Nicholas M Anstey

Summary

Affiliation: Menzies School of Health Research
Country: Australia

Publications

  1. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
  2. pmc Community-acquired bacteremic Acinetobacter pneumonia in tropical Australia is caused by diverse strains of Acinetobacter baumannii, with carriage in the throat in at-risk groups
    Nicholas M Anstey
    Menzies School of Health Research, Royal Darwin Hospital, Northern Territory Clinical School, Darwin, Northern Territory, Australia
    J Clin Microbiol 40:685-6. 2002
  3. pmc Improving case definitions for severe malaria
    Nicholas M Anstey
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Med 4:e267. 2007
  4. pmc Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation
    Nicholas M Anstey
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT 0811, Australia
    J Infect Dis 195:589-96. 2007
  5. doi request reprint The pathophysiology of vivax malaria
    Nicholas M Anstey
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin 0810, Australia
    Trends Parasitol 25:220-7. 2009
  6. ncbi request reprint Pulmonary manifestations of uncomplicated falciparum and vivax malaria: cough, small airways obstruction, impaired gas transfer, and increased pulmonary phagocytic activity
    Nicholas M Anstey
    Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia
    J Infect Dis 185:1326-34. 2002
  7. pmc Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Pathog 6:e1000868. 2010
  8. pmc Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in papua, Indonesia
    Graeme P Maguire
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 192:1966-74. 2005
  9. pmc Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 198:602-8. 2008
  10. pmc Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis
    Joshua S Davis
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS ONE 6:e17260. 2011

Detail Information

Publications87

  1. pmc Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT 0810, Australia
    J Exp Med 204:2693-704. 2007
    ..Clinical trials in SM of adjunctive agents to improve endothelial NO bioavailability, including l-arginine, are warranted...
  2. pmc Community-acquired bacteremic Acinetobacter pneumonia in tropical Australia is caused by diverse strains of Acinetobacter baumannii, with carriage in the throat in at-risk groups
    Nicholas M Anstey
    Menzies School of Health Research, Royal Darwin Hospital, Northern Territory Clinical School, Darwin, Northern Territory, Australia
    J Clin Microbiol 40:685-6. 2002
    ..Wet-season throat carriage of A. baumannii was found in 10% of community residents with excess levels of alcohol consumption, the major at-risk group for CAAP...
  3. pmc Improving case definitions for severe malaria
    Nicholas M Anstey
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Med 4:e267. 2007
  4. pmc Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation
    Nicholas M Anstey
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT 0811, Australia
    J Infect Dis 195:589-96. 2007
    ..The mechanisms underlying lung injury in vivax malaria are not well understood. Inflammatory responses to Plasmodium falciparum and P. vivax, to our knowledge, have not previously been compared at an organ level...
  5. doi request reprint The pathophysiology of vivax malaria
    Nicholas M Anstey
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin 0810, Australia
    Trends Parasitol 25:220-7. 2009
    ..In this review, we discuss potential mechanisms underlying the syndromes of uncomplicated and severe vivax malaria, identifying key areas for future research...
  6. ncbi request reprint Pulmonary manifestations of uncomplicated falciparum and vivax malaria: cough, small airways obstruction, impaired gas transfer, and increased pulmonary phagocytic activity
    Nicholas M Anstey
    Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia
    J Infect Dis 185:1326-34. 2002
    ....
  7. pmc Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS Pathog 6:e1000868. 2010
    ..72) in those with SM. ADMA is increased in SM and associated with decreased vascular and pulmonary NO bioavailability. Inhibition of NOS by ADMA may contribute to increased mortality in severe malaria...
  8. pmc Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in papua, Indonesia
    Graeme P Maguire
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 192:1966-74. 2005
    ..In patients with severe malaria, acute respiratory distress syndrome usually develops after the start of drug treatment and is a major cause of death. Its pathogenesis is not well understood...
  9. pmc Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 198:602-8. 2008
    ..L-Arginine infusion improves endothelial function in moderately severe malaria. Neither the longitudinal course of endothelial dysfunction nor factors associated with recovery have been characterized in severe malaria...
  10. pmc Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis
    Joshua S Davis
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS ONE 6:e17260. 2011
    ....
  11. doi request reprint Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responses
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    J Infect Dis 198:134-42. 2008
    ..In cross-sectional and longitudinal studies, we measured MSP5 antibody responses in Papuans with acute Plasmodium falciparum malaria, Plasmodium vivax malaria, and mixed P. falciparum and P. vivax malaria and in those with past exposure...
