Research Topics
Genomes and Genes | H G BurgerSummaryAffiliation: Monash University Country: Australia Publications
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Publications
Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of womenH G Burger
Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
J Clin Endocrinol Metab 84:4025-30. 1999....
Hormonal changes in the menopause transitionHenry G Burger
Prince Henry s Institute of Medical Research at Monash Medical Centre, Clayton, Victoria, Australia
Recent Prog Horm Res 57:257-75. 2002....
Androgen production in womenHenry G Burger
Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
Fertil Steril 77:S3-5. 2002..To describe the sources, production rates, circulating concentrations, and regulatory mechanisms of the major androgen precursors and androgens in women...
Physiological principles of endocrine replacement: estrogenH G Burger
Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton Road, Clayton 3168 Victoria, Australia
Horm Res 56:82-5. 2001....
The inhibins and ovarian cancerH G Burger
Prince Henry s Institute of Medical Research, PO Box 5152, VIC 3168, Clayton, Australia
Mol Cell Endocrinol 180:145-8. 2001..Findings to date have been largely negative with no evidence for activating mutations of the FSH receptor or of the post-receptor signalling pathway proteins...
A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transitionH G Burger
Prince Henry s Institute of Medical Research, Monash Medical Center, Clayton, Victoria, Australia
J Clin Endocrinol Metab 85:2832-8. 2000..DHEAS decreases as a function of age, not time relative to FMP, and T remains unchanged during the menopausal years. SHBG and DHEAS show a high degree of stability within an individual over time...
Both inhibin A and B respond to exogenous follicle-stimulating hormone in the follicular phase of the human menstrual cycleH G Burger
Prince Henry s Institute of Medical Research, Monash Medical Center, Clayton, Victoria, Australia
J Clin Endocrinol Metab 83:4167-9. 1998....
Bone turnover markers and bone density across the menopausal transitionP R Ebeling
Bone and Mineral Service, University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
J Clin Endocrinol Metab 81:3366-71. 1996..In conclusion, the perimenopause is associated with elevated bone resorption rates and declining BMD, and factors in addition to estrogen deficiency may also contribute to the pathogenesis of postmenopausal osteoporosis...
Inhibins/activins as diagnostic markers for ovarian cancerD M Robertson
Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, VIC 3168, Australia
Mol Cell Endocrinol 191:97-103. 2002..Furthermore, based on the high sensitivity/specificity characteristics of the respective assays for the various types of ovarian cancer, the combination of the inhibin assay with CA125 detects the majority of all ovarian cancers...
FSH-regulated gene expression profiles in ovarian tumours and normal ovariesS Chu
Prince Henry s Institute of Medical Research and the Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, 3168, Australia
Mol Hum Reprod 8:426-33. 2002..Comparison of the gene expression profiles between each tumour group suggests a molecular phenotype for GCT that is similar to that reported for FSH stimulated pre-ovulatory granulosa cells...
Combined inhibin and CA125 assays in the detection of ovarian cancerD M Robertson
Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
Clin Chem 45:651-8. 1999....
A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women's Midlife Health ProjectH G Burger
Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
Hum Reprod Update 13:559-65. 2007..This review provides the background for an accompanying manuscript in which a novel approach to modelling the hormonal changes during the transition is described...
Effects of 31 kDa bovine inhibin on FSH and LH in rat pituitary cells in vitro: antagonism of gonadotrophin-releasing hormone agonistsP G Farnworth
Medical Research Centre, Prince Henry s Hospital, Melbourne, Victoria, Australia
J Endocrinol 119:233-41. 1988..After a 3-day pretreatment, inhibin inhibited gonadotrophin release by buserelin less effectively than that by GnRH, but the pattern of antagonism was the same.(ABSTRACT TRUNCATED AT 250 WORDS)..
A prospective study of bone loss in menopausal Australian-born womenJ R Guthrie
Department of Psychiatry, Royal Melbourne Hospital, Victoria, Australia
Osteoporos Int 8:282-90. 1998..05), such that women with higher BMI had less bone loss. In conclusion, during the time of transition from peri- to post-menopause, women had accelerated BMD loss at both the hip and spine...
