Bart J Currie

Summary

Affiliation: Menzies School of Health Research
Country: Australia

Publications

  1. pmc Recovery of a Burkholderia thailandensis-like isolate from an Australian water source
    Jay E Gee
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    BMC Microbiol 8:54. 2008
  2. pmc Streptococcal necrotising fasciitis from diverse strains of Streptococcus pyogenes in tropical northern Australia: case series and comparison with the literature
    Marilyn Hassell
    Infectious Diseases Unit, Northern Territory Clinical School, Flinders University, Royal Darwin Hospital, Darwin Northern Territory, Australia
    BMC Infect Dis 4:60. 2004
  3. pmc Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    BMC Biol 7:78. 2009
  4. ncbi request reprint Prospective study of Chironex fleckeri and other box jellyfish stings in the "Top End" of Australia's Northern Territory
    Bart J Currie
    Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Med J Aust 183:631-6. 2005
  5. pmc Intensity of rainfall and severity of melioidosis, Australia
    Bart J Currie
    Menzies School of Health Research and Flinders University, Darwin, Northern Territory, Australia
    Emerg Infect Dis 9:1538-42. 2003
  6. doi request reprint Effectiveness of pressure-immobilization first aid for snakebite requires further study
    Bart J Currie
    Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia
    Emerg Med Australas 20:267-70. 2008
  7. doi request reprint The global distribution of Burkholderia pseudomallei and melioidosis: an update
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Trans R Soc Trop Med Hyg 102:S1-4. 2008
  8. pmc Identification of melioidosis outbreak by multilocus variable number tandem repeat analysis
    Bart J Currie
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Emerg Infect Dis 15:169-74. 2009
  9. ncbi request reprint Melioidosis: an important cause of pneumonia in residents of and travellers returned from endemic regions
    B J Currie
    Menzies School of Health Research, Flinders University, Darwin, Australia
    Eur Respir J 22:542-50. 2003
  10. doi request reprint Snakes, jellyfish and spiders
    Bart J Currie
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory, Australia
    Adv Exp Med Biol 609:43-52. 2008

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. pmc Recovery of a Burkholderia thailandensis-like isolate from an Australian water source
    Jay E Gee
    Bacterial Zoonoses Branch, Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    BMC Microbiol 8:54. 2008
    ..pseudomallei by the ability to utilize arabinose. During the course of environmental sampling for B. pseudomallei in the Northern Territory of Australia, an isolate, MSMB 43, was recovered that is arabinose positive...
  2. pmc Streptococcal necrotising fasciitis from diverse strains of Streptococcus pyogenes in tropical northern Australia: case series and comparison with the literature
    Marilyn Hassell
    Infectious Diseases Unit, Northern Territory Clinical School, Flinders University, Royal Darwin Hospital, Darwin Northern Territory, Australia
    BMC Infect Dis 4:60. 2004
    ..In this context we aimed to study GAS necrotising fasciitis (NF) in a region where there are high background rates of GAS carriage and disease...
  3. pmc Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    BMC Biol 7:78. 2009
    ..We compared and searched 43 whole genome sequences of B. pseudomallei and its closest relatives for single nucleotide polymorphisms in orthologous shared regions to use in phylogenetic reconstruction...
  4. ncbi request reprint Prospective study of Chironex fleckeri and other box jellyfish stings in the "Top End" of Australia's Northern Territory
    Bart J Currie
    Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Med J Aust 183:631-6. 2005
    ..To describe the epidemiology and clinical features of box jellyfish envenoming in the Top End of the Northern Territory and, in particular, confirmed stings from the major Australian box jellyfish, Chironex fleckeri...
  5. pmc Intensity of rainfall and severity of melioidosis, Australia
    Bart J Currie
    Menzies School of Health Research and Flinders University, Darwin, Northern Territory, Australia
    Emerg Infect Dis 9:1538-42. 2003
    ..023), bacteremic pneumonia (p=0.001), septic shock (p=0.005), and death (p<0.0001). Heavy monsoonal rains and winds may cause a shift towards inhalation of Burkholderia pseudomallei...
  6. doi request reprint Effectiveness of pressure-immobilization first aid for snakebite requires further study
    Bart J Currie
    Tropical Toxinology Program, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia
    Emerg Med Australas 20:267-70. 2008
    ....
  7. doi request reprint The global distribution of Burkholderia pseudomallei and melioidosis: an update
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Trans R Soc Trop Med Hyg 102:S1-4. 2008
    ....
  8. pmc Identification of melioidosis outbreak by multilocus variable number tandem repeat analysis
    Bart J Currie
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Emerg Infect Dis 15:169-74. 2009
    ..MLVA-4 can establish or refute that a clonal outbreak of melioidosis has occurred within 8 hours of receipt of bacterial strains...
