Geoffrey K Isbister

Summary

Affiliation: Menzies School of Health Research
Country: Australia

Publications

  1. ncbi Acute myocardial injury caused by Sydney funnel-web spider (Atrax robustus) envenoming
    G K Isbister
    Newcastle Mater Misericordiae Hospital, Waratah, New South Wales
    Anaesth Intensive Care 31:672-4. 2003
  2. ncbi The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brishane, Australia
    J Pharmacokinet Pharmacodyn 32:571-605. 2005
  3. ncbi Baclofen overdose: defining the spectrum of toxicity
    Nicola Y Leung
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Emerg Med Australas 18:77-82. 2006
  4. ncbi Safety of i.v. administration of redback spider antivenom
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Intern Med J 37:820-2. 2007
  5. doi Procoagulant snake toxins: laboratory studies, diagnosis, and understanding snakebite coagulopathy
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Semin Thromb Hemost 35:93-103. 2009
  6. pmc Does implementation of a paediatric asthma clinical practice guideline worksheet change clinical practice?
    Johann Gildenhuys
    Emergency Department, John Hunter Hospital, Newcastle, Australia
    Int J Emerg Med 2:33-9. 2009
  7. pmc Assessing risk of a prolonged QT interval-a survey of emergency physicians
    Amanda S Y Chan
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Int J Emerg Med 1:35-41. 2008
  8. ncbi Failure of antivenom to improve recovery in Australian snakebite coagulopathy
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    QJM 102:563-8. 2009
  9. ncbi Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Intensive Care Med 32:1060-5. 2006
  10. doi Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Vaccine 28:798-802. 2010

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. ncbi Acute myocardial injury caused by Sydney funnel-web spider (Atrax robustus) envenoming
    G K Isbister
    Newcastle Mater Misericordiae Hospital, Waratah, New South Wales
    Anaesth Intensive Care 31:672-4. 2003
    ..The mechanism by which funnel-web spider envenomation caused myocardial injury is unclear but follow-up nuclear studies in the patient demonstrated that she had minimal atherosclerotic disease...
  2. ncbi The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brishane, Australia
    J Pharmacokinet Pharmacodyn 32:571-605. 2005
    ..These findings suggest charcoal administration is potentially beneficial after citalopram overdose. The methodology explored seems promising for exploring the dose-exposure relationship in the toxicological settings...
  3. ncbi Baclofen overdose: defining the spectrum of toxicity
    Nicola Y Leung
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Emerg Med Australas 18:77-82. 2006
    ..To describe the spectrum of toxicity of baclofen in overdose, and investigate dose-related clinical effects...
  4. ncbi Safety of i.v. administration of redback spider antivenom
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Intern Med J 37:820-2. 2007
    ..In 32 patients followed up for 2 weeks, three (10%) developed serum sickness. RBSAV given i.v. had a low reaction rate...
  5. doi Procoagulant snake toxins: laboratory studies, diagnosis, and understanding snakebite coagulopathy
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Semin Thromb Hemost 35:93-103. 2009
    ..A better understanding of the coagulation effects arising from human envenoming will also improve treatment with antivenom and define the role of adjuvant therapies such as factor replacement...
  6. pmc Does implementation of a paediatric asthma clinical practice guideline worksheet change clinical practice?
    Johann Gildenhuys
    Emergency Department, John Hunter Hospital, Newcastle, Australia
    Int J Emerg Med 2:33-9. 2009
    ..Despite the development of evidence-based practice guidelines in many countries for asthma treatment in children, there is limited evidence that using such guidelines improves patient care...
  7. pmc Assessing risk of a prolonged QT interval-a survey of emergency physicians
    Amanda S Y Chan
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Int J Emerg Med 1:35-41. 2008
    ..CONCLUSIONS: EPs mainly relied on Bazett's correction as their method of TdP risk assessment, which may be problematic for bradycardic patients...
  8. ncbi Failure of antivenom to improve recovery in Australian snakebite coagulopathy
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    QJM 102:563-8. 2009
    ..Venom-induced consumption coagulopathy (VICC) is an important feature of snake envenoming...