  12. pmc Pharmacokinetics of L-arginine in adults with moderately severe malaria
    Tsin W Yeo
    Menzies School of Health Research, P O Box 41096, Casuarina, NT 0810, Australia
    Antimicrob Agents Chemother 52:4381-7. 2008
    ....
  13. pmc Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, Royal Darwin Hospital, Darwin, NT 0811, Australia
    J Infect Dis 200:1522-9. 2009
    ..We examined the relationship of plasma hemoglobin and myoglobin to endothelial dysfunction and disease severity in malaria...
  14. pmc Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin NT 0810, Australia
    Proc Natl Acad Sci U S A 105:17097-102. 2008
    ..Agents that improve endothelial NO, reduce WPB exocytosis, and/or antagonize Ang-2 may have therapeutic roles in SM...
  15. ncbi request reprint Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population
    Craig S Boutlis
    International Health Program, Infectious Diseases Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
    Am J Trop Med Hyg 69:569-73. 2003
    ..Neither the G-954C nor the C-1173T polymorphisms were identified in this population, indicating the variability and complexity of selection for NOS2 promoter polymorphisms in different malaria-endemic populations...
  16. pmc L-arginine and vitamin D adjunctive therapies in pulmonary tuberculosis: a randomised, double-blind, placebo-controlled trial
    Anna P Ralph
    Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia
    PLoS ONE 8:e70032. 2013
    ..Vitamin D (vitD) and L-arginine have important antimycobacterial effects in humans. Adjunctive therapy with these agents has the potential to improve outcomes in active tuberculosis (TB)...
  17. pmc Impaired pulmonary nitric oxide bioavailability in pulmonary tuberculosis: association with disease severity and delayed mycobacterial clearance with treatment
    Anna P Ralph
    Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory 0810, Australia
    J Infect Dis 208:616-26. 2013
    ..We investigated relationships between fractional exhale NO (FENO) and initial pulmonary tuberculosis severity, change during treatment, and relationship with conversion of sputum culture to negative at 2 months...
  18. doi request reprint Low-level Plasmodium falciparum blood-stage infection causes dendritic cell apoptosis and dysfunction in healthy volunteers
    Tonia Woodberry
    Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    J Infect Dis 206:333-40. 2012
    ..Dendritic cells (DCs) are highly specialized antigen-presenting cells that are crucial for initiation of immune responses. During naturally acquired malaria, DC number and function is reduced...
  19. pmc Ex vivo drug susceptibility of ferroquine against chloroquine-resistant isolates of Plasmodium falciparum and P. vivax
    Jutta Marfurt
    Menzies School of Health Research, P O Box 41096, Casuarina, NT 0811, Darwin, Australia
    Antimicrob Agents Chemother 55:4461-4. 2011
    ..falciparum and P. vivax highlights a promising role for FQ as a lead antimalarial against CQ-resistant Plasmodium and a useful partner drug for artemisinin-based combination therapy...
  20. ncbi request reprint Melioidosis epidemiology and risk factors from a prospective whole-population study in northern Australia
    Bart J Currie
    Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Trop Med Int Health 9:1167-74. 2004
    ..The aims of this study were to describe the epidemiology of melioidosis in tropical northern Australia and to assess the importance of defined risk factors...
  21. pmc Evaluation of the sensitivity of a pLDH-based and an aldolase-based rapid diagnostic test for diagnosis of uncomplicated and severe malaria caused by PCR-confirmed Plasmodium knowlesi, Plasmodium falciparum, and Plasmodium vivax
    Bridget E Barber
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    J Clin Microbiol 51:1118-23. 2013
    ..knowlesi. More sensitive RDTs are needed in regions of P. knowlesi endemicity...
  22. pmc Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study
    Joshua S Davis
    International Health Division, Menzies School of Health Research and Charles Darwin University, Rocklands Drive, Darwin, NT 0810, Australia
    Crit Care 13:R155. 2009
    ....
  23. ncbi request reprint Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua, Indonesia
    Tsin W Yeo
    International Health Division, Menzies School of Health Research and Charles Darwin University, and Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia
    J Infect Dis 202:109-12. 2010
    ..P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum...