The menopausal transition: a 9-year prospective population-based study. The Melbourne Women's Midlife Health ProjectJ R Guthrie
Office for Gender and Health, Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia
Climacteric 7:375-89. 2004..To determine the hormonal changes relating to the menopausal transition (MT) and how these affect quality of life, bone mineral density, body composition, cardiovascular disease (CVD) risk and memory...
Inhibin forms in serum from postmenopausal women with ovarian cancersD M Robertson
Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
Clin Endocrinol (Oxf) 50:381-6. 1999..The aim of the study was to identify the forms of inhibin found in a range of ovarian cancers using a range of inhibin assays with varying specificities...
Impaired fasting glycaemia in middle-aged women: a prospective studyJ R Guthrie
Office for Gender and Health, The University of Melbourne, RMH, Victoria, Australia
Int J Obes Relat Metab Disord 25:646-51. 2001....
Characterization of inhibin forms and their measurement by an inhibin alpha-subunit ELISA in serum from postmenopausal women with ovarian cancerD M Robertson
Prince Henry s Institute of Medical Research, Clayton, Victoria 3168, Australia
J Clin Endocrinol Metab 87:816-24. 2002..These new monoclonal antibody-based inhibin alphaC ELISAs now provide practical and sensitive assays suitable for evaluation as diagnostic tests for monitoring ovarian cancers...
Serum C-reactive protein and plasma homocysteine levels are associated with hormone therapy use and other factors: a population-based study of middle-aged Australian-born womenJ R Guthrie
Office for Gender and Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Climacteric 8:263-70. 2005..CONCLUSION: In middle-aged Australian-born women, HT use was associated with increased CRP and decreased homocysteine levels. High CRP levels were also associated with high relative weight, low exercise levels and no statin medication...
Inhibin/activin and ovarian cancerD M Robertson
Prince Henry s Institute of Medical Research, PO 5152, Clayton, Victoria 3168, Australia
Endocr Relat Cancer 11:35-49. 2004..In order to place these findings into perspective the biology of inhibin/activin and of other members of the TGFbeta superfamily is also discussed...
Testosterone therapy prevents gain in visceral adipose tissue and loss of skeletal muscle in nonobese aging menC A Allan
Prince Henry s Institute, Monash University, Clayton, Victoria 3168, Australia
J Clin Endocrinol Metab 93:139-46. 2008..Trials of testosterone therapy in aging men have demonstrated increases in fat-free mass (FFM) and skeletal muscle and decreases in fat mass (FM) but have not reported the impact of baseline body composition...
Inhibins and activins: clinical advances in reproductive medicineStephen Tong
Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia
Clin Endocrinol (Oxf) 58:115-27. 2003
A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profilesDavid M Robertson
Prince Henry s Institute, Monash Medical Centre, Clayton, Victoria, Australia
Menopause 15:1139-44. 2008..To characterize menstrual cycles in women in late reproductive age and the menopause transition, based on changes in serum hormone levels...
Cycle and hormone changes during perimenopause: the key role of ovarian functionHenry G Burger
Prince Henry s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria, Australia
Menopause 15:603-12. 2008..There is no specific endocrine marker of the early or late transition, making measurements of FSH or E2 unreliable in attempting to stage an individual with regard to approaching menopause...
Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive ageDavid M Robertson
Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
J Clin Endocrinol Metab 94:138-44. 2009..Ovarian hormones regulate pituitary gonadotropin secretion across the menstrual cycle via negative and positive feedback mechanisms. The contribution of individual hormones is complex and is a continuing area of research...
Effects of bovine 35 kDa FSH-suppressing protein on FSH and LH in rat pituitary cells in vitro: comparison with bovine 31 kDa inhibinD M Robertson
Department of Anatomy, Monash University, Clayton, Victoria, Australia
J Endocrinol 124:417-23. 1990..The effect of FSP on FSH cell content after 3 days in culture was insensitive to the neutralizing effects of an inhibin antiserum.(ABSTRACT TRUNCATED AT 250 WORDS)..
