Maarten van den Buuse

Summary

Affiliation: Mental Health Research Institute
Country: Australia

Publications

  1. ncbi Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects
    Maarten van den Buuse
    Mental Health Research Institute of Victoria, Parkville, Melbourne, Victoria 3052, Australia
    Schizophr Bull 36:246-70. 2010
  2. ncbi Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Australia
    Int J Neuropsychopharmacol 12:1383-93. 2009
  3. ncbi Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Neuropharmacology 61:209-16. 2011
  4. ncbi Disruption of prepulse inhibition by 3,4-methylenedioxymethamphetamine (MDMA): comparison between male and female wild-type and 5-HT(1A) receptor knockout mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Victoria, Australia
    Int J Neuropsychopharmacol 14:856-61. 2011
  5. ncbi Psychotropic drug-induced locomotor hyperactivity and prepulse inhibition regulation in male and female aromatase knockout (ArKO) mice: role of dopamine D1 and D2 receptors and dopamine transporters
    Carolina Chavez
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, 155 Oak Street, Parkville, Melbourne, Victoria, 3052, Australia
    Psychopharmacology (Berl) 206:267-79. 2009
  6. ncbi Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density
    Wah Chin Boon
    Florey Neuroscience Institute, Melbourne, Australia
    Behav Brain Res 209:27-35. 2010
  7. ncbi Differential involvement of 5-HT projections within the amygdala in prepulse inhibition but not in psychotomimetic drug-induced hyperlocomotion
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Vic. 3052, Australia
    Behav Brain Res 168:74-82. 2006
  8. ncbi Angiotensin-converting enzyme (ACE) interacts with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Neurosci Lett 380:6-11. 2005
  9. ncbi Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice
    Maren Klug
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Neurobiol Dis 46:722-31. 2012
  10. ncbi Early maternal deprivation reduces prepulse inhibition and impairs spatial learning ability in adulthood: no further effect of post-pubertal chronic corticosterone treatment
    Belinda Garner
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
    Behav Brain Res 176:323-32. 2007

Detail Information

Publications64

  1. ncbi Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects
    Maarten van den Buuse
    Mental Health Research Institute of Victoria, Parkville, Melbourne, Victoria 3052, Australia
    Schizophr Bull 36:246-70. 2010
    ..Taken together, the available studies reveal a wealth of available data which have already provided crucial new insight and mechanistic clues which could lead to new treatments or even prevention strategies for schizophrenia...
  2. ncbi Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Australia
    Int J Neuropsychopharmacol 12:1383-93. 2009
    ..These studies add to the knowledge about behavioural effects in this mouse model of impaired Nrg1 function and suggest that a number of the behavioural tests with relevance to schizophrenia are normal in these mice...
  3. ncbi Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Neuropharmacology 61:209-16. 2011
    ..As also suggested by previous studies using agonist and antagonist drugs, 5-HT(1A) receptors may play an important role in hallucinations and to modulate dopaminergic activity in the brain...
  4. ncbi Disruption of prepulse inhibition by 3,4-methylenedioxymethamphetamine (MDMA): comparison between male and female wild-type and 5-HT(1A) receptor knockout mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Victoria, Australia
    Int J Neuropsychopharmacol 14:856-61. 2011
    ..Average startle was reduced by 10 mg/kg and 20 mg/kg MDMA similarly in male and female mice and all genotypes. These results show an involvement of 5-HT(1A) receptors in the effect of MDMA on PPI in male, but not female mice...
  5. ncbi Psychotropic drug-induced locomotor hyperactivity and prepulse inhibition regulation in male and female aromatase knockout (ArKO) mice: role of dopamine D1 and D2 receptors and dopamine transporters
    Carolina Chavez
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, 155 Oak Street, Parkville, Melbourne, Victoria, 3052, Australia
    Psychopharmacology (Berl) 206:267-79. 2009
    ....
  6. ncbi Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density
    Wah Chin Boon
    Florey Neuroscience Institute, Melbourne, Australia
    Behav Brain Res 209:27-35. 2010
    ..These transgenic mice may be a model for the psychotic features associated with early Alzheimer's disease...
