M C Lawrence

Summary

Country: Australia

Publications

  1. ncbi The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein
    M C Lawrence
    Biomolecular Research Institute 343 Royal Parade Parkville Victoria 3052 Australia
    Structure 6:1553-61. 1998
  2. ncbi Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme
    J A Barbosa
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria, Australia
    J Mol Biol 303:405-21. 2000
  3. ncbi The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli
    T Izard
    Biomolecular Research Institute, Parkville, Australia
    Structure 2:361-9. 1994
  4. ncbi Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase
    M C Lawrence
    Biomolecular Research Institute, Parkville, Victoria, Australia
    J Mol Biol 266:381-99. 1997
  5. ncbi Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae
    P A Pilling
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Acta Crystallogr D Biol Crystallogr 54:1464-6. 1998
  6. ncbi The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli
    M Sahin-Toth
    Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, California 90095 1662, USA
    Biochemistry 40:13015-9. 2001
  7. ncbi Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells
    M C Lawrence
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107-2699, USA
    Mol Endocrinol 15:1758-67. 2001
  8. ncbi The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion
    L Chen
    Biomolecular Research Institute, Parkville, Victoria 3052, Australia
    Structure 9:255-66. 2001
  9. ncbi Crystallographic structure of allosterically inhibited phosphofructokinase at 7 A resolution
    P R Evans
    J Mol Biol 191:713-20. 1986
  10. ncbi Cloning, expression, and crystallization of the fusion protein of Newcastle disease virus
    L Chen
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Virology 290:290-9. 2001

Collaborators

  • J C Paton
  • T Izard
  • P R Evans
  • HOWARD KABACK
  • L Chen
  • L J Lawrence
  • M Sahin-Toth
  • P A Tulloch
  • P M Colman
  • J J Gorman
  • B J Smith
  • J A Barbosa
  • P A Pilling
  • T Nishio
  • J McKimm-Breschkin
  • L J Cosgrove
  • R DeGori
  • W R Jackson
  • E M Campi
  • H C Ooi
  • M Sommer
  • R Brossmer
  • S M Marcuccio
  • A D Ogunniyi
  • R A Lock
  • A M Berry

Detail Information

Publications10

  1. ncbi The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein
    M C Lawrence
    Biomolecular Research Institute 343 Royal Parade Parkville Victoria 3052 Australia
    Structure 6:1553-61. 1998
    ..PsaA is a putative ATP-binding cassette-type (ABC-type) binding protein involved in the uptake of Mn2+ and possibly Zn2+ and is considered to be both a potential drug target and and a candidate vaccine component...
  2. ncbi Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme
    J A Barbosa
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria, Australia
    J Mol Biol 303:405-21. 2000
    ....
  3. ncbi The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli
    T Izard
    Biomolecular Research Institute, Parkville, Australia
    Structure 2:361-9. 1994
    ..The enzyme plays an important role in the regulation of sialic acid metabolism in bacteria. The reverse reaction can be exploited for the synthesis of sialic acid and some of its derivatives...
  4. ncbi Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase
    M C Lawrence
    Biomolecular Research Institute, Parkville, Victoria, Australia
    J Mol Biol 266:381-99. 1997
    ..A fifth protein, MosA, is also confirmed to be a member of the sub-family although the involvement of an intermediate Schiff-base in its proposed reaction is unclear...
  5. ncbi Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae
    P A Pilling
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Acta Crystallogr D Biol Crystallogr 54:1464-6. 1998
    ..The crystals are rectangular rods and diffract to beyond 2.7 A resolution. The crystal space group is P212121 with unit-cell dimensions a = 59.9, b = 66.5 and c = 69.9 A...
  6. ncbi The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli
    M Sahin-Toth
    Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, California 90095 1662, USA
    Biochemistry 40:13015-9. 2001
    ..Moreover, the C-4 hydroxyl is identified as the major determinant of ligand binding, suggesting that sugar recognition in lactose permease may have evolved to discriminate primarily between gluco- and galactopyranosides...
  7. ncbi Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells
    M C Lawrence
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107-2699, USA
    Mol Endocrinol 15:1758-67. 2001
    ....
  8. ncbi The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion
    L Chen
    Biomolecular Research Institute, Parkville, Victoria 3052, Australia
    Structure 9:255-66. 2001
    ..The structure of NDV-F is fundamentally different than that of influenza virus hemagglutinin, in that the central coiled coil is in the opposite orientation with respect to the viral membrane...
  9. ncbi Crystallographic structure of allosterically inhibited phosphofructokinase at 7 A resolution
    P R Evans
    J Mol Biol 191:713-20. 1986
    ..It does not explain the heterotropic allosteric effects...
  10. ncbi Cloning, expression, and crystallization of the fusion protein of Newcastle disease virus
    L Chen
    Biomolecular Research Institute, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Virology 290:290-9. 2001
    ..Only the non-trypsin-treated product was thus suitable for crystallization and two crystal forms were obtained, diffracting to ca. 3.5 and 4.0 A, respectively. Both crystal forms were used in the structure determination...