N J Hoogenraad

Summary

Affiliation: La Trobe University
Country: Australia

Publications

  1. pmc A mitochondrial specific stress response in mammalian cells
    Quan Zhao
    Department of Biochemistry, La Trobe University, Melbourne, Victoria 3086, Australia
    EMBO J 21:4411-9. 2002
  2. ncbi request reprint Import and assembly of proteins into mitochondria of mammalian cells
    Nicholas J Hoogenraad
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    Biochim Biophys Acta 1592:97-105. 2002
  3. ncbi request reprint Translocation of proteins into mitochondria
    N J Hoogenraad
    Department of Biochemistry, La Trobe University, Melbourne, Australia
    IUBMB Life 51:345-50. 2001
  4. ncbi request reprint The complete primary structure of rat chaperonin 10 reveals a putative beta alpha beta nucleotide-binding domain with homology to p21ras
    D J Hartman
    Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    Biochim Biophys Acta 1164:219-22. 1993
  5. ncbi request reprint hTom34: a novel translocase for the import of proteins into human mitochondria
    S D Nuttall
    School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    DNA Cell Biol 16:1067-74. 1997
  6. ncbi request reprint Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence
    M T Ryan
    Department of Biochemistry, La Trobe University, Bundoora, Vic, Australia
    FEBS Lett 337:152-6. 1994
  7. ncbi request reprint The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoter
    M T Ryan
    School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    Gene 196:9-17. 1997
  8. ncbi request reprint A constitutive form of heat-shock protein 70 is located in the outer membranes of mitochondria from rat liver
    T Lithgow
    Department of Biochemistry, La Trobe University, Bundoora, Australia
    FEBS Lett 332:277-81. 1993
  9. ncbi request reprint cDNA cloning and efficient mitochondrial import of pre-mtHSP70 from rat liver
    T J Webster
    School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    DNA Cell Biol 13:1213-20. 1994
  10. ncbi request reprint Mitochondrial-nuclear communications
    Michael T Ryan
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    Annu Rev Biochem 76:701-22. 2007