  24. pmc Nitric oxide production and nitric oxide synthase activity in malaria-exposed Papua New Guinean children and adults show longitudinal stability and no association with parasitemia
    Craig S Boutlis
    Menzies School of Health Research, P O Box 41096, Casuarina, NT 0811, Australia
    Infect Immun 72:6932-8. 2004
    ..These results suggest that NO is unlikely to mediate killing of blood stage parasites in this setting and is unlikely to be the primary mediator in the acquisition or maintenance of malarial tolerance...
  25. pmc Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity
    Craig S Boutlis
    International Health Program, Division of Infectious Diseases, Menzies School of Health Research, Northern Territory University, Flinders University Northern Territory Clinical School, Darwin, Australia
    Infect Immun 71:6354-7. 2003
    ..Neither the IL-12 level nor NOS activity was associated with either of two IL12B polymorphisms, reflecting the diversity of genetic control over immune responses in different populations...
  26. ncbi request reprint Immunoglobulin G (IgG) responses to Plasmodium falciparum glycosylphosphatidylinositols are short-lived and predominantly of the IgG3 subclass
    Craig S Boutlis
    Infectious Diseases Division, Menzies School of Health Research, Darwin, Australia
    J Infect Dis 187:862-5. 2003
    ..falciparum GPIs is skewed toward the short-lived IgG(3) subclass, a vaccination strategy with GPI analogues would likely require augmentation by costimulatory molecules, to induce a more persistent anti-GPI response...
  27. pmc Safety profile of L-arginine infusion in moderately severe falciparum malaria
    Tsin W Yeo
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS ONE 3:e2347. 2008
    ..We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine infusion in adults with moderately severe malaria...
  28. pmc Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults
    Craig S Boutlis
    International Health Program, Division of Infectious Diseases, Menzies School of Health Research, Northern Territory University, Casuarina, Australia
    Infect Immun 71:3682-9. 2003
    ..NO production was associated with and may contribute to malaria tolerance in Papuan adults...
  29. pmc Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi
    Bridget E Barber
    Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 12:8. 2013
    ..Species misidentification by microscopy has been reported in areas co-endemic for vivax and falciparum malaria, and may be more frequent in regions where Plasmodium knowlesi also commonly occurs...
  30. pmc Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax
    Jutta Marfurt
    Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Antimicrob Agents Chemother 56:5258-63. 2012
    ..vivax. The high activity against drug-resistant strains of both Plasmodium species confirms these compounds to be promising candidates for future artemisinin-based combination therapy (ACT) regimens in regions of coendemicity...
  31. pmc Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
    Tonia Woodberry
    International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    Malar J 8:122. 2009
    ..It is not known whether natural exposure to Plasmodium falciparum stimulates HGXPRT T cell reactivity in humans...
  32. ncbi request reprint Community-acquired pneumonia in northern Australia: low mortality in a tropical region using locally-developed treatment guidelines
    Julian H Elliott
    Royal Darwin Hospital and Northern Territory Clinical School, Flinders University, Darwin, Australia
    Int J Infect Dis 9:15-20. 2005
    ..To investigate the epidemiology and outcome of adult community-acquired pneumonia (CAP) in tropical Australia...
  33. pmc A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics
    Tsin W Yeo
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
    PLoS ONE 8:e69587. 2013
    ..The safety, efficacy and pharmacokinetics of L-arginine or other agents to improve NO bioavailability in severe malaria have not been assessed...
  34. pmc Artemisinin combination therapy for vivax malaria
    Nicholas M Douglas
    Menzies School of Health Research, Darwin, NT, Australia
    Lancet Infect Dis 10:405-16. 2010
    ..Analyses of the cost-effectiveness of ACTs for both Plasmodium species are needed to assess the role of these drugs in the control and elimination of vivax malaria...
  35. pmc An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function
    Christabelle J Darcy
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    PLoS ONE 6:e21185. 2011
    ..0001). IDO-mediated tryptophan catabolism is associated with dysregulated immune responses and impaired microvascular reactivity in sepsis and may link these two fundamental processes in sepsis pathophysiology...
  36. pmc Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity
    Joshua S Davis
    International Health Division, Menzies School of Health Research and Charles Darwin University, Ellengowan Drive, Casuarina, Darwin, NT 0810, Australia
    Crit Care 14:R89. 2010
    ..Nitric oxide (NO) inhibits WPB exocytosis, and bioavailability of endothelial NO is decreased in sepsis. We hypothesized that endothelial NO bioavailability would be inversely correlated with ang-2 concentrations in sepsis...