Differing effects of low-dose estrogen-progestin therapy and pravastatin in postmenopausal hypercholesterolemic womenS R Davis
The Jean Hailes Foundation Research Unit, Clayton South, Victoria, Australia
Climacteric 5:341-50. 2002....
Estrogen receptor isoform gene expression in ovarian stromal and epithelial tumorsS Chu
Prince Henry s Institute of Medical Research and the Monash University Department of Obstetrics and Gynecology, Monash Medical Center, Clayton, Victoria, Australia
J Clin Endocrinol Metab 85:1200-5. 2000..As ERbeta(cx) has been shown to be a ligand-independent antagonist of ERalpha action, the relative ratios of ERbeta(cx), ERalpha, and ERbeta may influence the response of a tumor to antiestrogen therapy...
The relationship between the endocrine characteristics and the regularity of menstrual cycles in the approach to menopauseHenry G Burger
Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
Menopause 12:267-74. 2005..We sought to determine whether the onset of irregular menses, marking the menopause transition, signifies the occurrence of anovulatory, potentially infertile cycles...
The relative effect of endogenous estradiol and androgens on menopausal bone loss: a longitudinal studyJanet R Guthrie
Office for Gender and Health, Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Charles Connibere Building, Melbourne, Victoria, Australia
Osteoporos Int 15:881-6. 2004..The aim of this study was to assess the relative strength of the association of endogenous estradiol and androgens with bone loss at the lumbar spine and femoral neck during the menopausal transition...
Molecular pathogenesis of granulosa cell tumoursPeter J Fuller
Prince Henry s Institute of Medical Research, PO Box 5152, Clayton, VIC 3168, Australia
Mol Cell Endocrinol 191:89-96. 2002..These observations provide a basis for future studies of GCT, including further characterisation of signalling pathways known to be important in the regulation of granulosa cell growth and differentiation...
The ageing female reproductive axis IHenry G Burger
Prince Henry's Institute of Medical Research, Monash Medical Centre, Clayton, Australia
Novartis Found Symp 242:161-7; discussion 167-71. 2002..In contrast, total testosterone concentrations are maintained across the menopausal transition, with a fall in sex hormone binding globulin (SHBG) and hence a rise in free testosterone...
Inhibin-activin receptor subunit gene expression in ovarian tumorsPeter J Fuller
Prince Henry s Institute of Medical Research and Monash University, Department of Obstetrics and Gynecology, Monash Medical Center, Clayton, Victoria 3168, Australia
J Clin Endocrinol Metab 87:1395-401. 2002..Expression of betaglycan and p120 in most GCT argues against the hypothesis, but does not exclude the possibility that low or absent expression of p120 might be significant in a subset of these tumors...
Reproductive hormones: ageing and the perimenopauseDavid M Robertson
Prince Henry s Institute of Medical Research, Monash Medical Center, Clayton, Victoria, Australia
Acta Obstet Gynecol Scand 81:612-6. 2002..Hormonal patterns during the luteal phase of the menstrual cycle also show changes with age but these changes are poorly understood...
Inhibins and ovarian cancerDavid M Robertson
Prince Henry s Institute of Medical Research, Monash Medical Centre, P O Box 5152, Clayton, VIC 3168, Australia
Mol Cell Endocrinol 225:65-71. 2004..These studies are providing a platform for the introduction of the test into clinical practice...
Evidence-based assessment of the impact of the WHI on women's healthH G Burger
Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
Climacteric 15:281-7. 2012..The results of the re-analyses of the WHI data and new data from other studies do not justify the continuing negative attitude to HRT in symptomatic women who start HRT near menopause...
Response of serum inhibin B and pro-alphaC levels to gonadotrophic stimulation in normal men before and after steroidal contraceptive treatmentKati L Matthiesson
Prince Henry's Institute of Medical Research, Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia
Hum Reprod 18:734-43. 2003....
