M J Churchill

Summary

Affiliation: Macfarlane Burnet Institute for Medical Research and Public Health
Country: Australia

Publications

  1. pmc HIV-1 entry and trans-infection of astrocytes involves CD81 vesicles
    Lachlan R Gray
    Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    PLoS ONE 9:e90620. 2014
  2. pmc The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes
    Lachlan R Gray
    Centre for Virology, Burnet Institute, Melbourne, Victoria, Australia
    PLoS ONE 8:e62196. 2013
  3. pmc A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
    Michael Roche
    Center for Virology, Monash University, Melbourne, Victoria, Australia
    Retrovirology 10:43. 2013
  4. pmc CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm
    Kieran Cashin
    Center for Virology, Burnet Institute, 85 Commercial Rd, Melbourne 3004VIC, Australia
    Retrovirology 10:24. 2013
  5. doi request reprint Where does HIV hide? A focus on the central nervous system
    Melissa Churchill
    Centre for Virology, Burnet Institute, Melbourne, Australia
    Curr Opin HIV AIDS 8:165-9. 2013
  6. pmc Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, Victoria, Australia
    Virol J 4:75. 2007
  7. pmc HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry
    Michael Roche
    Center for Virology, Burnet Institute, Melbourne, Victoria, Australia
    Retrovirology 8:89. 2011
  8. pmc Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues
    Lachlan Gray
    Center for Virology, Burnet Institute, Commercial Rd, Melbourne 3004, Australia
    Retrovirology 8:42. 2011
  9. pmc Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:89. 2007
  10. pmc Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants emerging during AIDS progression
    Marie Borggren
    Dept Laboratory Medicine, Lund University, Lund, Sweden
    Retrovirology 5:28. 2008

