R K Andrews

Summary

Affiliation: Monash University
Country: Australia

Publications

  1. ncbi request reprint Structure-activity relationships of snake toxins targeting platelet receptors, glycoprotein Ib-IX-V and glycoprotein VI
    Robert K Andrews
    Vascular Biology Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton 3168, Australia
    Curr Med Chem Cardiovasc Hematol Agents 1:143-9. 2003
  2. ncbi request reprint Platelet receptor proteolysis: a mechanism for downregulating platelet reactivity
    Robert K Andrews
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Australia
    Arterioscler Thromb Vasc Biol 27:1511-20. 2007
  3. ncbi request reprint Glycoprotein Ib-IX-V
    R K Andrews
    Vascular Biology Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3168, Australia
    Int J Biochem Cell Biol 35:1170-4. 2003
  4. ncbi request reprint Platelet physiology and thrombosis
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Res 114:447-53. 2004
  5. ncbi request reprint Platelet interactions in thrombosis
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    IUBMB Life 56:13-8. 2004
  6. pmc Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of Type 1 diabetes
    J F Arthur
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne, VIC 3004, Australia
    J Diabetes Res 2013:370212. 2013
  7. ncbi request reprint Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane
    Jane F Arthur
    Department of Immunology, Monash University, Melbourne 3004, Australia
    J Biol Chem 282:30434-41. 2007
  8. doi request reprint TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    J Thromb Haemost 9:163-72. 2011
  9. doi request reprint Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex
    F T Mu
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Thromb Haemost 8:324-30. 2010
  10. ncbi request reprint Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa
    Elizabeth E Gardiner
    Department of Immunology, Monash University, Melbourne, Australia
    Blood 111:165-74. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Structure-activity relationships of snake toxins targeting platelet receptors, glycoprotein Ib-IX-V and glycoprotein VI
    Robert K Andrews
    Vascular Biology Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton 3168, Australia
    Curr Med Chem Cardiovasc Hematol Agents 1:143-9. 2003
    ..Anti-thrombotics based on snake venom GPIIb-IIIa inhibitors have been investigated clinically, however analogous proteins recognizing GPIb-IX-V or GPVI are yet to be therapeutically exploited...
  2. ncbi request reprint Platelet receptor proteolysis: a mechanism for downregulating platelet reactivity
    Robert K Andrews
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Australia
    Arterioscler Thromb Vasc Biol 27:1511-20. 2007
    ..In particular, a focus on proteolytic regulation of the platelet collagen receptor, glycoprotein (GP)VI, illustrates many of the key biochemical, cellular, and clinical implications of current research in this area...
  3. ncbi request reprint Glycoprotein Ib-IX-V
    R K Andrews
    Vascular Biology Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3168, Australia
    Int J Biochem Cell Biol 35:1170-4. 2003
    ..Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target...
  4. ncbi request reprint Platelet physiology and thrombosis
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Res 114:447-53. 2004
    ..This review will focus on the structure-function of primary platelet adhesion receptors, GPIb-IX-V and GPVI, and how they act together to regulate platelet thrombus formation in pathophysiology...
  5. ncbi request reprint Platelet interactions in thrombosis
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    IUBMB Life 56:13-8. 2004
    ..This arrangement may underlie common mechanisms of initiating thrombus formation in haemostasis or thrombotic disease...
  6. pmc Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of Type 1 diabetes
    J F Arthur
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne, VIC 3004, Australia
    J Diabetes Res 2013:370212. 2013
    ..These data indicate that glycaemic control is important in reducing GPVI-dependent platelet hyperreactivity and point to a potential antithrombotic therapeutic benefit of Syk inhibition in hyperglycaemic diabetes...
  7. ncbi request reprint Ligand binding rapidly induces disulfide-dependent dimerization of glycoprotein VI on the platelet plasma membrane
    Jane F Arthur
    Department of Immunology, Monash University, Melbourne 3004, Australia
    J Biol Chem 282:30434-41. 2007
    ....
  8. doi request reprint TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    J Thromb Haemost 9:163-72. 2011
    ....
  9. doi request reprint Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex
    F T Mu
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    J Thromb Haemost 8:324-30. 2010
    ....
  10. ncbi request reprint Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa
    Elizabeth E Gardiner
    Department of Immunology, Monash University, Melbourne, Australia
    Blood 111:165-74. 2008
    ..Activation of both pathways was observed with immunoglobulin from patients with heparin-induced thrombocytopenia (HIT), suggesting novel mechanisms for platelet dysfunction by FcgammaRIIa after immunologic insult...
  11. doi request reprint ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways
    J F Arthur
    Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
    J Thromb Haemost 10:1133-41. 2012
    ....
  12. doi request reprint Focusing on plasma glycoprotein VI
    M Al-Tamimi
    Australian Centre for Blood Diseases, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne 3004, Australia
    Thromb Haemost 107:648-55. 2012
    ..Here, we describe some of the critical mechanisms for generating soluble GPVI from platelets, and future avenues for exploiting this unique platelet-specific receptor for diagnosis and/or disease prevention...
