P I Bird

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. pmc The major human and mouse granzymes are structurally and functionally divergent
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology and 2Victorian Bioinformatics Consortium, Monash University, Victoria 3800, Australia
    J Cell Biol 175:619-30. 2006
  2. pmc Analysis of vertebrate genomes suggests a new model for clade B serpin evolution
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    BMC Genomics 6:167. 2005
  3. ncbi request reprint Production of recombinant serpins in Escherichia coli
    Phillip I Bird
    Department of Biochemistry and Molecular Biology, Monash University 3800, Australia
    Methods 32:169-76. 2004
  4. doi request reprint Endolysosomal proteases and their inhibitors in immunity
    Phillip I Bird
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Nat Rev Immunol 9:871-82. 2009
  5. ncbi request reprint Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins
    P I Bird
    Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia
    Immunol Cell Biol 77:47-57. 1999
  6. ncbi request reprint Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction
    C E Hirst
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800, Australia
    Mol Hum Reprod 7:1133-42. 2001
  7. ncbi request reprint A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
    J Sun
    Department of Medicine, Monash Medical School, Clive Ward Centre, Box Hill Hospital, Box Hill 3128, Australia
    J Biol Chem 272:15434-41. 1997
  8. ncbi request reprint Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25
    F L Scott
    Department of Medicine, Monash University Medical School, Box Hill, 3128, Australia
    Genomics 62:490-9. 1999
  9. ncbi request reprint The granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform moles
    M S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Australia
    Placenta 27:62-9. 2006
  10. pmc Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1
    C H Bird
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Mol Cell Biol 21:5396-407. 2001

Collaborators

Detail Information

Publications58

  1. pmc The major human and mouse granzymes are structurally and functionally divergent
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology and 2Victorian Bioinformatics Consortium, Monash University, Victoria 3800, Australia
    J Cell Biol 175:619-30. 2006
    ..These results demonstrate that even "orthologous" granzymes have species-specific functions, having evolved in distinct environments that pose different challenges...
  2. pmc Analysis of vertebrate genomes suggests a new model for clade B serpin evolution
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    BMC Genomics 6:167. 2005
    ....
  3. ncbi request reprint Production of recombinant serpins in Escherichia coli
    Phillip I Bird
    Department of Biochemistry and Molecular Biology, Monash University 3800, Australia
    Methods 32:169-76. 2004
    ..coli can generally be solubilized and refolded. Here, we outline the general approaches and procedures to be considered when contemplating the use of E. coli for recombinant serpin production...
  4. doi request reprint Endolysosomal proteases and their inhibitors in immunity
    Phillip I Bird
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Nat Rev Immunol 9:871-82. 2009
    ..In this Review, we highlight recent developments in this area and emphasize the importance of studying the role of endolysosomal proteases, and their natural inhibitors, in the initiation and regulation of immune responses...
  5. ncbi request reprint Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins
    P I Bird
    Department of Medicine, Monash Medical School, Box Hill Hospital, Victoria, Australia
    Immunol Cell Biol 77:47-57. 1999
    ..The purpose of the present review is to describe recent work on a group of intracellular serine proteinase inhibitors (serpins) which may function in leucocytes to prevent autolysis induced by the granule serine proteinases...
  6. ncbi request reprint Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction
    C E Hirst
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800, Australia
    Mol Hum Reprod 7:1133-42. 2001
    ..In the testis, graB may facilitate migration of developing germ cells, while in the placenta, it may contribute to extracellular matrix remodelling during parturition...
  7. ncbi request reprint A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)
    J Sun
    Department of Medicine, Monash Medical School, Clive Ward Centre, Box Hill Hospital, Box Hill 3128, Australia
    J Biol Chem 272:15434-41. 1997
    ....
  8. ncbi request reprint Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25
    F L Scott
    Department of Medicine, Monash University Medical School, Box Hill, 3128, Australia
    Genomics 62:490-9. 1999
    ....
  9. ncbi request reprint The granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform moles
    M S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Australia
    Placenta 27:62-9. 2006
    ....
  10. pmc Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1
    C H Bird
    Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia
    Mol Cell Biol 21:5396-407. 2001
    ..We conclude that the nucleocytoplasmic distribution of PI-9 and related serpins involves a nonconventional nuclear import pathway and Crm1p...
  11. ncbi request reprint A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes
    J Sun
    Department of Medicine, Monash Medical School, Clive Ward Centre, Box Hill Hospital, Box Hill Australia
    Cytogenet Cell Genet 82:273-7. 1998
    ..These findings do not support a previously proposed model for evolution of the clusters which invoked an inter-chromosomal duplication of the entire 6p25 group to 18q21.3...
