Research Topics
| N J HoogenraadSummaryAffiliation: La Trobe University Country: Australia Publications
| Collaborators
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Detail Information
Publications
A mitochondrial specific stress response in mammalian cellsQuan Zhao
Department of Biochemistry, La Trobe University, Melbourne, Victoria 3086, Australia
EMBO J 21:4411-9. 2002....
Import and assembly of proteins into mitochondria of mammalian cellsNicholas J Hoogenraad
Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
Biochim Biophys Acta 1592:97-105. 2002..We also discuss diseases associated with defects in import and assembly of mitochondrial proteins and what is currently known about the regulation of import in mammals...- Translocation of proteins into mitochondriaN J Hoogenraad
Department of Biochemistry, La Trobe University, Melbourne, Australia
IUBMB Life 51:345-50. 2001.... - The complete primary structure of rat chaperonin 10 reveals a putative beta alpha beta nucleotide-binding domain with homology to p21rasD J Hartman
Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
Biochim Biophys Acta 1164:219-22. 1993..This similarity may be the structural basis for the recently discovered complex between p21ras and chaperonin 60 in intact cells (Ikawa, S. and Weinberg, R.A. (1992) Proc. Natl. Acad. Sci. USA 89, 2012-2016)... - hTom34: a novel translocase for the import of proteins into human mitochondriaS D Nuttall
School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
DNA Cell Biol 16:1067-74. 1997.... - Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequenceM T Ryan
Department of Biochemistry, La Trobe University, Bundoora, Vic, Australia
FEBS Lett 337:152-6. 1994..Incubation of 3H- or 35S-labelled cpn10 with mitochondria confirms these conclusions and shows that cpn10 is imported into mitochondria in an energy-dependent process which is inhibited by the presence of 2,4-dinitrophenol... - The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoterM T Ryan
School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
Gene 196:9-17. 1997.... - A constitutive form of heat-shock protein 70 is located in the outer membranes of mitochondria from rat liverT Lithgow
Department of Biochemistry, La Trobe University, Bundoora, Australia
FEBS Lett 332:277-81. 1993..A sensitive immunoassay with an anti-HSP73 monoclonal antibody, revealed the association of HSP73 with mitochondrial outer membrane vesicles at a level similar to that of preprotein import receptors... - cDNA cloning and efficient mitochondrial import of pre-mtHSP70 from rat liverT J Webster
School of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
DNA Cell Biol 13:1213-20. 1994..We show that the precursor of mtHSP70 is efficiently imported into isolated mitochondria from rat liver and processed from 74 kD to the mature 69-kD protein... - Mitochondrial-nuclear communicationsMichael T Ryan
Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
Annu Rev Biochem 76:701-22. 2007..This review covers the mechanisms of mitochondrial biogenesis and the way cells respond to external signals to maintain mitochondrial function and cellular homeostasis... - Import of nuclear-encoded proteins into mitochondriaDiana Stojanovski
Department of Biochemistry, La Trobe University 3086, Melbourne, Australia
Exp Physiol 88:57-64. 2003..We also outline the various targeting pathways that preproteins can take in order to reach their appropriate sub-mitochondrial compartment... - Dissection of the mitochondrial import and assembly pathway for human Tom40Adam D Humphries
Department of Biochemistry, La Trobe University, Melbourne 3086, Australia
J Biol Chem 280:11535-43. 2005..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies... - Comparison of native and mutant proteins provides a sequence-specific assignment of the cysteinyl ligand proton NMR resonances in the 2[Fe4S4] ferredoxin from Clostridium pasteurianumS D Scrofani
Department of Chemistry, La Trobe University, Bundoora, Victoria, Australia
Biochemistry 33:14486-95. 1994..Each of the eight low-field resonances is assigned to a beta-proton from a different cysteinyl ligand, and so connectivities established from previous TOCSY and HMQC data allow assignment of all 24 cysteinyl ligand protons... - Affinity-purification and identification of GrpE homologues from mammalian mitochondriaD J Naylor
School of Biochemistry, La Trobe University, Bundoora, Vic, Australia
Biochim Biophys Acta 1248:75-9. 1995..cerevisiae and about 30% identity to the bacterial counterparts. Thus, GrpE homologues from higher and lower eukaryotes are highly conserved... - A (1-->4)-beta-mannan-specific monoclonal antibody and its use in the immunocytochemical location of galactomannansF A Pettolino
Department of Biochemistry, La Trobe University, Victoria, Australia
Planta 214:235-42. 2001..The pattern and intensity of antibody labelling varied for each type of coconut at the mature and immature stages, indicating differences in the galactomannan composition of the endosperm walls... - Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elementsJonathan E Aldridge
Department of Biochemistry, La Trobe University, Melbourne, Victoria, Australia
PLoS ONE 2:e874. 2007..Mutation of each of these elements substantially reduced the mtUPR responsiveness of the promoters suggesting that these elements coordinately regulate mtUPR... - Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitroD J Hartman
Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia
Proc Natl Acad Sci U S A 89:3394-8. 1992..The Cpn-mediated protein-folding apparatus, thus, exhibits a high degree of conservation between prokaryotes and mitochondria of higher eukaryotes... - Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membraneAmelia J Johnston
Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
J Biol Chem 277:42197-204. 2002..These results indicate that the levels of Tom22 within mitochondria dictate the assembly of TOM complexes and hence may regulate its biogenesis... - Mitochondrial morphology and distribution in mammalian cellsAnn E Frazier
Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
Biol Chem 387:1551-8. 2006..Here we review our current understanding of the functions of the main players involved in mitochondrial fission, fusion and distribution in mammalian cells... - The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein responseTomohisa Horibe
Department of Biochemistry, La Trobe University, Melbourne, Victoria, Australia
PLoS ONE 2:e835. 2007..Thus CHOP can be induced separately in response to 2 different stress response pathways. We also discuss the potential signal pathway between mitochondria and the nucleus for the mtUPR... - Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70Jason C Young
Cellular Biochemistry, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
Cell 112:41-50. 2003..We outline a novel mechanism in which chaperones are recruited for a specific targeting event by a membrane-bound receptor... - Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70Stewart D Nuttall
CSIRO Health Sciences and Nutrition, Parkville, Victoria, Australia
Eur J Biochem 270:3543-54. 2003....