  9. ncbi request reprint Melioidosis: an important cause of pneumonia in residents of and travellers returned from endemic regions
    B J Currie
    Menzies School of Health Research, Flinders University, Darwin, Australia
    Eur Respir J 22:542-50. 2003
    ..Melioidosis has been increasingly recognised in returning travellers in Europe and recently melioidosis and colonisation with B. pseudomallei have been documented in cystic fibrosis patients visiting or resident in endemic areas...
  10. doi request reprint Snakes, jellyfish and spiders
    Bart J Currie
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory, Australia
    Adv Exp Med Biol 609:43-52. 2008
  11. doi request reprint Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, and Northern Territory Clinical School, Flinders University, Darwin, Northern Territory Australia
    Trans R Soc Trop Med Hyg 102:225-7. 2008
    ..pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events...
  12. ncbi request reprint First documentation of in vivo and in vitro ivermectin resistance in Sarcoptes scabiei
    Bart J Currie
    Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Clin Infect Dis 39:e8-12. 2004
    ..5 years, respectively. As predicted, ivermectin resistance in scabies mites can develop after intensive ivermectin use...
  13. pmc Australian and Thai isolates of Burkholderia pseudomallei are distinct by multilocus sequence typing: revision of a case of mistaken identity
    Bart J Currie
    Menzies School of Health Research, Casuarina, Northern Territory, Australia
    J Clin Microbiol 45:3828-9. 2007
    ..pseudomallei isolates. The B. pseudomallei MLST database has been corrected, and there is no ST common to isolates verified as obtained from Australia or from Thailand...
  14. pmc Using BOX-PCR to exclude a clonal outbreak of melioidosis
    Bart J Currie
    Northern Territory Clinical School, Flinders University, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    BMC Infect Dis 7:68. 2007
    ..pseudomallei isolates, but they are time consuming and technically challenging for many laboratories...
  15. ncbi request reprint Group A streptococcal infections of the skin: molecular advances but limited therapeutic progress
    Bart J Currie
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0811, Australia
    Curr Opin Infect Dis 19:132-8. 2006
    ..This review focuses on group A Streptococcus skin infections and summarizes data published in the English language medical literature in 2004 and 2005...
  16. ncbi request reprint Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Trop Med Int Health 9:1167-74. 2004
    ..The aims of this study were to describe the epidemiology of melioidosis in tropical northern Australia and to assess the importance of defined risk factors...
  17. ncbi request reprint Snakebite in tropical Australia: a prospective study in the "Top End" of the Northern Territory
    Bart J Currie
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 181:693-7. 2004
    ..To describe the epidemiology of snakebite in the "Top End" of the Northern Territory, and the envenoming syndromes of individual snake species...
  18. ncbi request reprint Treatment of snakebite in Australia: the current evidence base and questions requiring collaborative multicentre prospective studies
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Northern Territory Clinical School Flinders University, and Royal Darwin Hospital, PO Box 41096, Casuarina, Darwin, Northern Territory 0811, Australia
    Toxicon 48:941-56. 2006
    ....
  19. ncbi request reprint Marine antivenoms
    Bart J Currie
    Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia
    J Toxicol Clin Toxicol 41:301-8. 2003
    ..It remains uncertain whether stonefish antivenom is efficacious in stings from spines of other venomous fish, and the recommendation of giving the antivenom intramuscularly needs reassessment...
  20. pmc The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study
    Bart J Currie
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Casuarina, Northern Territory, Australia
    PLoS Negl Trop Dis 4:e900. 2010
    ..Over 20 years, from October 1989, the Darwin prospective melioidosis study has documented 540 cases from tropical Australia, providing new insights into epidemiology and the clinical spectrum...
  21. ncbi request reprint Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature
    B J Currie
    Division of Medicine and Pathology Department, Royal Darwin Hospital, Northern Territory Clinical School, Flinders University, Casaurina, Northern Territory, Australia
    Clin Infect Dis 31:981-6. 2000
    ..Strategies are needed to decrease the high mortality with melioidosis septic shock. Preliminary data on granulocyte colony-stimulating factor therapy are very encouraging...
  22. ncbi request reprint Childhood infections in the tropical north of Australia
    B J Currie
    Department of Medicine, Northern Territory Clinical School, Flinders University, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    J Paediatr Child Health 37:326-30. 2001
    ..With global warming, these infections may become more common and more widespread within Australia and the potential for establishment of introduced infections such as Japanese encephalitis and malaria may increase...
  23. ncbi request reprint Melioidosis: acute and chronic disease, relapse and re-activation
    B J Currie
    Division of Medicine, Royal Darwin Hospital Clinical School, Flinders University, Northern Territory, Australia
    Trans R Soc Trop Med Hyg 94:301-4. 2000
    ..Following initial intensive therapy with ceftazidime or meropenem for at least 14 days, eradication therapy with trimethoprim-sulphamethoxazole monotherapy for at least 3 months had been more successful...
