Gavin W Lambert

Summary

Country: Australia

Publications

  1. doi request reprint Sympathetic nervous activation in obesity and the metabolic syndrome--causes, consequences and therapeutic implications
    Gavin W Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Pharmacol Ther 126:159-72. 2010
  2. doi request reprint Health-related quality of life after renal denervation in patients with treatment-resistant hypertension
    Gavin W Lambert
    Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Hypertension 60:1479-84. 2012
  3. doi request reprint The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 96:E503-8. 2011
  4. pmc Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:1126-32. 2009
  5. ncbi request reprint Renal nerve ablation reduces augmentation index in patients with resistant hypertension
    Dagmara Hering
    aNeurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia bDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland cHeart Centre Alfred Hospital dDepartment of Epidemiology and Preventive Medicine eFaculty of Medicine, Nursing and Health Sciences and Department of Physiology, Monash University, Melbourne, Victoria, Australia fDepartment of Medicine and Cardiology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota gMedtronic ARDIAN Inc, Mountain View, California, USA hUniversitätsklinikum des Saarlandes, Homburg Saar, Germany
    J Hypertens 31:1893-900. 2013
  6. pmc Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 59:71-9. 2010
  7. pmc Neuroadrenergic dysfunction along the diabetes continuum: a comparative study in obese metabolic syndrome subjects
    Nora E Straznicky
    Laboratory of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 61:2506-16. 2012
  8. pmc Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
    Elisabeth A Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Physiol 589:2597-605. 2011
  9. doi request reprint Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters and Heart Failure Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Am J Clin Nutr 89:27-36. 2009
  10. doi request reprint Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension
    Dagmara Hering
    Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    Hypertension 61:457-64. 2013