  7. ncbi Differential involvement of 5-HT projections within the amygdala in prepulse inhibition but not in psychotomimetic drug-induced hyperlocomotion
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Vic. 3052, Australia
    Behav Brain Res 168:74-82. 2006
    ..Thus, the present study supports the view that 5-HT in the amygdala may be involved in aspects of schizophrenia and a target for antipsychotic drug action...
  8. ncbi Angiotensin-converting enzyme (ACE) interacts with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Neurosci Lett 380:6-11. 2005
    ..Further studies are needed to ascertain if angiotensin or other neuropeptides are involved in these interactions and to investigate the neurochemical mechanism behind these effects...
  9. ncbi Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice
    Maren Klug
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Neurobiol Dis 46:722-31. 2012
    ..These results could be important for our understanding of the interaction of neurodevelopmental stress and BDNF deficiency in cognitive and anxiety-related symptoms of psychiatric illnesses, such as schizophrenia...
  10. ncbi Early maternal deprivation reduces prepulse inhibition and impairs spatial learning ability in adulthood: no further effect of post-pubertal chronic corticosterone treatment
    Belinda Garner
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
    Behav Brain Res 176:323-32. 2007
    ..Our findings further support maternal deprivation as an animal model of specific aspects of schizophrenia...
  11. ncbi Interaction of glutathione depletion and psychotropic drug treatment in prepulse inhibition in rats and mice
    Olivia Dean
    Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Pharmacol Biochem Behav 97:293-300. 2010
    ..The significance of these results for schizophrenia is discussed...
  12. ncbi Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats
    Kwok Ho Christopher Choy
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    Eur Neuropsychopharmacol 18:1-13. 2008
    ....
  13. ncbi The effect of 'two hit' neonatal and young-adult stress on dopaminergic modulation of prepulse inhibition and dopamine receptor density
    Kwok Ho Christopher Choy
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    Br J Pharmacol 156:388-96. 2009
    ....
  14. ncbi Prepulse inhibition of acoustic startle in spontaneously hypertensive rats
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Behav Brain Res 154:331-7. 2004
    ..In conclusion, these data further reveal altered dopaminergic regulation of behaviour in SHR, but also shows that caution is needed about the control strain used to compare these animals with...
  15. ncbi Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation
    Laura Gray
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Int J Neuropsychopharmacol 12:45-60. 2009
    ..These results highlight both the interactions between mGluR5 and NMDA receptors in the determination of schizophreniform behaviours and the potential for the effects of clozapine to be mediated by NMDA receptor regulation...
  16. ncbi Brain serotonin depletion by lesions of the median raphe nucleus enhances the psychotomimetic action of phencyclidine, but not dizocilpine (MK-801), in rats
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
    Brain Res 1049:217-26. 2005
    ..Thus, MRN projections may play an inhibitory role in mechanisms involved in symptoms of schizophrenia...
  17. ncbi Estrogen treatment blocks 8-hydroxy-2-dipropylaminotetralin- and apomorphine-induced disruptions of prepulse inhibition: involvement of dopamine D1 or D2 or serotonin 5-HT1A, 5-HT2A, or 5-HT7 receptors
    Andrea Gogos
    Behavioral Neuroscience Laboratory, Mental Health Research Institute, 155 Oak St, Parkville Melbourne, Victoria 3052, Australia
    J Pharmacol Exp Ther 333:218-27. 2010
    ..Estrogen may prevent disruptions of PPI induced by both 8-OH-DPAT and apomorphine by an action on dopamine D(2) receptors downstream of 5-HT(1A) receptors...
  18. ncbi Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: possible role of 5-HT(2C) receptors in the dorsal hippocampus
    Wendy Adams
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Neuropharmacology 61:458-67. 2011
    ..These findings suggest that 5-HT(2C) receptors in the dorsal hippocampus may contribute to risperidone-induced enhancement of PPI...