  24. ncbi request reprint Skin infections and infestations in Aboriginal communities in northern Australia
    B J Currie
    Tropical Medicine and International Health Unit, Menzies School of Health Research, Flinders University, Casuarina, Northern Territory, Australia
    Australas J Dermatol 41:139-43; quiz 144-5. 2000
    ..Sustainable and long-term improvements in scabies, skin sores and GAS-related disease and tinea require fundamental changes that address social and economic inequities and, in particular, living conditions and overcrowding...
  25. ncbi request reprint The epidemiology of melioidosis in Australia and Papua New Guinea
    B J Currie
    Division of Medicine, Royal Darwin Hospital Clinical School and Tropical Medicine and International Health Unit, Menzies School of Health Research, Casuarina, NT, Australia
    Acta Trop 74:121-7. 2000
    ..Further prospective collaborative studies are required to evaluate whether there are truly regional differences in clinical features of melioidosis and to better understand how B. pseudomallei is acquired from the environment...
  26. ncbi request reprint Neurological melioidosis
    B J Currie
    Division of Medicine, Royal Darwin Hospital Clinical School and Tropical Medicine and International Health Unit, Menzies School of Health Research, Casuarina, NT, Australia
    Acta Trop 74:145-51. 2000
    ..pseudomallei responsible for CNS melioidosis end further studies are required to determine if the apparent higher rate of CNS disease in Australia is due to true regional differences or is from increased ascertainment...
  27. ncbi request reprint A cluster of melioidosis cases from an endemic region is clonal and is linked to the water supply using molecular typing of Burkholderia pseudomallei isolates
    B J Currie
    Menzies School of Health Research and Royal Darwin Hospital Clinical School, Northern Territory, Australia
    Am J Trop Med Hyg 65:177-9. 2001
    ..While the exact mode of transmission to humans and the reasons for cessation of the outbreak remain uncertain, contamination of the unchlorinated community water supply is a likely explanation...
  28. doi request reprint Skin disorders, including pyoderma, scabies, and tinea infections
    Ross M Andrews
    Menzies School of Health Research, Charles Darwin University, PO Box 41096, Darwin, Northern Territory 0811, Australia
    Pediatr Clin North Am 56:1421-40. 2009
    ..The lack of standard, evidence-based recommendations is of much concern. The current evidence base for clinical diagnosis and treatment of these common childhood skin disorders is highlighted...
  29. pmc Phylogenetically distinct Staphylococcus aureus lineage prevalent among indigenous communities in northern Australia
    Jacklyn W S Ng
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    J Clin Microbiol 47:2295-300. 2009
    ..Sequencing of gap, rpoB, sodA, tuf, and hsp60 and the multilocus sequence typing loci revealed a clear separation between conventional S. aureus and CC75 and significant diversity within CC75...
  30. pmc Genetic diversity of Burkholderia pseudomallei isolates in Australia
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    J Clin Microbiol 46:249-54. 2008
    ..pseudomallei, where new sequence types are primarily generated by reassortment of existing alleles...
  31. ncbi request reprint Low rates of streptococcal pharyngitis and high rates of pyoderma in Australian aboriginal communities where acute rheumatic fever is hyperendemic
    Malcolm I McDonald
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Casuarina, NT, Australia
    Clin Infect Dis 43:683-9. 2006
    ..A link between pyoderma and acute rheumatic fever has been proposed but is yet to be proven. Group C beta-hemolytic streptococci and group G beta-hemolytic streptococci have also been also implicated in the pathogenesis...
  32. doi request reprint Community-associated strains of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus in indigenous Northern Australia: epidemiology and outcomes
    Steven Y C Tong
    Menzies School of Health Research, Charles Darwin University, Royal Darwin Hospital, Darwin, Australia
    J Infect Dis 199:1461-70. 2009
    ..Some strains of non-multidrug-resistant, methicillin-resistant Staphylococcus aureus (nmMRSA) in Australia are likely to have emerged from strains of methicillin-susceptible S. aureus (MSSA) in remote Aboriginal communities...
  33. pmc Epidemiology of Streptococcus dysgalactiae subsp. equisimilis in tropical communities, Northern Australia
    Malcolm McDonald
    Menzies School of Health Research, Charles Darwin University, Casuarina, Northern Territory, Australia
    Emerg Infect Dis 13:1694-700. 2007
    ..These communities already have high levels of streptococcal and poststreptococcal disease. GCS/GGS may increase in importance as it acquires key virulence factors from GAS by lateral gene transfer...
  34. doi request reprint Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia
    Steven Y C Tong
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Infect Dis 202:760-9. 2010
    ..Regional differences in the prevalence of Panton-Valentine leukocidin (PVL) and PVL isoform-harboring strains as well as in the local population structure of Staphylococcus aureus may influence the clinical spectrum of S. aureus infections...