  37. pmc High morbidity during treatment and residual pulmonary disability in pulmonary tuberculosis: under-recognised phenomena
    Anna P Ralph
    Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Northern Territory, Australia Department of Infectious Diseases, Division of Medicine, Royal Darwin Hospital, Northern Territory, Australia
    PLoS ONE 8:e80302. 2013
    ..In pulmonary tuberculosis (PTB), morbidity during treatment and residual pulmonary disability can be under-estimated...
  38. pmc Increased carboxyhemoglobin in adult falciparum malaria is associated with disease severity and mortality
    Tsin W Yeo
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Royal Darwin Hospital, Darwin, Australia
    J Infect Dis 208:813-7. 2013
    ..Increased carboxyhemoglobin levels during severe malaria and sepsis may exacerbate organ dysfunction by reducing oxygen carriage and cautions against the use of adjunctive CO therapy, which was proposed on the basis of mouse models. ..
  39. pmc Epidemiology of Plasmodium knowlesi malaria in north-east Sabah, Malaysia: family clusters and wide age distribution
    Bridget E Barber
    Global Health Division, Menzies School of Health Research, PO Box 41096, Casuarina 0810, Northern Territory, Australia
    Malar J 11:401. 2012
    ..The simian parasite Plasmodium knowlesi is a common cause of human malaria in Malaysian Borneo, with a particularly high incidence in Kudat, Sabah. Little is known however about the epidemiology in this substantially deforested region...
  40. pmc Impaired skeletal muscle microvascular function and increased skeletal muscle oxygen consumption in severe falciparum malaria
    Tsin W Yeo
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    J Infect Dis 207:528-36. 2013
    ..However, host microvascular function (defined as the capacity to increase oxygen delivery in response to ischemia) and oxygen consumption have not been assessed...
  41. pmc The anaemia of Plasmodium vivax malaria
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, PO Box 41096, Casuarina, NT 0811, Australia
    Malar J 11:135. 2012
    ..Anaemia can be averted by early and effective anti-malarial treatment...
  42. pmc The burden and treatment of HIV in tuberculosis patients in Papua Province, Indonesia: a prospective observational study
    Gysje J Pontororing
    Menzies School of Health Research National Institute of Health Research and Development Research Program, Timika, Papua, Indonesia
    BMC Infect Dis 10:362. 2010
    ..We aimed to measure TB-HIV co-infection rates, examine longitudinal trends, compare management with World Health Organisation (WHO) recommendations, and document progress and outcome...
  43. pmc Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum
    Muhammad Karyana
    International Health Division, Menzies School of Health Research, Darwin, Australia
    Malar J 7:148. 2008
    ..Multidrug resistance has emerged to both Plasmodium vivax and Plasmodium falciparum and yet the comparative epidemiology of these infections is poorly defined...
  44. ncbi request reprint Sepsis in the tropical Top End of Australia's Northern Territory: disease burden and impact on Indigenous Australians
    Joshua S Davis
    Royal Darwin Hospital, Darwin, NT joshua davisATmenzies edu au
    Med J Aust 194:519-24. 2011
    ....
  45. pmc Malaria tolerance--for whom the cell tolls?
    Craig S Boutlis
    Division of Tropical and Emerging Infectious Diseases, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT 0811, Australia
    Trends Parasitol 22:371-7. 2006
    ....
  46. pmc Outcomes of patients with melioidosis treated with meropenem
    Allen C Cheng
    Menzies School of Health Research, Charles Darwin University, Casuarina NT 0811, Northern Territory, Darwin, Australia
    Antimicrob Agents Chemother 48:1763-5. 2004
    ..The use of meropenem may be associated with improved outcomes in patients with severe sepsis associated with melioidosis...
  47. doi request reprint Eosinophils in severe sepsis in northern australia: do the usual rules apply in the tropics?
    Matthew C Pitman
    1Department of Infectious Diseases, Royal Darwin Hospital, Tiwi, Northern Territory, Australia 2Global and Tropical Health Division, Menzies School of Health Research, Casuarina, Northern Territory, Australia
    Crit Care Med 41:e286-8. 2013
    ..We aim to determine how common eosinophilia in severe sepsis is in the tropics, where there is a higher background rate of eosinophilia due to parasitic infection...