  9. ncbi Application of pharmacokinetic-pharmacodynamic modelling in management of QT abnormalities after citalopram overdose
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Intensive Care Med 32:1060-5. 2006
    ..To develop guidelines for the management of QT prolongation after citalopram overdose, including decontamination with single-dose activated charcoal (SDAC) and cardiac monitoring...
  10. doi Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Vaccine 28:798-802. 2010
    ..However, they did cross-neutralise the procoagulant effects of both procoagulant venoms. This supports the idea of developing antivenoms against groups of snake toxins rather than individual snake venoms...
  11. pmc A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Br J Clin Pharmacol 65:139-43. 2008
    ..There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV)...
  12. ncbi Antipsychotic poisoning in young children: a systematic review
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School for Health Research, Sydney, Australia
    Drug Saf 28:1029-44. 2005
    ..Most cases resolve with good supportive care. Toxic doses are only estimates that are based on limited data and should be used with caution until prospective studies are undertaken...
  13. pmc Electrocardiogram changes and arrhythmias in venlafaxine overdose
    Geoffrey K Isbister
    Charles Darwin University, Darwin and Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, Australia
    Br J Clin Pharmacol 67:572-6. 2009
    ..To investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias following venlafaxine overdose...
  14. doi Antivenom efficacy or effectiveness: the Australian experience
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Toxicology 268:148-54. 2010
    ....
  15. ncbi Human methyl parathion poisoning
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School for Health Research, Charles Darwin University, Australia
    Clin Toxicol (Phila) 45:956-60. 2007
    ..Methyl parathion is classed as an extremely hazardous pesticide with a rodent LD50 of 6 to 24 mg/kg. It has been banned in numerous countries, but there are few reports of acute methyl parathion poisoning...
  16. ncbi Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studies
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NSW, Australia
    Toxicon 49:57-67. 2007
    ..One vial of antivenom appears to be sufficient to bind and neutralise all venom in patients with severe brown snake envenoming...
  17. doi Human anti-snake venom IgG antibodies in a previously bitten snake-handler, but no protection against local envenoming
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, New South Wales, Australia
    Toxicon 55:646-9. 2010
    ..However, despite the presence of antibodies to death adder venom and free venom not being detected, the patient still developed significant local myotoxicity...
  18. ncbi Activated charcoal decreases the risk of QT prolongation after citalopram overdose
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Ann Emerg Med 50:593-600, 600.e1-46. 2007
    ..We determine whether single-dose activated charcoal (SDAC) administration after citalopram overdose reduces the proportion of patients developing abnormal QT prolongation...
  19. ncbi Clinically applicable laboratory end-points for treating snakebite coagulopathy
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Pathology 38:568-72. 2006
    ..To determine which coagulation tests best reflect the return of clotting function after snakebite venom induced consumptive coagulopathy (VICC)...
  20. ncbi Thrombotic microangiopathy from Australian brown snake (Pseudonaja) envenoming
    G K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Intern Med J 37:523-8. 2007
    ..A proportion of cases go on to develop thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic haemolytic anaemia (MAHA) and acute renal failure (ARF)...
  21. doi A randomised controlled trial of intramuscular vs. intravenous antivenom for latrodectism--the RAVE study
    G K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    QJM 101:557-65. 2008
    ..Widow spider-bite causes latrodectism and is associated with significant morbidity worldwide. Antivenom is given by both the intravenous (IV) and intramuscular (IM) routes and it is unclear which is more effective...
  22. ncbi Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 42:277-85. 2004
    ..They appear to be safer in overdose, but there is little information on their spectrum of toxicity in overdose, or relative toxicity of each agent...
  23. doi Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia
    Ann Emerg Med 56:392-401.e1. 2010
    ..We determine whether droperidol, midazolam, or the combination is more effective for intramuscular sedation in violent and acute behavioral disturbance in the emergency department (ED)...