  12. doi request reprint Control of granzymes by serpins
    D Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, Building 77, Wellington Road, Clayton, Victoria 3800, Australia
    Cell Death Differ 17:586-95. 2010
    ..We also discuss some of the pitfalls inherent in using rodent models of granzyme-serpin interactions and the ways in which our understanding of serpins can help resolve some of the current, contentious issues in granzyme biology...
  13. ncbi request reprint Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop
    J Sun
    Department of Biochemistry and Molecular Biology, Monash University, 3800, Melbourne, Victoria, Australia
    J Biol Chem 276:15177-84. 2001
    ....
  14. ncbi request reprint A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
    J Sun
    Department of Medicine, Monash Medical School, Box Hill Hospital, Box Hill 3128, Australia
    J Biol Chem 271:27802-9. 1996
    ..These results suggest that PI-9 serves to inactivate misdirected granzyme B following cytotoxic cell degranulation. This may explain why cytotoxic cells are not damaged by their own granzyme B during destruction of abnormal cells...
  15. ncbi request reprint The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix
    Ruby H P Law
    The Protein Crystallography Unit, Monash Centre for Synchrotron Science and The Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Faculty of Medicine, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 280:22356-64. 2005
    ..The high resolution crystal structure of maspin provides a detailed molecular framework to elucidate the mechanism of function of this important tumor suppressor...
  16. ncbi request reprint The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses
    M S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, 3800, Australia
    Cell Immunol 210:21-9. 2001
    ..We postulate that PI-9 is present in these lining cell types to protect against misdirected, free granzyme B released during a local immune response...
  17. ncbi request reprint A common fold mediates vertebrate defense and bacterial attack
    Carlos J Rosado
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Science 317:1548-51. 2007
    ..Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection...
  18. ncbi request reprint Proteinase inhibitor 6 (PI-6) expression in human skin: induction of PI-6 and a PI-6/proteinase complex during keratinocyte differentiation
    F L Scott
    Department of Medicine, Monash University, Box Hill Hospital 3128, Melbourne, Australia
    Exp Cell Res 245:263-71. 1998
    ..We postulate that a physiological role of PI-6 is to regulate a serine proteinase associated with keratinocyte differentiation...
  19. pmc The human serpin proteinase inhibitor-9 self-associates at physiological temperatures
    Lauren N Benning
    Department of Biochemistry and Molecular Biology, Monash University, P O Box 13D, Clayton, Victoria 3800, Australia
    Protein Sci 13:1859-64. 2004
    ..Our data show that in vitro wild-type PI-9 forms aggregates at physiological temperatures. The biological implications of PI-9 aggregates at physiological temperatures are discussed...
  20. ncbi request reprint Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity
    Jiuru Sun
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne 3800, Victoria, Australia
    J Biol Chem 279:16907-11. 2004
    ..We conclude that the RAH allele represents a neutral polymorphism in the GrB gene...
  21. ncbi request reprint Mechanisms of serpin dysfunction in disease
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Expert Rev Mol Med 8:1-19. 2006
    ....
  22. doi request reprint Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement
    Monica D Prakash
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    Immunol Cell Biol 87:249-54. 2009
    ..Our findings also predict the existence of an extracellular activator of GrB...
  23. ncbi request reprint Serpins 2005 - fun between the beta-sheets. Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia)
    James C Whisstock
    The Department of Biochemistry and Molecular Biology, Monash University Clayton Campus, Melbourne, Victoria, Australia
    FEBS J 272:4868-73. 2005
    ..This review reports on recent major discoveries in the serpin field, based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia)...
  24. pmc Cathepsin H is an additional convertase of pro-granzyme B
    Michael E D'Angelo
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 Victoria, Australia
    J Biol Chem 285:20514-9. 2010
    ..This indicates a great deal of functional redundancy in GrB maturation, which would prevent pathogen-mediated immune suppression by via convertase inhibition...
  25. ncbi request reprint The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency
    Claire E Hirst
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
    J Immunol 170:805-15. 2003
    ..In conclusion, the presence and subcellular localization of PI-9 in leukocytes and DCs are consistent with a protective role against ectopic or misdirected grB during an immune response...
  26. ncbi request reprint Serpins: finely balanced conformational traps
    Robert N Pike
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
    IUBMB Life 54:1-7. 2002
    ....
  27. pmc Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions
    James C Whisstock
    From the Department of Biochemistry and Molecular Biology and ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 285:24307-12. 2010
    ..Finally, recent structural studies reveal how the serpin fold has been adapted for non-inhibitory functions such as hormone binding...
  28. doi request reprint The role of serpins in vertebrate immunity
    M S J Mangan
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Tissue Antigens 72:1-10. 2008
    ..This review focuses on the role of intracellular (clade B) serpins in maintaining viability of both innate and adaptive immune cells...
