Shelley F Walton
Affiliation: Menzies School of Health Research
- New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabiesS F Walton
Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia
Br J Dermatol 158:1247-55. 2008....
- Problems in diagnosing scabies, a global disease in human and animal populationsShelley F Walton
Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, and Department of Medicine, Royal Darwin Hospital, Casuarina NT 0811, Australia
Clin Microbiol Rev 20:268-79. 2007....
- Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-olShelley F Walton
Menzies School of Health Research, and Northern Territory Clinical School, Flinders University, Darwin, Australia
Arch Dermatol 140:563-6. 2004..To compare the acaricidal activity of Melaleuca alternifolia (tea tree) oil (TTO) and some of its individual active components on the itch mite Sarcoptes scabiei var hominis...
- Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistanceKate E Mounsey
Charles Darwin University, Menzies School of Health Research, Darwin, Northern Territory, Australia
Future Microbiol 3:57-66. 2008..These may assist in overcoming many of the current difficulties in monitoring treatment efficacy and allow the development of more sensitive tools for monitoring emerging resistance...
- A diagnostic test for scabies: IgE specificity for a recombinant allergen of Sarcoptes scabieiRama Jayaraj
Menzies School of Health Research, Darwin, Northern Territory 0810, Australia
Diagn Microbiol Infect Dis 71:403-7. 2011..3. This study shows that quantification of levels of IgE antibody to rSar s 14.3 is a highly sensitive method for diagnosis of scabies infestation in clinical practice...
- Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabiesAnnette Dougall
Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
Am J Trop Med Hyg 73:977-84. 2005..In addition, the specific IgE response to rSsGST01 did not correlate with the total IgE level of the patient. These results suggest that GST may play a role in the pathophysiology associated with crusted scabies...
- Scabies: new future for a neglected diseaseShelley F Walton
Menzies School of Health Research, Australia and Charles Darwin University, Darwin, Australia
Adv Parasitol 57:309-76. 2004..scabiei cDNA libraries and EST projects. Ultimately this knowledge may aid early identification of disease, novel forms of chemotherapy, vaccine development and new treatment possibilities for this important but neglected parasite...
- Identification of a homologue of a house dust mite allergen in a cDNA library from Sarcoptes scabiei var hominis and evaluation of its vaccine potential in a rabbit/S. scabiei var. canis modelPearly Harumal
Menzies School of Health Research, Darwin, Northern Territory, Australia
Am J Trop Med Hyg 68:54-60. 2003..Although it was not found to be protective in a challenge trial, the rabbits did not exhibit typical crust characteristics. This work shows that it is now possible to conduct such challenge trials with cloned scabies antigens...
- Molecular characterisation of a pH-gated chloride channel from Sarcoptes scabieiKate E Mounsey
Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, NT, Australia
Invert Neurosci 7:149-56. 2007..These results provide the first confirmation that this group of LGIC exists in arachnids, and suggest that SsCl may be an in vivo target of ivermectin in S. scabiei...
- First documentation of in vivo and in vitro ivermectin resistance in Sarcoptes scabieiBart J Currie
Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
Clin Infect Dis 39:e8-12. 2004..5 years, respectively. As predicted, ivermectin resistance in scabies mites can develop after intensive ivermectin use...
- A DNA fingerprinting system for the ectoparasite Sarcoptes scabieiS F Walton
Menzies School of Health Research, Casuarina, Australia
Mol Biochem Parasitol 85:187-96. 1997....
- Crusted scabies: A molecular analysis of Sarcoptes scabiei variety hominis populations from patients with repeated infestationsS F Walton
Menzies School of Health Research, Casuarina, Darwin, NT 0811, Australia
Clin Infect Dis 29:1226-30. 1999....
- Studies in vitro on the relative efficacy of current acaricides for Sarcoptes scabiei var. hominisS F Walton
Menzies School of Health Research, Darwin, Northern Territory, Australia
Trans R Soc Trop Med Hyg 94:92-6. 2000..Despite the slower killing time with 5% permethrin, there was no evidence of any mite tolerance in vivo or treatment failure in any patients or contact cases...