  24. ncbi Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP-11)
    Andrew Churchman
    Emergency Department, Princess Alexandra Hospital, Brisbane, QLD, Australia
    Med J Aust 193:696-700. 2010
    ..To describe the clinical features and laboratory findings in patients with definite red-bellied black snake (RBBS; Pseudechis porphyriacus) bites, including correlation with results of venom assays...
  25. ncbi Changes in serial laboratory test results in snakebite patients: when can we safely exclude envenoming?
    Graham Ireland
    Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
    Med J Aust 193:285-90. 2010
    ....
  26. doi Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, Australia
    J Clin Psychopharmacol 30:391-5. 2010
    ..Amisulpride overdose commonly causes QT prolongation, bradycardia, and hypotension. Torsades de pointes occurred commonly enough to suggest that amisulpride is highly cardiotoxic in overdose...
  27. ncbi Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 188:473-6. 2008
    ..To investigate current use of Australian snake antivenoms and the frequency and severity of immediate-type hypersensitivity reactions...
  28. pmc Pharmacokinetic-pharmacodynamic modelling of QT interval prolongation following citalopram overdoses
    Lena E Friberg
    School of Pharmacy, University of Queensland, Brisbane, Australia
    Br J Clin Pharmacol 61:177-90. 2006
    ....
  29. ncbi Snakebite in Australia: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 199:763-8. 2013
    ..However, recovery may be delayed as many clinical and laboratory effects of venom are not immediately reversible. For expert advice on envenoming, contact the National Poisons Information Centre on 13 11 26...
  30. pmc Clinical effects and antivenom dosing in brown snake (Pseudonaja spp.) envenoming--Australian snakebite project (ASP-14)
    George E Allen
    Emergency Department, Queen Elizabeth II Jubilee Hospital, Brisbane, Australia
    PLoS ONE 7:e53188. 2012
    ..We aimed to investigate the clinical and laboratory features of definite brown snake (Pseudonaja spp.) envenoming, and determine the dose of antivenom required...
  31. ncbi Envenoming by the rough-scaled snake (Tropidechis carinatus): a series of confirmed cases
    Melissa Gan
    Emergency Department, Gold Coast Hospital, Gold Coast, QLD, Australia
    Med J Aust 191:183-6. 2009
    ..To describe demographic, geographical and clinical features of envenoming by the rough-scaled snake (RSS) (Tropidechis carinatus)...
  32. doi Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom
    Geoffrey K Isbister
    Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Toxicon 56:75-85. 2010
    ..ETP is a useful assay to investigate mechanisms of other procoagulant venoms and is a robust method of assessing antivenom efficacy...
  33. pmc Death adder envenoming causes neurotoxicity not reversed by antivenom--Australian Snakebite Project (ASP-16)
    Christopher I Johnston
    School of Medicine Sydney, University of Notre Dame Australia, Darlinghurst, New South Wales, Australia
    PLoS Negl Trop Dis 6:e1841. 2012
    ..Death adders (Acanthophis spp) are found in Australia, Papua New Guinea and parts of eastern Indonesia. This study aimed to investigate the clinical syndrome of death adder envenoming and response to antivenom treatment...
  34. ncbi Population pharmacokinetics of intravenous, intramuscular, and intranasal naloxone in human volunteers
    Jonathonm Dowling
    Clinical and Experimental Toxicology Unit, Prince of Wales Hospital and Prince of Wales Clinical School, University of NSW, Sydney, Australia
    Ther Drug Monit 30:490-6. 2008
    ..Intranasal naloxone had poor bioavailability compared with intramuscular. Combined intravenous and intramuscular administration may be a useful alternative to naloxone infusions...
  35. pmc The impact of a standardised intramuscular sedation protocol for acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Emerg Med 10:14. 2010
    ..Acute behavioural disturbance (ABD) is an increasing problem in emergency departments. This study aimed to determine the impact of a structured intramuscular (IM) sedation protocol on the duration of ABD in the emergency department...
  36. ncbi Funnel-web spider bite: a systematic review of recorded clinical cases
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 182:407-11. 2005
    ..To investigate species-specific envenoming rates and spectrum of severity of funnel-web spider bites, and the efficacy and adverse effects of funnel-web spider antivenom...