  29. doi request reprint Expression, purification and characterization of recombinant Z alpha(1)-antitrypsin--the most common cause of alpha(1)-antitrypsin deficiency
    Vita Levina
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Protein Expr Purif 68:226-32. 2009
    ..A recombinant source of pathological Z alpha(1)AT will increase the chances of elucidating the mechanism of its polymerization and thus the development of therapeutic strategies...
  30. ncbi request reprint The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress
    C H Bird
    Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Vic, Australia
    Cell Death Differ 21:876-87. 2014
    ..The GrB-Sb9 nexus may therefore represent an additional mechanism of limiting lymphocyte lifespan and populations...
  31. ncbi request reprint Tissue distribution and intracellular localisation of the 75-kDa inositol polyphosphate 5-phosphatase
    C J Speed
    Department of Medicine, Monash Medical School, Box Hill Hospital, Melbourne, Australia
    Eur J Biochem 234:216-24. 1995
    ..This study demonstrates the tissue distribution and intracellular location of the 75-kDa 5-phosphatase and reveals a novel location for an enzyme involved in phosphatidylinositol turnover...
  32. ncbi request reprint Alpha1A- and alpha1B-adrenoceptors are the major subtypes in human saphenous vein
    M Yan
    Department of Cardiology, Box Hill Hospital, Australia
    Life Sci 68:1191-8. 2001
    ..89 and r=0.98, respectively), but not the alpha1D-AR subtype (r=0.67). Our results indicate that alpha1A- and alpha1B-ARs are the main functional and expressed receptor subtypes in HSV...
  33. ncbi request reprint Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, 3800, Australia
    Genomics 79:349-62. 2002
    ..Compared with human, this larger mouse serpin repertoire probably reflects the need to regulate a larger proteinase repertoire arising from differing evolutionary pressures on the reproductive and immune systems...
  34. pmc Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells
    Catherina H Bird
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
    Mol Cell Biol 25:7854-67. 2005
    ..In this electrostatic "exchange-adsorption" model, cs1 and cs2 participate in binding of GrB to the cell surface, thereby promoting its uptake and eventual release into the cytoplasm...
  35. pmc Structure of granzyme C reveals an unusual mechanism of protease autoinhibition
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia
    Proc Natl Acad Sci U S A 106:5587-92. 2009
    ..Overall, these observations describe a broadly applicable mechanism of protease regulation that cannot be predicted by template-based modeling or bioinformatic approaches alone...
  36. doi request reprint Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor
    Marguerite S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    J Biol Chem 283:22498-504. 2008
    ..GrB also cleaves the matrix form of fibrinogen at several sites. These studies suggest extracellular GrB may help control localized coagulation during inflammation...
  37. ncbi request reprint Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells
    Katherine Baran
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne 3002, Victoria, Australia
    J Biol Chem 281:30485-91. 2006
    ..We conclude that cathepsin B is not essential for protection of cytotoxic lymphocytes from the toxic effects of their secreted perforin...
  38. ncbi request reprint Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase
    K M Laxminarayan
    Department of Medicine, Box Hill Hospital, Monash Medical School, Victoria, Australia
    J Biol Chem 269:17305-10. 1994
    ..As shown by RNA analysis the 43-kDa membrane-associated 5-phosphatase appears to be predominantly expressed in heart, brain, and skeletal muscle...
  39. pmc Maspin (SERPINB5) is an obligate intracellular serpin
    Sonia S Y Teoh
    Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia
    J Biol Chem 285:10862-9. 2010
    ..It is probably released only as a consequence of cell damage or necrosis...
  40. ncbi request reprint A retained selection cassette increases reporter gene expression without affecting tissue distribution in SPI3 knockout/GFP knock-in mice
    Katrina L Scarff
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Genesis 36:149-57. 2003
    ....
  41. ncbi request reprint Elucidation of the substrate specificity of the C1s protease of the classical complement pathway
    Felicity K Kerr
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 280:39510-4. 2005
    ....
  42. ncbi request reprint Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin
    Marguerite S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia
    J Biol Chem 280:23549-58. 2005
    ..It may also contribute to tissue destruction in diseases in which extracellular GrB is evident, such as rheumatoid arthritis and atherosclerosis...
  43. ncbi request reprint SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes
    Fiona L Scott
    Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia
    J Biochem 142:435-42. 2007
    ..Taken together, these results suggest that serpinB6 is a physiologically relevant inhibitor of hK8 in skin. We postulate that serpinB6 protects the intracellular compartment of keratinocytes from ectopic hK8...
  44. ncbi request reprint Modulation and redistribution of proteinase inhibitor 8 (Serpinb8) during kidney regeneration
    Anneliese Gillard
    Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    Am J Nephrol 26:34-42. 2006
    ..Given the presence of mouse PI8 (mPI8) in kidney, the UUO technique was used to investigate its potential role in kidney disease and regeneration...
