Jacqueline M Matthews

Summary

Country: Australia

Publications

  1. ncbi request reprint A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution
    Belinda K Sharpe
    Department of Biochemistry, University of Sydney, New South Wales 2006, Australia
    Structure 10:639-48. 2002
  2. ncbi request reprint Zinc fingers--folds for many occasions
    Jacqueline M Matthews
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    IUBMB Life 54:351-5. 2002
  3. pmc Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex
    Janet E Deane
    School of Molecular and Microbial Biosciences, University of Sydney, Australia
    EMBO J 23:3589-98. 2004
  4. pmc Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction
    Chu Kong Liew
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 102:583-8. 2005
  5. pmc A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers
    Roland Gamsjaeger
    From the School of Molecular Biosciences, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 288:35180-91. 2013
  6. ncbi request reprint Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif
    Manu J Dubin
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 279:26932-8. 2004
  7. ncbi request reprint Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers
    Belinda J Westman
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Biochemistry 43:13318-27. 2004
  8. pmc Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
    Mugdha Bhati
    School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    EMBO J 27:2018-29. 2008
  9. ncbi request reprint CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions
    Raina J Y Simpson
    School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 278:28011-8. 2003
  10. pmc Stabilization of a binary protein complex by intein-mediated cyclization
    Cy M Jeffries
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    Protein Sci 15:2612-8. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution
    Belinda K Sharpe
    Department of Biochemistry, University of Sydney, New South Wales 2006, Australia
    Structure 10:639-48. 2002
    ..Our data support the idea that zinc binding domains may arise frequently. Additionally, such structures may prove useful as scaffolds for protein design, given their stability and robustness...
  2. ncbi request reprint Zinc fingers--folds for many occasions
    Jacqueline M Matthews
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    IUBMB Life 54:351-5. 2002
    ..We review the similarities and differences in structure and functions of different ZnF classes and highlight the versatility of this fold...
  3. pmc Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex
    Janet E Deane
    School of Molecular and Microbial Biosciences, University of Sydney, Australia
    EMBO J 23:3589-98. 2004
    ..These combined properties provide a mechanism for the binding of Ldb1 to numerous LMO and LIM-HD proteins. Furthermore, the modular extended interface may form a general mode of binding to tandem LIM domains...
  4. pmc Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction
    Chu Kong Liew
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 102:583-8. 2005
    ..Details of the architecture of the contact domains and their physical properties provide a molecular explanation for how the GATA-1 mutations contribute to distinct but related genetic diseases...
  5. pmc A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers
    Roland Gamsjaeger
    From the School of Molecular Biosciences, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 288:35180-91. 2013
    ..Analysis of the human and mouse genomes based on our structural data reveals three putative MyT1 target genes involved in neuronal development. ..
  6. ncbi request reprint Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif
    Manu J Dubin
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 279:26932-8. 2004
    ..These results suggest a specific model for CtIP homodimerization via its N terminus and contribute to an improved understanding of how this protein might assemble other factors required for its role as a transcriptional corepressor...
  7. ncbi request reprint Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers
    Belinda J Westman
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Biochemistry 43:13318-27. 2004
    ..These studies provide the first structural insights into how EosC mediates protein-protein interactions and contributes to our understanding of why it does not exhibit high-affinity DNA binding...
  8. pmc Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
    Mugdha Bhati
    School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    EMBO J 27:2018-29. 2008
    ..The resulting alternate protein complexes can target different genes to regulate key biological events...
  9. ncbi request reprint CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions
    Raina J Y Simpson
    School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 278:28011-8. 2003
    ....
  10. pmc Stabilization of a binary protein complex by intein-mediated cyclization
    Cy M Jeffries
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    Protein Sci 15:2612-8. 2006
    ..Thus, the restriction of the more stable component of a complex may enhance stability to a greater extent than restraining less stable components...
  11. ncbi request reprint Identification of the key LMO2-binding determinants on Ldb1
    Daniel P Ryan
    School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia
    J Mol Biol 359:66-75. 2006
    ..The delineation of this region reveals some specific differences when compared to the equivalent LMO4:Ldb1 interaction that hold promise for the development of reagents to specifically bind LMO2 in the treatment of leukemia...