  37. ncbi Cross-neutralisation of Australian brown and tiger snake venoms with commercial antivenoms: Cross-reactivity or antivenom mixtures?
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle, NSW, Australia
    Toxicon 50:206-13. 2007
    ..Single-polyvalent antivenom for brown snake and tiger snake may be feasible in the future...
  38. doi Sedation assessment tool to score acute behavioural disturbance in the emergency department
    Leonie A Calver
    Discipline of Clinical Pharmacology, Faculty of Health, University of Newcastle, Newcastle, New South Wales, Australia
    Emerg Med Australas 23:732-40. 2011
    ..The objective of the study was to evaluate the effectiveness of the sedation assessment tool (SAT) in assessing patient response to treatment for acute behavioural disturbance (ABD)...
  39. doi Digital Holter measurement of QT prolongation in ziprasidone overdose
    Ingrid Berling
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, Australia
    Clin Toxicol (Phila) 49:694-6. 2011
    ..We report a case of ziprasidone overdose with QT prolongation, demonstrating different methods of measuring the QT interval...
  40. doi Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal
    Geoffrey K Isbister
    aDepartment of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, Australia
    Int Clin Psychopharmacol 24:174-80. 2009
    ..SDAC seems to have only modest effects on outcomes but may be considered within 2 h for large ingestions. Electrocardiogram monitoring is unlikely to be necessary...
  41. ncbi Quetiapine poisoning: a case series
    Corrine R Balit
    New South Wales Poisons Information Centre, The Children s Hospital at Westmead, Sydney, Australia
    Ann Emerg Med 42:751-8. 2003
    ..We describe the effects of quetiapine in overdose...
  42. doi Risperidone overdose causes extrapyramidal effects but not cardiac toxicity
    Colin B Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    J Clin Psychopharmacol 30:387-90. 2010
    ..The aim of this study was to describe the clinical and electrocardiographic features of risperidone overdose, including the frequency of dystonic reactions...
  43. doi An examination of the activity of expired and mistreated commercial Australian antivenoms
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    Trans R Soc Trop Med Hyg 103:937-42. 2009
    ..CSL antivenoms are more robust than indicated on their label and maintain useful activity long past their nominated expiry dates...
  44. pmc A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit
    Leonie Calver
    Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    BMC Psychiatry 13:225. 2013
    ..This study aimed to investigate sedation for ABD in an acute mental healthcare unit, including the effectiveness and safety of high dose sedation...
  45. pmc Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW 2298, Australia
    Br J Clin Pharmacol 76:48-57. 2013
    ..This risk assessment then allows the safer commencement of drugs therapeutically or management of drug induced effects in overdose...
  46. ncbi Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom-antivenom complexes
    Margaret A O'Leary
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Waratah NSW, Australia
    Toxicon 48:4-11. 2006
    ..Quantification of venom and antivenom will help to determine the dose of antivenom required to bind venom and to establish appropriate end points for antivenom treatment...
  47. doi Bites in Australian snake handlers--Australian snakebite project (ASP-15)
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Calvary Mater Newcastle, Waratah NSW 2298, Australia
    QJM 105:1089-95. 2012
    ..Snakebites in snake handlers are an important clinical problem that may differ to bites in the general population...
  48. ncbi Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13)
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW
    Med J Aust 197:173-7. 2012
    ..To describe the clinical syndrome associated with definite tiger snake (Notechis spp) envenoming and to examine the ability of tiger snake antivenom (TSAV) to bind free venom in vivo...
  49. ncbi Effects of envenoming by comb-footed spiders of the genera Steatoda and Achaearanea (family Theridiidae: Araneae) in Australia
    Geoffrey K Isbister
    University of Newcastle, Newcastle, Australia
    J Toxicol Clin Toxicol 41:809-19. 2003
    ..The family Theridiidae (comb-footed spiders) contains the well-known and medically important widow spider group (Latrodectus spp.). Little is known about the effects of envenoming by other common members of this family...