  35. ncbi request reprint Apparent contrasting rates of pharyngitis and pyoderma in regions where rheumatic heart disease is highly prevalent
    Malcolm McDonald
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Heart Lung Circ 16:254-9. 2007
    ....
  36. ncbi request reprint Diversity of emm sequence types in group A beta-haemolytic streptococci in two remote Northern Territory Indigenous communities: implications for vaccine development
    Leisha J Richardson
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Vaccine 28:5301-5. 2010
    ..A vaccine based on such a variable antigen is unlikely to provide effective protection in the highest risk populations...
  37. pmc Isolates of Burkholderia pseudomallei from Northern Australia are distinct by multilocus sequence typing, but strain types do not correlate with clinical presentation
    Allen C Cheng
    Menzies School of Health Research, Darwin University, P O Box 41096, Casuarina NT 0811, Darwin, Australia
    J Clin Microbiol 42:5477-83. 2004
    ..It is possible that the distinct but diverse strain types found in this study reflect Australia's geographical isolation over many millions of years...
  38. ncbi request reprint The fibronectin-binding capacity and host cell adherence of Streptococcus pyogenes strains are discordant with each other
    Mandy L Edwards
    Menzies School of Health Research, Darwin, Australia
    Microbes Infect 6:1156-62. 2004
    ..We suggest that while Fn binding is important for adhesion, for many GAS strains the extent of Fn binding is not the critical determinant of adherence...
  39. doi request reprint Rapid detection of H and R Panton-Valentine leukocidin isoforms in Staphylococcus aureus by high-resolution melting analysis
    Steven Y C Tong
    Menzies School of Health Research, Darwin, PO Box 41096 Casuarina, NT 0811, Australia
    Diagn Microbiol Infect Dis 67:399-401. 2010
    ..Of 223 Staphylococcus aureus isolates from northern Australia, isoforms clustered by clonal complex (CC). All CC93 isolates harbored the arginine isoform...
  40. pmc Melioidosis from contaminated bore water and successful UV sterilization
    Evan McRobb
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 89:367-8. 2013
    ..We have shown that UV treatment is highly effective for remediation of water contaminated with B. pseudomallei and recommend its consideration in households where individuals may be at heightened risk of contracting melioidosis...
  41. pmc Out of the ground: aerial and exotic habitats of the melioidosis bacterium Burkholderia pseudomallei in grasses in Australia
    Mirjam Kaestli
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Environ Microbiol 14:2058-70. 2012
    ..The ongoing spread of these introduced grasses creates new habitats suitable for B.pseudomallei survival and may be an important factor in the evolving epidemiology of melioidosis seen both in northern Australia and elsewhere globally...
  42. pmc Acute post-streptococcal glomerulonephritis in the Northern Territory of Australia: a review of 16 years data and comparison with the literature
    Catherine S Marshall
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Am J Trop Med Hyg 85:703-10. 2011
    ..Improvements in preventative and outbreak control strategies are needed...
  43. pmc Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia
    Mirjam Kaestli
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Negl Trop Dis 3:e364. 2009
    ..Despite the detection of B. pseudomallei in various soil and water samples from endemic areas, the environmental habitat of B. pseudomallei remains unclear...
  44. ncbi request reprint Extreme weather events and environmental contamination are associated with case-clusters of melioidosis in the Northern Territory of Australia
    Allen C Cheng
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Australia
    Int J Epidemiol 35:323-9. 2006
    ..We defined case-clusters in northern Australia, determined their contribution to the observed rate of melioidosis, and explored clinical features and associated environmental factors...
  45. ncbi request reprint Community-acquired pneumonia in northern Australia: low mortality in a tropical region using locally-developed treatment guidelines
    Julian H Elliott
    Royal Darwin Hospital and Northern Territory Clinical School, Flinders University, Darwin, Australia
    Int J Infect Dis 9:15-20. 2005
    ..To investigate the epidemiology and outcome of adult community-acquired pneumonia (CAP) in tropical Australia...
  46. pmc A novel clinical grading scale to guide the management of crusted scabies
    Joshua S Davis
    Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    PLoS Negl Trop Dis 7:e2387. 2013
    ..Here, we describe a clinical grading scale for crusted scabies and its utility in real world practice...
  47. ncbi request reprint Indirect hemagglutination assay in patients with melioidosis in northern Australia
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 74:330-4. 2006
    ..The IHA has limited utility as a diagnostic test for acute disease, and most patients subsequently have persistently positive titers after recovery from illness...
  48. pmc Clinic attendances during the first 12 months of life for Aboriginal children in five remote communities of northern Australia
    Therese Kearns
    Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS ONE 8:e58231. 2013
    ..Such data can be used to help guide public health policy and practice...
