R N Price

Summary

Affiliation: Menzies School of Health Research
Country: Australia

Publications

  1. pmc The anaemia of Plasmodium vivax malaria
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Malar J 11:135. 2012
  2. pmc Towards optimal design of anti-malarial pharmacokinetic studies
    Julie A Simpson
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Victoria, Australia
    Malar J 8:189. 2009
  3. pmc Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum
    Muhammad Karyana
    International Health Division, Menzies School of Health Research, Darwin, Australia
    Malar J 7:148. 2008
  4. pmc The effect of varying analytical methods on estimates of anti-malarial clinical efficacy
    Wendy J Verret
    Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    Malar J 8:77. 2009
  5. pmc In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax
    A R Hasugian
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Antimicrob Agents Chemother 53:1094-9. 2009
  6. doi request reprint New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance
    Ric N Price
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Curr Opin Infect Dis 22:430-5. 2009
  7. pmc Vivax malaria: neglected and not benign
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Casuarina, Darwin, Northern Territory 0811, Australia
    Am J Trop Med Hyg 77:79-87. 2007
  8. pmc Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria
    A R Hasugian
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Clin Infect Dis 44:1067-74. 2007
  9. pmc Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison
    A Ratcliff
    International Health Programme, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Lancet 369:757-65. 2007
  10. pmc Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malaria
    R N Price
    Information Health Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, NT 0811, Australia
    Antimicrob Agents Chemother 51:4090-7. 2007