  12. ncbi request reprint Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting
    Belinda K Sharpe
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney NSW 2006, Australia
    Structure 13:257-66. 2005
    ..These results both highlight the robust nature of small zinc binding domains and underscore the complexity of designing functional proteins, even using such small, highly ordered scaffolds as templates...
  13. ncbi request reprint A classic zinc finger from friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3
    Raina J Y Simpson
    School of Molecular and Microbial Biosciences, G08, University of Sydney, NSW 2006, Australia
    J Biol Chem 279:39789-97. 2004
    ..Our data demonstrate the versatility of cZFs and have implications for the analysis of many as yet uncharacterized cZF proteins...
  14. pmc Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions
    Mugdha Bhati
    School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 7:e40719. 2012
    ..Thus the mutation would affect the formation of Lhx3-containing transcription factor complexes, particularly in the pituitary gland where these complexes are required for the production of multiple pituitary cell types and hormones...
  15. pmc A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions
    Morgan S Gadd
    School of Molecular Bioscience, Building G08, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 288:21924-35. 2013
    ..The intramolecular interaction in Isl1 may provide protection against aggregation, minimize unproductive DNA binding, and facilitate cofactor exchange within the cell. ..
  16. ncbi request reprint Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12
    Daniel P Ryan
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Proteins 70:1461-74. 2008
    ..Our data provide biophysical evidence for a mechanism, by which LMO2 and TAL1 both regulate transcription in normal blood cell development, and synergistically disrupt E2A function in T-cells to promote the onset of leukaemia...
  17. ncbi request reprint A complex mechanism determines polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilis
    Iain G Duggin
    School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales 2006 and Research School of Chemistry, Australian National University, Australian Capital Territory 0200, Australia
    J Biol Chem 280:13105-13. 2005
    ..Furthermore, efficient fork arrest relies on features in addition to the tight binding of RTP to terminator DNA...
  18. ncbi request reprint Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain
    Philippa H Stokes
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    Biochem Biophys Res Commun 354:197-202. 2007
    ..Thus dimerization may increase the apparent stability of the proteins and/or the lifetime of the complexes...
  19. ncbi request reprint Crystallization of FLINC4, an intramolecular LMO4-ldb1 complex
    Janet E Deane
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    Acta Crystallogr D Biol Crystallogr 59:1484-6. 2003
    ..3 and 1.7 A resolution, respectively. Anomalous Patterson maps calculated with data collected at the peak wavelength show strong peaks sufficient to determine the positions of four Zn atoms per asymmetric unit...
  20. doi request reprint Competition between LIM-binding domains
    Jacqueline M Matthews
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW, Australia
    Biochem Soc Trans 36:1393-7. 2008
    ..Through our and other studies, it is emerging that the multiple layers of competitive binding involving LMO and LIM-HD proteins and their partner proteins contribute significantly to cell fate specification and development...
  21. pmc Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4
    Janet E Deane
    School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia
    EMBO J 22:2224-33. 2003
    ..These findings constitute the first molecular definition of LIM-mediated protein-protein interactions and suggest a mechanism by which ldb1 can bind a variety of LIM domains that share low sequence homology...
  22. ncbi request reprint Structural analysis of MED-1 reveals unexpected diversity in the mechanism of DNA recognition by GATA-type zinc finger domains
    Jason A Lowry
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 284:5827-35. 2009
    ..Our data expand the versatility of DNA recognition by GATA-type zinc fingers and perhaps shed new light on the DNA-binding properties of mammalian GATA factors...
  23. pmc Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex
    Siavoush Dastmalchi
    School of Molecular Bioscience, University of Sydney, Sydney, New South Wales 2006, Australia
    Protein Sci 21:1768-74. 2012
    ....
  24. ncbi request reprint Engineering a protein scaffold from a PHD finger
    Ann H Y Kwan
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006 Australia
    Structure 11:803-13. 2003
    ..These results represent a step toward designing new regulatory proteins for modulating aberrant gene expression in vivo...
  25. pmc Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
    Lorna Wilkinson-White
    School of Molecular Bioscience, University of Sydney, New South Wales, 2006 Sydney, Australia
    Proc Natl Acad Sci U S A 108:14443-8. 2011
    ....
