Graeme I Lancaster

Summary

Country: Australia

Publications

  1. doi request reprint The immunomodulating role of exercise in metabolic disease
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia Electronic address
    Trends Immunol 35:262-9. 2014
  2. pmc Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, Australia
    PLoS ONE 7:e39100. 2012
  3. doi request reprint IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Biochem J 442:723-32. 2012
  4. pmc A proteomic analysis of C-reactive protein stimulated THP-1 monocytes
    Steffen U Eisenhardt
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Proteome Sci 9:1. 2011
  5. doi request reprint Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats
    Anna G Holmes
    Diabetes and Metabolism Division, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Endocrinol 198:367-74. 2008
  6. pmc HSP72 protects against obesity-induced insulin resistance
    Jason Chung
    Cellular and Molecular Metabolism Laboratory, Clinical Physiology, and Human Vascular Biology, Baker Heart Research Institute, Prahran, P O Box 6492, Victoria 8008, Australia
    Proc Natl Acad Sci U S A 105:1739-44. 2008
  7. pmc The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    PLoS ONE 9:e111524. 2014
  8. doi request reprint Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
    Michael J Kraakman
    Cellular and Molecular Metabolism Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia
    Cell Metab 21:403-16. 2015
  9. pmc Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue
    Hayley T Nicholls
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes 60:1100-10. 2011
  10. ncbi request reprint Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Endocrinology 147:2077-85. 2006

Collaborators

Detail Information

Publications13

  1. doi request reprint The immunomodulating role of exercise in metabolic disease
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia Electronic address
    Trends Immunol 35:262-9. 2014
    ..Here we review the anti-inflammatory and immunomodulatory mechanisms by which the beneficial effects of exercise on chronic metabolic diseases may be mediated. ..
  2. pmc Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, Australia
    PLoS ONE 7:e39100. 2012
    ..These findings argue that Tpl2 does not play a non-redundant role in obesity-associated metabolic dysfunction...
  3. doi request reprint IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Biochem J 442:723-32. 2012
    ....
  4. pmc A proteomic analysis of C-reactive protein stimulated THP-1 monocytes
    Steffen U Eisenhardt
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Proteome Sci 9:1. 2011
    ..The hypothesis to be tested was that mCRP induces specific changes in the protein expression profile of THP-1 cells that differ from that of pCRP...
  5. doi request reprint Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats
    Anna G Holmes
    Diabetes and Metabolism Division, Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Endocrinol 198:367-74. 2008
    ..Our results do not support the notion that prolonged chronically elevated IL-6 impairs insulin action in vivo...
  6. pmc HSP72 protects against obesity-induced insulin resistance
    Jason Chung
    Cellular and Molecular Metabolism Laboratory, Clinical Physiology, and Human Vascular Biology, Baker Heart Research Institute, Prahran, P O Box 6492, Victoria 8008, Australia
    Proc Natl Acad Sci U S A 105:1739-44. 2008
    ..These findings identify an essential role for HSP72 in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding...
  7. pmc The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice
    Graeme I Lancaster
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    PLoS ONE 9:e111524. 2014
    ..These data indicate that rather than DUSP2 being a pan regulator of MAPK dependent immune cell mediated inflammation, it appears to differentially regulate inflammatory responses that have a MAPK component. ..
  8. doi request reprint Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance
    Michael J Kraakman
    Cellular and Molecular Metabolism Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia
    Cell Metab 21:403-16. 2015
    ....
  9. pmc Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue
    Hayley T Nicholls
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes 60:1100-10. 2011
    ..Accordingly, we hypothesized that it plays a role in saturated fatty acid-induced macrophage lipid accumulation and proinflammatory activation...
  10. ncbi request reprint Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
    Endocrinology 147:2077-85. 2006
    ..These data support the use of CNTF as a potential therapeutic means to combat lipid-induced insulin resistance...
  11. pmc Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes
    Aino Soro-Paavonen
    Albert Einstein Juvenile Diabetes Research Foundation Centre for Diabetes Complications, Diabetes Metabolism Division, Baker Heart Research Institute, Melbourne, Australia
    Diabetes 57:2461-9. 2008
    ..This study examines the effects of deletion of RAGE on the development of atherosclerosis in the diabetic apoE(-/-) model of accelerated atherosclerosis...
  12. pmc Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1
    Martin Whitham
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    J Biol Chem 287:10771-9. 2012
    ..Importantly, exercise did not increase IL-6 mRNA expression in skeletal muscle-specific JNK-deficient mice. These data identify a novel contraction-mediated transcriptional regulatory pathway for IL-6 in skeletal muscle...
  13. pmc Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin
    Catherine E Winbanks
    Division of Metabolism and Obesity, Baker IDI Heart and Diabetes Institute, Victoria 3004, Australia
    J Cell Biol 197:997-1008. 2012
    ..These findings identify a critical role of Smad3/Akt/mTOR/S6K/S6RP signaling in follistatin-mediated muscle growth that operates independently of myostatin-driven mechanisms...