  13. pmc Platelet adhesion: a game of catch and release
    Robert K Andrews
    Department of Immunology, Alfred Medical Research and Education Precinct AMREP, Monash University, Melbourne, Victoria, Australia
    J Clin Invest 118:3009-11. 2008
    ..Together, these studies reveal molecular mechanisms regulating GPIbalpha-vWF bond formation and platelet adhesion under shear stress...
  14. ncbi request reprint Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha
    James C Whisstock
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Thromb Haemost 87:329-33. 2002
    ..This provides the basis for relating these genetic lesions to abnormal function of the receptor...
  15. ncbi request reprint Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
    Thromb Haemost 98:1285-90. 2007
    ....
  16. ncbi request reprint Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases
    E E Gardiner
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, VIC Australia
    J Thromb Haemost 5:1530-7. 2007
    ..Platelet glycoprotein (GP)VI that binds collagen, and GPIb-IX-V that binds von Willebrand factor, initiate thrombus formation...
  17. ncbi request reprint Programmed autologous cleavage of platelet receptors
    M C Berndt
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
    J Thromb Haemost 5:212-9. 2007
    ..This review discusses the underlying mechanisms for dual proteolytic pathways of receptor regulation, and the impact of these pathways on thrombus formation and stability in vivo...
  18. doi request reprint Measuring soluble platelet glycoprotein VI in human plasma by ELISA
    Mohammad Al-Tamimi
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Platelets 20:143-9. 2009
    ..Characterization of this sensitive ELISA should facilitate analysis of functional/diagnostic role(s) for soluble GPVI in human plasma associated with thrombotic/immune dysfunction...
  19. ncbi request reprint Snake venom probes of platelet adhesion receptors and their ligands
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, VIC 3168, Australia
    Toxicon 45:1051-61. 2005
    ..Whether homologous adhesion/counter-receptors on platelets and other vascular cells are also potential snake venom targets is as yet largely unexplored...
  20. doi request reprint Platelet receptor redox regulation
    Jane F Arthur
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne 3004, Victoria, Australia
    Platelets 19:1-8. 2008
    ....
  21. doi request reprint Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura
    E E Gardiner
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    J Thromb Haemost 6:1175-82. 2008
    ..Receptors on platelets that contain immunoreceptor tyrosine-based activation motifs (ITAMs) include collagen receptor glycoprotein (GP) VI, and FcgammaRIIa, a low affinity receptor for immunoglobulin (Ig) G...
  22. ncbi request reprint Platelet physiology: in cold blood
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3168, Victoria, Australia
    Curr Biol 13:R282-4. 2003
    ..New evidence suggests that this clearance is mediated in the liver by the Mac-1 integrin on Kupffer cells recognizing clustered GPIb receptor on platelets, leading to platelet phagocytosis...
  23. pmc Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3004, Australia
    J Biol Chem 285:11793-9. 2010
    ..Together, these results suggest that NGF can function as a metalloproteinase inhibitor...
  24. pmc Calmodulin interacts with the platelet ADP receptor P2Y1
    Jane F Arthur
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
    Biochem J 398:339-43. 2006
    ..These results suggest that the interaction of calmodulin with the P2Y1 C-terminal tail may regulate P2Y1-dependent platelet aggregation...
  25. ncbi request reprint Role of calmodulin in platelet receptor function
    Elizabeth E Gardiner
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3168, Australia
    Curr Med Chem Cardiovasc Hematol Agents 3:283-7. 2005
    ..Further studies should define the precise functional role of calmodulin in thrombus formation initiated by GPIb-IX-V or GPVI...
  26. ncbi request reprint Primary platelet adhesion receptors
    Jana Yip
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    IUBMB Life 57:103-8. 2005
    ....
  27. ncbi request reprint Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets
    Jane F Arthur
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3168, Australia
    Thromb Haemost 93:716-23. 2005
    ..A contribution of GPIb-IX-V to GPVI-induced platelet responses, and vice versa, therefore warrants further investigation...
  28. doi request reprint GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events
    Elizabeth E Gardiner
    The Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Platelets 21:244-52. 2010
    ..These data indicate signaling events triggered by specific ligation of GPIbalpha can lead to robust platelet activation and help define GPIb-IX-V as both an adhesion and signaling receptor on platelets...
  29. ncbi request reprint Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase
    Elizabeth E Gardiner
    Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia, 3800
    Blood 104:3611-7. 2004
    ..This process may represent a potential mechanism to regulate GPVI-dependent platelet adhesion...
  30. doi request reprint Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor
    Marguerite S Buzza
    Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Victoria, Australia
    J Biol Chem 283:22498-504. 2008
    ..GrB also cleaves the matrix form of fibrinogen at several sites. These studies suggest extracellular GrB may help control localized coagulation during inflammation...
