- Should patients with chronic heart failure be treated with "statins"?Emma Ashton
NHMRC Centre of Clinical Research Excellence, Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, Victoria 3004, Australia
Heart Fail Monit 3:82-6. 2003..The importance of such a trial is further highlighted by the already commonplace usage of statins amongst patients with CHF...
- Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE studyEmma Ashton
Department of Health Science, Monash University, Frankston Vic 3119, Melbourne, Australia
Int J Cardiol 146:404-7. 2011..These agents may also possess additional properties, independent of effects on blood lipid levels, which may have an effect on cardiac remodeling. However, beneficial effects were not observed in the recent UNIVERSE trial...
- Double-blind, randomized, placebo-controlled study of high-dose HMG CoA reductase inhibitor therapy on ventricular remodeling, pro-inflammatory cytokines and neurohormonal parameters in patients with chronic systolic heart failureHenry Krum
Monash University, Alfred Hospital, Melbourne, Victoria, Australia
J Card Fail 13:1-7. 2007..However, chronic heart failure (CHF) patients were often excluded in such trials. Statins possess pharmacologic properties (independent of cholesterol lowering) that may be beneficial on ventricular remodeling in such patients...