  50. ncbi Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Waratah, NSW, Australia geoffrey isbister menzies edu au
    Clin Toxicol (Phila) 47:884-8. 2009
    ..To assess interobserver agreement when trained healthcare staff measure the QT interval using a standardized approach across a range of QT lengths...
  51. doi Spider bite
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Lancet 378:2039-47. 2011
    ..Antivenoms are an important treatment for spider envenomation but have been less successful than have those for snake envenomation, with concerns about their effectiveness for both latrodectism and loxoscelism...
  52. doi A turbidimetric assay for the measurement of clotting times of procoagulant venoms in plasma
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, New South Wales, Australia
    J Pharmacol Toxicol Methods 61:27-31. 2010
    ..Assessment of the procoagulant effect of snake venoms is important for understanding their effects. The aim of this study was to develop a simple automated method to measure clotting times to assess procoagulant venoms...
  53. ncbi Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 184:354-6. 2006
    ....
  54. ncbi A randomised controlled trial of hot water (45 degrees C) immersion versus ice packs for pain relief in bluebottle stings
    Conrad Loten
    Hunter New England Area Health Service, Newcastle, NSW
    Med J Aust 184:329-33. 2006
    ..To investigate the effectiveness of hot water immersion for the treatment of Physalia sp. (bluebottle or Portuguese Man-of-War) stings...
  55. doi Investigating pressure bandaging for snakebite in a simulated setting: bandage type, training and the effect of transport
    Elizabeth Canale
    Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, and Northern Territory Clinical School, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    Emerg Med Australas 21:184-90. 2009
    ..The clinical evidence base for the use of pressure bandaging in snakebite is limited. We aimed to investigate if pressure bandages (PB) generated and maintained presumptive optimal pressures in a simulated setting...
  56. doi Indications for single-dose activated charcoal administration in acute overdose
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle and Discipline of Clinical Pharmacology, University of Newcastle, New South Wales, Australia
    Curr Opin Crit Care 17:351-7. 2011
    ..There has been a significant decrease in the use of single-dose activated charcoal (SDAC) in recent years based on little new evidence and possibly because the overall mortality in overdose patients is low...
  57. ncbi Clinical consequences of spider bites: recent advances in our understanding
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, Newcastle, NSW 2298, Australia
    Toxicon 43:477-92. 2004
    ..Most spiders only cause minor effects, including a large number of groups that have been implicated in necrotic arachnidism...
  58. ncbi Prospective study of definite caterpillar exposures
    Corrine R Balit
    NSW Poisons Information Centre, The Children s Hospital, Westmead, Corner Hawkesbury Rd and Hainsworth Street, Locked Bag 4001, Westmead, Sydney, NSW 2145, Australia
    Toxicon 42:657-62. 2003
    ..This is the first prospective study of caterpillar exposures within Australia and demonstrates that exposures can result in a variety of reactions depending on the family and species involved...
  59. pmc Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 56:441-50. 2003
    ..To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters...
  60. ncbi Arsenic trioxide poisoning: a description of two acute overdoses
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia
    Hum Exp Toxicol 23:359-64. 2004
    ..Arsenic quantification in blood, urine and faeces suggested that enhanced gastrointestinal decontamination was minimally effective for decontamination and that DMSA for at least two weeks was required...
  61. ncbi A prospective study of definite bites by spiders of the family Sparassidae (huntsmen spiders) with identification to species level
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Clinical Toxicologist and Emergency Physician, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building Edith St, Waratah, NSW 2298, Australia
    Toxicon 42:163-71. 2003
    ..The mechanism of effects appeared to be trauma rather than envenoming. There were no major differences between genera, and Neosparassus spp. did not cause major effects...
  62. ncbi Bupropion overdose: QTc prolongation and its clinical significance
    Geoffrey K Isbister
    University of Newcastle, Waratah, Australia
    Ann Pharmacother 37:999-1002. 2003
    ..To investigate the cardiotoxicity of bupropion hydrochloride in deliberate self-poisoning...