  31. ncbi request reprint Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding
    Mohammad Al-Tamimi
    Department of Immunology, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
    Platelets 20:75-82. 2009
    ..In conclusion, this analysis of anti-GPVI mAbs provides useful tools for studying the functional role of platelet GPVI...
  32. ncbi request reprint Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor
    Yang Shen
    Department of Immunology and the Department of Biochemistry and Molecular Biology, Monash University, Victoria, 3800, Australia
    J Biol Chem 281:26419-23. 2006
    ..Together, these data demonstrate that LRR2-4, encompassing a pronounced negative charge patch on human GPIbalpha, is essential for GPIbalpha.VWF-dependent adhesion as hydrodynamic shear increases...
  33. ncbi request reprint The 14-3-3zeta-GPIb-IX-V complex as an antiplatelet target
    Robert K Andrews
    Department of Immunology, Monash University, Melbourne, Australia
    Drug News Perspect 20:285-92. 2007
    ..The unique recognition sequences and arrangement of functional 14-3-3zeta-binding sites found within the cytoplasmic domain of GPIb-IX-V increase the likelihood of selective targeting of this interaction...
  34. ncbi request reprint Fractionation of snake venom metalloproteinases by metal ion affinity: a purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose
    Lakshmi C Wijeyewickrema
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3008 Victoria, Australia
    Toxicon 50:1064-72. 2007
    ..The combined results support the general concept of using Ni(2+)-agarose to fractionate snake venom metalloproteinases...
  35. ncbi request reprint Snake venom toxins affecting platelet function
    Robert K Andrews
    Department of Biochemistry and Molecular Biology, Monas University, Clayton, Victoria, Australia
    Methods Mol Biol 273:335-48. 2004
  36. pmc A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex
    Fi Tjen Mu
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Australia
    Blood 111:4580-7. 2008
    ..Together, these data suggest the GPIb alpha C-terminus regulates signaling through independent association of 14-3-3zeta and PI3-kinase...
  37. doi request reprint New insights into the haemostatic function of platelets
    Andrew H Wei
    The Australian Centre for Blood Diseases, Monash University, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia
    Br J Haematol 147:415-30. 2009
    ....
  38. doi request reprint The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2
    Zon W Lai
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    Endocrinology 150:2376-81. 2009
    ..In summary, we have demonstrated that calmodulin is able to bind ACE2 and suggest that the ACE2 ectodomain shedding and/or sheddase(s) activation regulated by calmodulin is independent from the phorbol ester-induced shedding...
  39. ncbi request reprint Platelet glycoprotein VI-related clinical defects
    Jane F Arthur
    Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Vic, Australia
    Br J Haematol 139:363-72. 2007
    ..Clinical consequences of GPVI-related defects may be uniquely informative about the role of platelet GPVI in health and disease...
  40. pmc Glycoprotein IIb-IIIa-dependent aggregation by glycoprotein Ibalpha is reinforced by a Src family kinase inhibitor (PP1)-sensitive signalling pathway
    Stuart J Marshall
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 361:297-305. 2002
    ..In contrast, activation of GPIbalpha in washed platelets does not promote functional responses...
  41. ncbi request reprint Functional analysis of the C-terminal flanking sequence of platelet glycoprotein Ib alpha using canine-human chimeras
    Yang Shen
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 99:145-50. 2002
    ....
  42. doi request reprint New direction for WE thrombin
    Michael C Berndt
    Arterioscler Thromb Vasc Biol 28:205-7. 2008
  43. pmc Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 378:1023-9. 2004
    ..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V...
  44. ncbi request reprint Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V
    Tong Shi
    St George Hospital, University of New South Wales, Sydney, New South Wales, Australia
    Arthritis Rheum 54:2558-67. 2006
    ..We undertook this study to investigate the possible contribution of the GPIb-IX-V receptor to platelet activation mediated by the anti-beta2GPI antibody-beta2GPI complex...
  45. ncbi request reprint A familial platelet function disorder associated with abnormal signalling through the glycoprotein VI pathway
    Scott Dunkley
    Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Br J Haematol 137:569-77. 2007
    ..A genetic defect in GPVI/Fcgamma signalling compromising platelet function is hypothesised in this family...
  46. ncbi request reprint Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI
    Robert K Andrews
    Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia
    Blood 99:4219-21. 2002
    ..His269-Pro287 is analogous to the calmodulin-binding sequence in GPIbbeta. The novel interaction of GPVI and calmodulin may regulate aspects of GPVI function...
  47. ncbi request reprint Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 277:21561-6. 2002
    ..These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI...
  48. ncbi request reprint Proteolytic cleavage of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) is regulated by a calmodulin-binding motif
    Mae Xhum Wong
    Kronheimer Building, Austin Research Institute, Austin Hospital, Heidelberg, Vic, Australia
    FEBS Lett 568:70-8. 2004
    ..Taken together, these results suggest that this highly charged cluster of amino acids in the PECAM-1 cytoplasmic domain directly interacts with CaM and this novel interaction appears to regulate cleavage of PECAM-1...