  49. pmc Burkholderia pseudomallei in unchlorinated domestic bore water, Tropical Northern Australia
    Mark Mayo
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Emerg Infect Dis 17:1283-5. 2011
    ..Multilocus sequence typing identified 15 sequence types. The B. pseudomallei sequence type from 1 water sample matched a clinical isolate from a resident with melioidosis on the same property...
  50. doi request reprint Trimethopim-sulfamethoxazole compared with benzathine penicillin for treatment of impetigo in Aboriginal children: a pilot randomised controlled trial
    Steven Y C Tong
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Paediatr Child Health 46:131-3. 2010
    ..Trimethoprim-sulfamethoxazole achieved microbiological clearance and healing of sores from which beta-hemolytic streptococci and community-associated methicillin-resistant Staphylococcus aureus were initially cultured...
  51. doi request reprint Irukandji syndrome case series from Australia's Tropical Northern Territory
    Christopher P Nickson
    Royal Darwin Hospital, Darwin, Northern Territory, Australia
    Ann Emerg Med 54:395-403. 2009
    ..We describe Irukandji syndrome (a painful hypercatecholaminergic condition caused by jellyfish envenoming) in Australia's Northern Territory...
  52. doi request reprint Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance
    Kate E Mounsey
    Charles Darwin University, Menzies School of Health Research, Darwin, Northern Territory, Australia
    Future Microbiol 3:57-66. 2008
    ..These may assist in overcoming many of the current difficulties in monitoring treatment efficacy and allow the development of more sensitive tools for monitoring emerging resistance...
  53. pmc Recovering streptococci from the throat, a practical alternative to direct plating in remote tropical communities
    Malcolm McDonald
    Menzies School of Health Research, P O Box 41096, Casuarina, 0811, NT, Australia
    J Clin Microbiol 44:547-52. 2006
    ..In tropical and remote settings, cold-box transport with desiccant and subsequent inoculation of culture plates in the laboratory is a practical alternative to direct plating...
  54. pmc Melioidosis as a consequence of sporting activity
    Audrey A Hill
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 89:365-6. 2013
    ..Melioidosis is uncommon in otherwise healthy sports persons in melioidosis-endemic regions but still needs consideration in persons with abrasion injuries that involve contact with soil...
  55. pmc Clinical evaluation of a type III secretion system real-time PCR assay for diagnosing melioidosis
    Ella M Meumann
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    J Clin Microbiol 44:3028-30. 2006
    ..The PCR was positive in 30/33 (91%) patients with culture-confirmed melioidosis. All six patients with melioidosis septic shock were blood PCR positive, suggesting potential for rapid diagnosis and commencement of appropriate therapy...
  56. doi request reprint A diagnostic test for scabies: IgE specificity for a recombinant allergen of Sarcoptes scabiei
    Rama Jayaraj
    Menzies School of Health Research, Darwin, Northern Territory 0810, Australia
    Diagn Microbiol Infect Dis 71:403-7. 2011
    ..3. This study shows that quantification of levels of IgE antibody to rSar s 14.3 is a highly sensitive method for diagnosis of scabies infestation in clinical practice...
  57. ncbi request reprint Prevention of opportunistic infections in immunosuppressed patients in the tropical top end of the Northern Territory
    Joshua S Davis
    Division of Medicine, Royal Darwin Hospital, Rocklands Drive, Tiwi, Northern Territory
    Commun Dis Intell 27:526-32. 2003
    ..Details of the rationale, evidence base, and proposed investigations and therapy for such patients are discussed...
  58. ncbi request reprint Short report: application of a polymerase chain reaction to detect Burkholderia pseudomallei in clinical specimens from patients with suspected melioidosis
    Daniel Gal
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 73:1162-4. 2005
    ..The PCR based on the B. pseudomallei TTS1 has the potential to substantially improve the timeliness of diagnosis of melioidosis...
  59. ncbi request reprint Pneumonia risk stratification in tropical Australia: does the SMART-COP score apply?
    Joshua S Davis
    Menzies School of Health Research and Charles Darwin University, Darwin, NT
    Med J Aust 192:133-6. 2010
    ..To examine the performance in tropical northern Australia of SMART-COP, a simple scoring system developed in temperate Australia to predict the need for intensive respiratory or vasopressor support (IRVS) in pneumonia patients...
  60. pmc Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities
    Malcolm McDonald
    Menzies School of Health Research, P O Box 41096, Casuarina, 0811 Northern Territory, Australia
    J Clin Microbiol 44:3720-7. 2006
    ..Monthly tracking of SNP-based cc types showed a highly dynamic process. ST75-MRSA-IV appears to be unique to the region and probably evolved de novo in remote Aboriginal communities...