  63. doi Dexmedetomidine in the emergency department: assessing safety and effectiveness in difficult-to-sedate acute behavioural disturbance
    Leonie Calver
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, New South Wales, Australia
    Emerg Med J 29:915-8. 2012
    ..To investigate the safety and effectiveness of dexmedetomidine for sedating patients in whom previous attempts at sedation in the emergency department have failed...
  64. ncbi Antivenom, anecdotes and evidence
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, NSW
    Med J Aust 181:685-6. 2004
  65. ncbi Serotonin toxicity: a practical approach to diagnosis and treatment
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 187:361-5. 2007
    ..Treatment should focus on cessation of the serotonergic medication and supportive care. Some antiserotonergic agents have been used in clinical practice, but the preferred agent, dose and indications are not well defined...
  66. doi A pharmacological approach to first aid treatment for snakebite
    Megan E Saul
    Department of Nuclear Medicine, John Hunter Hospital, New Lambton, New South Wales, Australia
    Nat Med 17:809-11. 2011
    ..This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment...
  67. ncbi 'Red as a beet and blind as a bat' Anticholinergic delirium in adolescents: lessons for the paediatrician
    Kim A Ramjan
    The Children s Hospital at Westmead, Westmead, New South Wales, Australia
    J Paediatr Child Health 43:779-80. 2007
    ..A high index of suspicion is often required in the paediatric setting due to infrequent acute hospital presentation...
  68. ncbi Developing a decision tree algorithm for the diagnosis of suspected spider bites
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med Australas 16:161-6. 2004
    ....
  69. ncbi Bites by Australian mygalomorph spiders (Araneae, Mygalomorphae), including funnel-web spiders (Atracinae) and mouse spiders (Actinopodidae: Missulena spp)
    Geoffrey K Isbister
    Emergency Department, Newcastle Mater Misericordiae Hospital and the University of Newcastle, The Children s Hospital at Westmead, Sydney, Australia
    Toxicon 43:133-40. 2004
    ..Mouse spider bites are unlikely to cause major envenoming but the clinical effects are consistent with neurotoxic venom and are more severe than the trapdoor spiders...
  70. ncbi Two cases of bites by the black-bellied swamp snake (Hemiaspis signata)
    Geoffrey K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Locked Bag 7, Hunter Region Main Centre, Newcastle, NSW 2310, Australia
    Toxicon 40:317-9. 2002
    ..These cases indicate the potential for coagulopathy and local symptoms following bites by large specimens of H. signata in young children...
  71. ncbi Bites by spiders of the family Theraphosidae in humans and canines
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Waratah, NSW 2298, Australia
    Toxicon 41:519-24. 2003
    ..Bites by these spiders are unlikely to cause major problems in humans. The study also demonstrates that the venom is far more toxic to canines...
  72. ncbi White-tail spider bite: a prospective study of 130 definite bites by Lampona species
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
    Med J Aust 179:199-202. 2003
    ..To investigate the circumstances and clinical effects of bites by white-tail spiders, including the two species Lampona cylindrata and L. murina commonly encountered by humans, and the incidence of necrotic lesions...
  73. pmc Alprazolam is relatively more toxic than other benzodiazepines in overdose
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, Australia
    Br J Clin Pharmacol 58:88-95. 2004
    ..To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines...
  74. ncbi Australian scorpion stings: a prospective study of definite stings
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Clinical Sciences Building, Level 5 Edith Street, Waratah, NSW 2298, Australia
    Toxicon 41:877-83. 2003
    ..This differs from other parts of the world, where severe envenoming is reported. The major clinical effect is severe pain, consistent with other scorpion stings. Most stings occurred indoors and at night...
  75. ncbi Antivenom treatment in arachnidism
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, NSW, Australia
    J Toxicol Clin Toxicol 41:291-300. 2003
    ..Although envenomation from arthropods is common, no antivenoms exist for these, excepting Lonomia caterpillars in South America, and Ixodes paralysis ticks in Australia...
  76. ncbi The dark side of the moon
    Leonie A Calver
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    Med J Aust 191:692-4. 2009
    ..We investigated the possibility that there is an association between only extreme behavioural disturbance and the full moon...