  26. ncbi request reprint Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1
    Roland Gamsjaeger
    School of Molecular and Microbial Biosciences, University of Sydney, Building G08, New South Wales, Sydney 2006, Australia
    J Biol Chem 283:5158-67. 2008
    ..Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains...
  27. ncbi request reprint Dimers, oligomers, everywhere
    Jacqueline M Matthews
    School of Molecular Bioscience, University of Sydney, Sydney, Australia
    Adv Exp Med Biol 747:1-18. 2012
    ....
  28. pmc Crystallization and diffraction of an Lhx4-Isl2 complex
    Morgan S Gadd
    School of Molecular and Microbial Biosciences, University of Sydney, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:151-3. 2009
    ..The monoclinic crystals belonged to space group P2(1), with unit-cell parameters a = 46.8, b = 88.7, c = 49.9 A, beta = 111.9 degrees, and diffracted to 2.16 A resolution...
  29. pmc Crystallization and diffraction of an Isl1-Ldb1 complex
    Morgan S Gadd
    School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1398-401. 2012
    ..The orthorhombic crystals belonged to space group P222(1), with unit-cell parameters a=57.2, b=56.7, c=179.8 Å, and diffracted to 3.10 Å resolution...
  30. doi request reprint The tandem β-zipper: modular binding of tandem domains and linear motifs
    Jacqueline M Matthews
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    FEBS Lett 587:1164-71. 2013
    ....
  31. ncbi request reprint Characterization of the conserved interaction between GATA and FOG family proteins
    Kasper Kowalski
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney New South Wales 2006, Australia
    J Biol Chem 277:35720-9. 2002
    ..Taken together, these results suggest that the CCHC zinc binding topology is required for the integrity of GATA-FOG interactions and that weak interactions can play important roles in vivo...
  32. ncbi request reprint TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer
    Margaret Sunde
    School of Molecular and Microbial Biosciences and Discipline of Medicine, University of Sydney, Australia
    Cancer Res 64:2766-73. 2004
    ..These results suggest that overexpression of TC-1 may be important in thyroid carcinogenesis...
  33. ncbi request reprint Protein-protein interactions in human disease
    Daniel P Ryan
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales 2006, Australia
    Curr Opin Struct Biol 15:441-6. 2005
    ..A range of approaches are being developed to generate inhibitors of protein-protein interactions that may form useful therapeutics for human disease...
  34. ncbi request reprint LIM domain binding proteins 1 and 2 have different oligomeric states
    Arwen J Cross
    School of Molecular Bioscience, Building G08, The University of Sydney, NSW 2006, Australia
    J Mol Biol 399:133-44. 2010
    ..The abilities of Ldb1 and Ldb2 to form trimers and higher oligomers, respectively, should be considered in models of transcriptional regulation by Ldb1-containing complexes in a wide range of biological processes...
  35. doi request reprint Backbone and side-chain assignments of a tethered complex between LMO4 and DEAF-1
    Soumya Joseph
    School of Molecular Bioscience, University of Sydney, Sydney, NSW, 2006, Australia
    Biomol NMR Assign 8:141-4. 2014
    ..Analysis of the assignments indicates the presence of structure in the DEAF-1 part of the complex supporting the presence of a physical interaction between the two proteins. ..
  36. doi request reprint ¹H, ¹⁵N and ¹³C assignments of an intramolecular LMO4-LIM1/CtIP complex
    Chu Wai Liew
    School of Molecular Bioscience, University of Sydney, Building G08, Sydney, NSW 2006, Australia
    Biomol NMR Assign 6:31-4. 2012
    ..Here we report backbone and side chain NMR assignments for an engineered intramolecular complex of the N-terminal LIM domain from LMO4 tethered to residues 641-685 of C-terminal binding protein interacting protein (CtIP/RBBP8)...
  37. ncbi request reprint The power of two: protein dimerization in biology
    Neelan J Marianayagam
    School of Molecular and Microbial Biosciences, University of Sydney, Sydney, NSW 2006, Australia
    Trends Biochem Sci 29:618-25. 2004
    ..Specific protein dimerization is integral to biological function, structure and control, and must be under substantial selection pressure to be maintained with such frequency throughout biology...