  48. pmc Gametocyte dynamics and the role of drugs in reducing the transmission potential of Plasmodium vivax
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research, Charles Darwin University, Darwin 0811, Australia
    J Infect Dis 208:801-12. 2013
    ..Designing interventions that will reduce transmission of vivax malaria requires knowledge of Plasmodium vivax gametocyte dynamics...
  49. pmc Major burden of severe anemia from non-falciparum malaria species in Southern Papua: a hospital-based surveillance study
    Nicholas M Douglas
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
    PLoS Med 10:e1001575; discussion e1001575. 2013
    ..The burden of anemia attributable to non-falciparum malarias in regions with Plasmodium co-endemicity is poorly documented. We compared the hematological profile of patients with and without malaria in southern Papua, Indonesia...
  50. doi request reprint HPLC analysis of asymmetric dimethylarginine, symmetric dimethylarginine, homoarginine and arginine in small plasma volumes using a Gemini-NX column at high pH
    Catherine E Jones
    Menzies School of Health Research, Rocklands Drive, Tiwi, Darwin, NT, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 878:8-12. 2010
    ....
  51. pmc Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax
    Jutta Marfurt
    Menzies School of Health Research, P O Box 41096, Casuarina, Darwin, NT 0811, Australia
    Antimicrob Agents Chemother 55:961-6. 2011
    ..and defining drug interaction with common antimalarial compounds are warranted to investigate the role of HDAC inhibitors in antimalarial therapy...
  52. doi request reprint New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance
    Ric N Price
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Curr Opin Infect Dis 22:430-5. 2009
    ..vivax infection. We review the evidence for severe disease and the spread of drug-resistant P. vivax and speculate how these maybe related...
  53. ncbi request reprint Epidemiology of community-acquired and nosocomial bloodstream infections in tropical Australia: a 12-month prospective study
    Mark W Douglas
    Department of Infectious Diseases, Royal Darwin Hospital, Casuarina, NT, Australia
    Trop Med Int Health 9:795-804. 2004
    ..To define the relative incidence of organisms causing blood stream infections in a tropical setting with a very low prevalence of human immunodeficiency virus infection (<1%)...
  54. ncbi request reprint Pneumonia risk stratification in tropical Australia: does the SMART-COP score apply?
    Joshua S Davis
    Menzies School of Health Research and Charles Darwin University, Darwin, NT
    Med J Aust 192:133-6. 2010
    ..To examine the performance in tropical northern Australia of SMART-COP, a simple scoring system developed in temperate Australia to predict the need for intensive respiratory or vasopressor support (IRVS) in pneumonia patients...
  55. ncbi request reprint Combining parasite lactate dehydrogenase-based and histidine-rich protein 2-based rapid tests to improve specificity for diagnosis of malaria Due to Plasmodium knowlesi and other Plasmodium species in Sabah, Malaysia
    Matthew J Grigg
    Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia Infectious Disease Unit, Clinical Research Centre, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia Infectious Diseases Society Sabah Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia
    J Clin Microbiol 52:2053-60. 2014
    ..knowlesi malaria is endemic. Sensitive P. knowlesi-specific RDTs and/or alternative molecular diagnostic tools are needed in areas where P. knowlesi malaria is endemic. ..
  56. pmc Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults
    Craig S Boutlis
    Department of Tropical Medicine and International Health, Menzies School of Health Research, Casuarina, Australia
    Infect Immun 70:5052-7. 2002
    ....
  57. ncbi request reprint Prevention of opportunistic infections in immunosuppressed patients in the tropical top end of the Northern Territory
    Joshua S Davis
    Division of Medicine, Royal Darwin Hospital, Rocklands Drive, Tiwi, Northern Territory
    Commun Dis Intell 27:526-32. 2003
    ..Details of the rationale, evidence base, and proposed investigations and therapy for such patients are discussed...
  58. pmc Plasmodium knowlesi malaria in children
    Bridget E Barber
    Menzies School of Health Research, Darwin, Northern Territory, Australia
    Emerg Infect Dis 17:814-20. 2011
    ..P. knowlesi is the most common cause of childhood malaria in Kudat. Although infection is generally uncomplicated, anemia is common and thrombocytopenia universal. Transmission dynamics in this region require additional investigation...
  59. pmc Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms
    Rossarin Suwanarusk
    International Health Program, Infectious Diseases Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    PLoS ONE 2:e1089. 2007
    ..vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined...
  60. pmc Plasmodium vivax treatments: what are we looking for?