  77. ncbi Suspected snakebite: one year prospective study of emergency department presentations
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med (Fremantle) 15:160-9. 2003
    ..Snakebite is an uncommon, but potentially life-threatening condition. The more common clinical scenario is suspected snake-bite. Our aim was to characterise the epidemiology, diagnosis and management of patients with suspected snakebites...
  78. ncbi Nefazodone poisoning: toxicokinetics and toxicodynamics using continuous data collection
    Geoffrey K Isbister
    University of Newcastle, Newcastle, Australia
    J Toxicol Clin Toxicol 41:167-73. 2003
    ..Bradycardia, hypotension, and drowsiness are the most significant effects and are maximal in the first 12 hours when parent and metabolite concentrations are high...
  79. ncbi Australian wolf spider bites (Lycosidae): clinical effects and influence of species on bite circumstances
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, Newcastle Mater Misericordiae Hospital, University of Newcastle, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 42:153-61. 2004
    ..Necrotic arachnidism continues to be attributed to wolf spider bites. This study investigates the clinical effects of bites by wolf spiders in Australia (family Lycosidae)...
  80. doi Commercial monovalent antivenoms in Australia are polyvalent
    Margaret A O'Leary
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    Toxicon 54:192-5. 2009
    ..However, it would be possible for the manufacturer to reduce the number of types of snake antivenoms available in Australia to two polyvalent antivenoms which would simplify treatment of snakebite...
  81. ncbi Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Emerg Med (Fremantle) 15:376-82. 2003
    ..To investigate the pattern and epidemiology of anticholinergic plant poisoning, and to characterize its time course and clinical features...
  82. pmc The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report
    Colin Page
    Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle Hospital, Newcastle, NSW, Australia
    J Med Toxicol 5:139-43. 2009
    ..Although the metoprolol concentrations measured in plasma were approximately 100-200 times therapeutic concentrations, the pharmacokinetics appeared to be similar to therapeutic metoprolol dosing...
  83. ncbi Spotted black snake (Pseudechis guttatus) envenoming
    Melanie Jansen
    School of Medical Practice and Population Health, University of Newcastle, Newcastle, NSW, Australia
    Med J Aust 186:41-2. 2007
    ..Neither patient developed significant coagulopathy, myolysis or neuromuscular paralysis. Bites by this species appear to cause effects similar to those of the more common red-bellied black snake (P. porphyriacus)...
  84. ncbi Effectiveness of pressure-immobilization first aid for snakebite requires further study
    Bart J Currie
    Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia
    Emerg Med Australas 20:267-70. 2008
    ....
  85. doi Reviewing deaths in the emergency department: deaths in the department or deaths within 48 h
    Sally Clunas
    Emergency Department, John Hunter Hospital, Newcastle, NSW, Australia
    Emerg Med Australas 21:117-23. 2009
    ..To investigate an ED death audit process that included deaths occurring within 48 h of admission in addition to deaths in the ED...
  86. ncbi Black house spiders are unlikely culprits in necrotic arachnidism: a prospective study
    G K Isbister
    Clinical Envenoming Research Group, University of Newcastle and Newcastle Mater Misericordiae Hospital, Newcastle, Australia
    Intern Med J 34:287-9. 2004
    ..5% confidence interval 0-14%). Black house spiders (Badumna spp.) are unlikely to cause necrosis, contrary to reports of suspected bites. Patients can be reassured and do not require any further investigation or treatment...
  87. ncbi Data collection in clinical toxinology: debunking myths and developing diagnostic algorithms
    Geoffrey K Isbister
    University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    J Toxicol Clin Toxicol 40:231-7. 2002
    ....
  88. ncbi Acute allergic reaction following contact with a spider
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Level 5, Clinical Sciences Building, Edith Street, Waratah, NSW 2298, Australia
    Toxicon 40:1495-7. 2002
    ..He recovered within 6 h and had no further problems. The early allergic reaction in this case was most likely the result of contact with the spider...
