R. Local and systemic effects of targeted zinc redistribution in Drosophila neuronal and gastrointestinal tissues. Biometals. 2015;28:967-74 pubmed publisher
Dechen K, Richards C, Lye J, Hwang J, Burke R. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Int J Biochem Cell Biol. 2015;60:23-33 pubmed publisher
..This research highlights the differential effects that redistribution of zinc can have within a particular tissue and identifies the Golgi as being particularly sensitive to both excess and insufficient zinc. ..
Mercer S, Wang J, Burke R. In Vivo Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease. J Biol Chem. 2017;292:4113-4122 pubmed publisher
Wang J, Binks T, Warr C, Burke R. Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake. Metallomics. 2014;6:2100-8 pubmed publisher
..These results suggest that metal ion transport is particularly sensitive to disturbances in cellular protein localization processes. ..
Hwang J, de Bruyne M, Warr C, Burke R. Copper overload and deficiency both adversely affect the central nervous system of Drosophila. Metallomics. 2014;6:2223-9 pubmed publisher
..We conclude that both copper overload and excess have detrimental effects on Drosophila neuronal function, reducing overall fly viability as well as impacting on a specific neuropeptide pathway. ..
Richards C, Warr C, Burke R. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. Int J Biochem Cell Biol. 2015;69:11-9 pubmed publisher
..We postulate that dZIP89B works in concert with the closely related dZIP42C.1 and 2 to ensure optimal zinc absorption under a range of dietary conditions. ..
Richards C, Burke R. A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila. Arch Biochem Biophys. 2016;611:142-149 pubmed publisher
..Finally, the future research potential of the fly in nutrient metabolism is explored, with reference to emerging experimental technologies. ..