Central abdominal fat and endogenous hormones during the menopausal transitionJanet R Guthrie
Office for Gender and Health, Royal Melbourne Hospital, Victoria, Australia
Fertil Steril 79:1335-40. 2003..To investigate the effect of endogenous hormone levels on central abdominal fat during the menopausal transition in a population-based cohort of Australian-born women...
Mammographic densities during the menopausal transition: a longitudinal study of Australian-born womenJanet R Guthrie
Office for Gender and Health, Department of Psychiatry, The University of Melbourne, and St Vincent s BreastScreen, St Vincent s Hospital, Victoria, Australia
Menopause 14:208-15. 2007..The objective of this study was to investigate hormonal and other factors associated with mammographic density during the menopausal transition and in postmenopause...
Association between hormonal changes at menopause and the risk of a coronary event: a longitudinal studyJanet R Guthrie
Office for Gender and Health, Department of Psychiatry, University of Melbourne, RMH, Victoria, Australia
Menopause 11:315-22. 2004....
Hot flushes during the menopause transition: a longitudinal study in Australian-born womenJanet R Guthrie
Office for Gender and Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia
Menopause 12:460-7. 2005..To investigate factors associated with the presence, severity, and frequency of hot flushes...
Androgen insufficiency in women: diagnostic and therapeutic implicationsL M Rivera-Woll
The Jean Hailes Foundation Research Unit, 173 Carinish Road, Clayton, Victoria, Australia, 3168
Hum Reprod Update 10:421-32. 2004..There is a need for formulations of testosterone therapy specifically designed for use in women, along with clear guidelines regarding optimal therapeutic doses and long-term safety data...
A clinical update on female androgen insufficiency--testosterone testing and treatment in women presenting with low sexual desireHenry G Burger
The Jean Hailes Foundation, Clayton, Australia
Sex Health 3:73-8. 2006..Currently, available methods include testosterone implants and testosterone creams, and transdermal patches and sprays are in development...
Modeling women's health during the menopausal transition: a longitudinal analysisLorraine Dennerstein
Office for Gender and Health, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Victoria, Australia
Menopause 14:53-62. 2007....
The role of androgen therapyHenry G Burger
Prince Henry's Institute of Medical Research, 246 Clayton Road, Clayton, Victoria 3168, Australia
Best Pract Res Clin Obstet Gynaecol 16:383-93. 2002..Clinical symptoms of androgen deficiency include lethargy, tiredness and loss of sex drive and interest, and have responded well to androgen replacement, generally without significant side-effects...
A prospective study of the association between endogenous hormones and depressive symptoms in postmenopausal womenJoanne Ryan
Department of Psychiatry, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
Menopause 16:509-17. 2009..Across a woman's lifetime, variations in hormone levels are known to influence mood and well-being. Whether absolute or changes in hormone levels over time are associated with depression among postmenopausal women remains unclear...
Surgical or medical treatment of polycystic ovary syndrome: a cost-benefit analysisG T Kovacs
Ovulation Induction Service, Department of Obstetrics and Gynaecology, Monash University, Prince Henry's Institute of Medical Research, Victoria, Australia
Gynecol Endocrinol 16:53-5. 2002..Because of the potential advantages of ovarian cautery, we recommend this surgery as the next line of treatment if clomiphene citrate fails to induce ovulation in PCOS patients, before gonadotropins are introduced...
The role of androgen therapySusan R Davis
The Jean Hailes Research Unit, Clayton, Victoria, Australia
Best Pract Res Clin Endocrinol Metab 17:165-75. 2003..Clinical symptoms of androgen insufficiency include loss of libido, diminished well-being, fatigue and blunted motivation and have been reported to respond well to T replacement, generally without significant side-effects...
WHI risks: any relevance to menopause management?Henry G Burger
Prince Henry s Institute and Jean Hailes Foundation For Women s Health, Clayton, Victoria, Australia
Maturitas 57:6-10. 2007..Other risks are analysed similarly...
Are we drawing the right conclusions from randomised placebo-controlled trials? A post-hoc analysis of data from a randomised controlled trialM Diana van Die
School of Health Sciences, RMIT University, Bundoora, Victoria, Australia
BMC Med Res Methodol 9:41. 2009..A substantial placebo response was observed but no significant difference in efficacy between the two arms...