  61. pmc Fibronectin-binding protein gene recombination and horizontal transfer between group A and G streptococci
    Rebecca J Towers
    Menzies School of Health Research, Casuarina, Northern Territory 0811, Australia
    J Clin Microbiol 42:5357-61. 2004
    ..Because the identified group G streptococcus gfbA types possess DNA cassettes that can be identified in a number of group A streptococcus strains, it appears that homologous recombination is occurring between these species...
  62. doi request reprint Autoantigens identified by screening a human heart cDNA library with acute rheumatic fever sera
    Rebecca J Towers
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Darwin, Australia
    Ann N Y Acad Sci 1173:83-91. 2009
    ..These antigens are promising candidates for the development of a serological assay for the diagnosis of ARF. The nature of the proteins identified has exciting implications for future research into the pathogenesis of ARF...
  63. ncbi request reprint Melioidosis in northern Australia, 2001-02
    Allen C Cheng
    Menzies School of Health Research, Darwin, Northern Territory
    Commun Dis Intell Q Rep 27:272-7. 2003
    ..Despite improvements in recognition and treatment, melioidosis is still associated with a high morbidity and mortality, particularly in Indigenous Australians...
  64. ncbi request reprint Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabies
    Annette Dougall
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 73:977-84. 2005
    ..In addition, the specific IgE response to rSsGST01 did not correlate with the total IgE level of the patient. These results suggest that GST may play a role in the pathophysiology associated with crusted scabies...
  65. ncbi request reprint Contamination of hand wash detergent linked to occupationally acquired melioidosis
    Daniel Gal
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 71:360-2. 2004
    ..Environmental sampling identified B. pseudomallei in a container of commercial hand wash detergent as the likely source of infection, although there were multiple isolates of different PFGE types to the clinical isolates...
  66. ncbi request reprint Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis
    Geoffrey K Isbister
    Menzies School of Health Research, Charles Darwin University, Darwin, NT
    Med J Aust 188:473-6. 2008
    ..To investigate current use of Australian snake antivenoms and the frequency and severity of immediate-type hypersensitivity reactions...
  67. pmc Consensus guidelines for dosing of amoxicillin-clavulanate in melioidosis
    Allen C Cheng
    Department of Medicine, University of Melbourne, Melbourne, Australia
    Am J Trop Med Hyg 78:208-9. 2008
    ..For eradication therapy for melioidosis, we recommend 20/5 mg/kg orally, three times daily...
  68. pmc Comparison of TaqMan PCR assays for detection of the melioidosis agent Burkholderia pseudomallei in clinical specimens
    Mirjam Kaestli
    Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    J Clin Microbiol 50:2059-62. 2012
    ....
  69. ncbi request reprint A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Clin Infect Dis 45:308-14. 2007
    ..Melioidosis is a tropical infectious disease associated with significant mortality. Most deaths occur early and are caused by fulminant sepsis...
  70. doi request reprint Melioidosis and Aboriginal seasons in northern Australia
    Allen C Cheng
    Department of Medicine, University of Melbourne, c o Victorian Infectious Diseases Service, 9th Floor, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia
    Trans R Soc Trop Med Hyg 102:S26-9. 2008
    ..This observation supports the hypothesis that in the wet seasons there may be changes in the mode and/or magnitude of exposure to B. pseudomallei, with a shift from percutaneous inoculation to aerosol inhalation, for instance...
  71. ncbi request reprint Epidemiology of community-acquired and nosocomial bloodstream infections in tropical Australia: a 12-month prospective study
    Mark W Douglas
    Department of Infectious Diseases, Royal Darwin Hospital, Casuarina, NT, Australia
    Trop Med Int Health 9:795-804. 2004
    ..To define the relative incidence of organisms causing blood stream infections in a tropical setting with a very low prevalence of human immunodeficiency virus infection (<1%)...
  72. doi request reprint Global implications of the emergence of community-associated methicillin-resistant Staphylococcus aureus in Indigenous populations
    Steven Y C Tong
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Clin Infect Dis 46:1871-8. 2008
    ..Combating the worldwide emergence and spread of community-associated MRSA may require novel community-level control strategies targeted at specific groups, such as remote Indigenous populations...
  73. ncbi request reprint Challenging perceptions of non-compliance with rheumatic fever prophylaxis in a remote Aboriginal community
    Zinta Harrington
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Med J Aust 184:514-7. 2006
    ..To identify factors that affect rheumatic fever prophylaxis for remote-living Aboriginal patients, and to determine the proportion who received adequate prophylaxis...
  74. ncbi request reprint Burkholderia pseudomallei strain type, based on pulsed-field gel electrophoresis, does not determine disease presentation in melioidosis
    Allen C Cheng
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Microbes Infect 7:104-9. 2005
    ..There was evidence of geographical localisation. This study suggests that the variation in strain type may not be as important as host and environmental factors in determining the pattern of disease...
  75. ncbi request reprint Success of a scabies control program in an Australian aboriginal community
    J R Carapetis
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Pediatr Infect Dis J 16:494-9. 1997
    ..To adapt, implement and evaluate a model of scabies control in an Australian Aboriginal community...