Detail Information

Publications42

  1. doi request reprint Sympathetic nervous activation in obesity and the metabolic syndrome--causes, consequences and therapeutic implications
    Gavin W Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Pharmacol Ther 126:159-72. 2010
    ..Importantly, the benefit may not necessarily be weight related but may be associated with a reduction in end organ damage...
  2. doi request reprint Health-related quality of life after renal denervation in patients with treatment-resistant hypertension
    Gavin W Lambert
    Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Hypertension 60:1479-84. 2012
    ..In this pre- and post-hypothesis generating study, several aspects of QoL were improved after renal denervation; however, this was not directly associated with the magnitude of BP reduction...
  3. doi request reprint The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 96:E503-8. 2011
    ..Sympathetic nervous system (SNS) overactivity participates in both the pathogenesis and adverse clinical complications of metabolic syndrome (MetS) obesity...
  4. pmc Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 58:1126-32. 2009
    ..The purpose of this study was to examine the effects of weight loss on sympathetic nervous system responsiveness to glucose ingestion in obese subjects with metabolic syndrome, in whom such responses are reportedly blunted...
  5. ncbi request reprint Renal nerve ablation reduces augmentation index in patients with resistant hypertension
    Dagmara Hering
    aNeurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia bDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland cHeart Centre Alfred Hospital dDepartment of Epidemiology and Preventive Medicine eFaculty of Medicine, Nursing and Health Sciences and Department of Physiology, Monash University, Melbourne, Victoria, Australia fDepartment of Medicine and Cardiology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota gMedtronic ARDIAN Inc, Mountain View, California, USA hUniversitätsklinikum des Saarlandes, Homburg Saar, Germany
    J Hypertens 31:1893-900. 2013
    ..Whether alterations of arterial stiffness may contribute to BP-lowering effects of RDN is unknown...
  6. pmc Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 59:71-9. 2010
    ..This study was conducted to examine the effects of lifestyle interventions (weight loss alone or together with exercise) on SNS function...
  7. pmc Neuroadrenergic dysfunction along the diabetes continuum: a comparative study in obese metabolic syndrome subjects
    Nora E Straznicky
    Laboratory of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes 61:2506-16. 2012
    ..35, P = 0.047). These findings demonstrate that progression to T2D is associated with increased central sympathetic drive, blunted sympathetic responsiveness, and altered norepinephrine disposition...
  8. pmc Single-unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
    Elisabeth A Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Physiol 589:2597-605. 2011
    ..05). This study indicates that multiple within-burst firing and increased single-unit firing rates of the sympathetic outflow to the skeletal muscle vasculature is associated with high cardiac noradrenaline spillover...
  9. doi request reprint Blunted sympathetic neural response to oral glucose in obese subjects with the insulin-resistant metabolic syndrome
    Nora E Straznicky
    Human Neurotransmitters and Heart Failure Division, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Am J Clin Nutr 89:27-36. 2009
    ..Glucose ingestion stimulates sympathetic nervous system (SNS) activity in lean subjects, whereas blunted responses have been reported in the obese...
  10. doi request reprint Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension
    Dagmara Hering
    Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    Hypertension 61:457-64. 2013
    ..Whether the earlier changes in single-unit firing patterns may predict long-term BP response to RDN warrants further exploration...
  11. doi request reprint Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals
    Nora E Straznicky
    Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    J Hypertens 29:553-64. 2011
    ..This study was conducted to examine the effects of lifestyle interventions on renal parameters and putative metabolic, neuroadrenergic and hemodynamic mediators of renal injury...
  12. doi request reprint The relation of glucose metabolism to left ventricular mass and function and sympathetic nervous system activity in obese subjects with metabolic syndrome
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria, Australia a
    J Clin Endocrinol Metab 98:E227-37. 2013
    ..Altered cardiac structure and function have been reported in prediabetic and diabetic populations; however, the contribution of the sympathetic nervous system (SNS) to these changes has yet to be delineated...
  13. doi request reprint Baseline sympathetic nervous system activity predicts dietary weight loss in obese metabolic syndrome subjects
    Nora E Straznicky
    Laboratory of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 97:605-13. 2012
    ..The sympathetic nervous system is an important physiological modulator of basal and postprandial energy expenditure...
  14. doi request reprint Renal sympathetic activation from long-term low-dose angiotensin II infusion in rabbits
    John Luis Moretti
    Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Hypertens 30:551-60. 2012
    ..We examined whether the function of central pathways influencing sympathetic activity is altered in conscious rabbits given a low dose of AngII that produces a modest hypertension and, therefore, limited secondary complications...
  15. ncbi request reprint The role of sympathetic nervous activity in renal injury and end-stage renal disease
    Kazuko Masuo
    Nucleus Network Ltd, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Hypertens Res 33:521-8. 2010