    Ric N Price
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Curr Opin Infect Dis 24:578-85. 2011
    ..We review the recent advances in P. vivax chemotherapy that may influence the future management of this neglected pathogen...
  61. doi request reprint Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock
    Dianne P Stephens
    Intensive Care, Royal Darwin Hospital, Darwin, Australia
    Crit Care Med 36:448-54. 2008
    ..To investigate the effect of early administration of granulocyte colony-stimulating factor (G-CSF) on hospital mortality in nonneutropenic patients with septic shock, excluding patients with melioidosis...
  62. doi request reprint Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis
    Joshua S Davis
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia
    Crit Care Med 39:380-5. 2011
    ..Plasma concentrations of L-arginine are decreased after trauma or surgery but have been variably reported to be normal or decreased in patients with sepsis...
  63. doi request reprint A simple, valid, numerical score for grading chest x-ray severity in adult smear-positive pulmonary tuberculosis
    Anna P Ralph
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Australia
    Thorax 65:863-9. 2010
    ..The aim of this study was to generate and validate a numerical score for grading chest x-ray (CXR) severity and predicting response to treatment in adults with smear-positive pulmonary TB...
  64. pmc Vivax malaria: neglected and not benign
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Casuarina, Darwin, Northern Territory 0811, Australia
    Am J Trop Med Hyg 77:79-87. 2007
    ..Without these, vivax malaria will continue to be neglected by ministries of health, policy makers, researchers, and funding bodies...
  65. ncbi request reprint Plasmodium vivax: clinical spectrum, risk factors and pathogenesis
    Nicholas M Anstey
    Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
    Adv Parasitol 80:151-201. 2012
    ..falciparum is associated with a similar risk of severe anaemia. Mechanisms underlying the pathogenesis of severe vivax syndromes remain incompletely understood...
  66. ncbi request reprint C-reactive protein in the diagnosis of melioidosis
    Allen C Cheng
    Infectious Diseases Unit, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia
    Am J Trop Med Hyg 70:580-2. 2004
    ..Admission levels of CRP are not a sensitive marker for the presence of melioidosis and a normal level cannot be used to exclude acute, chronic, or relapsed melioidosis in febrile patients in or from endemic regions...
  67. ncbi request reprint A proposed scoring system for predicting mortality in melioidosis
    Allen C Cheng
    Menzies School of Health Research and Northern Territory Clinical School, Flinders University, Casuarina, Australia
    Trans R Soc Trop Med Hyg 97:577-81. 2003
    ....
  68. pmc Effective preparation of Plasmodium vivax field isolates for high-throughput whole genome sequencing
    Sarah Auburn
    Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia
    PLoS ONE 8:e53160. 2013
    ..vivax genome. This uniform coverage will greatly facilitate the detection of SNPs and copy number variants across the genome, enabling unbiased exploration of the natural diversity in P. vivax populations...
  69. ncbi request reprint Chemotherapeutic strategies for reducing transmission of Plasmodium vivax malaria
    Nicholas M Douglas
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Adv Parasitol 80:271-300. 2012
    ..vivax to a greater extent than strategies focused on treatment of symptomatic patients. An efficacious hypnozoitocidal agent with a short curative treatment course would be particularly useful in mass drug administration campaigns...
  70. doi request reprint Tuberculosis into the 2010s: is the glass half full?
    Anna P Ralph
    International Health Division, Menzies School of Health Research, PO Box 41096, Casuarina NT 0811, Australia
    Clin Infect Dis 49:574-83. 2009
    ..The incorporation of these recent advances into optimized directly observed treatment, short course (DOTS), programs, in conjunction with more widespread deployment and enhanced political will, all provide grounds for improved control...
  71. ncbi request reprint Murray Valley encephalitis in an adult traveller complicated by long-term flaccid paralysis: case report and review of the literature
    Mark W Douglas
    Royal Darwin Hospital, PO Box 41326, Casuarina, NT 0811, Australia
    Trans R Soc Trop Med Hyg 101:284-8. 2007
    ..Our case highlights the potential severity of flavivirus-induced encephalitis and the importance of avoiding mosquito bites while travelling through endemic areas...
  72. doi request reprint L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis
    Anna P Ralph
    International Health Division, Menzies School of Health Research, Building 58, Royal Darwin Hospital Campus, Casuarina, Northern Territory, 0810, Australia
    Trends Microbiol 16:336-44. 2008
    ..By enhancing mycobacterial killing in macrophages, L-arginine and vitamin D might have the potential to enable shorter duration of treatment, reduced infectivity and improved response in drug-resistant TB...
