Research Topics
Genomes and GenesSpecies | R K AndrewsSummaryAffiliation: Monash University Country: Australia Publications
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Publications
Platelet receptor proteolysis: a mechanism for downregulating platelet reactivityRobert K Andrews
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Australia
Arterioscler Thromb Vasc Biol 27:1511-20. 2007..In particular, a focus on proteolytic regulation of the platelet collagen receptor, glycoprotein (GP)VI, illustrates many of the key biochemical, cellular, and clinical implications of current research in this area...- Structure-activity relationships of snake toxins targeting platelet receptors, glycoprotein Ib-IX-V and glycoprotein VIRobert K Andrews
Vascular Biology Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton 3168, Australia
Curr Med Chem Cardiovasc Hematol Agents 1:143-9. 2003..Anti-thrombotics based on snake venom GPIIb-IIIa inhibitors have been investigated clinically, however analogous proteins recognizing GPIb-IX-V or GPVI are yet to be therapeutically exploited... - Platelet interactions in thrombosisRobert K Andrews
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
IUBMB Life 56:13-8. 2004..This arrangement may underlie common mechanisms of initiating thrombus formation in haemostasis or thrombotic disease... - Platelet physiology and thrombosisRobert K Andrews
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
Thromb Res 114:447-53. 2004..This review will focus on the structure-function of primary platelet adhesion receptors, GPIb-IX-V and GPVI, and how they act together to regulate platelet thrombus formation in pathophysiology... - Glycoprotein Ib-IX-VR K Andrews
Vascular Biology Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3168, Australia
Int J Biochem Cell Biol 35:1170-4. 2003..Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target... - Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membraneJane F Arthur
Department of Immunology, Monash University, Melbourne 3004, Australia
J Biol Chem 282:30434-41. 2007.... 
Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complexF T Mu
Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
J Thromb Haemost 8:324-30. 2010....- TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human plateletsJ F Arthur
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
J Thromb Haemost 9:163-72. 2011.... - Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIaElizabeth E Gardiner
Department of Immunology, Monash University, Melbourne, Australia
Blood 111:165-74. 2008..Activation of both pathways was observed with immunoglobulin from patients with heparin-induced thrombocytopenia (HIT), suggesting novel mechanisms for platelet dysfunction by FcgammaRIIa after immunologic insult... - Focusing on plasma glycoprotein VIM Al-Tamimi
Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne 3004, Australia
Thromb Haemost 107:648-55. 2012..Here, we describe some of the critical mechanisms for generating soluble GPVI from platelets, and future avenues for exploiting this unique platelet-specific receptor for diagnosis and/or disease prevention... 
Platelet adhesion: a game of catch and releaseRobert K Andrews
Department of Immunology, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne, Victoria, Australia
J Clin Invest 118:3009-11. 2008..Together, these studies reveal molecular mechanisms regulating GPIbalpha-vWF bond formation and platelet adhesion under shear stress...- ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathwaysJ F Arthur
Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
J Thromb Haemost 10:1133-41. 2012.... - Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VILakshmi C Wijeyewickrema
Department of Biochemistry and Molecular Biology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
Thromb Haemost 98:1285-90. 2007.... - Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alphaJames C Whisstock
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
Thromb Haemost 87:329-33. 2002..This provides the basis for relating these genetic lesions to abnormal function of the receptor... - Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinasesE E Gardiner
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, VIC Australia
J Thromb Haemost 5:1530-7. 2007..Platelet glycoprotein (GP)VI that binds collagen, and GPIb-IX-V that binds von Willebrand factor, initiate thrombus formation... - Programmed autologous cleavage of platelet receptorsM C Berndt
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
J Thromb Haemost 5:212-9. 2007..This review discusses the underlying mechanisms for dual proteolytic pathways of receptor regulation, and the impact of these pathways on thrombus formation and stability in vivo... - Measuring soluble platelet glycoprotein VI in human plasma by ELISAMohammad Al-Tamimi
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
Platelets 20:143-9. 2009..Characterization of this sensitive ELISA should facilitate analysis of functional/diagnostic role(s) for soluble GPVI in human plasma associated with thrombotic/immune dysfunction... - Platelet receptor redox regulationJane F Arthur
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Victoria, Australia
Platelets 19:1-8. 2008.... - Snake venom probes of platelet adhesion receptors and their ligandsLakshmi C Wijeyewickrema
Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Vic. 3168, Australia
Toxicon 45:1051-61. 2005..Whether homologous adhesion/counter-receptors on platelets and other vascular cells are also potential snake venom targets is as yet largely unexplored... - Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpuraE E Gardiner
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
J Thromb Haemost 6:1175-82. 2008..Receptors on platelets that contain immunoreceptor tyrosine-based activation motifs (ITAMs) include collagen receptor glycoprotein (GP) VI, and FcgammaRIIa, a low affinity receptor for immunoglobulin (Ig) G... - GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation eventsElizabeth E Gardiner
The Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
Platelets 21:244-52. 2010..These data indicate signaling events triggered by specific ligation of GPIbalpha can lead to robust platelet activation and help define GPIb-IX-V as both an adhesion and signaling receptor on platelets... - Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VILakshmi C Wijeyewickrema
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3004, Australia
J Biol Chem 285:11793-9. 2010..Together, these results suggest that NGF can function as a metalloproteinase inhibitor... - Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factorMarguerite S Buzza
Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
J Biol Chem 283:22498-504. 2008..GrB also cleaves the matrix form of fibrinogen at several sites. These studies suggest extracellular GrB may help control localized coagulation during inflammation... - Platelet physiology: in cold bloodRobert K Andrews
Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3168, Victoria, Australia
Curr Biol 13:R282-4. 2003..New evidence suggests that this clearance is mediated in the liver by the Mac-1 integrin on Kupffer cells recognizing clustered GPIb receptor on platelets, leading to platelet phagocytosis... - Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinaseElizabeth E Gardiner
Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia, 3800
Blood 104:3611-7. 2004..This process may represent a potential mechanism to regulate GPVI-dependent platelet adhesion... - Calmodulin interacts with the platelet ADP receptor P2Y1Jane F Arthur
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Biochem J 398:339-43. 2006..These results suggest that the interaction of calmodulin with the P2Y1 C-terminal tail may regulate P2Y1-dependent platelet aggregation... - Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated plateletsJane F Arthur
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
Thromb Haemost 93:716-23. 2005..A contribution of GPIb-IX-V to GPVI-induced platelet responses, and vice versa, therefore warrants further investigation... - Role of calmodulin in platelet receptor functionElizabeth E Gardiner
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3168, Australia
Curr Med Chem Cardiovasc Hematol Agents 3:283-7. 2005..Further studies should define the precise functional role of calmodulin in thrombus formation initiated by GPIb-IX-V or GPVI... - Primary platelet adhesion receptorsJana Yip
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
IUBMB Life 57:103-8. 2005.... - The 14-3-3zeta-GPIb-IX-V complex as an antiplatelet targetRobert K Andrews
Department of Immunology, Monash University, Melbourne, Australia
Drug News Perspect 20:285-92. 2007..The unique recognition sequences and arrangement of functional 14-3-3zeta-binding sites found within the cytoplasmic domain of GPIb-IX-V increase the likelihood of selective targeting of this interaction... - Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain sheddingMohammad Al-Tamimi
Department of Immunology, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
Platelets 20:75-82. 2009..In conclusion, this analysis of anti-GPVI mAbs provides useful tools for studying the functional role of platelet GPVI... - Snake venom toxins affecting platelet functionRobert K Andrews
Department of Biochemistry and Molecular Biology, Monas University, Clayton, Victoria, Australia
Methods Mol Biol 273:335-48. 2004 - Fractionation of snake venom metalloproteinases by metal ion affinity: a purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agaroseLakshmi C Wijeyewickrema
Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3008 Victoria, Australia
Toxicon 50:1064-72. 2007..The combined results support the general concept of using Ni(2+)-agarose to fractionate snake venom metalloproteinases... - Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factorYang Shen
Department of Immunology and the Department of Biochemistry and Molecular Biology, Monash University, Victoria, 3800, Australia
J Biol Chem 281:26419-23. 2006..Together, these data demonstrate that LRR2-4, encompassing a pronounced negative charge patch on human GPIbalpha, is essential for GPIbalpha.VWF-dependent adhesion as hydrodynamic shear increases... - A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complexFi Tjen Mu
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
Blood 111:4580-7. 2008..Together, these data suggest the GPIb alpha C-terminus regulates signaling through independent association of 14-3-3zeta and PI3-kinase... - New insights into the haemostatic function of plateletsAndrew H Wei
The Australian Centre for Blood Diseases, Monash University, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia
Br J Haematol 147:415-30. 2009.... - The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2Zon W Lai
Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
Endocrinology 150:2376-81. 2009..In summary, we have demonstrated that calmodulin is able to bind ACE2 and suggest that the ACE2 ectodomain shedding and/or sheddase(s) activation regulated by calmodulin is independent from the phorbol ester-induced shedding... - Platelet glycoprotein VI-related clinical defectsJane F Arthur
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
Br J Haematol 139:363-72. 2007..Clinical consequences of GPVI-related defects may be uniquely informative about the role of platelet GPVI in health and disease... - Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signalingKatsue Suzuki-Inoue
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
J Biol Chem 277:21561-6. 2002..These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI... - Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathwayStuart J Marshall
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Biochem J 361:297-305. 2002..In contrast, activation of GPIbalpha in washed platelets does not promote functional responses... - Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VIRobert K Andrews
Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
Blood 99:4219-21. 2002..His269-Pro287 is analogous to the calmodulin-binding sequence in GPIbbeta. The novel interaction of GPVI and calmodulin may regulate aspects of GPVI function... - New direction for WE thrombinMichael C Berndt
Arterioscler Thromb Vasc Biol 28:205-7. 2008 - Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sitesKatsue Suzuki-Inoue
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Biochem J 378:1023-9. 2004..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V... - Proteolytic cleavage of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is regulated by a calmodulin-binding motifMae Xhum Wong
Kronheimer Building, Austin Research Institute, Austin Hospital, Heidelberg, Vic, Australia
FEBS Lett 568:70-8. 2004..Taken together, these results suggest that this highly charged cluster of amino acids in the PECAM-1 cytoplasmic domain directly interacts with CaM and this novel interaction appears to regulate cleavage of PECAM-1... - Functional analysis of the C-terminal flanking sequence of platelet glycoprotein Ib alpha using canine-human chimerasYang Shen
Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
Blood 99:145-50. 2002.... - A familial platelet function disorder associated with abnormal signalling through the glycoprotein VI pathwayScott Dunkley
Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Br J Haematol 137:569-77. 2007..A genetic defect in GPVI/Fcgamma signalling compromising platelet function is hypothesised in this family... - Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-VTong Shi
St. George Hospital, University of New South Wales, Sydney, New South Wales, Australia
Arthritis Rheum 54:2558-67. 2006..CONCLUSION: Our findings show that inappropriate platelet activation by the anti-beta2GPI antibody-beta2GPI complex via the GPIbalpha receptor may contribute to the prothrombotic tendency associated with APS...