Hormone therapy in the WHI eraHenry G Burger
Prince Henry s Institute of Medical Research and Jean Hailes Foundation for Women s Health, Clayton, Victoria, Australia
Aust N Z J Obstet Gynaecol 46:84-91. 2006..Tibolone has emerged as an alternative treatment for menopausal symptoms, but its long-term benefits and risks have yet to be documented...
Predictors of placebo response in a randomized, controlled trial of phytotherapy in menopauseMargaret Diana van Die
Royal Melbourne Institute of Technology University, Bundoora, Victoria, Australia
Menopause 16:792-6. 2009..The aim of this study was to evaluate predictors of the placebo response in a randomized, placebo-controlled, double-blind trial of a phytotherapeutic combination for the treatment of menopausal symptoms...
Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaintsMargaret Diana van Die
Royal Melbourne Institute of Technology RMIT University, Bundoora, Victoria, Australia
J Altern Complement Med 15:853-62. 2009..Here we review the evidence for this application of Vitex based on evidence from pharmacological studies and clinical research...
Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trialM Diana van Die
Royal Melbourne Institute of Technology University, Victoria, Australia
Menopause 16:156-63. 2009..To evaluate the effectiveness of a phytotherapeutic intervention comprising a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) in the management of menopausal symptoms...
Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infantCatherine S Choong
Department of Pediatric Endocrinology, Mater Misericordiae Hospitals, South Brisbane, Queensland 4104, Australia
J Clin Endocrinol Metab 87:49-56. 2002....
New findings from non-linear longitudinal modelling of menopausal hormone changesLorraine Dennerstein
Office for Gender and Health, Department of Psychiatry, Royal Melbourne Hospital Melbourne, The University of Melbourne, Victoria 3050, Australia
Hum Reprod Update 13:551-7. 2007..These findings have clinical relevance in identifying which symptoms will be triggered by steep transitions of E2 such as sudden withdrawal and which health parameters may require a maintenance level of E2...
Endocrine features of menstrual cycles in middle and late reproductive age and the menopausal transition classified according to the Staging of Reproductive Aging Workshop (STRAW) staging systemGeorgina E Hale
Department of Obstetrics and Gynecology, University of Sydney, New South Wales, Australia 2006
J Clin Endocrinol Metab 92:3060-7. 2007..Female reproductive aging based on changes in menstrual cycle length and frequency progresses through a number of stages as defined by the Stages of Reproductive Aging Workshop (STRAW) staging criteria...
The association between obesity and the diagnosis of androgen deficiency in symptomatic ageing menCarolyn A Allan
Prince Henry's Institute, Melbourne, Vic, Australia
Med J Aust 185:424-7. 2006..Studies of testosterone therapy in this group of ageing men are needed to determine whether androgen replacement is beneficial...
Menopause transition: Annual changes in serum hormonal patterns over the menstrual cycle in women during a nine-year period prior to menopauseBritt-Marie Landgren
Department of Clinical Science, Division of Obstetrics and Gynaecology, Karolinska Institutet, Huddinge University Hospital, SE-14186 Stockholm, Sweden
J Clin Endocrinol Metab 89:2763-9. 2004..The data amplify and clarify current concepts of the endocrine basis of the menopause transition...
Induction of spermatogenesis by recombinant follicle-stimulating hormone (puregon) in hypogonadotropic azoospermic men who failed to respond to human chorionic gonadotropin alonePierre-Marc G Bouloux
Department of Endocrinology, The Royal Free Hospital, London, United Kingdom
J Androl 24:604-11. 2003..In conclusion, a weekly dose of 450 IU (3 x 150 IU or 2 x 225 IU) recFSH, in addition to hCG, was able to induce spermatogenesis in many hypogonadotropic azoospermic men who failed to respond to treatment with hCG alone...
Should testosterone be added to estrogen-progestin therapy for breast protection?Henry G Burger
Menopause 14:159-62. 2007