Collaborators

Detail Information

Publications31

  1. pmc The anaemia of Plasmodium vivax malaria
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Malar J 11:135. 2012
    ..Anaemia can be averted by early and effective anti-malarial treatment...
  2. pmc Towards optimal design of anti-malarial pharmacokinetic studies
    Julie A Simpson
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Victoria, Australia
    Malar J 8:189. 2009
    ....
  3. pmc Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum
    Muhammad Karyana
    International Health Division, Menzies School of Health Research, Darwin, Australia
    Malar J 7:148. 2008
    ..Multidrug resistance has emerged to both Plasmodium vivax and Plasmodium falciparum and yet the comparative epidemiology of these infections is poorly defined...
  4. pmc The effect of varying analytical methods on estimates of anti-malarial clinical efficacy
    Wendy J Verret
    Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
    Malar J 8:77. 2009
    ..The aim of this study was to quantify the magnitude of the differences between efficacy estimates derived from these approaches and identify the factors underlying these differences...
  5. pmc In vivo and in vitro efficacy of amodiaquine monotherapy for treatment of infection by chloroquine-resistant Plasmodium vivax
    A R Hasugian
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Antimicrob Agents Chemother 53:1094-9. 2009
    ..001). Although amodiaquine results in a rapid clinical response, the risk of recurrence by day 28 is unacceptably high, reducing its suitability as an alternative treatment of infection by chloroquine-resistant P. vivax in this region...
  6. doi request reprint New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance
    Ric N Price
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Curr Opin Infect Dis 22:430-5. 2009
    ..vivax infection. We review the evidence for severe disease and the spread of drug-resistant P. vivax and speculate how these maybe related...
  7. pmc Vivax malaria: neglected and not benign
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Casuarina, Darwin, Northern Territory 0811, Australia
    Am J Trop Med Hyg 77:79-87. 2007
    ..Without these, vivax malaria will continue to be neglected by ministries of health, policy makers, researchers, and funding bodies...
  8. pmc Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria
    A R Hasugian
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Clin Infect Dis 44:1067-74. 2007
    ..In southern Papua, Indonesia, where both strains of plasmodia coexist, we have been conducting a series of studies to optimize treatment strategies...
  9. pmc Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison
    A Ratcliff
    International Health Programme, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Lancet 369:757-65. 2007
    ..Our aim was to compare the safety and efficacy of dihydroartemisinin-piperaquine with that of artemether-lumefantrine in patients with uncomplicated malaria caused by multidrug-resistant P falciparum and P vivax...
  10. pmc Clinical and pharmacological determinants of the therapeutic response to dihydroartemisinin-piperaquine for drug-resistant malaria
    R N Price
    Information Health Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Darwin, NT 0811, Australia
    Antimicrob Agents Chemother 51:4090-7. 2007
    ..Lower plasma piperaquine concentrations and higher failure rates in children suggest that dose revision may be warranted in this age group...
  11. pmc In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax
    R N Price
    Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Antimicrob Agents Chemother 54:5146-50. 2010
    ..vivax and P. falciparum highlights the suitability of the drug as a novel partner for artemisinin-based combination therapy in regions where the two species are coendemic...
  12. pmc In vivo and in vitro efficacy of chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia
    H Siswantoro
    National Institute of Health Research and Development, Jakarta, Indonesia
    Antimicrob Agents Chemother 55:197-202. 2011
    ..8 nM). Chloroquine retains adequate efficacy against P. ovale and P. malariae, but its marked stage specificity of action may account for reports of delayed parasite clearance times...
  13. doi request reprint Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax
    R Suwanarusk
    International Health Division, Menzies School of Health Research, Darwin, Australia
    J Infect Dis 198:1558-64. 2008
    ..Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia...
  14. pmc Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia
    A Ratcliff
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
    Trans R Soc Trop Med Hyg 101:351-9. 2007
    ..falciparum and P. vivax exists both to first- and second-line therapies. Preliminary data indicate that amodiaquine retains superior efficacy compared with CQ for CQ-resistant P. vivax...
  15. pmc Determinants of in vitro drug susceptibility testing of Plasmodium vivax
    B Russell
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Antimicrob Agents Chemother 52:1040-5. 2008
    ..vivax and suggest that susceptibility to chloroquine may be associated with variable growth rates. These findings have important implications for the phenotypic and downstream genetic characterization of P. vivax...
  16. pmc Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms
    Rossarin Suwanarusk
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    PLoS ONE 2:e1089. 2007
    ..vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined...
  17. pmc Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in papua, Indonesia
    Graeme P Maguire
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 192:1966-74. 2005
    ..In patients with severe malaria, acute respiratory distress syndrome usually develops after the start of drug treatment and is a major cause of death. Its pathogenesis is not well understood...
  18. pmc Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation
    Nicholas M Anstey
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT 0811, Australia
    J Infect Dis 195:589-96. 2007
    ..The mechanisms underlying lung injury in vivax malaria are not well understood. Inflammatory responses to Plasmodium falciparum and P. vivax, to our knowledge, have not previously been compared at an organ level...
  19. pmc Improving case definitions for severe malaria
    Nicholas M Anstey
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Med 4:e267. 2007
  20. pmc Comparison of three molecular methods for the detection and speciation of Plasmodium vivax and Plasmodium falciparum
    Prapaporn Boonma
    Department of Parasitology, Faculty of Public Health, Mahidol University, Bangkok, Thailand
    Malar J 6:124. 2007
    ..PCR assays offer an alternative to microscopy which has been shown to have superior sensitivity and specificity. Unfortunately few comparative studies have been done on the various molecular based speciation methods...
  21. pmc Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic
    Jeanne Rini Poespoprodjo
    District Health Authority, School of Health Research National Institute of Health Research and Development Malaria Research Program, Indonesia
    Clin Infect Dis 46:1374-81. 2008
    ..Plasmodium falciparum infection exerts a considerable burden on pregnant women, but less is known about the adverse consequences of Plasmodium vivax infection...
  22. doi request reprint Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responses
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Infect Dis 198:134-42. 2008
    ..In cross-sectional and longitudinal studies, we measured MSP5 antibody responses in Papuans with acute Plasmodium falciparum malaria, Plasmodium vivax malaria, and mixed P. falciparum and P. vivax malaria and in those with past exposure...
  23. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia...
  24. ncbi request reprint Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria
    Ric N Price
    Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    Clin Infect Dis 42:1570-7. 2006
    ..Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)...
  25. pmc Plasmodium vivax trophozoites insensitive to chloroquine
    Wesley W Sharrock
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Malar J 7:94. 2008
    ..vivax clinical isolates suggest that only ring stages (early trophozoites) are sensitive to chloroquine. In this study, the stage specific action of chloroquine was investigated in synchronous cryopreserved isolates of P. vivax...
  26. pmc World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria
    Christopher V Plowe
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, Maryland 21201, USA
    Malar J 6:121. 2007
    ....
  27. ncbi request reprint Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria
    Oliver T Mytton
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Am J Trop Med Hyg 77:447-50. 2007
    ..At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram...
  28. pmc Safety profile of L-arginine infusion in moderately severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS ONE 3:e2347. 2008
    ..We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in adults with moderately severe malaria...
  29. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    ..Clinical trials in SM of adjunctive agents to improve endothelial NO bioavailability, including l-arginine, are warranted...
  30. pmc Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 198:602-8. 2008
    ..L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria...
  31. ncbi request reprint Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
    ..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...