Collaborators

Detail Information

Publications25

  1. pmc HIV-1 entry and trans-infection of astrocytes involves CD81 vesicles
    Lachlan R Gray
    Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
    PLoS ONE 9:e90620. 2014
    ..The ability of astrocytes to transfer virus, without de novo viral synthesis suggests they are capable of sequestering and protecting virus and thus, they could potentially facilitate viral dissemination in the CNS. ..
  2. pmc The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes
    Lachlan R Gray
    Centre for Virology, Burnet Institute, Melbourne, Victoria, Australia
    PLoS ONE 8:e62196. 2013
    ..Our data suggest that 3TC, d4T and ZDV may not adequately target astrocyte infection in vivo, which has potential implications for their inclusion in Neuro-cART regimens...
  3. pmc A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
    Michael Roche
    Center for Virology, Monash University, Melbourne, Victoria, Australia
    Retrovirology 10:43. 2013
    ..To more precisely understand mechanisms of resistance to MVC in vivo, we characterized Envs isolated from 2 subjects who experienced virologic failure on MVC...
  4. pmc CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm
    Kieran Cashin
    Center for Virology, Burnet Institute, 85 Commercial Rd, Melbourne 3004VIC, Australia
    Retrovirology 10:24. 2013
    ..In this study, we elucidated the V3 sequence determinants of C-HIV coreceptor usage, and used this knowledge to develop and validate a novel, user friendly, and highly sensitive C-HIV specific coreceptor usage prediction algorithm...
  5. doi request reprint Where does HIV hide? A focus on the central nervous system
    Melissa Churchill
    Centre for Virology, Burnet Institute, Melbourne, Australia
    Curr Opin HIV AIDS 8:165-9. 2013
    ..To review the literature on infection and evolution of HIV within the brain in the context for understanding the nature of the brain reservoir and its consequences...
  6. pmc Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, Victoria, Australia
    Virol J 4:75. 2007
    ..To better understand mechanisms underlying the pathogenicity of nef-deleted HIV-1, we examined the phenotype and env sequence diversity of sequentially isolated viruses (n = 2) from 3 SBBC members...
  7. pmc HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry
    Michael Roche
    Center for Virology, Burnet Institute, Melbourne, Victoria, Australia
    Retrovirology 8:89. 2011
    ..However, the CCR5-using CC1/85 strain appears to be uniquely predisposed to acquiring resistance to several CCR5 antagonists in vitro including MVC, vicriviroc and AD101...
  8. pmc Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues
    Lachlan Gray
    Center for Virology, Burnet Institute, Commercial Rd, Melbourne 3004, Australia
    Retrovirology 8:42. 2011
    ....
  9. pmc Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:89. 2007
    ....
  10. pmc Evolution of DC-SIGN use revealed by fitness studies of R5 HIV-1 variants emerging during AIDS progression
    Marie Borggren
    Dept Laboratory Medicine, Lund University, Lund, Sweden
    Retrovirology 5:28. 2008
    ..e. at the chronic stage and during end-stage disease, with regard to efficiency of DC-SIGN use in trans-infections...
  11. pmc Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
    Paul R Gorry
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:66. 2007
    ....
  12. ncbi request reprint c-Myb influences HIV type 1 gene expression and virus production
    M J Churchill
    AIDS Molecular Biology Unit, National Centre in HIV Virology Research, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria 3078, Australia
    AIDS Res Hum Retroviruses 17:1481-8. 2001
    ..These data show that c-myb expression affects HIV-1 replication in CD4(+) T cells...
  13. doi request reprint Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia
    Melissa J Churchill
    Centre for Virology, The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Ann Neurol 66:253-8. 2009
    ..Our data indicate that astrocytes can be extensively infected with HIV, and suggest an important role for HIV-infected astrocytes in HIV neuropathogenesis...
  14. pmc Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus
    Melissa J Churchill
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Retrovirology 4:43. 2007
    ..Therefore, to determine whether defects in other viral genes contribute to attenuation of these HIV-1 strains, we characterized dominant HIV-1 rev alleles that persisted in 4 SBBC subjects; C18, C64, C98 and D36...
  15. ncbi request reprint Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues
    Melissa J Churchill
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Neurovirol 12:146-52. 2006
    ..The ability of HIV-1 to integrate in terminally differentiated astrocytes suggests a permanent reservoir of provirus in brain that will impact the development and likely success of strategies aimed at eradicating HIV-1...
  16. ncbi request reprint Transcriptional activity of blood-and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia
    Melissa J Churchill
    The Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    J Neurovirol 12:219-28. 2006
    ..Thus, nef and LTR mutations that augment transcription may contribute to neuropathogenesis of nef-deleted HIV-1...
  17. pmc Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source
    Melissa J Churchill
    Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne 3001, Victoria, Australia
    J Virol 80:1047-52. 2006
    ..The in vivo pathogenicity of attenuated HIV-1 is therefore dictated by viral and/or host factors other than those that impose a unidirectional selection pressure on the nef/LTR region of the HIV-1 genome...
  18. pmc HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism
    Michael Roche
    Centers for Virology, Monash University, Australia
    J Virol 85:4330-42. 2011
    ....
  19. ncbi request reprint Astrocyte specific viral strains in HIV dementia
    Katherine A Thompson
    Neurovirology Research Laboratory, Macfarlane Burnet Institute for Medical Research and Public Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia
    Ann Neurol 56:873-7. 2004
    ..These results demonstrate cell-specific compartmentalization of distinct R5-like viral strains in the central nervous system microenvironment...
  20. pmc An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes
    Jasminka Sterjovski
    Center for Virology, Burnet Institute, Melbourne, Victoria, Australia
    Virology 404:269-78. 2010
    ..Thus, enhanced gp120-CCR5 interactions may contribute to M-tropism of R5 HIV-1 strains through different structural mechanisms...
  21. ncbi request reprint HIV-1 entry inhibitors: classes, applications and factors affecting potency
    Jasminka Sterjovski
    Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
    Curr HIV Res 4:387-400. 2006
    ....
  22. pmc Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne 3001, Victoria, Australia
    J Virol 80:3684-91. 2006
    ..The persistence of CCR5-using HIV-1 in two CCR5delta32 homozygotes suggests the conserved CCR5 binding domain of Env is highly stable and provides new mechanistic insights important for HIV-1 transmission and persistence...
  23. pmc Tissue-specific sequence alterations in the human immunodeficiency virus type 1 envelope favoring CCR5 usage contribute to persistence of dual-tropic virus in the brain
    Lachlan Gray
    Macfarlane Burnet Institute for Medical Research and Public Health, Victoria, Australia
    J Virol 83:5430-41. 2009
    ....
  24. ncbi request reprint Characterization of interactions between transcription factors and a regulatory region spanning nt -320 to -281 of the HIV-1 LTR in T-lymphoid and non-T-lymphoid cells
    Lloyd A Pereira
    Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre, Utrecht, The Netherlands
    J Biomed Sci 9:68-81. 2002
    ..These findings suggest that this region is an important component of the HIV-1 LTR required for response to different cellular transcription factors...
  25. ncbi request reprint Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge
    Johanna Repits
    Department of Laboratory Medicine, Lund University, Sweden
    Virology 379:125-34. 2008
    ..In summary, this study suggests that R5 HIV-1 variants with increased gp120 net charge emerge in an opportunistic manner during severe immunodeficiency. Thus, we here propose a new mechanism by which HIV-1 may gain fitness...