  19. ncbi Effects of N-acetyl-cysteine treatment on glutathione depletion and a short-term spatial memory deficit in 2-cyclohexene-1-one-treated rats
    Kwok Ho Christopher Choy
    Mental Health Research Institute, Parkville, Victoria, Australia
    Eur J Pharmacol 649:224-8. 2010
    ..These effects appear to be dose-dependent and region-specific. These results may be relevant to the understanding and management of the cognitive symptoms of schizophrenia and bipolar disorder...
  20. ncbi Prepulse inhibition in fawn-hooded rats: increased sensitivity to 5-HT1A receptor stimulation
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Victoria 3052, Australia
    Eur Neuropsychopharmacol 14:373-9. 2004
    ..This study shows increased sensitivity of FH rats to the disruption of PPI caused by 5-HT(1A) receptor stimulation, suggesting a link between 5-HT(1A) receptors, sensorimotor gating and aspects of the FH rat phenotype...
  21. ncbi Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice?
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville Melbourne, Victoria 3052, Australia
    Neuropharmacology 54:399-404. 2008
    ..Our previous results on the effects of reduced ACE activity could be explained by mechanisms other than angiotensin, such as effects on enkephalin or bradykinin metabolism...
  22. ncbi Altered N-methyl-D-aspartate receptor function in reelin heterozygous mice: male-female differences and comparison with dopaminergic activity
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 37:237-46. 2012
    ..These results suggest that the role of reelin deficiency in schizophrenia may be particularly mediated by altered NMDA receptor responses, with some of these effects being strictly sex-specific...
  23. ncbi Mice deficient in the alpha subunit of G(z) show changes in pre-pulse inhibition, anxiety and responses to 5-HT(1A) receptor stimulation, which are strongly dependent on the genetic background
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Psychopharmacology (Berl) 195:273-83. 2007
    ..In the present study, we investigated behaviour of mice deficient in the alpha subunit of G(z) and focused on pre-pulse inhibition (PPI) and anxiety-like responses and the role of serotonin-1A (5-HT(1A)) receptors...
  24. ncbi Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice
    Nicola Ingram
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Neuropharmacology 48:80-92. 2005
    ..In situations of high circulating levels of corticosterone, nicotine may be beneficial to restore disruption of PPI...
  25. ncbi 8-OH-DPAT-induced effects on prepulse inhibition: pre- vs. post-synaptic 5-HT1A receptor activation
    Andrea Gogos
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, VIC 3052, Australia
    Pharmacol Biochem Behav 81:664-72. 2005
    ..Taken together, these data suggest that the disruption of PPI observed in rats with systemic 8-OH-DPAT treatment is predominantly due to an activation of post-synaptic, rather than pre-synaptic, 5-HT1A receptors...
  26. ncbi Phencyclidine-induced locomotor hyperactivity is enhanced in mice after stereotaxic brain serotonin depletion
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    Behav Brain Res 191:289-93. 2008
    ..Dysfunction of this pathway could be involved in psychosis and its stimulation could be a potential mechanism of action of antipsychotic drugs...
  27. ncbi N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: relevance to schizophrenia and bipolar disorder
    Olivia M Dean
    The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Neurosci Lett 499:149-53. 2011
    ..While NAC was shown to be beneficial in this model, the lack of additional glutathione depletion by amphetamine in combination with CHX does not support a summative interaction between oxidative stress and altered dopamine transmission...
  28. ncbi Differential effect of amphetamine on c-fos expression in female aromatase knockout (ArKO) mice compared to wildtype controls
    Carolina Chavez
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Melbourne, Australia
    Psychoneuroendocrinology 36:761-8. 2011
    ..These results could be important for our understanding of the role of sex steroid hormones in psychosis...
  29. ncbi A genetic epilepsy rat model displays endophenotypes of psychosis
    Nigel C Jones
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Melbourne, Vic, Australia
    Neurobiol Dis 39:116-25. 2010
    ..GAERS provide an opportunity to study the neurodevelopmental, genetic and therapeutic aspects of psychiatric comorbidities associated with epilepsy...
