Research Topics
Genomes and Genes | Brendan J JenkinsSummaryAffiliation: Ludwig Institute for Cancer Research Country: Australia Publications
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Publications
Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expressionBrendan J Jenkins
Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, Parkville, Victoria, Australia
Mol Cell Biol 24:1453-63. 2004....
Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signalingBrendan J Jenkins
Ludwig Institute for Cancer Research, Molecular Biology Laboratory, Victoria, Australia
Exp Hematol 30:1248-56. 2002..This study examined the specific contribution of gp130-mediated STAT1/3 signaling to the regulation of hematopoiesis...- The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesisBrendan J Jenkins
Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
Blood 105:3512-20. 2005.... - Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesisBrendan J Jenkins
Ludwig Institute for Cancer Research, Victoria, Australia
Blood 109:2380-8. 2007..Collectively, these data genetically define distinct roles of IL-6 and IL-11 in driving pathologic hematopoietic and lymphoid responses mediated by STAT3 hyperactivation... - Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant miceSaleela M Ruwanpura
Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash Univ, Clayton, Victoria, Australia
Am J Physiol Lung Cell Mol Physiol 302:L627-39. 2012..We propose that while discrete targeting of Stat3 may alleviate pulmonary inflammation, global targeting of IL-6 potentially represents a therapeutically advantageous approach to combat COPD phenotypes where emphysema predominates... - STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant miceMatthias Ernst
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
J Clin Invest 118:1727-38. 2008..Collectively, our data have identified IL-11 as a crucial cytokine promoting chronic gastric inflammation and associated tumorigenesis mediated by excessive activation of STAT3 and STAT1... - IL-6 regulates neutrophil trafficking during acute inflammation via STAT3Ceri A Fielding
Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
J Immunol 181:2189-95. 2008.... - IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammationRachel M McLoughlin
Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom
Proc Natl Acad Sci U S A 102:9589-94. 2005..Consequently, STAT3 plays a defining role in IL-6-mediated T cell migration... - Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27Christine Brender
Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
Blood 110:2528-36. 2007..We conclude that enhanced responses to TCR ligation by SOCS3-deficient CD8 T cells are not caused by aberrant TCR-signaling pathways but, rather, that increased IL-27 signaling drives unregulated proliferation in the absence of SOCS3... - LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signalingClaire J Greenhill
Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
Immunol Cell Biol 90:559-63. 2012..Collectively, the substantial transcriptional reprogramming of LPS-responsive genes in gp130(F/F) mice emphasizes non-haemopoietic gp130 signaling as a key regulator of systemic inflammatory responses during LPS-induced endotoxemia... - IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3Claire J Greenhill
Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
J Immunol 186:1199-208. 2011.... - Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signalingBrendan J Jenkins
Ludwig Institute for Cancer Research, Parkville, VIC 3050, Australia
Nat Med 11:845-52. 2005.... - Acquiring signalling specificity from the cytokine receptor gp130Matthias Ernst
Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
Trends Genet 20:23-32. 2004..The second mechanism is based on the capacity of certain cell types to integrate the often-conflicting information transduced by these two pathways, and to prevent pathological responses... - STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesisLouise M Judd
Department of Medicine, University of Melbourne at Western Hospital, Footscray 3001, Australia
Gastroenterology 131:1073-85. 2006..Furthermore, the interaction among STAT3, the microbial environment, and tumorigenesis was evaluated... - Interleukin-11 receptor signaling is required for normal bone remodelingNatalie A Sims
Department of Medicine at St Vincent s Hospital, The University of Melbourne, Fitzroy, Australia
J Bone Miner Res 20:1093-102. 2005..Furthermore, IL-11 signaling was not required for the effects of estradiol or estrogen deficiency on the mouse skeleton... - Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130Louise M Judd
Department of Medicine, University of Melbourne, Melbourne, Australia
Gastroenterology 126:196-207. 2004..We have developed a mouse model of gastric cancer that resembles human intestinal-type adenocarcinoma. The aim of this study was to determine the identity and temporal changes in mediators of IL-6 signaling regulating tumor development... - Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathwaysNatalie A Sims
Department of Medicine at St Vincent s Hospital, The University of Melbourne, Fitzroy, Victoria, Australia
J Clin Invest 113:379-89. 2004..Furthermore, the latter pathway can directly inhibit osteoclastogenesis in vivo... - Interleukin-6 promotes pulmonary emphysema associated with apoptosis in miceSaleela M Ruwanpura
Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Victoria, Australia
Am J Respir Cell Mol Biol 45:720-30. 2011..We propose that the discrete targeting of IL-6 signaling may provide an effective therapeutic strategy against human lung disease... - Gab3, a new DOS/Gab family member, facilitates macrophage differentiationIngrid Wolf
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Mol Cell Biol 22:231-44. 2002..These results suggest that Gab3 is important for macrophage differentiation and that differentiation requires the early phosphorylation of Gab2 followed by induction and subsequent phosphorylation of Gab3... - Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the beta-subunit of the GM-CSF receptorTimothy J Blake
Hanson Institute, Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia
J Leukoc Biol 72:1246-55. 2002..The implications of these data are discussed as are our findings that activated hbeta(c) mutants can functionally interact with certain other cytokine receptors...