  73. ncbi request reprint Systemic nitric oxide production in human malaria. I. Analysis of NO metabolites in biological fluids
    Nicholas M Anstey
    Tropical Medicine and International Health Unit, Menzies School of Health Research, Division of Medicine, Royal Darwin Hospital, Darwin, Australia
    Methods Mol Med 72:461-7. 2002
  74. ncbi request reprint Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression
    Jocelyn R Saunders
    Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Australia
    Methods Mol Med 72:469-74. 2002
  75. ncbi request reprint Adjunctive granulocyte colony-stimulating factor for treatment of septic shock due to melioidosis
    Allen C Cheng
    Menzies School of Health Research, Royal Darwin Hospital, Northern Territory Clinical School, Flinders University, Casuarina NT, Darwin, Australia
    Clin Infect Dis 38:32-7. 2004
    ..We conclude that G-CSF may have contributed to the reduction in the mortality rate among patients with septic shock due to melioidosis...
  76. ncbi request reprint Enteric pathogens, intestinal permeability and nitric oxide production in acute gastroenteritis
    Renata Kukuruzovic
    Northern Territory Clinical School, Flinders University, c o Royal Darwin Hospital, Australia
    Pediatr Infect Dis J 21:730-9. 2002
    ..Aboriginal children hospitalized with diarrheal disease in northern Australia have high rates of acidosis, hypokalemia and osmotic diarrhea, as well as abnormal small bowel permeability and elevated nitric oxide (NO) production...
  77. ncbi request reprint The relationship between age and the manifestations of and mortality associated with severe malaria
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Clin Infect Dis 47:151-7. 2008
    ..The reported case-fatality rate associated with severe malaria varies widely. Whether age is an independent risk factor is uncertain...
  78. pmc Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic
    Jeanne Rini Poespoprodjo
    District Health Authority, School of Health Research National Institute of Health Research and Development Malaria Research Program, Indonesia
    Clin Infect Dis 46:1374-81. 2008
    ..Plasmodium falciparum infection exerts a considerable burden on pregnant women, but less is known about the adverse consequences of Plasmodium vivax infection...
  79. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia...
  80. ncbi request reprint A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children
    Maurine R Hobbs
    Department of Internal Medicine, University of Utah and VA Medical Centers, Salt Lake City, UT, USA
    Lancet 360:1468-75. 2002
    ..We postulated that NOS2 promoter polymorphisms would affect resistance to severe malaria...
  81. pmc Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Australia
    Antimicrob Agents Chemother 46:3947-53. 2002
    ....
  82. ncbi request reprint Higher gametocyte prevalence following failure of treatment of Plasmodium falciparum malaria with sulfadoxine-pyrimethamine and the combination of chloroquine plus sulfadoxine-pyrimethamine: implications for progression of anti-folate resistance
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    Trans R Soc Trop Med Hyg 96:434-7. 2002
    ..Adding SP to CQ, after significant resistance has emerged to both drugs, may not prevent enhanced transmission of dual-resistant strains and progression of anti-folate resistance...
  83. ncbi request reprint Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production
    Bert K Lopansri
    Division of Infectious Diseases, VA and University of Utah Medical Centers, Salt Lake City, UT, USA
    Lancet 361:676-8. 2003
    ..Hypoargininaemia may contribute to limited NO production in children with cerebral malaria and to severe disease...
  84. ncbi request reprint Fatal community-associated methicillin-resistant Staphylococcus aureus pneumonia after influenza
    Steven Y C Tong
    Med J Aust 188:61. 2008
  85. pmc Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications
    Bert K Lopansri
    Division of Infectious Diseases, VA and University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Infect Immun 74:3355-9. 2006
    ..Determination of the mechanism of this abnormality may contribute to the understanding of neurological complications in malaria...
  86. ncbi request reprint Improving the availability of artesunate for treatment of severe malaria
    Nicholas M Anstey
    Med J Aust 184:3-4. 2006
  87. pmc Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from papua new Guinea
    Katharine R Trenholme
    Division of Infectious Diseases and Immunology, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Am J Trop Med Hyg 72:708-13. 2005
    ..While CLAG 9 peptides are immunogenic in humans, longitudinal studies will be required to determine the longevity of antibody responses to CLAG 9 and their role in protection from disease...