    ..These insights may be useful to improve prevention and treatment of renal injury in these patients...
  16. doi request reprint Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise
    Kazuko Masuo
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Hypertens Res 35:41-7. 2012
    ..D and EX might, perhaps, exert different mechanisms on weight loss and weight loss-induced BP reduction; however, a combination of caloric restriction and exercise is preferred to control BP levels in obese hypertensive patients...
  17. doi request reprint Enhanced responses to ganglion blockade do not reflect sympathetic nervous system contribution to angiotensin II-induced hypertension
    John Luis Moretti
    Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Hypertens 27:1838-48. 2009
    ....
  18. ncbi request reprint Cardiovascular and renal complications of type 2 diabetes in obesity: role of sympathetic nerve activity and insulin resistance
    Kazuko Masuo
    Nucleus Network Ltd, Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria 3004, Australia
    Curr Diabetes Rev 6:58-67. 2010
    ..Further, to clarify the pathogenesis and mechanisms of the association between obesity, diabetes, and hypertension may lead to reductions in cardiovascular and renal risk...
  19. ncbi request reprint Leptin-receptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic nerve activation in a Caucasian male population
    Kazuko Masuo
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 31:1093-100. 2008
    ..We therefore hypothesize that leptin-receptor play a role in the development of obesity through leptin resistance and blunted leptin-mediated sympathetic nerve activity...
  20. ncbi request reprint Effects of weight loss on renal function in overweight Japanese men
    Kazuko Masuo
    Human Neurotransmitters Laboratory, Melbourne, Victoria, Australia
    Hypertens Res 34:915-21. 2011
    ..Suppression of sympathetic nervous activation associated with WL may have a role in the ameliorative effects on renal function...
  21. ncbi request reprint Specific serotonin reuptake inhibition in major depressive disorder adversely affects novel markers of cardiac risk
    Tye Dawood
    Baker Heart Research Institute, Melbourne, Australia
    Hypertens Res 30:285-93. 2007
    ..Mechanisms potentially responsible for generating cardiac risk in patients treated with selective serotonin reuptake inhibitors may need to be therapeutically targeted to reduce the incidence of coronary heart disease in this population...
  22. ncbi request reprint The effects of dietary weight loss on indices of norepinephrine turnover: modulatory influence of hyperinsulinemia
    Nora E Straznicky
    Laboratories of Human Neurotransmitters, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Obesity (Silver Spring) 22:652-62. 2014
    ..This study was conducted to examine (1) the effects of dietary weight loss on indices of norepinephrine (NE) turnover and (2) whether baseline hyperinsulinemia modulates sympathetic neural adaptations...
  23. doi request reprint Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy
    David A Barton
    Department of Psychological Medicine, Alfred Hospital, Monash University, Melbourne, Victoria, Australia
    Arch Gen Psychiatry 65:38-46. 2008
    ..The biological basis for the development of major depressive disorder (MDD) remains incompletely understood...
  24. ncbi request reprint Effects of dietary weight loss on sympathetic activity and cardiac risk factors associated with the metabolic syndrome
    Nora E Straznicky
    Cardiovascular Nutrition Laboratory, Wynn Domain, Baker Heart Research Institute, P O Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Clin Endocrinol Metab 90:5998-6005. 2005
    ....
  25. ncbi request reprint Sustained sympathetic and blood pressure reduction 1 year after renal denervation in patients with resistant hypertension
    Dagmara Hering
    From the Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia D H, P M, E A L, G W L, M D E, M P S Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland D H, K N Heart Centre Alfred Hospital, Melbourne, Australia A S W, H K, M D E, M P S and Department of Physiology, Faculty of Medicine, Nursing and Health Sciences E A L, G W L, M P S and Department of Epidemiology and Preventive Medicine H K, Monash University, Melbourne, Australia
    Hypertension 64:118-24. 2014
    ..These observations are compatible with the hypothesis of a substantial contribution of afferent renal nerve signaling to increased BP in resistant hypertension and argue against a relevant reinnervation at 1 year after procedure. ..
  26. doi request reprint Feasibility of catheter-based renal nerve ablation and effects on sympathetic nerve activity and blood pressure in patients with end-stage renal disease
    Markus P Schlaich
    Neurovascular Hypertension and Kidney Disease and Human Neurotransmitters Laboratories Baker IDI Heart and Diabetes Institute, Alfred Hospital, Melbourne, Australia Heart Centre, Alfred Hospital, Melbourne, Australia Faculty of Medicine, Nursing and Health Sciences and Department of Physiology, Monash University, Melbourne, Victoria, Australia Electronic address
    Int J Cardiol 168:2214-20. 2013
    ..Efferent sympathetic outflow and afferent neural signalling from the failing native kidneys are key mediators and can be targeted by renal denervation (RDN). Whether this is feasible and effective in ESRD is not known...
  27. pmc Renal denervation in moderate to severe CKD
    Dagmara Hering
    Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    J Am Soc Nephrol 23:1250-7. 2012
    ..In conclusion, this study suggests a favorable short-term safety profile and beneficial BP effects of catheter-based renal nerve ablation in patients with stage 3-4 CKD and resistant hypertension...
  28. pmc Effects of selective serotonin reuptake inhibitor treatment on plasma oxytocin and cortisol in major depressive disorder
    Charlotte Keating
    Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and the Alfred, Melbourne, Australia