  89. ncbi Prospective cohort study of definite spider bites in Australian children
    G K Isbister
    Clinical Envenoming Research Group, University of Newcastle, and Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    J Paediatr Child Health 40:360-4. 2004
    ..To describe the clinical effects of spider bites in a paediatric population and compare to bites in an adult population...
  90. ncbi Acute conjunctival inflammation following contact with squashed spider contents
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, and Newcastle Mater Misericordiae Hospital, Waratah, New South Wales, Australia
    Am J Ophthalmol 136:563-4. 2003
    ..To report the effects to the eye following contact with spider contents...
  91. ncbi A prospective study of 750 definite spider bites, with expert spider identification
    G K Isbister
    Discipline of Clinical Pharmacology, Level 5, Clinical Sciences Building, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah NSW 2298, Sydney, Australia
    QJM 95:723-31. 2002
    ..Clinical experience and small studies suggest otherwise, but this has not been confirmed by prospective studies of bites by identified spiders...
  92. ncbi Scorpion stings in Australia: five definite stings and a review
    G K Isbister
    Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia
    Intern Med J 34:427-30. 2004
    ..The stings from Australian buthid scorpions cause more severe effects than from the larger species in the families Urodacidae (genus Urodacus) and Liochelidae (genus Liocheles)...
  93. pmc Snake antivenom research: the importance of case definition
    G K Isbister
    Charles Darwin University, Darwin and Newcastle Mater Hospital, Newcastle, Australia
    Emerg Med J 22:399-400. 2005
  94. pmc Valproate overdose: a comparative cohort study of self poisonings
    Geoffrey K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Level 5, Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Newcastle, Australia
    Br J Clin Pharmacol 55:398-404. 2003
    ..Based on individual case reports of massive overdoses, valproate is often regarded as having significant toxicity. This study aimed to describe the epidemiology of valproate poisoning and the spectrum of its clinical effects...
  95. doi Safety of nitrous oxide administration in patients with Charcot-Marie-Tooth disease
    Geoffrey K Isbister
    Clinical Pharmacology, The Children s Hospital at Westmead Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Neurol Sci 268:160-2. 2008
    ....
  96. ncbi Clinical effects of stings by sponges of the genus Tedania and a review of sponge stings worldwide
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Toxicon 46:782-5. 2005
    ..Blistering and desquamation occurred in the female adult and limited desquamation in one child. Similar delayed effects have been reported in Tedania spp. stings previously...
  97. ncbi Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal
    G K Isbister
    Department of Clinical Toxicology and Pharmacology, Newcastle Mater Hospital, Newcastle and Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Clin Pharmacol Ther 81:821-7. 2007
    ..9-8.4 h). Charcoal was estimated to reduce fraction absorbed by 35%. Co-ingested CYP3A4 inhibitors appeared to decrease clearance and CYP3A4 inducers increase clearance. Charcoal administration may be beneficial after quetiapine overdose...
  98. ncbi Suspected white-tail spider bite and necrotic ulcers
    G K Isbister
    Discipline of Clinical Pharmacology, University of Newcastle, Newcastle Mater Misericordiae Hospital, Waratah, NSW 2298, Australia
    Intern Med J 34:38-44. 2004
    ..To describe the clinical features, investigation, diagnosis and treatment of ulcers attributed to white-tail (WT) spider bites or necrotic arachnidism...
  99. ncbi Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom
    Volker Herzig
    Monash Venom Group, Department of Pharmacology, Monash University, Victoria, Australia
    Toxicon 51:1167-77. 2008
    ..bradleyi venom in vertebrates. These findings are consistent with clinical reports that mouse spiders, particularly species other than male M. bradleyi, do not appear to be a major medical problem in humans...
  100. ncbi Coagulopathy from tiger snake envenoming and its treatment
    Geoffrey K Isbister
    Pathology 34:588-90; author reply 590. 2002
  101. ncbi High rate of immediate systemic hypersensitivity reactions to tiger snake antivenom
    Geoffrey K Isbister
    Med J Aust 184:419-20.. 2006