  30. ncbi Oestrogen modulation of the effect of 8-OH-DPAT on prepulse inhibition: effects of aromatase deficiency and castration in mice
    Andrea Gogos
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Victoria, 3052, Australia
    Psychopharmacology (Berl) 188:100-10. 2006
    ..This effect can be mimicked in male control mice by castration. The differential involvement of oestrogen and testosterone in these animal models is discussed...
  31. ncbi SCH 23390 in the prefrontal cortex enhances the effect of apomorphine on prepulse inhibition of rats
    Inge E M de Jong
    Behavioural Neuroscience Laboratory, The Mental Health Research Institute of Victoria, Parkville, Melbourne, Vic. 3052, Australia
    Neuropharmacology 51:438-46. 2006
    ..Antagonism of this inhibitory component by SCH 23390 therefore leads to a larger disruption of PPI...
  32. ncbi Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats
    Maren Klug
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Vic, Australia
    Behav Brain Res 233:305-13. 2012
    ..These results indicate that early developmental disruptions and young-adult cannabis use on their own or in combination can differentially and sex-specifically affect behaviours related to neuropsychiatric disorders...
  33. ncbi The role of estrogen and testosterone in female rats in behavioral models of relevance to schizophrenia
    Andrea Gogos
    Behavioural Neuroscience Laboratory, The Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    Psychopharmacology (Berl) 219:213-24. 2012
    ..We previously found that estrogen treatment inhibited serotonin-1A (5-HT(1A)) and dopamine D(2) receptor-mediated disruptions of prepulse inhibition (PPI), a measure of sensorimotor gating which is deficient in schizophrenia...
  34. ncbi Combined neonatal stress and young-adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: effects on learning and memory
    Kwok Ho Christopher Choy
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Melbourne, Australia
    Hippocampus 18:655-67. 2008
    ..This study demonstrates a persistent effect of two developmental disruptions on BDNF expression in the hippocampus, with parallel, but not completely correlative changes in learning and memory...
  35. ncbi Differential role of serotonergic projections arising from the dorsal and median raphe nuclei in locomotor hyperactivity and prepulse inhibition
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
    Neuropsychopharmacology 28:2138-47. 2003
    ..This study may help to explain the role of different serotonin projections in the brain in the pathophysiology of schizophrenia...
  36. ncbi Differential role of serotonin projections from the dorsal and median raphe nuclei in phencyclidine-induced hyperlocomotion and fos-like immunoreactivity in rats
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, University of Melbourne, Parkville, Victoria, Australia
    Synapse 66:885-92. 2012
    ..These results support our previous studies suggesting a role of serotonergic projections from the MRN to the dorsal hippocampus in some of the symptoms of schizophrenia...
  37. ncbi Sex-specific and region-specific changes in BDNF-TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice
    Yeewen Candace Wu
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Brain Res 1452:10-7. 2012
    ....
  38. ncbi The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: an autoradiography study
    Carolina Chavez
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Melbourne, Australia
    Brain Res 1321:51-9. 2010
    ..e. on both DAT and dopamine D(2) receptor density, is involved. These data could also be relevant for our understanding of the potential protective effect of estrogen treatment in schizophrenia...
  39. ncbi Alpha-synuclein transgenic mice exhibit reduced anxiety-like behaviour
    Sonia George
    Department of Pathology, The Centre for Neuroscience, The University of Melbourne, Parkville, Victoria, 3010, Australia
    Exp Neurol 210:788-92. 2008
    ..In the open field, transgenic mice showed a trend towards reduced locomotor habituation and increased thigmotaxis. These results indicate a possible role for alpha-synuclein in anxiety-like behaviours...
  40. ncbi Effects of haloperidol and clozapine on sensorimotor gating deficits induced by 5-hydroxytryptamine depletion in the brain
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Br J Pharmacol 147:800-7. 2006
    ..The present findings highlight the importance of the 5-HT systems in cognitive models of schizophrenia...
  41. ncbi Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice
    Olivia Dean
    Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Behav Brain Res 198:258-62. 2009
    ..In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses...