  38. pmc LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins
    Jacqueline M Matthews
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    EMBO Rep 4:1132-7. 2003
    ....
  39. doi request reprint ATP binding equilibria of the Na(+),K(+)-ATPase
    Anne Pilotelle-Bunner
    School of Chemistry, University of Sydney, Sydney NSW 2006, Australia
    Biochemistry 47:13103-14. 2008
    ....
  40. doi request reprint 1H, 15N and 13C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex
    Lorna E Wilkinson-White
    School of Molecular Bioscience, Building G08, University of Sydney, Sydney, NSW, 2006, Australia
    Biomol NMR Assign 4:203-6. 2010
    ..Here we report backbone and side chain NMR assignments for an engineered intramolecular complex of the C-terminal LIM domain from Lmo2 tethered to the LIM interaction domain (LID) from LIM domain binding protein 1 (Ldb1)...
  41. ncbi request reprint Designed metal-binding sites in biomolecular and bioinorganic interactions
    Jacqueline M Matthews
    School of Molecular and Microbial Biosciences, The University of Sydney, NSW 2006, Australia
    Curr Opin Struct Biol 18:484-90. 2008
    ....
  42. doi request reprint Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules
    Leo Corcilius
    School of Chemistry, The University of Sydney, NSW 2006, Australia
    Bioorg Med Chem 21:3569-81. 2013
    ....
  43. doi request reprint Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants
    Yves S Y Hsieh
    School of Chemistry, The University of Sydney, NSW 2006, Australia
    Org Lett 14:1910-3. 2012
    ..The synthetic glycopeptides were shown to possess primarily an α-helical secondary structure by CD and NMR studies...
  44. ncbi request reprint The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2
    Jeremy Turner
    School of Molecular and Microbial Biosciences, G08, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 278:12786-95. 2003
    ..However, we find FHL3 can repress transcription. We suggest that LIM proteins like FHL3 are important in assembling specific repression or activation complexes, depending on conditions such as cofactor availability and promoter context...
  45. doi request reprint Semiquantitative and quantitative analysis of protein-DNA interactions using steady-state measurements in surface plasmon resonance competition experiments
    Roland Gamsjaeger
    School of Science and Health, University of Western Sydney, Penrith, NSW 2751, Australia
    Anal Biochem 440:178-85. 2013
    ..We compare our approach to existing methods, highlighting specific advantages as well as limitations. ..
  46. ncbi request reprint The PA207 peptide inhibitor of LIM-only protein 2 (Lmo2) targets Zinc Finger domains in a non-specific manner
    Lorna Wilkinson-White
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Protein Pept Lett 21:132-9. 2014
    ..Thus, PA207 and other cysteine-containing peptide aptamers for Lmo2 may form a class of general zinc finger inhibitors. ..
  47. pmc Mechanism of allosteric regulation of transglutaminase 2 by GTP
    Gillian E Begg
    Victor Chang Cardiac Research Institute, University of New South Wales, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 103:19683-8. 2006
    ..Although not essential for GTP-mediated inhibition of cross-linking, this H bond enhances the rate of formation of the inactive conformer...
  48. ncbi request reprint Stabilization of native protein fold by intein-mediated covalent cyclization
    Neal K Williams
    Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia
    J Mol Biol 346:1095-108. 2005
    ..Global unfolding of the N-terminal domain of E.coli DnaB is thus promoted strongly by spatial separation of the N and C termini, whereas their proximity is much less important for folding...
  49. pmc Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction
    Lauren K Ely
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 103:6641-6. 2006
    ....
  50. pmc Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation
    Corrine J Porter
    School of Biomedical and Chemical Sciences, University of Western Australia, WA 6009, Australia
    BMC Struct Biol 7:58. 2007
    ..Recently, an inhibitory peptide (G7-18NATE) has been developed which binds specifically to the Grb7 SH2 domain and is able to attenuate cancer cell proliferation and migration in various cancer cell lines...
  51. ncbi request reprint Protein interactions: is seeing believing?
    Joel P Mackay
    Trends Biochem Sci 32:530-1. 2007