Brendan J Jenkins

Summary

Affiliation: Ludwig Institute for Cancer Research
Country: Australia

Publications

  1. ncbi Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Molecular Biology Laboratory, Victoria, Australia
    Exp Hematol 30:1248-56. 2002
  2. pmc Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, Parkville, Victoria, Australia
    Mol Cell Biol 24:1453-63. 2004
  3. ncbi The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 105:3512-20. 2005
  4. ncbi Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Victoria, Australia
    Blood 109:2380-8. 2007
  5. doi Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash Univ, Clayton, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L627-39. 2012
  6. pmc STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
    Matthias Ernst
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    J Clin Invest 118:1727-38. 2008
  7. ncbi IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
    Ceri A Fielding
    Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 181:2189-95. 2008
  8. pmc IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
    Rachel M McLoughlin
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom
    Proc Natl Acad Sci U S A 102:9589-94. 2005
  9. doi IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Respirology 19:419-27. 2014
  10. ncbi Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27
    Christine Brender
    Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
    Blood 110:2528-36. 2007

Collaborators

Detail Information

Publications23

  1. ncbi Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Molecular Biology Laboratory, Victoria, Australia
    Exp Hematol 30:1248-56. 2002
    ..This study examined the specific contribution of gp130-mediated STAT1/3 signaling to the regulation of hematopoiesis...
  2. pmc Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, Parkville, Victoria, Australia
    Mol Cell Biol 24:1453-63. 2004
    ....
  3. ncbi The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Colon Molecular and Cell Biology Laboratory, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Blood 105:3512-20. 2005
    ....
  4. ncbi Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Victoria, Australia
    Blood 109:2380-8. 2007
    ..Collectively, these data genetically define distinct roles of IL-6 and IL-11 in driving pathologic hematopoietic and lymphoid responses mediated by STAT3 hyperactivation...
  5. doi Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash Univ, Clayton, Victoria, Australia
    Am J Physiol Lung Cell Mol Physiol 302:L627-39. 2012
    ..We propose that while discrete targeting of Stat3 may alleviate pulmonary inflammation, global targeting of IL-6 potentially represents a therapeutically advantageous approach to combat COPD phenotypes where emphysema predominates...
  6. pmc STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
    Matthias Ernst
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    J Clin Invest 118:1727-38. 2008
    ..Collectively, our data have identified IL-11 as a crucial cytokine promoting chronic gastric inflammation and associated tumorigenesis mediated by excessive activation of STAT3 and STAT1...
  7. ncbi IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
    Ceri A Fielding
    Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 181:2189-95. 2008
    ....
  8. pmc IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
    Rachel M McLoughlin
    Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Cardiff CF14 4XN, Wales, United Kingdom
    Proc Natl Acad Sci U S A 102:9589-94. 2005
    ..Consequently, STAT3 plays a defining role in IL-6-mediated T cell migration...
  9. doi IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Respirology 19:419-27. 2014
    ..We therefore evaluated a causal role for IL-17A in the IL-6-driven gp130(F/F) mouse model for spontaneous pulmonary inflammation and emphysema...
  10. ncbi Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27
    Christine Brender
    Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
    Blood 110:2528-36. 2007
    ..We conclude that enhanced responses to TCR ligation by SOCS3-deficient CD8 T cells are not caused by aberrant TCR-signaling pathways but, rather, that increased IL-27 signaling drives unregulated proliferation in the absence of SOCS3...
  11. doi LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling
    Claire J Greenhill
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Immunol Cell Biol 90:559-63. 2012
    ..Collectively, the substantial transcriptional reprogramming of LPS-responsive genes in gp130(F/F) mice emphasizes non-haemopoietic gp130 signaling as a key regulator of systemic inflammatory responses during LPS-induced endotoxemia...
  12. ncbi Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Parkville, VIC 3050, Australia
    Nat Med 11:845-52. 2005
    ....
  13. doi IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
    Claire J Greenhill
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    J Immunol 186:1199-208. 2011
    ....
  14. pmc Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    PLoS ONE 8:e78095. 2013
    ..In addition, we reveal that Mal differentially facilitates the anti-apoptotic, but not oxidant suppressive, activities of TLR4 in the lung, both of which appear to be essential for TLR4 to prevent the onset of emphysema. ..
  15. doi Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Victoria, Australia
    Am J Respir Cell Mol Biol 45:720-30. 2011
    ..We propose that the discrete targeting of IL-6 signaling may provide an effective therapeutic strategy against human lung disease...
  16. ncbi Acquiring signalling specificity from the cytokine receptor gp130
    Matthias Ernst
    Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Victoria 3050, Australia
    Trends Genet 20:23-32. 2004
    ..The second mechanism is based on the capacity of certain cell types to integrate the often-conflicting information transduced by these two pathways, and to prevent pathological responses...
  17. ncbi STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis
    Louise M Judd
    Department of Medicine, University of Melbourne at Western Hospital, Footscray 3001, Australia
    Gastroenterology 131:1073-85. 2006
    ..Furthermore, the interaction among STAT3, the microbial environment, and tumorigenesis was evaluated...
  18. ncbi Interleukin-11 receptor signaling is required for normal bone remodeling
    Natalie A Sims
    Department of Medicine at St Vincent s Hospital, The University of Melbourne, Fitzroy, Australia
    J Bone Miner Res 20:1093-102. 2005
    ..Furthermore, IL-11 signaling was not required for the effects of estradiol or estrogen deficiency on the mouse skeleton...
  19. ncbi Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130
    Louise M Judd
    Department of Medicine, University of Melbourne, Melbourne, Australia
    Gastroenterology 126:196-207. 2004
    ..We have developed a mouse model of gastric cancer that resembles human intestinal-type adenocarcinoma. The aim of this study was to determine the identity and temporal changes in mediators of IL-6 signaling regulating tumor development...
  20. pmc Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways
    Natalie A Sims
    Department of Medicine at St Vincent s Hospital, The University of Melbourne, Fitzroy, Victoria, Australia
    J Clin Invest 113:379-89. 2004
    ..Furthermore, the latter pathway can directly inhibit osteoclastogenesis in vivo...
  21. pmc Gab3, a new DOS/Gab family member, facilitates macrophage differentiation
    Ingrid Wolf
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 22:231-44. 2002
    ..These results suggest that Gab3 is important for macrophage differentiation and that differentiation requires the early phosphorylation of Gab2 followed by induction and subsequent phosphorylation of Gab3...
  22. doi Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers
    Hazel Tye
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Cancer Sci 104:1139-45. 2013
    ....
  23. ncbi Functional cross-talk between cytokine receptors revealed by activating mutations in the extracellular domain of the beta-subunit of the GM-CSF receptor
    Timothy J Blake
    Hanson Institute, Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia
    J Leukoc Biol 72:1246-55. 2002
    ..The implications of these data are discussed as are our findings that activated hbeta(c) mutants can functionally interact with certain other cytokine receptors...