  76. ncbi request reprint Identification of a homologue of a house dust mite allergen in a cDNA library from Sarcoptes scabiei var hominis and evaluation of its vaccine potential in a rabbit/S. scabiei var. canis model
    Pearly Harumal
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 68:54-60. 2003
    ..Although it was not found to be protective in a challenge trial, the rabbits did not exhibit typical crust characteristics. This work shows that it is now possible to conduct such challenge trials with cloned scabies antigens...
  77. ncbi request reprint Impact of single dose azithromycin on group A streptococci in the upper respiratory tract and skin of Aboriginal children
    Tania M Shelby-James
    Menzies School of Health Research, Darwin, Australia
    Pediatr Infect Dis J 21:375-80. 2002
    ..Aboriginal children living in remote Australia experience high rates of bacterial infection such as trachoma, otitis media and streptococcal skin infection, which often progress to associated chronic diseases in later life...
  78. pmc Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia
    A DelVecchio
    Menzies School of Health Research, Darwin, Australia
    Epidemiol Infect 128:391-6. 2002
    ..We suggest that S. pyogenes may recruit different FBPs for different purposes...
  79. ncbi request reprint Mortality due to acute rheumatic fever and rheumatic heart disease in the Northern Territory: a preventable cause of death in aboriginal people
    J R Carapetis
    Menzies School of Health Research, Northern Territory
    Aust N Z J Public Health 23:159-63. 1999
    ..To determine the death rates and effect on premature mortality in the Northern Territory of acute rheumatic fever and rheumatic heart disease...
  80. ncbi request reprint Use of terbinafine for tinea in Australian Aboriginal communities in the Top End
    Karen J Koh
    Royal Darwin Hospital and Northern Territory Clinical School, Darwin, South Australia, Australia
    Australas J Dermatol 44:243-9. 2003
    ..Twenty (80%) of followed-up patients complied fully with treatment. Terbinafine was found to be a well-tolerated and effective treatment of tinea of the skin and nails...
  81. pmc NAD-glycohydrolase production and speA and speC distribution in Group A streptococcus (GAS) isolates do not correlate with severe GAS diseases in the Australian population
    Armando DelVecchio
    Menzies School of Health Research, Darwin, Australia
    J Clin Microbiol 40:2642-4. 2002
    ..No direct correlation of these characteristics with a propensity to cause invasive diseases was observed...
  82. ncbi request reprint A DNA fingerprinting system for the ectoparasite Sarcoptes scabiei
    S F Walton
    Menzies School of Health Research, Casuarina, Australia
    Mol Biochem Parasitol 85:187-96. 1997
    ....
  83. ncbi request reprint The challenge of acute rheumatic fever diagnosis in a high-incidence population: a prospective study and proposed guidelines for diagnosis in Australia's Northern Territory
    Anna Ralph
    Royal Darwin Hospital, NT, Australia
    Heart Lung Circ 15:113-8. 2006
    ....
  84. pmc Sensitive and specific molecular detection of Burkholderia pseudomallei, the causative agent of melioidosis, in the soil of tropical northern Australia
    Mirjam Kaestli
    Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, Northern Territory 0811, Australia
    Appl Environ Microbiol 73:6891-7. 2007
    ..Furthermore, analysis of the 104 collected soil samples revealed a significant association between B. pseudomallei-positive sites and the presence of animals at these locations and also with moist, reddish brown-to-reddish gray soils...
  85. doi request reprint Cutaneous melioidosis in the tropical top end of Australia: a prospective study and review of the literature
    Katherine B Gibney
    Infectious Diseases Unit and Northern Territory Clinical School, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    Clin Infect Dis 47:603-9. 2008
    ..Burkholderia pseudomallei is endemic in northern Australia, and melioidosis is a common cause of sepsis in the region...
  86. pmc Further evaluation of a rapid diagnostic test for melioidosis in an area of endemicity
    Mathew O'Brien
    Menzies School of Health Research, Charles Darwin University, and Microbiology Laboratory, Pathology Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    J Clin Microbiol 42:2239-40. 2004
    ..ICT IgM kits are unreliable for diagnosis of melioidosis, but ICT IgG kits may be useful for diagnosing travelers presenting with possible melioidosis who return from regions where melioidosis is endemic...
  87. ncbi request reprint Snakebite in Australia: the role of the Venom Detection Kit
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Royal Darwin Hospital, Darwin, Northern Territory, Australia
    Emerg Med Australas 16:384-6. 2004
  88. ncbi request reprint An audit of the use of granulocyte colony-stimulating factor in septic shock
    D P Stephens
    Royal Darwin Hospital, Tiwi, Northern Territory, Australia
    Intern Med J 32:143-8. 2002
    ..In septic shock, the immune system can be considered one of the failing organ systems. G-CSF improves immune function and may be a useful adjunctive therapy in patients with septic shock...