  45. pmc The MACPF/CDC family of pore-forming toxins
    Carlos J Rosado
    Department of Biochemistry, Monash University, Clayton, Victoria 3800, Australia
    Cell Microbiol 10:1765-74. 2008
    ..Together with biochemical studies, these structural data suggest that lytic MACPF proteins use a CDC-like mechanism of membrane disruption, and will help understand the roles these proteins play in immunity and development...
  46. pmc Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke
    Katrina L Scarff
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Cell Biol 24:4075-82. 2004
    ....
  47. ncbi request reprint Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
    Felicity K Kerr
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    Mol Immunol 45:670-7. 2008
    ..C1-inhibitor inhibited MASP-2 50-fold faster than C1s and much faster than any other protease tested to date, implying that MASP-2 is a major physiological target of C1-inhibitor...
  48. ncbi request reprint A role for granzyme M in TLR4-driven inflammation and endotoxicosis
    Desiree A Anthony
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, 8006, East Melbourne, Victoria, Australia
    J Immunol 185:1794-803. 2010
    ..Most importantly, these data demonstrate that granzymes should no longer be considered solely as mediators of apoptosis, but additionally as potential key regulators of inflammation...
  49. ncbi request reprint Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid
    Eugene Estella
    St Vincent s Institute, 41 Victoria Parade, Fitzroy, Victoria, 3065, Australia
    Diabetes 55:2212-9. 2006
    ..Our data suggest that Bid cleavage by granzyme B precedes mitochondrial disruption and apoptosis in pancreatic islets...
  50. ncbi request reprint Production of serpins using yeast expression systems
    Philip A Pemberton
    Arriva Pharmaceuticals Inc, 2430B Mariner Square Loop, Alameda, CA 94501, USA
    Methods 32:185-90. 2004
    ..However, for the intracellular production of serpins, in particular the clade B serpins that do not have complex post-translational modifications, yeast expression systems should be among the first systems considered...
  51. ncbi request reprint Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1)
    Charaf Benarafa
    Center for Blood Research, Boston, Massachusetts 02115, USA
    J Biol Chem 277:42028-33. 2002
    ..These data demonstrate that the four murine homologs of MNEI have met different evolutionary fates, and that EIA is the mouse ortholog of MNEI...
  52. ncbi request reprint Distribution of serine proteinase inhibitor, clade B, member 6 (Serpinb6) in the adult mouse brain
    Tadaaki Kishi
    Division of Structural Cell Biology, Nara Institute of Science and Technology NAIST, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    Brain Res Gene Expr Patterns 1:175-80. 2002
    ..Second, Serpinb6 mRNA and the protein were strongly expressed in most somatic and visceral motoneurons among cranial nerve nuclei. This suggests that another serine protease is regulated by Serpinb6 in motoneurons and/or fibers...
  53. ncbi request reprint Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood
    Evgenya Y Popova
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, 17033, USA
    Exp Hematol 34:453-62. 2006
    ....
  54. ncbi request reprint Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis
    Thomas Welss
    Department of Dermatology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Biochemistry 42:7381-9. 2003
    ..Given that lysosomal disruption, release of catL, and catL-mediated caspase activation are known to occur in response to cellular stress, we propose that a physiological role of hurpin is to protect epithelial cells from ectopic catL...
  55. ncbi request reprint Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death
    Hiroaki Ida
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Eur J Immunol 33:3284-92. 2003
    ..We suggest that granzyme B leakage-induced cell death is an important determinant of activation-induced NK cell death and that this process may be important for the fate of NK cells which encounter malignant or virus-infected cells...
  56. ncbi request reprint Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6
    Tae Woo Kim
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 64:400-5. 2004
    ..Our results suggest that DNA vaccines combining strategies that enhance MHC class I and II antigen processing with SPI-6 have potential clinical implications for control of viral infection and neoplasia...
  57. ncbi request reprint Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9
    Elizabeth J Blink
    Nuclear Signalling Laboratory, Division for Biochemistry and Molecular Biology, John Curtin School of Medical Research, Canberra City, Australia
    J Cell Biochem 95:598-610. 2005
    ..We conclude that GrB nuclear import exhibits complex regulation by IMPs; that heterodimerization with PI-9 can modulate the interaction has implications for protection against apoptosis...
  58. ncbi request reprint Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus
    Filip Sk├Âldberg
    Department of Medical Sciences, Uppsala University, University Hospital, 751 85 Uppsala, Sweden
    Biochem Biophys Res Commun 291:951-8. 2002
    ..This is the first report that AHNAK can be targeted by the immune system in autoimmune disease...