    BMC Psychiatry 13:124. 2013
    ..g., oxytocin and cortisol) and MDD. Our objective was to measure oxytocin and cortisol in patients with MDD before and following treatment with selective serotonin reuptake inhibitors, SSRI...
  29. ncbi request reprint Surgical approaches to the treatment of obesity
    John B Dixon
    Baker IDI Heart and Diabetes Institute, PO Box 6492 St Kilda Road Central, Melbourne, VIC 3004, Australia
    Nat Rev Gastroenterol Hepatol 8:429-37. 2011
    ..Gastroenterologists also need to be familiar with the risks and benefits of current and emerging procedures as they are likely to be increasingly involved in the integrated care of these patients...
  30. doi request reprint Raised CRP levels in obese patients: symptoms of depression have an independent positive association
    John B Dixon
    Centre for Obesity Research and Education, Monash University, Alfred Hospital, Melbourne, Victoria, Australia
    Obesity (Silver Spring) 16:2010-5. 2008
    ..Are the effects of depression and obesity related or do they influence CRP levels independently?..
  31. doi request reprint A sympathetic view of human obesity
    Elisabeth A Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia
    Clin Auton Res 23:9-14. 2013
    ..Targeting the SNS may be an attractive and important avenue for the pharmacological treatment of obesity-related disturbances...
  32. pmc Predicting the glycemic response to gastric bypass surgery in patients with type 2 diabetes
    John B Dixon
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Diabetes Care 36:20-6. 2013
    ..Predicting the improvement in glycemic control in those with type 2 diabetes after bariatric surgery may help in patient selection...
  33. doi request reprint Neuroadrenergic dysfunction in obesity: an overview of the effects of weight loss
    Nora E Straznicky
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Curr Opin Lipidol 21:21-30. 2010
    ..Weight loss is recommended as first-line treatment for obesity. This review examines the effects of nonpharmacological weight loss on sympathetic nervous system function under basal and stimulated conditions...
  34. doi request reprint Stress and its role in sympathetic nervous system activation in hypertension and the metabolic syndrome
    Elisabeth A Lambert
    Human Neurotransmitters Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, VIC 8008, Australia
    Curr Hypertens Rep 13:244-8. 2011
    ..Notably, evidence of subclinical organ damage is evident even in young, normotensive, overweight persons, thereby reinforcing the need to develop and implement effective early intervention...
  35. ncbi request reprint Sympathetic and cardiac baroreflex function in panic disorder
    Elisabeth A Lambert
    Human Neurotransmitter Laboratory, Baker Heart Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia
    J Hypertens 20:2445-51. 2002
    ..The cause is not known, but possibly involves sympathetic nervous activation. In this study, we evaluated the arterial baroreflex control of vascular sympathetic nervous outflow and cardiac baroreflex function in panic disorder patients...
  36. ncbi request reprint Paradoxical structural effects in the unilaterally denervated spontaneously hypertensive rat kidney
    Amany Shweta
    Department of Physiology, Monash University, Victoria, Australia
    J Hypertens 23:851-9. 2005
    ..To determine the effects of chronic denervation on renal vascular structure and function in young adult spontaneously hypertensive rats (SHRs)...
  37. pmc Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome
    Elisabeth Lambert
    Human Neurotransmitters, Baker IDI Heart and Diabetes Institute Melbourne, Vic, Australia
    Front Physiol 2:52. 2011
    ..The sympathoinhibition associated with weight loss involves marked changes, not only in the rate but also in the firing pattern of active vasoconstrictive fibers...
  38. ncbi request reprint Renal sympathetic neuroeffector function in renovascular and angiotensin II-dependent hypertension in rabbits
    Sandra L Burke
    Baker Heart Research Institute, Melbourne, Australia
    Hypertension 49:932-8. 2007
    ..This effect appears to be mediated postjunctionally, not through enhanced neural norepinephrine release, and may contribute to the development and/or maintenance of hypertension in these models...
  39. doi request reprint Severely obese people with diabetes experience impaired emotional well-being associated with socioeconomic disadvantage: results from diabetes MILES - Australia
    John B Dixon
    Clinical Obesity Research, Baker IDI Heart and Diabetes Institute, Melbourne, Australia
    Diabetes Res Clin Pract 101:131-40. 2013
    ..To examine the emotional well-being of severely obese Australians with type 2 diabetes, along with markers of social and economic disadvantage, using the Diabetes MILES - Australia dataset...
  40. ncbi request reprint Evidence for increased atrial sympathetic innervation in persistent human atrial fibrillation
    Paul A Gould
    Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Vic, Australia
    Pacing Clin Electrophysiol 29:821-9. 2006
    ..In this study, we aimed to compare the level of atrial sympathetic innervation in human atrial fibrillation (AF) to that in sinus rhythm (SR)...
  41. pmc Relationships of adrenoceptor polymorphisms with obesity
    Kazuko Masuo
    Nucleus Network, Ltd, Baker IDI Heart and Diabetes Research Institute, 89 Commercial Road, Melbourne, VIC 3004, Australia
    J Obes 2011:609485. 2011
    ..This paper will discuss the current topics involving the influence of the sympathetic nervous system and β2- and β3-adrenoceptor polymorphisms in obesity...
  42. ncbi request reprint Norepinephrine turnover is increased in suprabulbar subcortical brain regions and is related to whole-body sympathetic activity in human heart failure
    Anuradha Aggarwal
    Baker Medical Research Institute, Melbourne, Australia
    Circulation 105:1031-3. 2002
    ....