  42. ncbi Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology
    Andrea Gogos
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Melbourne, Australia
    Behav Pharmacol 19:548-61. 2008
    ..These comparative results allow a theoretical framework of receptor interactions, which may guide further studies on the involvement of 5-HT1A receptors in schizophrenia...
  43. ncbi Serotonin depletion in the dorsal and ventral hippocampus: effects on locomotor hyperactivity, prepulse inhibition and learning and memory
    Wendy Adams
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Melbourne, Victoria 3052, Australia
    Neuropharmacology 55:1048-55. 2008
    ..The results provide new insight into the role of serotonin in the dorsal hippocampus in aspects of schizophrenia...
  44. ncbi Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    Br J Pharmacol 142:543-50. 2004
    ..4 These results in behavioural animal models of schizophrenia suggest an important role of the stress hormone CORT in modulating dopaminergic activity in this illness...
  45. ncbi Estrogen and progesterone prevent disruption of prepulse inhibition by the serotonin-1A receptor agonist 8-hydroxy-2-dipropylaminotetralin
    Andrea Gogos
    Behavioral Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    J Pharmacol Exp Ther 309:267-74. 2004
    ..Thus, these hormones could be protective against sensorimotor gating deficits, at least those induced by 5-HT(1A) receptor stimulation, and may therefore be beneficial against some symptoms of schizophrenia...
  46. ncbi Functional dissociation between serotonergic pathways in dorsal and ventral hippocampus in psychotomimetic drug-induced locomotor hyperactivity and prepulse inhibition in rats
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    Eur J Neurosci 20:3424-32. 2004
    ..This suggests that these serotonin projections may be involved in the pathophysiology of schizophrenia symptomology...
  47. ncbi Serotonergic lesions of the dorsal hippocampus differentially modulate locomotor hyperactivity induced by drugs of abuse in rats: implications for schizophrenia
    Wendy Adams
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Psychopharmacology (Berl) 206:665-76. 2009
    ..We previously found that serotonergic lesions of the dorsal, but not ventral, hippocampus in rats result in enhanced phencyclidine-induced locomotor hyperactivity...
  48. ncbi Estrogen prevents 5-HT1A receptor-induced disruptions of prepulse inhibition in healthy women
    Andrea Gogos
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Vic, Australia
    Neuropsychopharmacology 31:885-9. 2006
    ..Estrogen treatment, administered in the appropriate experimental conditions, prevented PPI deficits induced by 5-HT(1A) receptor activation and may therefore also play a protective role in sensorimotor gating deficits in schizophrenia...
  49. ncbi Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout mice
    Rachel A Hill
    Behavioral Neuroscience Laboratory, Mental Health Research Institute, Parkville, Victoria, Australia 3052
    Hippocampus 21:434-45. 2011
    ..05). In conclusion, loss of 5-HT(2C) receptor expression leads to a marked and selective increase in levels of the mature form of BDNF in the hippocampus. Despite this marked increase, 5-HT(2C) KO show only subtle behavioral changes...
  50. ncbi Reduced startle habituation and prepulse inhibition in mice lacking the adenosine A2A receptor
    Jian Hong Wang
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Vic, Australia
    Behav Brain Res 143:201-7. 2003
    ..These data support the involvement of adenosine A(2A) receptors in regulation of PPI and startle habituation...
  51. ncbi Castration reduces the effect of serotonin-1A receptor stimulation on prepulse inhibition in rats
    Andrea Gogos
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Behav Neurosci 117:1407-15. 2003
    ..Ovariectomized and sham-operated rats showed similar PPI in response to 8-OH-DPAT. These data suggest that the effect of 8-OH-DPAT on PPI in male rats depends on circulating hormone levels, particularly testosterone...
  52. ncbi Deficient prepulse inhibition of acoustic startle in Hooded-Wistar rats compared with Sprague-Dawley rats
    Maarten van den Buuse
    Department of Pharmacology, University of Melbourne and Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Victoria, Australia
    Clin Exp Pharmacol Physiol 30:254-61. 2003
    ..5. These data suggest that the Hooded-Wistar line could be a useful genetic animal model to study the interaction of glutamatergic and dopaminergic mechanisms in anxiety and schizophrenia...