  89. ncbi request reprint Antibiotic susceptibility of Burkholderia pseudomallei from tropical northern Australia and implications for therapy of melioidosis
    A W Jenney
    Infectious Diseases Unit, Royal Darwin Hospital, Darwin, NT 0810, Australia
    Int J Antimicrob Agents 17:109-13. 2001
    ....
  90. ncbi request reprint C-reactive protein in the diagnosis of melioidosis
    Allen C Cheng
    Infectious Diseases Unit, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia
    Am J Trop Med Hyg 70:580-2. 2004
    ..Admission levels of CRP are not a sensitive marker for the presence of melioidosis and a normal level cannot be used to exclude acute, chronic, or relapsed melioidosis in febrile patients in or from endemic regions...
  91. ncbi request reprint Chlorination and pH of drinking water do not correlate with rates of melioidosis in the Northern Territory, Australia
    Alien C Cheng
    Menzies School of Health Research and NT Clinical School, Flinders University, Casuarina, NT, Darwin, Australia
    Trans R Soc Trop Med Hyg 97:511-2. 2003
    ..However, following adjustment for rainfall, such associations were not apparent in a multivariate regression model...
  92. ncbi request reprint Venomous snakebites worldwide with a focus on the Australia-Pacific region: current management and controversies
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University Darwin, Australia
    J Intensive Care Med 19:259-69. 2004
    ..The availability, efficacy, and safety of antivenoms vary throughout the world, with a current crisis in antivenom supplies...
  93. ncbi request reprint Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis
    Allen C Cheng
    Menzies School of Health Research, Royal Darwin Hospital, Northern Territory Clinical School, Flinders University, Casuarina NT, Darwin, Australia
    Clin Infect Dis 38:32-7. 2004
    ..We conclude that G-CSF may have contributed to the reduction in the mortality rate among patients with septic shock due to melioidosis...
  94. pmc Problems in diagnosing scabies, a global disease in human and animal populations
    Shelley F Walton
    Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, and Department of Medicine, Royal Darwin Hospital, Casuarina NT 0811, Australia
    Clin Microbiol Rev 20:268-79. 2007
    ....
  95. ncbi request reprint Scabies: new future for a neglected disease
    Shelley F Walton
    Menzies School of Health Research, Australia and Charles Darwin University, Darwin, Australia
    Adv Parasitol 57:309-76. 2004
    ..scabiei cDNA libraries and EST projects. Ultimately this knowledge may aid early identification of disease, novel forms of chemotherapy, vaccine development and new treatment possibilities for this important but neglected parasite...
  96. pmc Ethical problems of evaluating a new treatment for melioidosis
    Allen C Cheng
    Menzies School of Health Research and Northern Territory Clinical School, Flinders University, PO Box 41096, Casuarina NT 0811, Darwin, Australia
    BMJ 327:1280-2. 2003
  97. ncbi request reprint Efficacy of antivenom against the procoagulant effect of Australian brown snake (Pseudonaja sp.) venom: in vivo and in vitro studies
    Geoffrey K Isbister
    Tropical Toxinology Unit, Menzies School of Health Research, Charles Darwin University, Darwin, NSW, Australia
    Toxicon 49:57-67. 2007
    ..One vial of antivenom appears to be sufficient to bind and neutralise all venom in patients with severe brown snake envenoming...
  98. pmc A regional initiative to reduce skin infections amongst aboriginal children living in remote communities of the Northern Territory, Australia
    Ross M Andrews
    Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Negl Trop Dis 3:e554. 2009
    ..Many of those with pyoderma will also have scabies. We report the results of a community-based collaboration within the East Arnhem Region, which aimed to reduce the prevalence of both skin infections in Aboriginal children...
  99. ncbi request reprint The scourge of scabies
    David J Kemp
    The Queensland Institute of Medical Research, Darwin, Australia
    Biologist (London) 49:19-24. 2002
    ..It has long been thought that dogs may act as a reservoir for human infections. However, genetic studies cast doubt over this supposition...
  100. ncbi request reprint Granulocyte colony-stimulating factor and an in vitro whole blood model of melioidosis
    A C Cheng
    Infectious Diseases Unit, Menzies School of Health Research and NT Clinical School, Flinders University, PO Box 41096, Casuarina, Darwin, NT 0811, Australia
    Eur J Clin Microbiol Infect Dis 23:205-7. 2004
    ....
  101. pmc Saccade dysfunction associated with chronic petrol sniffing and lead encephalopathy
    S Cairney
    The Neuropsychology Laboratory, Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    J Neurol Neurosurg Psychiatry 75:472-6. 2004
    ..Neurological abnormalities associated with lead encephalopathy involve the cortex, basal ganglia, cerebellum, and brain stem...