- Identification of ABC transporters in Sarcoptes scabieiK E Mounsey
Menzies School of Health Research, Darwin NT AustraliaInstitute of Advanced Studies, Charles Darwin University, Darwin NT Australia
Parasitology 132:883-92. 2006..This work forms an important foundation for further studies to elucidate the potential role of ABC transporters in ivermectin resistance of S. scabiei...
- Genetic epidemiology of Sarcoptes scabiei (Acari: Sarcoptidae) in northern AustraliaS F Walton
Queensland Institute of Medical Research, Brisbane, QLD, Australia
Int J Parasitol 34:839-49. 2004..The genetic division of dog and human derived scabies mites also has important implications in vaccine and diagnostic test development as well as the emergence and monitoring of drug resistance in S. scabiei in northern Australia...
- The scourge of scabiesDavid J Kemp
The Queensland Institute of Medical Research, Darwin, Australia
Biologist (London) 49:19-24. 2002..It has long been thought that dogs may act as a reservoir for human infections. However, genetic studies cast doubt over this supposition...
- Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literatureL J Roberts
Infectious Diseases Unit, Northern Territory Clinical School, Flinders University, Royal Darwin Hospital, Darwin, Northern Territory, Australia
J Infect 50:375-81. 2005..To describe the clinical and immunological features of crusted scabies in a prospectively ascertained cohort of 78 patients...
- Analysis of Sarcoptes scabiei finds no evidence of infection with WolbachiaK E Mounsey
Menzies School of Health Research, Darwin, NT, Australia
Int J Parasitol 35:131-5. 2005..scabiei or, involved in the inflammatory disease pathogenesis of scabies unlike its activity in filarial infection...
- Evidence incriminating midges (Diptera: Ceratopogonidae) as potential vectors of Leishmania in AustraliaAnnette M Dougall
Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia
Int J Parasitol 41:571-9. 2011..These findings have considerable implications in the understanding of the Leishmania life cycle worldwide...
- The immunology of susceptibility and resistance to scabiesS F Walton
Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
Parasite Immunol 32:532-40. 2010..scabiei infestations in the context of earlier studies and attempt to reconcile apparent differences and emphasize those aspects of the Th1/Th2 model that are supported or refined...
- Mechanisms for a novel immune evasion strategy in the scabies mite sarcoptes scabiei: a multigene family of inactivated serine proteasesDeborah C Holt
Queensland Institute of Medical Research and The Australian Center for International and Tropical Health and Nutrition, Brisbane, Australia
J Invest Dermatol 121:1419-24. 2003..The identification of this family, and elucidation of its value to the parasite, may present an unanticipated approach to protective vaccination...
- Circulating IgE in patients with ordinary and crusted scabiesLarry G Arlian
Department of Biological Sciences, Wright State University, Dayton, OH 45435 0001, USA
J Med Entomol 41:74-7. 2004..The results of this study indicate that patients with crusted scabies showed a pronounced IgE response to scabies mites, whereas patients with ordinary scabies did not...
- Scabies mite inactivated serine protease paralogues are present both internally in the mite gut and externally in fecesCharlene Willis
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Am J Trop Med Hyg 75:683-7. 2006..SMIPPs may well function in both of these compartments to evade host proteases...
- Generation and characterization of cDNA clones from Sarcoptes scabiei var. hominis for an expressed sequence tag library: identification of homologues of house dust mite allergensKatja Fischer
The Queensland Institute of Medical Research, The Australian Centre for International and Tropical Health and Nutrition, and The University of Queensland, Brisbane, Australia
Am J Trop Med Hyg 68:61-4. 2003..The availability of cDNA libraries from S. scabiei var. hominis and S. scabiei var. vulpes and the emerging public sequence databases from both opens up new possibilities in scabies research...
- A multigene family of inactivated cysteine proteases in Sarcoptes scabieiDeborah C Holt
J Invest Dermatol 123:240-1. 2004