  53. ncbi Involvement of serotonin1A receptors in cardiovascular responses to stress: a radio-telemetry study in four rat strains
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Vic, Australia
    Eur J Pharmacol 507:187-98. 2005
    ..These results could be important for our understanding of possible anxiolytic properties of antipsychotic drugs with affinity for the 5-HT1A receptor...
  54. ncbi Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Neurosci Lett 373:237-42. 2005
    ..These data suggest a role of gastrin in the brain in modulating dopamine release in areas involved in PPI...
  55. ncbi Differential effects of antipsychotic drugs on serotonin-1A receptor-mediated disruption of prepulse inhibition
    Maarten van den Buuse
    Behavioral Neuroscience Laboratory, The Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria 3052, Australia
    J Pharmacol Exp Ther 320:1224-36. 2007
    ..The action of aripiprazole could be mediated by its partial agonist properties at 5-HT(1A) receptors or its dopamine D(2)-blocking properties...
  56. ncbi Gender differences in prepulse inhibition (PPI) in bipolar disorder: men have reduced PPI, women have increased PPI
    Andrea Gogos
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Vic, Australia
    Int J Neuropsychopharmacol 12:1249-59. 2009
    ..This gender difference highlights the need to consider men and women with BD as two distinct groups, at least in PPI studies...
  57. ncbi Acute effects of antipsychotic drugs on cardiovascular responses to stress
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Eur J Pharmacol 464:55-62. 2003
    ..Such anxiolytic effects could contribute to the beneficial clinical effects of atypical antipsychotic drugs in patients with schizophrenia...
  58. ncbi Effect of atropine or atenolol on cardiovascular responses to novelty stress in freely-moving rats
    Maarten van den Buuse
    Neuropharmacology Laboratory, Baker Medical Research Institute, Prahran, Melbourne, Australia
    Stress 5:227-31. 2002
    ..These data suggest that the cardiac responses to stress include predominantly cardiac sympathetic activation and a minor component of vagal withdrawal...
  59. ncbi Impaired spatial reference memory in aromatase-deficient (ArKO) mice
    Sally Martin
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia
    Neuroreport 14:1979-82. 2003
    ..After gonadectomy, there was no significant difference between wildtype and ArKO mice. For the first time using ArKO mice, our findings confirm the importance of estrogen in memory in both males and females...
  60. ncbi Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice
    Rachel A Hill
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Brain Res 1384:51-60. 2011
    ..These results provide new insight into sex-dependent BDNF signaling in forebrain regions and assist in understanding the role of neurotrophins in schizophrenia...
  61. ncbi Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis
    Belinda Garner
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
    Biol Psychiatry 58:417-23. 2005
    ..032). CONCLUSIONS: The phase before the onset of psychosis is associated with a larger pituitary volume, suggesting activation of the HPA axis...
  62. ncbi Non-symmetrical double-logistic analysis of 24-h blood pressure recordings in normotensive and hypertensive rats
    Geoffrey A Head
    Neuropharmacology Laboratory, Baker Heart Research Institute, P O Box 6492, St Kilda Rd Central, Melbourne, Victoria, 8008, Australia
    J Hypertens 22:2075-85. 2004
    ..To determine the suitability of a new logistic curve fitting procedure to measure the diurnal rates of transition from the active to the asleep periods separately...
  63. ncbi Modafinil disrupts prepulse inhibition in mice: strain differences and involvement of dopaminergic and serotonergic activation
    Perrin Kwek
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Eur J Pharmacol 699:132-40. 2013
    ....
  64. ncbi Drugs of abuse and increased risk of psychosis development
    Anand Gururajan
    Mental Health Research Institute, University of Melbourne, Melbourne, Australia
    Aust N Z J Psychiatry 46:1120-35. 2012
    ..However, the neurobiological mechanisms involved in drug abuse-associated psychosis remain largely unclear...