Collaborators

Detail Information

Publications22

  1. pmc A mitochondrial specific stress response in mammalian cells
    Quan Zhao
    Department of Biochemistry, La Trobe University, Melbourne, Victoria 3086, Australia
    EMBO J 21:4411-9. 2002
    ....
  2. ncbi request reprint Import and assembly of proteins into mitochondria of mammalian cells
    Nicholas J Hoogenraad
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    Biochim Biophys Acta 1592:97-105. 2002
    ..We also discuss diseases associated with defects in import and assembly of mitochondrial proteins and what is currently known about the regulation of import in mammals...
  3. ncbi request reprint Translocation of proteins into mitochondria
    N J Hoogenraad
    Department of Biochemistry, La Trobe University, Melbourne, Australia
    IUBMB Life 51:345-50. 2001
    ....
  4. ncbi request reprint The complete primary structure of rat chaperonin 10 reveals a putative beta alpha beta nucleotide-binding domain with homology to p21ras
    D J Hartman
    Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    Biochim Biophys Acta 1164:219-22. 1993
    ..This similarity may be the structural basis for the recently discovered complex between p21ras and chaperonin 60 in intact cells (Ikawa, S. and Weinberg, R.A. (1992) Proc. Natl. Acad. Sci. USA 89, 2012-2016)...
  5. ncbi request reprint hTom34: a novel translocase for the import of proteins into human mitochondria
    S D Nuttall
    School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    DNA Cell Biol 16:1067-74. 1997
    ....
  6. ncbi request reprint Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence
    M T Ryan
    Department of Biochemistry, La Trobe University, Bundoora, Vic, Australia
    FEBS Lett 337:152-6. 1994
    ..Incubation of 3H- or 35S-labelled cpn10 with mitochondria confirms these conclusions and shows that cpn10 is imported into mitochondria in an energy-dependent process which is inhibited by the presence of 2,4-dinitrophenol...
  7. ncbi request reprint The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoter
    M T Ryan
    School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    Gene 196:9-17. 1997
    ....
  8. ncbi request reprint A constitutive form of heat-shock protein 70 is located in the outer membranes of mitochondria from rat liver
    T Lithgow
    Department of Biochemistry, La Trobe University, Bundoora, Australia
    FEBS Lett 332:277-81. 1993
    ..A sensitive immunoassay with an anti-HSP73 monoclonal antibody, revealed the association of HSP73 with mitochondrial outer membrane vesicles at a level similar to that of preprotein import receptors...
  9. ncbi request reprint cDNA cloning and efficient mitochondrial import of pre-mtHSP70 from rat liver
    T J Webster
    School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    DNA Cell Biol 13:1213-20. 1994
    ..We show that the precursor of mtHSP70 is efficiently imported into isolated mitochondria from rat liver and processed from 74 kD to the mature 69-kD protein...
  10. ncbi request reprint Mitochondrial-nuclear communications
    Michael T Ryan
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    Annu Rev Biochem 76:701-22. 2007
    ..This review covers the mechanisms of mitochondrial biogenesis and the way cells respond to external signals to maintain mitochondrial function and cellular homeostasis...
  11. ncbi request reprint Import of nuclear-encoded proteins into mitochondria
    Diana Stojanovski
    Department of Biochemistry, La Trobe University 3086, Melbourne, Australia
    Exp Physiol 88:57-64. 2003
    ..We also outline the various targeting pathways that preproteins can take in order to reach their appropriate sub-mitochondrial compartment...
  12. ncbi request reprint Dissection of the mitochondrial import and assembly pathway for human Tom40
    Adam D Humphries
    Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
    J Biol Chem 280:11535-43. 2005
    ..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies...
  13. ncbi request reprint Comparison of native and mutant proteins provides a sequence-specific assignment of the cysteinyl ligand proton NMR resonances in the 2[Fe4S4] ferredoxin from Clostridium pasteurianum
    S D Scrofani
    Department of Chemistry, La Trobe University, Bundoora, Victoria, Australia
    Biochemistry 33:14486-95. 1994
    ..Each of the eight low-field resonances is assigned to a beta-proton from a different cysteinyl ligand, and so connectivities established from previous TOCSY and HMQC data allow assignment of all 24 cysteinyl ligand protons...
  14. ncbi request reprint Affinity-purification and identification of GrpE homologues from mammalian mitochondria
    D J Naylor
    School of Biochemistry, La Trobe University, Bundoora, Vic, Australia
    Biochim Biophys Acta 1248:75-9. 1995
    ..cerevisiae and about 30% identity to the bacterial counterparts. Thus, GrpE homologues from higher and lower eukaryotes are highly conserved...
  15. ncbi request reprint A (1-->4)-beta-mannan-specific monoclonal antibody and its use in the immunocytochemical location of galactomannans
    F A Pettolino
    Department of Biochemistry, La Trobe University, Victoria, Australia
    Planta 214:235-42. 2001
    ..The pattern and intensity of antibody labelling varied for each type of coconut at the mature and immature stages, indicating differences in the galactomannan composition of the endosperm walls...
  16. pmc Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements
    Jonathan E Aldridge
    Department of Biochemistry, La Trobe University, Melbourne, Victoria, Australia
    PLoS ONE 2:e874. 2007
    ..Mutation of each of these elements substantially reduced the mtUPR responsiveness of the promoters suggesting that these elements coordinately regulate mtUPR...
  17. pmc Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro
    D J Hartman
    Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
    Proc Natl Acad Sci U S A 89:3394-8. 1992
    ..The Cpn-mediated protein-folding apparatus, thus, exhibits a high degree of conservation between prokaryotes and mitochondria of higher eukaryotes...
  18. ncbi request reprint Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane
    Amelia J Johnston
    Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
    J Biol Chem 277:42197-204. 2002
    ..These results indicate that the levels of Tom22 within mitochondria dictate the assembly of TOM complexes and hence may regulate its biogenesis...
  19. ncbi request reprint Mitochondrial morphology and distribution in mammalian cells
    Ann E Frazier
    Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
    Biol Chem 387:1551-8. 2006
    ..Here we review our current understanding of the functions of the main players involved in mitochondrial fission, fusion and distribution in mammalian cells...
  20. pmc The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response
    Tomohisa Horibe
    Department of Biochemistry, La Trobe University, Melbourne, Victoria, Australia
    PLoS ONE 2:e835. 2007
    ..Thus CHOP can be induced separately in response to 2 different stress response pathways. We also discuss the potential signal pathway between mitochondria and the nucleus for the mtUPR...
  21. ncbi request reprint Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
    Jason C Young
    Cellular Biochemistry, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 112:41-50. 2003
    ..We outline a novel mechanism in which chaperones are recruited for a specific targeting event by a membrane-bound receptor...
  22. ncbi request reprint Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70
    Stewart D Nuttall
    CSIRO Health Sciences and Nutrition, Parkville, Victoria, Australia
    Eur J Biochem 270:3543-54. 2003
    ....